1XHB,2D7I,2FFU


Conserved Protein Domain Family
pp-GalNAc-T

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cd02510: pp-GalNAc-T 
Click on image for an interactive view with Cn3D
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans.
UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.
Statistics
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PSSM-Id: 133004
View PSSM: cd02510
Aligned: 40 rows
Threshold Bit Score: 385.789
Threshold Setting Gi: 38505153
Created: 7-Oct-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Mn binding siteligand binding
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:Mn binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1XHB_A       32 SVVIVFHNEawSTLLRTVHSVINrsprhmIEEIVLVDDASErdflkrple------syvkklkvpVHVIRMEQRSGLIRA 105
gi 51316021 113 SVVISFHNEarSMLLRTIVSLLSrspedyLHELILVDDGSQrdvtllddlkrwmggvfgsryrlgLTFLRNQERMGLIWS 192
gi 51316007 170 TVIIAFHDEhlSVLLRSITSIINrspvelLKQIVLVDDDSNlpelgqqlee-----ivaqnfpkiIHILRLPERRGSIKA 244
gi 51316119 131 SVVITYHNEeaSVLLRTLSSLRSrtpiqlLREVILVDDGSTqadeklndf-------ikikflnmVQHRRITTQVGLMHA 203
gi 27448053 113 SIVIAIQQEhpHTLLRGIYSVITqtspylLKEIVLVHDGHPdldlirh----------ihhklpiVIQLEMESSKGIIHA 182
gi 51316006 196 SVIFIFFNEhfNTLLRSIYSVINrtppelLKQIVLVDDGSEwdvlkqpldd-----yvqqhfphlVTIVRNPERQGLIGA 270
gi 51316023 194 SVILCFHDEawSTLLRTVHSILDtvprafLKEIILVDDLSQqgqlksals-------eyvarlegVKLLRSNKRLGAIRA 266
gi 51315804 110 SVVVIHHNEalSTILRMINGIIEftpkslLKEIVLYEDASEedhvltkhlek---fakikgledkLIIKRSEYRQGLIRA 186
gi 37622171  47 SLIIPIRDEd-EFISKTISFTLGlnnknlLKEIIVVDDCSKrevsdllnk------elpssylkyIKVIRLDKCEGLIRS 119
gi 34391433 155 SVIIPVRNEe-AYLPKTLTFLFEvtpierIREVIVVDDHSDkpikailek------tlpqhildkTRVIRFDSPQGLIRG 227
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       # #                                                             
1XHB_A      106 RLKGAAVSrgQVITFLDAHCECTAGWLEPLLARIKhdrrTVVCPIIDVIsddtFEYMAGsdm-tyGGFNWKLNFRWYpvp 184
gi 51316021 193 RNRGASLAsgRYVLFLDSHCEVNEGWLEPLLERLAlntnLAVSPLLDPIdpttLSYRKGnel-lkGGFDWSLHFHWLkrq 271
gi 51316007 245 RMEAIRVSscQVLVFLDSHIEVNTNWLPPLLEPIVinphIVTRPILDAIsrktFAYAKQntm-trSGFNWWLESESLpif 323
gi 51316119 204 RVVGAELAlaDVLVFLDSHVEVTKGWLEPLIAPILednrTCTTPIIDTIdfdnFAYRRGkp--srGFFNWEFNYIQLpll 281
gi 27448053 183 RLTGAGVAtgDILVFLNGHMEVTRGWLPPLLEPILlnnqTVTEPIVDAIsresFAYRKLvep-eqLAFDWQLDHIFLpld 261
gi 51316006 271 RIAGAKVAvgQVMVFFDSHIEVNYNWLPPLIEPIAinpkISTCPMVDTIshedFSYFSGnkdgarGGFDWKMLYKQLpvl 350
gi 51316023 267 RMLGATRAtgDVLVFMDAHCECHPGWLEPLLSRIAgdrsRVVSPVIDVIdwktFQYYPSkdl-qrGVLDWKLDFHWEplp 345
gi 51315804 187 KVHASRLAtgEVIVFMDSHCEVAERWLEPLLQPIKedpkSIVLPVVDLInpvsFDYSPSmv--akSGFDWGFTFKWIylp 264
gi 37622171 120 RILGADASksSVIVFMDGHCRPKENWIEPLINRLKekpkAIVCPMIEDIdrytWKDLGTfg--lkMMFDWNFEFNWYed- 196
gi 34391433 228 RVAGAAIAtsDNFFFLDGHCRPKVGWAEPLLAHLKtnyrRIACPKIYDIyldsWEDVGThg--tkMMFEWTFEFGWFed- 304
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                               #       
1XHB_A      185 qremdrrkgdrtlPVRTPTmaGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFR---- 260
gi 51316021 272 ltn----qeslemPYQSPAfaGGVLMMSREWFLKLGSFNPYLKIWGGESIELAIKLWLCGGQIEIVPCSRIGHIFR---- 343
gi 51316007 324 ped----kspdstPYRTPVl-SGAMAIDRNYFLNLGGFDEQLDTWEAEKFEISFKVWMCGGMMLYVPCARVGHIGKr--- 395
gi 51316119 282 kee----avampaPHKNPImnGGLFAIGREWFSELGGYDKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRdg-- 355
gi 27448053 262 qhs----wnslpkPYPSSQleGRVFAIDRKWFWHLGGWDEGLRDYGGDALELSLKVWQCGGLILAVPCSRVGIIYKrdel 337
gi 51316006 351 ped----aldksmPYRSPVmmGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRg--- 423
gi 51316023 346 ehvrk-alqspisPIRSPVvpGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQnq-- 422
gi 51315804 265 weyfe-tpennvkPFNSPAmpGGLLAMRKEYFVELGEYDMGMEIWGSENIELSLKAWLCGGRVVVAPCSRVGHVFR---- 339
gi 37622171 197 ------------fTDVIPIasGGLYAITREWWEESGKYDPGMLEWGGENIEQSIRIWRCGGEIVAEKKSRVGHIFKr--- 261
gi 34391433 305 ------------lEDEVPVlaGGILAMTKKWWIESGLYDEGMLEWGGENLEQSIRSWLCGGEIVAVQESKIGHIFSr--- 369
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1XHB_A      261 --KATPYTFpggtg-------qiinkNNRRLAEVWMDEFKNFFYIispgvtk-----vdygdiSSRLGLRRKLQCKpFSW 326
gi 51316021 344 --RRHAFDFppqsdrqlspaqetylhNSKIIAESWLDEYKNMFYAlrpaarr----ipldhtyDELQRMRKERRCHpFEW 417
gi 51316007 396 --PMKSISSpgyhn--------flarNYKRVAEVWMDNYKKYVYDknpklyk----managllFQRKTKRNALECKtFDW 461
gi 51316119 356 -nFQIRYTNkdknse-----kklisrNYRRVAEIWLDEYKDKLFAnmphltv-----ipvgnlAEQRDLKNRLHCKpFKW 424
gi 27448053 338 eaQMAPNRNpslq----------vqkNFKRVVDVWLDEYKLHFYRynpklrn-----ltaeslDKPRDLRRRLNCKsFEW 402
gi 51316006 424 --PMKPRGNprghn--------fvakNHKRVAEVWMDEYKQYVYKrdpktyd----nldagdlTRQRGVRERLKCKsFHW 489
gi 51316023 423 -dSHSPLDQeat------------lrNRVRIAETWLGSFKETFYKhspeafsl--skaekpdcMERLQLQRRLGCRtFHW 487
gi 51315804 340 --MRRPYTSkpgmd--------talyNAVRVAKTWLGEYESKFFAvkprgak-----mvfgdlTEPMQVKDRLKCKdMKW 404
gi 37622171 262 --DPKPNPEnklvl--------qvqrNQKRAAMVWLDKKRYKYFEtihdvvkslnetqsgvdlEQRHSIKERLKCKpFSW 331
gi 34391433 370 --PPKPNPGnrlvi--------qvqkNQKRGAKVWLDEYYFLFYKyhrevrg----hqegditQRKKLRYEQLTCMpFQW 435

                ....*.
Feature 1             
1XHB_A      327 YLENIY 332
gi 51316021 418 YLRHVS 423
gi 51316007 462 YMTKVA 467
gi 51316119 425 FLDNLA 430
gi 27448053 403 YRSQVA 408
gi 51316006 490 FMTEVA 495
gi 51316023 488 FLANVY 493
gi 51315804 405 FIENVY 410
gi 37622171 332 YVDKFR 337
gi 34391433 436 YVEKFK 441

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