2CU2,2QH5


Conserved Protein Domain Family
GDP-M1P_Guanylyltransferase

?
cd02509: GDP-M1P_Guanylyltransferase 
Click on image for an interactive view with Cn3D
GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose.
GDP-mannose-1-phosphate guanylyltransferase, also called GDP-mannose pyrophosphorylase (GDP-MP), catalyzes the formation of GDP-Mannose from mannose-1-phosphate and GTP. Mannose is a key monosaccharide for glycosylation of proteins and lipids. GDP-Mannose is the activated donor for mannosylation of various biomolecules. This enzyme is known to be bifunctional, as both mannose-6-phosphate isomerase and mannose-1-phosphate guanylyltransferase. This CD covers the N-terminal GDP-mannose-1-phosphate guanylyltransferase domain, whereas the isomerase function is located at the C-terminal half. GDP-MP is a member of the nucleotidyltransferase family of enzymes.
Statistics
?
PSSM-Id: 133003
View PSSM: cd02509
Aligned: 63 rows
Threshold Bit Score: 275.995
Threshold Setting Gi: 68195211
Created: 7-Oct-2002
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
Substrate
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:Substrate binding site
Evidence:
  • Comment:Predicted ligand binding site based on similar proteins.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             # #                                                                        
2CU2_A         3 TYALVMAGGRGERLWPLSREDRPKPFLPLfeg----ktLLEATLERLAplvppeRTLLAVR-RDQEAVARPya-----dg 72
gi 68195211    1 MNIVLLSGGSGKRLWPLSNDIRSKQFIKIfktedgyesMVQRVYRQIKkvdkdaTVTIATS-KTQVSAIHNhlg----ed 75
gi 50843158    2 QHILILAGGSGTRLWPLSHQGEPKQLLELidg----vsLLRMAYERVAglvpdaNILVCTG-SSYADTVAKllpe--vpa 74
gi 71017713  289 LWAVVPAGGAGTRLWPLSRESYPKFLLDLtgs---grtLLQSTWDRLLplagqaQMMIVTG-QAHVGGVSAqlpd--leq 362
gi 16554511    5 VAAVLLAGGTGTRLYPASRSHRPKQLLALgdd---drsLLRRTADRAAfa---dDLLAVTR-EAYADRVRDev-----pe 72
gi 94499769    4 IYPIILAGGMGTRLWPLSREEYPKQCLPLnde---hwsLLQQTLLRTQglqdcaPITVICH-EQHRFLVAEqclqtgvkh 79
gi 147887200  17 MIVVIIAGGSGTRLWPLSTSDYPKHLLQLmdn----dsLLQSTYKRAKkl--skHIYVQTAgEEQLKLVREqlpe--lgd 88
gi 159901332   1 MDILVLAGGTGSRLWPRSRRTKPKQFLPLlsn----rtMLQETVDRVRplieegRVFVVTG-SDYEELIREqlnd--vpr 73
gi 159882078   1 MKSIILAGGRGTRLFPLSRKELPKQFVRLgn-----rsLFQRTLERHSd----fPVYVSLK-EDYTSLAKEqaee-vgig 69
gi 28493323    6 LYSVIPAGGIGSRLWPLSRAASPKFLHKLtgt---etsLLRDTWDRLVpisgvdRIMVVIG-SDHFDAVTSqlpe--lkg 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                  #                                     
2CU2_A        73 IRLLLEPLGRDTAGAVLLGVAealk------egaeRLLVLPADHYVgddeAYREALATMLEAAe--eGFVVALGLRPTRP 144
gi 68195211   76 VCVSVEPCRRDTFPAIALATAylvdvm--gvnpeeSVVVCPVDPYVe--dDYFEALKSLSDQAdkgeANLVLMGIEPTYP 151
gi 50843158   75 ENILGEPVGRDSLSAVAWPAGiiadr-----dpdgVMAVVTADHIIrpvdDFRAALQHGFDLAntdpTALVTFGVVPTEP 149
gi 71017713  363 ANVLAEPSPKESMAAIGLAAAvllqr-----dpeaVLGSFAADHIIsgrdAFESAVTEAVATAk--aGYLVTIGIAPSHP 435
gi 16554511   73 ATVLVEPAGKDTGPALAYAASevrar----fgedaVMLCLPSDHVVg--dGFQETAETAVDVAar-tDGLVTIGIEPDRP 145
gi 94499769   80 FPILLEPEARNTAAAIASAVAfllaqdsvkadkdaVFCCLPADHAIeqsdAFITSLNQAVQLAreysQSLLTLGIEPTSA 159
gi 147887200  89 DAFPIEPARRDTAGAFIAALAhvqar----hdhdePIALIAADHYTrdvqGFVQSFKIAEKASrd-eGRICLVGIEPTYP 163
gi 159901332  74 NNVILEPSGRGTASAIGLAAIhmrrs-----apdaVMAVLSADHLIlrneAFRQALQAAEVAAr--eGYLVTLGVKPSFA 146
gi 159882078  70 ANLIKEPSPKNTFPAIVWSLYvmriey--glkdddIVAVVPADQYIepveTYREDLSLARECAk--gGYVVLFGVKPNRP 145
gi 28493323   80 HNVILEPEPKDSTAAICLAAAilntr-----epdvIIGSFPADHVIktspLFQQSVAQAVVAAn--eGYVVTIAITPTEP 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2CU2_A       145 ETEYGYIRLGprega------wyrgEGFVEKPSYAEALEYIr-kGYVWNGGVFAFAPATMAELFRRHlpSHHEALerlla 217
gi 68195211  152 SEKYGYIIPEsakq-------tafvNTFKEKPTEAVAKEYIt-qGALWNGGVFAYKLKYVMERAHQLidFVDYQDl---- 219
gi 50843158  150 NTGFGYLHRGgrlrpg---srahqvLEFVEKPSAEVARQYLdsgEYWWNSGMFVWRAATLLDCLSQLkpQTRHHVdelva 226
gi 71017713  436 STGFGYIKLGekldvse-apnarrvTEFKEKPDARTASAYLstgDYRWNGGMFVVKAQVLLDLLKGTvpELHEGLtriaa 514
gi 16554511  146 ATGYGYIEPGddhgd------hsevAVFREKPDAETASRLVd-rGCLWNAGMFAWTPTAFLDAARSGplDPLVDAlatd- 217
gi 94499769  160 HTGYGYIQAGepvsteeypkagfkvQHFKEKPDAQTAQSYLeqgNYYWNAGIFMGTACAWQSAFTVYqpELWQHAkntlq 239
gi 147887200 164 ATGFGYIQKDgqlegs---slvynvMMFKEKPDFDTAKKYVqsgEYLWNASYFIGSVNTFLRTMEEYapELKKNYerlva 240
gi 159901332 147 NTGYGYIQCGeliteah-nhkihrvQRFAEKPDHDTAERYLaqgNYFWNAGIFVWQTKTFLDAIGRHmpELRNQLnqvqa 225
gi 159882078 146 DTGFGYIKLGkkldk------afrvEEFTEKPSYEKALEYVksgKYLWNSGIFVFSFKTFEEECKLYqpFAYKLLntksr 219
gi 28493323  153 ATQFGYILCGdsagikg-apqvlsvKRFVEKPSQKDADRYLssgKYLWNAGMFIAKACVLLEQLEKArpDIHSLIidian 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                                                                   
2CU2_A       218 --------gasleEVYAGlPKISIDYGVMEKAERV------RVVLGRFPWDDVGNWRAL 262
gi 68195211  220 ------------fNKYETlTKISFDYAVVEHEDKI------QVQRFAGMWKDLGTWNTL 260
gi 50843158  227 d-------psrlaEVYPCmEKVSVDIAVMEPASHGgcgvhvAAIPLEIQWYDVGSYEAL 278
gi 71017713  515 swds-dardtvmsEVWPTlPKIAIDHAVAEPASKVgk---vAVVPATFGWDDVGDFASL 569
gi 16554511  218 ---------adpaTAFERvDPVSVDYAVLERAADV------RVVPAAFDWDDLGAWNAL 261
gi 94499769  240 qaqadldflrlssEQYSLlPCMPFDVAIMEQLSNA------FMVSLDAGWSDLGEWQAL 292
gi 147887200 241 tk-----srkeyeEVFLSfDKISIDYAMMDHTKDL------LVVPAAFDWADLGSFADA 288
gi 159901332 226 sfgk-sryhdtlaHVWENvENITVDYGIMERAPNV------AVVPVDIGWSDVGDWHTL 277
gi 159882078 220 ---------dealYVFNKlQSEPIDKAIMEKSKRT------VCIPFRANWSDVGTFKGL 263
gi 28493323  232 sp----dldsalkKNWPKmPRIAIEYSVAEPCAAEgr---mVTVPAKFEWNDAGDFSSI 283

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap