1FRW


Conserved Protein Domain Family
MobA

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cd02503: MobA 
Click on image for an interactive view with Cn3D
MobA catalyzes the formation of molybdopterin guanine dinucleotide.
The prokaryotic enzyme molybdopterin-guanine dinucleotide biosynthesis protein A (MobA). All mononuclear molybdoenzymes bind molybdenum in complex with an organic cofactor termed molybdopterin (MPT). In many bacteria, including Escherichia coli, molybdopterin can be further modified by attachment of a GMP group to the terminal phosphate of molybdopterin to form molybdopterin guanine dinucleotide (MGD). This GMP attachment step is catalyzed by MobA, by linking a guanosine 5'-phosphate to MPT forming molybdopterin guanine dinucleotide. This reaction requires GTP, MgCl2, and the MPT form of the cofactor. It is a reaction unique to prokaryotes, and therefore may represent a potential drug target.
Statistics
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PSSM-Id: 133000
View PSSM: cd02503
Aligned: 120 rows
Threshold Bit Score: 103.424
Threshold Setting Gi: 50841996
Created: 7-Oct-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
GTP binding
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             ### #            #                              #                   #      
1FRW_A         7 ITGVVLAGGKARRMGgv----dKGLLELng-kpLWQHVADALMtq--lsHVVVNANrhqei--yqasgLKVIEDsla-dy 76
gi 166218979   1 MKAIILAGGHSVRFGk-----pKAFAEVng-etFYSRVIKTLEstnmfnEIIISTNaqlat---qfkyPNVVIDdenhnd 71
gi 29898389    4 YAGIVLAGGMSSRFGe-----pKALAIWke-ttFVEHIVKVMGnt--lqDIVVISHtdikerveqfvqVPVIEDiphykg 75
gi 13124356    6 RIGVILAGGKSTRFGr-----pKAMVQYqe-ryFYEASLDALQhh--tdQVLIISHptltnqfrrnegIRVIEDdpryqg 77
gi 56419298    5 IAGAVLAGGQSRRFGr-----pKAFALHeg-apFFTWSVAALDpi--adELYIVSHpslvdefrrqtdIPVLLDvercrg 76
gi 13124337    3 HVNVLLAGGASRRFGe-----pKAFVKWkg-rmLYECAKEALGe-----QTVIISRpefidrfqengeNEVYQDaepfqg 71
gi 126652321   3 VAGVILAGGQSSRYGq-----pKMFETFag-lpLYKHSLNALQenq-lhPLVIATNaslhpr-fgpedVQWIIEqq--ph 72
gi 78778213    5 TPCIIFAGGKSSRMGe-----dKALLPFgsydtLVEFQLYHLSki--fkTVYISCKeksk----fnfeAAFIEDiktlpl 73
gi 12230357    9 IPCVLLAGGKSSRFIinnipinKALMPLksypsLLEYQYTRLLkl--fkQVIISAKksy------elnAPYLLEkeg-gl 79
gi 32262569    6 IPCVILAGGKSSRLGe-----dKTQVAFgk-enLSQWVFTHLSki--ceKVYISTKdkkk----ftfdAPFLIErs--ri 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                 # #                                                      
1FRW_A        77 PGPLAGMLSVMQqea-gewFLFCPCDTPYIPpdLAARLnhqr------kdaPVVWVHdgerDHPTIALVNraiePLLLEY 149
gi 166218979  72 KGPLAGIYTIMKqhpeeelFFVVSVDTPMITgkAVSTLyqflvshlienhlDVAAFKedgrFIPTIAFYSpnalGAITKA 151
gi 29898389   76 NGPLAGIVSGMEyie-adwYAIMPCDAPNVSheWFTILleqt-----nneyDAVVPIingrKQPLLAAYHnrvkEKIYAL 149
gi 13124356   78 CGPLAGIFTAIEkes-aywYLTAPCDTPFLKkeIYDILfsyld---qepdkKAVIPVvngrKQPLIGLYHrsclAPIQSL 153
gi 56419298   77 CGPLAGLYTVMEqsr-adwVFVLPCDMPYMRreVTERLasyi-----dpmfDAIVPLhgvrPEPLVALYHrrlrSVIAEL 150
gi 13124337   72 MGPLAGIYTAFKktd-gdlYTVLSCDTPLIQrrTMLELkrlm-----iagaDAVVPIsdgqVQPLIAIYHkrimPVLYDQ 145
gi 126652321  73 QGPLFALYHILTafpevewFFVVASDMPYMNapFIEEMldni-----ndsyDAIVPKqnsrYQPLAALYRrtalPLAKQL 147
gi 78778213   74 YAPTAGFISVYNhlk-sdnFFAISVDTPFITrsIIEKLlhvd-----knthDATIAKvnglIQPMCGVYHrslsEKFSQM 147
gi 12230357   80 FSPLFGIHNAFLtlq-tpyIFFIAIDTPLVSfeSIKILcgi-------qnfSVVYAKsptkEHYLISLWHqsilNALNYT 151
gi 32262569   72 YAPIIGMINAFEklk-tqeILFVSVDTPFVRgeTLRQLads--------naPITYAQsadkAHYLISKWHksmlDALIWA 142
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
Feature 1                                                  
1FRW_A       150 LqagerrVMVFMRLag-gHAVDFsdh---kdaFVNVNTPEEL 187
gi 166218979 152 LhsdnysFKNIYHEls-tDYLDVrdvdapsywYKNINYQHDL 192
gi 29898389  150 LqeekrsMGQLLSQcn-vKYVSGedvqanadwFINVNTKEEY 190
gi 13124356  154 Leqq-ryKVGFLFQlvdtLFVEDkafeqlhssFVNINRPEDL 194
gi 56419298  151 LdagerrMISLLDRar-vRYVDAqqlaadetvWRNVNTEGEY 191
gi 13124337  146 LsekrlrISDLLGRis-vCYVQAeniganpaeFININTRDDF 186
gi 126652321 148 MeqnkrsMKVLLDQlr-vSYVPFnen---cptFININAQHDW 185
gi 78778213  148 LqnnshkLGYLLKNsn-tFYVEFede----ksFFNLNHPHEY 184
gi 12230357  152 LktqnyrLSDLIKNas-sTAIHFdke----eeFLNLNTLKDY 188
gi 32262569  143 YksksyaLHRIIEShp-hQSVLAte-----keCFNINTMDDY 178

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