Conserved Protein Domain Family
YjgF_YER057c_UK114_like_1

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cd02199: YjgF_YER057c_UK114_like_1 
Click on image for an interactive view with Cn3D
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Statistics
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PSSM-Id: 100006
View PSSM: cd02199
Aligned: 100 rows
Threshold Bit Score: 72.4927
Threshold Setting Gi: 120402342
Created: 8-Feb-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
homotrimerputative active
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Structure:2OTM; Shewanella oneidensis putative endoribonuclease trimer
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                           ##  # #  # # ##                                              
2OTM_A        12 AAGLELPEVAAAlg----nYEPYSIVGSQLXTSGQFPylq---gklLYQGQLGady-tvSEGYAACRLATLNAIAQLKQA 83
gi 89055935   10 DLGLRLPPPTRLpdglhlpFALINLRGDRLLFSGHPKtard-gsigGPFGTLGadm-stDQGYAEARDILLSVLANMKAE 87
gi 111021001   9 DLGLVLPRAVQLppgvelpFSWVRVHGRRVLVSGHGPlaed-gtpaGPFGSVPadv-saADATHSARLTALAVLAGVRRA 86
gi 86356114   10 EMGLELPEPLKVrdglklpFTWVRVRGSRAYISGHVAcnpd-gtlaKPLGKVGaev-spEQGYASARLVALAHLASLKRA 87
gi 149173199   9 ELGLVFEPIEPGy------LKLCIRSGNQLLTSGHVS---------DQKGRLGenv-svEEGQAAARDCAIKILRSVRDE 72
gi 126728594  11 EMGLDLPPSAPSra----lFLPGKITGNLLFLSGQICewe---gepKYFGPVAdgf-dmAEGQAAARMCALNLLFCIKKV 82
gi 163734393  11 KLGLELPPDWTPrg----qFLPFRRDGAIVYLSGQICewd---gavTHTGPAQdtpegiKTARKAAQICALNLLYRLREA 83
gi 87311075   10 ELGFPVERTTPEgs----lVDAVSTVGNLLYASGQVPfdg---dqlKYVGKVPtev-slDDATQAAALCTANILRAVRKE 81
gi 168702857  10 AAGFPLDRGPKEgp----vIDLLSVLGDTVYASGQVPyda---gvlTSKGKVPsqv-svEEATRAAALCAANILRAVVLK 81
gi 116254529  12 DMSIVLGGYREPas----rYKPAIRVGNLLYFSGQLSameydgvvaGITGQLGsei-gvDAGYEAARQCAIGLLNRAQTM 86
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                 # ## # #              #  #   #         #########         # # #  
2OTM_A        84 c-GELSrIKQIYRLEGVLNVHQSCIEHPKALDGASDLLLEIFGe--aGRHSRXIWTNpVXPLNSLCLVYLFAE 153
gi 89055935   88 i-DELSrITGWTRVFGMVTSAPGYTEQHLVVNGFSDLVVEVFGpe-iGRHARSAIGVaALPLGFAMEIEGEVS 158
gi 111021001  87 v-GDLDlIGAWLTVTGFVNAEPGYDQTTAVLNGFSEVVLDVFGpd-vGDHARTAIGVaALPLNLPVVVAAELE 157
gi 86356114   88 v-GDLDrVTAWLRVFAMVNVAPGFNETPLVTNGYSDLILELYGpe-aGAHARSSIGM-AIPLNAPVNCEAEVE 157
gi 149173199  73 h-GTLD-GLKVVKLLGCVNSTPDFTDQHLVINGASDLFHELYGksgdGYHARSALGFaALPTGVAVEIEAVFE 143
gi 126728594  83 a-GSLSrVKEVVRLGGFVAAPPDFGDGPMIVNGASQLFIDLYGd--aGRHARTAVNVsSLPAKALVEVDAVIE 152
gi 163734393  84 cdGDLDrVDAVLRLGGFVNCTSGFGQSPAVINGATELFIALFGe--dGWHARTAVGVsGLPGNAMVEVDAIVR 154
gi 87311075   82 i-GSLEtIERVVRITGYVNCEADFTQQHLVINGASQLVRDVFGe--aGRHARTALGMqQLPLGASVEVEMILL 151
gi 168702857  82 l-GSLDrIERVVRVTGYVNTDPDFTDCHLVINGATDLLKAVFGpd-aGRHARTALGMgQLPLGTSVEVEAIFQ 152
gi 116254529  87 l-GDLSrIRQIARLTGYINSGPGFTDQHLVLNGCSDVLIAALGe--aGTHTRLAIGVvGLSFNTSVEVDCIVE 156

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