Conserved Protein Domain Family
AdoMet_MTases

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cd02440: AdoMet_MTases 
Click on image for an interactive view with Cn3D
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Statistics
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PSSM-Id: 100107
View PSSM: cd02440
Aligned: 102 rows
Threshold Bit Score: 29.3203
Threshold Setting Gi: 15988002
Created: 29-May-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
S-adenosylmet..
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:S-adenosylmethionine binding site [chemical binding site]
Evidence:
  • Structure:2DPM, Streptococcus pneumoniae Dpn II DNA methylase with bound S-adenosylmethionine
    View structure with Cn3D
  • Citation:PMID 9862809

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #######                        ##                                           
2DPM_A       38 RYFEPFVGGGALFFDla----------pKDA-VINDFnaelincyqqikdnpqelieilkvhqeynskeyyldlrsadrd 106
1FBN_A       77 KILYLGASAGTTPSHvadi------adkGIV-YAIEYaprixrell---------------------------------- 115
1JQE_A       55 KILSIGGGAGEIDLQilskvqaqypgvcINN-EVVEPsaeqiakykel-------------------------------- 101
1NW3_A      158 LFVDLGSGVGQVVLQvaaa------tncKHH-YGVEKadipakyaetmdre----------------------------- 201
2O57_A       85 KGLDLGAGYGGAARFlvr-------kfgVSI-DCLNIapvqnkrnee--------------------------------- 123
2P7H_A       45 NLLELGSFKGDFTSRlq---------ehFNDiTCVEAseeaisha----------------------------------- 80
2PY6_A      229 KXVDCGASIGESLAGligvt----kgkfERV-WXIEPdrinlqtlqnvl------------------------------- 272
2QE6_A       80 QFLDLGSGLPTVQNThevaq---svnpdARV-VYVDIdpxvlthgr---------------------------------- 121
gi 6226464   25 EVIEVGAGSGFVAERlkg--------kcKCI-LTTDIspfaam------------------------------------- 58
gi 13472986  97 KAAVLFCQTSAAADVlaa--------sgKVA-DIVRVeadta-------------------------------------- 129
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                            ###        
2DPM_A      107 eridmmsevqraarilymlrvnfnglyrvnsknqfnvpygryknpkivdeelisaisvyinnnqLEIKVGDFekaiv--- 183
1FBN_A      116 --------------------------------------------------------dacaerenIIPILGDAnkpqey-- 137
1JQE_A      102 -----------------------------------------------------vakisnlenvkFAWHKETSseyqsrml 128
1NW3_A      202 --------------------------------------------------frkwmkwygkkhaeYTLERGDFlseewr-- 229
2O57_A      124 ------------------------------------------------------ynnqagladnITVKYGSFleipc--- 146
2P7H_A       81 ---------------------------------------------------------qgrlkdgITYIHSRFedaq---- 99
2PY6_A      273 -----------------------------------------------------rrytdtnfasrITVHGCGAgentirvp 299
2QE6_A      122 --------------------------------------------------------allakdpnTAVFTADVrdpeyiln 145
gi 6226464   59 ----------------------------------------------------------elrrkgLDVVMTDIakgi---- 76
gi 13472986 130 -----------------------------------------------------------fltggGAGLIAPFetvpf--- 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                 #                                     
2DPM_A      184 --------------------------------dvrtGDFVYFDppyiplsetsaftsythegfsfadqvRLRDAFKrls- 230
1FBN_A      138 ------------------------------anivekVDVIYEDvaqp-------------------nqaEILIKNAkwfl 168
1JQE_A      129 -----------------------------ekkelqkWDFIHMIqmlyy----------------vkdipATLKFFHsll- 162
1NW3_A      230 -------------------------------erianTSVIFVNnfafg----------------pevdhQLKERFAnmk- 261
2O57_A      147 --------------------------------ednsYDFIWSQdaflh----------------spdklKVFQECArvl- 177
2P7H_A      100 --------------------------------lprrYDNIVLThvleh----------------iddpvALLKRINddwl 131
2PY6_A      300 fnhegghggfvkpadadhepadlidvrpiddiiddaPTFIKXDieg--------------------selSALKGARrais 359
2QE6_A      146 hp------------------------dvrrxidfsrPAAIXLVgxlhyl--------------spdvvdRVVGAYRdal- 186
gi 6226464   77 ---------------------------------rkkFSLVLFNppyvele-------------delrrgDWLDVAIdgg- 109
gi 13472986 148 --------------------------------epesLDLAVSLlsmqa----------------mndipGMLIQIRral- 178
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2DPM_A      231 dtgAYVMLSnsssalveelykdfnihyv---------------------------------------------------- 258
1FBN_A      169 kkgGYGXIAikarsidvtkdpkeifkeqkei------------------------------------------------- 199
1JQE_A      163 gtnAKMLIIvvsgssgwdklwkkygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdllwd 242
1NW3_A      262 -egGRIVSSkpfaplnfrinsrnlsdigti-------------------------------------------------- 290
2O57_A      178 kprGVXAITdpxkedgidkssiqpildriklhdxgslglyrslakecglvtlrtfsrpds--------------lvhhys 243
2P7H_A      132 aegGRLFLVcpnanavsrqiavkxgiishnsavteaefahghrctyaldtlerdasrag---------------lqvtyr 196
2PY6_A      360 ehkPKLAISayhrstdlldltnyilsi----------------------------------------------------- 386
2QE6_A      187 apgSYLFXTslvdtglpaqqklaritrenlgegwartpeeierqf----------------------------------- 231
gi 6226464  110 -kkGVKVIKkf--------------------------------------------------------------------- 119
gi 13472986 179 rpdGLFLGAfa--------------------------------------------------------------------- 189
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
Feature 1                                                       
2DPM_A      259 -------------------------eatrtngaksssrgkiseiIVTN 281
1FBN_A      200 ----------------------leaggfkivdevdiepfekdhvXFVG 225
1JQE_A      243 fltetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsFIVI 290
1NW3_A      291 -----------------------mrvvelsplkgsvswtgkpvsYYLH 315
2O57_A      244 kvkaelikrsseiasfcspefqanxkrglehwieggragkltwgGXLF 291
2P7H_A      197 sgiffkalanfqwdqilqtdilskeyldgcyqlgqqypdlcasiFLLC 244
2PY6_A      387 --------------------------rpdyqiglrhhtpdrwdtCLYF 408
2QE6_A      232 ---------gdfelvepgvvytalwrpdepvdpdnlspgeqlgxAGIG 270
gi 6226464  120 ------------------------------------------ldSLDE 125
gi 13472986 190 ------------------------------------------gaGTLF 195

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