1YP4,3BRK


Conserved Protein Domain Family
ADP_Glucose_PP

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cd02508: ADP_Glucose_PP 
Click on image for an interactive view with Cn3D
ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch.
ADP-glucose pyrophosphorylase (glucose-1-phosphate adenylyltransferase) catalyzes a very important step in the biosynthesis of alpha 1,4-glucans (glycogen or starch) in bacteria and plants: synthesis of the activated glucosyl donor, ADP-glucose, from glucose-1-phosphate and ATP. ADP-glucose pyrophosphorylase is a tetrameric allosterically regulated enzyme. While a homotetramer in bacteria, in plant chloroplasts and amyloplasts, it is a heterotetramer of two different, yet evolutionary related, subunits. There are a number of conserved regions in the sequence of bacterial and plant ADP-glucose pyrophosphorylase subunits. It is a subfamily of a very diverse glycosy transferase family 2.
Statistics
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PSSM-Id: 133002
View PSSM: cd02508
Aligned: 50 rows
Threshold Bit Score: 182.742
Threshold Setting Gi: 47459233
Created: 7-Oct-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingoligomer
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site
Evidence:
  • Structure:1YP4,potato ADP glucose pyrophosphorylase in complex with ADP-glucose defined by 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           # ##                                                                         
1YP4_A        23 GIILGGGAGTRLy-pLTKKRAKPAVPLgANYRLIDIPVSNCLNSNISKIYVLTQFnsASLNRHLSRAYASnmggyknegF 101
gi 2811061     7 GVIDATTYIEALe-pLIEQRSIAAVPFaGRYRLIDFVLSSMVNSGIESVAIFPKYqyRSLMDHLGSGKNWdlnr--krdG 83
gi 729583      8 GVIDETTYKHSLq-dLTAQRSLGAIPFaGRYRLIDFMLSNMVNADIRSVAIFPKYryRSLMDHLGAGKEWdlhr--kkdG 84
gi 154498810   7 GIIFAYRSNADLr-eLTQVRNTCSVPYgGRYRTIDFMLSNFVNAGMVDVGIIVHAnyQSLLDHLGSGKDWdlsr--khgG 83
gi 10173701    6 GVVNLDHDQDLLh-eLTYFRSVAGVPFgGRYRMIDFVLSNMVNSGIQDIAVFARNkyRSLMDHLGTGAPWdlnr--krgG 82
gi 121534015   6 GLINLHEPEEKAlaeLTGHRPLAAVPFgGRYRLIDFALSNMVNSGIRNVGILFKQkyRSLFDHLRSGKDWdlar--khgG 83
gi 89210657    6 GIIDDTQEDSFLk-dLTFHRSVASVPFgSRYRLIDFILSNMVNSGIRNIGILVKNkhRSLLDHLGPGKEWdldr--krdG 82
gi 15025238    7 SILSLNENDNDIk-sLTKARPLASIPIaGRYRIIDFILSNLVNSGVKNIGILTQCksRSLLDHLGSGKPWdldr--klnG 83
gi 18143726    6 GIINLDENESKIg-eLAKNRPLAAVPIaGRYRIIDFILSNMTNAGIESLGILSKNksRSLVDHLTNGRPWdlhr--krdG 82
gi 126698460   7 GIINLNKKGDPAinkLNYGRPIASTPIaGRYRIIDFALSNMINSGITKVGIFAKEkyRSLTDHIGSGKDWdlsr--kkgG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          # #                       ##                                  
1YP4_A       102 VEVLAAQQspe--npDWFQGTADAVRQYLWLFEEHtvlEYLILAGDHLYRMDYeKFIQAHRETDADITVAALpmdekrat 179
gi 2811061    84 LFFFPSPDllf--sgERRVGAFAHFEQHIDYFLRSrqkYAVIANGYTVCNIDFdAVLNRHIENGCDVTEIRHr------- 154
gi 729583     85 LFFFPSPHlh---heYDEFGSFRQFSDHLDYFHRStqqYAVISNSHTVCNIQFqYVLKRHQEVGCDVTEVFQd------- 154
gi 154498810  84 LRILPPFGyankqrgGVCRGRMDALEGVYSYLTKIkqeHVVLAGGDIAVNLPMrEIYEQHIKSGADITAVCTrnpkgdpr 163
gi 10173701   83 LFILPPDWnd---ptDISKGDLRHFHNHRDFFHRGnadHVLVSGSQFISKVDYeDAFKRHQETKADVTVLYKkvdqlepe 159
gi 121534015  84 LIMLPPSDh------ADDRGDLGNFFANLEFIRRShepYVAVSGTATVCNIDLrEALAVHRAHSADLTIVYCeqprpkdc 157
gi 89210657   83 LFLLPPAQnn---ghHNSNSNIPFFKDNLDYLYNSrqeYVIFSSTNIIYNLNFkEVFSKHKKMGADLTIISHdipddrds 159
gi 15025238   84 LFIFNFSGi------TSTLSDIEMLKSNMEYLYRStqeKVILSSSAVICNIDFqRAAEFHEKSGKDITLIYKrtnngkrk 157
gi 18143726   83 LRVFNFGEr------DPYYDDITNLYENLEFLTKSrreYVIMSPSYMICNIDLkEALEYHKKNDNDITVIYKkvkdadsn 156
gi 126698460  85 LSIFSPENtkyrntySHREGDIYTILANLDYIEKSeeeYILIAPSYMLCNLNYsQALEYHKKSHNDITIIYKnvnnankd 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   # ## 
1YP4_A       180 afglmkideegriiefaekpqgeqlqamkvdttilglddkrakempfiASMGIYVISkdVMLNLLrdkf--pganDFGSE 257
gi 2811061   155 -----------------------------------------------gRSLEMYLLEtsLLLDLIadyk--nhgyYSIVD 185
gi 729583    155 -----------------------------------------------gQSLQIYIMSttLLKDLIyghs--ekgyKTIQE 185
gi 154498810 164 ssdyftvgd----------------------dgritdvsvhpyapvgcESLEVYILSksLLLSLVdncaa-hnipSFSQG 220
gi 10173701  160 dryrmklef----------------------dsfgnvksitndemnsnLYMQMYIIRkeLLLELLnhcigyhkqdLFVDG 217
gi 121534015 158 adttyeltida------------------dgrvkdvalatsssgkrinIPLNMFILTkdVLIDLVtagsargdycFFHHG 219
gi 89210657  160 nylylktsk-----------------------qgwiteltdnpdngskISLETYILKksLLIDIIdycis-hnkkDFVRD 215
gi 15025238  158 flncsvlnmdk-------------------nnnvisigkntglddvqnISLGMFIMNkkLLINILnncir-tgfsLSLKQ 217
gi 18143726  157 fidcdvlnfde-------------------cgfiksigknlgreeesnISLEMYILRtdLLIEIIyecir-rgshRKFKS 216
gi 126698460 165 fagnltlnlds-------------------nnrvinvgnnlgkfpranICMETYIMKreDFVECIynivn-kgnyCYLEE 224
                        250       260
                 ....*....|....*....|....
Feature 1                                
1YP4_A       258 VIPGATSlgmRVQAYLYdGYWEDI 281
gi 2811061   186 VIRDYHRs-lSICEYEYsGYAAVI 208
gi 729583    186 AVEKESSa-lTICPYEYsGYAAVI 208
gi 154498810 221 VLQSMVHt-lKIVPYIFdGYAARI 243
gi 10173701  218 IMSNLNEl--AIRAYEYkGYLSII 239
gi 121534015 220 IIQKLPRl--KAYAYRFlGHVAHI 241
gi 89210657  216 GIAHYLGk-lRAYAYHHnGYAGII 238
gi 15025238  218 CIRKHMNn-fTVNAYEFnGYAEYI 240
gi 18143726  217 YLKEFLDe-iKVGGFEFkGYLSCV 239
gi 126698460 225 FIIEEAEn-mKIGAYEYtGYLKCV 247

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