1LL2,1LL0


Conserved Protein Domain Family
GT8_Glycogenin

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cd02537: GT8_Glycogenin 
Click on image for an interactive view with Cn3D
Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen.
Glycogenin initiates the biosynthesis of glycogen by incorporating glucose residues through a self-glucosylation reaction at a Tyr residue, and then acts as substrate for chain elongation by glycogen synthase and branching enzyme. It contains a conserved DxD motif and an N-terminal beta-alpha-beta Rossmann-like fold that are common to the nucleotide-binding domains of most glycosyltransferases. The DxD motif is essential for coordination of the catalytic divalent cation, most commonly Mn2+. Glycogenin can be classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. It is placed in glycosyltransferase family 8 which includes lipopolysaccharide glucose and galactose transferases and galactinol synthases.
Statistics
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PSSM-Id: 133018
View PSSM: cd02537
Aligned: 38 rows
Threshold Bit Score: 195.173
Threshold Setting Gi: 134115829
Created: 28-Oct-2011
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site
Evidence:
  • Structure:1ll2_a; Rabbit Muscle Glycogenin Complexed With Udp-Glucose And Manganese, defined by distance of 3.5A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1LL2_A         4 QAFVTLTTNd--AYAKGALVLGSSLKQHRt-----SRRLAVLTTpq-vSDTMRKALEIvf----dEVITVDILdsgdsah 71
gi 116783451  24 RAYVTFLAGc-gDYVKGVVGLAKGLRNVKs-----AYPLVVAVLad-vPEDHRLQLRRqg----cIVRQIQPIdppdnev 92
gi 10176846   22 RAYVTFLAGn-kDYWMLVVGLAKGLRKVKs-----AYPLVVATLpd-vPEEHRQILVDqg----cIIRDIEPVyppentt 90
gi 28918810    9 MIWSTLVTKr--AYLGGALVLNHSLKKVGs-----RYQLKIMVTr---EAQADKEFMAvfaaagiPTIVIETIeparq-- 76
gi 71019391   25 CAWATLLTSe--HLLPGVVVFAHSLLVQHk----sRFPLVIMATst-lSARARTMLTNmlassriIVRDISPIyptstat 97
gi 50547063   12 RVWTTLITNt--KYLDGLLTLDYSLKRVGs-----QYRLIALYTds-fEKEGHDALAErg----iPSKHVEYLipakskd 79
gi 66807513   90 NVYVTFADNa--EYLKGIVALRMSMINTKc-----NYGLIVFVTkq-vEQQDREPLQLld----cDVREIEMVdipkevs 157
gi 70869564  103 IAYLTFISNe--KFVDGALVLGTSLRKTSvflqhgVADLVITITsncvSAVSRKRLLEegg--ytHVFEVPSLagriha- 177
gi 50256257   62 EAYVTFLSNedpYYFQSARLLVYALQHDPlta-dpSRPVIVLTTpg-vPASYSRKLEAeg----aIVIEKPFItslpmv- 134
gi 62424723  266 CAYVTMCDSq--DYLWGVRALANSLGRVS------DVPLILMVPp--gFDCGDITFEMgn----vRLYEVNSIrsphqpk 331
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  ##  #             # ###                                #              
1LL2_A        72 ltlmkrpelGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFer------------eELSAAPDpgw----------- 128
gi 116783451  93 --qfsmpyyVLNYSKLRIWEFEEYSKMVYLDADIQVFDNIDHLFdlr----------dgYFYAVMDcfcektwshtpqyk 160
gi 10176846   91 --gysmayyVINYSKLRIWEFVEYEKMIYLDGDIQVFKNIDHLFdtp----------rgYLYAVKDcfcevswsktpqyk 158
gi 28918810   77 -----gkvnKAFWQKLAPWAMTEYERIVLLDSDQVILQNIDHLMtlhl--------pegHIACSHActcnprklahypkd 143
gi 71019391   98 --glaytrfNEVWTKLRAFELTEYDRVGLVDSDMLVLENMDELFseehvfglgrnegeeWIGASWActcnpnriatypad 175
gi 50547063   80 --ysqdvrfYDCWSKLQPFSLFEYDKVVQLDSDMVVVQNMDELFdlpvges-ngngstwAFAASHActcnpynkphypkd 156
gi 66807513  158 ---vqidrwRPAFTKFRAWQLVEYERVIWLDSDMLLLKSLDHLFdlvdi------gnpkLLYAAIDadanscv------- 221
gi 70869564  178 ----ksgifRDTFDKIYMFNLTMYEKIVFLDADMIAIRSMDKLFskpki------wgpdYVAAVGGn------------- 234
gi 50256257  135 ---qtnprwKDVYTKLWIFNMTSYDRLVYYDADHLVLRPVDSIWeaens------wpesGLAALGSgdggy--------- 196
gi 62424723  332 ---qhqsrfSNTYTKLEAFGLTFLDRVAFIDADTVVLQSTDELFef------------eGFAAAPDfglr---------- 386
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            ###                                   ##    
1LL2_A       129 --------------------------------pdCFNSGVFVYQPSvETYNQLLHVASEQgs--------fdGGDQGLLN 168
gi 116783451 161 igycq-----------qcpekvswpielgqrpslYFNAGMFVFEPSqLTFDCLLETLMATvp--------tpFAEQDFLN 221
gi 10176846  159 igycq----------qspekvtwpveslgapppvYFNAGMLVFGPNlVTYEDLLRVVQITtp--------tyFAEQDFLN 220
gi 28918810  144 wvpqncpf----tsadqhtgspapitpssprthhLLNSGTVVLTPSkPQFDALLDAINTHpdvp-----hmvFPDQDILA 214
gi 71019391  176 wtpsncgftrqslpeaasissvvqpsestarparLINSGLVMLTPSsSTMSEMIQRINTDaqia-----hyrFPDQDFLA 250
gi 50547063  157 wirencaf----tnisksddlknplfqscnlglgICNGGLQVVKPDpELYDKIIDAVSAPatg------eydFADQSLLS 226
gi 66807513  222 ---------------------------fnsdrlkLINSGIMLLSPSiDVYNLLIDGMVVVsklp----nqstVNDQDVIN 270
gi 70869564  235 ---------------------------------dYFQTGMMIIIPTqEMFNCIYDRLIRGtppngfqftgssARDGVLLR 281
gi 50256257  197 -----------------------------vedsdYFLAGFFLAIPKeEIMEGLLAERGYDp----------vFPEQNLMN 237
gi 62424723  387 ------------------------------leshRFNSGVFVCSPSsELYMSIIDAIPDTps--------ydGGDQGFLN 428
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                ##                   # ##      #                        
1LL2_A       169 TFFNswattdirKHLPFI--YNLSSISiysylpafkafganAKVVHFLGq----TKPWNYtydtktksvrseghdptmth 242
gi 116783451 222 MFFEki-----yKPIPLA--YNLVLAMmwrhpq--nvdldtVKVVHYCAa---gSKPWRFsgkeenme--------redi 281
gi 10176846  221 IYFRdi-----yKPIPST--YNLVMAMlwrhpe--hidldqISVVHYCAn---gSKPWKFdeaeehmd--------redi 280
gi 28918810  215 IVYRgk-----wKPLPYV--YNALKPMrdchas--lwrdedVKILHYIL-----NKPWESrdfden-----------dkv 269
gi 71019391  251 DFFTrsngnrhiRYLPYI--YNALKKLrsvhtn--iwsdthAKNVHYIL-----DKPWTLgrpatksnv-----dakdpd 316
gi 50547063  227 DVFKdr-----wIGLSYR--YNALKTLrvfhke--lwddsvIKNIHYIIt----PKPWEVeedeye------------dt 281
gi 66807513  271 TTLPh------wRSLSYPe-YGVQITHcectseprlwnftnTYFLHFTAglkelPKPWSLlkksqneakdi-fkqmptci 342
gi 70869564  282 DVFQtr-----fHAINPKysRNLNPRHrldmkl---pgkqsIVAVHLRGi----IKPWHDrrlpnphte-----lgkkef 344
gi 50256257  238 KYFSrdgl-rpwAPLNPI--HERISPKye----------hvEQGAHTIH-----EKCWQGwverrlae--------lfye 291
gi 62424723  429 VIMDe------iTWLPHQ--FNTLRRAlgrypd--virgdeARIVHFVG-----PKPWSLngepewsdl-----dglwfa 488
                        330
                 ....*....|....
Feature 1                      
1LL2_A       243 pqfLNVWWDIFTTS 256
gi 116783451 282 ktlVQKWWDIYNDP 295
gi 10176846  281 kmlVKKWWEIYEDS 294
gi 28918810  270 estHRLWWGVWEEV 283
gi 71019391  317 aeiHAWWWNVFDQL 330
gi 50547063  282 tgtFKWWWDINKER 295
gi 66807513  343 eqiYLNWINTYKEA 356
gi 70869564  345 gftYLHWWTLYEEE 358
gi 50256257  292 rlgRMEGYWLAKES 305
gi 62424723  489 qlsEREKIQFIIEL 502

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