Conserved Protein Domain Family
Beta4Glucosyltransferase

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cd02511: Beta4Glucosyltransferase 
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide.
UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.
Statistics
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PSSM-Id: 133005
View PSSM: cd02511
Aligned: 72 rows
Threshold Bit Score: 127.405
Threshold Setting Gi: 46399727
Created: 7-Oct-2002
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative metal
Feature 1:putative metal binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 1175279    3 TISVAMIIKNEAQDLANCLDTVKdwvdEIIILDSGSTDNTKEIal-----syGAKFyensdwQGFGKQRQLAQQYVTSDY 77
gi 15643520   5 LLSVAMIVKDEEHNIRRALESIKdvvdEIVVVDTGSTDRTPEIvr-----eyTDKLyfhewkNDFSEARNFSLKFPTCEW 79
gi 91200806   8 TISACLIVKNEERFLPNCLNSVKnavdEIVVVDTGSTDNTVNIak-----efSAKVyfyswnNNYSEARNYAIRHATKEW 82
gi 20807006  18 TLSLCLITKNEEKNISRCINSVKdivdEIVVVDTGSTDRTIEIak-----sfGAKViqikweDDFSKARNTAIESATGDW 92
gi 88705690   2 RLSLCMIVKDEAFFIEECLAAAAphvdEIVVVDTGSTDGTRDIaa-----ryADTLldfewiENFSAARNAGLAAATGDW 76
gi 1175702    9 QVSLCMIVRDEAELLPRCLASVKdqvdELIVLDTGSRDRTPAIat-----eaGAKLlhtdwaDDFSAARNQAIAAATGDW 83
gi 16410077   4 LISICMIVKNEAHILRQSLASFRkfteEIIIVDTGSTDETKEIaq-----efTDFVydfewtGNFSDARNFAAKHATGKW 78
gi 29377941  69 EVSVCIIAKNEQDSIRKCINSIYefsdEIIFIDTGSIDLTKKIvkei--aseKVKIfdytwqDDFSDARNYSIQKASKEW 146
gi 22299970   4 LLSLCMIVKNEAHQLRRCLQSVQpwvdEIIIVDTGSTDGTIAIac-----efTPHVhavawqGDFAAARNAALAQATGEW 78
gi 88770853  71 TISAVYIVKNERDTLLKSLESLNgladEIIIVDTGSTDGTLEMlatpskndgSISLysfewcDDFSKARNFANSKANGDW 150
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           # #                                                                         
gi 1175279   78 VLWLDADErvTPKLQQAILsavkndre-------ntvyeiprVSEVFGREirhsgw------ypdyvvRLYRTNYAqynd 144
gi 15643520  80 VLILDADEeaSEEFRQNIRsfleslpe-------dvntvylpTVSYLDWDfkrte--------iastpRIFRNGTVyyk- 143
gi 91200806  83 ILMIDADEelEQNDIPVLKqsisnd-----------nyngviIAIYSKVKsgmhk---------fyntRVFRREKAfyk- 141
gi 20807006  93 ILFLDADEeiKKEDVSKIKsllyddt---------veaylfkFVNYAGSSinsglt------einynyRLFRNNGKlkyi 157
gi 88705690  77 ILVLDADEriAAEDYPRLReamattafdgfylttrnytsnttRSDFILATpddsmsrgyagyalhpimKLFRARDDirye 156
gi 1175702   84 ILVLDADEelILEAWTELRsqld---------------qpeaLAFTVLREetqagqv-----pysrlsRLFRNRPDirfq 143
gi 16410077  79 ILAIDADEclEEESYRKLEkqlkspt---------epiqmaqIISFTGEKgrvtt--------tnqmaRVYKNDGTicfr 141
gi 29377941 147 ILIIDADEyvSSDELTKLRllidmld----------rfkfkdSLRVSCAIyqldnv------ithgqsRLFRNNNKikyy 210
gi 22299970  79 VFYIDADEelVVTDAHWQDqltapg------------ahainQWSLLRREqssdrnw-----sefwnvRFGRRFPDlhfa 141
gi 88770853 151 IISFDADEkiTDFKSLKLLltylqifg-------dypktvfnLNIVRDEItyk-------------tgKIIQNLPCfsyk 210
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 1175279  145 slVHEKVEFpagtkve---------kltgdleHFTYKSIHHyl-----------------vKSAGYAkawad-------- 190
gi 15643520 144 niVHNQAVYkpkvvh-----------apfviyHYGYIWTRKl-------------------KKNKYErtatl-------- 185
gi 91200806 142 giIHEQVVIegkrlp-----------seihlyHYGYDLDEDt------------------mRKKWHRttqllekqialnd 192
gi 20807006 158 ypVHENLRNieenrppia------kkadvtilHYGYLADIRke----------------knKSERYIkl----------- 204
gi 88705690 157 ggVHEIVDGsivdsrrg--------tldaiihHYGEANPERpk----------------kdRALRYLsmmenepyfkedg 212
gi 1175702  144 rpYHELVDDsllalqqqepnwritawptpvirHYGYGRDRLqqrgtaermrqsletwladhPEDAYLcsklggl------ 217
gi 16410077 142 gvIHEQLEAidkrpiaa-------gvaevkiyHYGYMSEIVek----------------qdKSDRNLrlle--------- 189
gi 29377941 211 glIHEELRNnkgldpifn------veseitffHDGYKEILRk------------------eKCERNIrllakm------- 259
gi 22299970 142 gaLHEQLCYrereavvg-------elqgvyliHHNQQSQEQfl----------------akIRDRNIpile--------- 189
gi 88770853 211 grVHETYFSavg------------------dvHYANIDIDIi-------------------SQNRTTse----------- 242
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 1175279  191 --------------------qrqaKGKKAtlwqgish--------------------------------algcfvkmYLL 218
gi 15643520 186 -------------------ireqlKTVKNpiekiyyliq----------------------------lyktektggrKHE 218
gi 91200806 193 ndsfawlnlirnyctqqlfrdgikTGKEAlkritpeanl----------------------------hhfimilyemADC 244
gi 20807006 205 ----------------------isKYLEShpedkfqhan----------------------------laveyfnigdYQK 234
gi 88705690 213 rlls---magsaamyfaedyakanRYLRRaaelgyepsrslega-------------------aeaayrhgnygeaqDLY 270
gi 1175702  218 -----------------lvqegdlKAAQRwlkqglkqg------------------------------rpepavryeLLY 250
gi 16410077 190 --------------------kevkNNKNSgfvhfnigqe----------------------------mnrlgnkkeaLKE 221
gi 29377941 260 ------------------lekepdNVRWAylycrdsfsinanidfekillpfliknmdesisyenilltnythlilfLIT 321
gi 22299970 190 --------------------tmvqQGDRRlqnlvclgdhya-------------------------acgdsdrsqawYEQ 224
gi 88770853 243 ----------------------kvEYYNRlllltikd--------------------------------eplnlrwlYLY 268
                       330
                ....*....|....
Feature 1                     
gi 1175279  219 KAGFLDGKQGFLLA 232
gi 15643520 219 ENRIAWETLQEIMK 232
gi 91200806 245 YLNTGNTAEAKKMC 258
gi 20807006 235 ALKHLLIATKGMDV 248
gi 88705690 271 RRLYDDGQRTTSLC 284
gi 1175702  251 HLALLERRQGDLDA 264
gi 16410077 222 FSEAFRLRDHNHYI 235
gi 29377941 322 KKYIIDGKSSLASK 335
gi 22299970 225 ALEEIASAVEQGIL 238
gi 88770853 269 LRDNFDSIKYTQMK 282

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