1G97,1HV9


Conserved Protein Domain Family
GT2_GlmU_N_bac

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cd02540: GT2_GlmU_N_bac 
Click on image for an interactive view with Cn3D
N-terminal domain of bacterial GlmU.
The N-terminal domain of N-Acetylglucosamine-1-phosphate uridyltransferase (GlmU). GlmU is an essential bacterial enzyme with both an acetyltransferase and an uridyltransferase activity which have been mapped to the C-terminal and N-terminal domains, respectively. This family represents the N-terminal uridyltransferase. GlmU performs the last two steps in the synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc), which is an essential precursor in both the peptidoglycan and the lipopolysaccharide metabolic pathways in Gram-positive and Gram-negative bacteria, respectively.
Statistics
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PSSM-Id: 133020
View PSSM: cd02540
Aligned: 80 rows
Threshold Bit Score: 236.643
Threshold Setting Gi: 42520463
Created: 7-Oct-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
SubstrateMg++ binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Substrate binding site
Evidence:
  • Structure:1g97_a; N-Acetylglucosamine-1-phosphate Uridyltransferase binds to UDP-N-Glucosamine
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           ###                                        #                                 
1G97_A         5 AIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAiqpeKTVTVVGHk-AELVEEVLag---------qTEFVTQSE 74
gi 67906680    4 SVILGAGKSTRMKANKSKLLFSIAGKPVINHIVSSLKDakakHIICVINNs-SAELKKILea--------enISFTYQKT 74
gi 109892130   8 IVILAAGKGSRMKSSKAKVLHPICGKEMLYYIIKTSRAis-dDVSVVVAHq-RDAVVESMsry------fndINFVTQDA 79
gi 15611691    4 VIILAAGKGTRMHSSLPKTLHTICGEPMLFYILEVAFSis-nDVHLVLHHq-QERIKEAVskr------fkgVIFHAQIV 75
gi 81666111    5 VVILAAGAGTRMKSHIPKVLHKICGKEMLFYSIDEALKis-dDVHIVLFHq-ENVIKERLlcaykqayadgaLHFHLQDH 82
gi 189040835   7 IIILAAGLGTRMKSKRPKVLFELCGEPMIIHILKQAYAit-nDVSVVLHYe-KELISKKIkei------fpqTKIFEQDL 78
gi 118474348   6 IIILAAGNGTRMKSNKSKVLHTLCGEPMISHILKKSYEis-nDVRIVLSYq-FEEVKNSVlse------fkdVKIYKQDT 77
gi 30721656    5 ILILAAGLGTRIKSQKPKVLQELCQKSMILHILKKAFAls-dDVSVVLSHq-KERVEKEIley------fpkTQILEQDL 76
gi 75498108    2 FIILAAGHGKRMNSGLPKVLHKIGNFSMLQHIIYNARQlnpeNISVVANLplIERLKCLEd-----------IQLITQES 70
gi 42520463    5 LIILAAGKSSRMNSQYSKTLHLVGNFTLLEHIIHNAKPlslkSLSIVINKpfLKELERFStlkdi--idkynIKLIIQEN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #  #                         # #                                           
1G97_A        75 Q--LGTGHAVMMTEPileg-------lsghTLVIAGDTPLITGESLKNLIDFHinhknVATILTAETDNPFGYGRIVRnd 145
gi 67906680   75 L--DGTAGAVKAALKvkkt-------snekLLIICGDIPFITSSSIKKLISKLkn--yDAVVGTVELESPKGYGRIIRvn 143
gi 109892130  80 InfPGTGGAMKGVNIkn-----------erVLVLNGDMPLVEKSSLDGFLEAQg----DVVMSIFNLQNPSGYGRVIIed 144
gi 15611691   76 EkySGTGGAIMQENKtpipt------qherVLILNADMPLITKDALTPLLESH-----NNAIGLLHLADPKGYGRVILen 144
gi 81666111   83 AhyPGTGGALMQGQNaganakkpfcyqydeILILNGDMPLVCSQTLKSLCQNKa----QIVMSVLHLQNPDGYGRVVMes 158
gi 189040835  79 AnfPGTAGAIKGVNLsg-----------ekVLVTCGDMPLVRSTDLMRLANAEa----DVVMSSFEAANPFGYGRVIIkn 143
gi 118474348  78 InrPGTAGAAEAALEnln---------skkTLVICGDMPLVEVNELKSLCDNTa----DISLSAFRAKNPFGYGRVVLnq 144
gi 30721656   77 QnyPGTAGALSGFEPkn-----------erVLILCGDMPLVEQTSLEALLSNNa----KLNLAVFKARDPKSYGRVVIkn 141
gi 75498108   71 T--LGTGDAVKTAVRnmkel-----sdsniIVVQYGDTPLIKNSTITQMVSCLe---gKALVCLGFKTSNKEYGRLIIen 140
gi 42520463   83 I--TGTGTAVKIALEslerl-----sdqdiVLIQYGDTPFISSDTVMRMTDCLkc-nnKNLVLLGFNSQDKQYGRLVIdd 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1G97_A       146 naeVLRIVEQKDatdfekqikEINTGTYVFDnERLFEALKNINTNnaqGEYYITDVIGIFretGEKVGAYTlkdfdESLG 225
gi 67906680  144 -nkFHSIVEEKEttptqrlirEVNTGIIAIQeKVLRQYISLITNNnqkKEYYLTDIIKILidnKKKVTTFKfsnetEVKG 222
gi 109892130 145 -aeVKKIVEQKDatlqelkvqSVNAGIYAFSkKIIEKYIPLLQNNnaqEEYYLTDIISMArndGIKITPLLvn-enEYKG 222
gi 15611691  145 -hqVKKIVEEKDandeektikSVNAGVYFFErKFLERYLPKLHDQnaqKEYYLTDLIALGikgNEKIDAIFle-eeCFLG 222
gi 81666111  159 -gvVQRIIEQKDakesellikDVNAGVYKIHkSILDLYLPQVGNAnnqQEFYLTDVVFYAkenGIEIAALEvk-eeEFMG 236
gi 189040835 144 -gkVEAIVEQKDaseaqlaikSVNAGCYCFKrEALEQILPLINNQnaqKEYYLTDAIKIAnekGLKCVAVNvn-eqNFMG 221
gi 118474348 145 -qnVIKIVEQKDanddekkidLCNAGAYCFDtNLLKNIIPLIKNEnasREFYLTDAIELAlkqGFMVKSVLvd-etNFMG 222
gi 30721656  142 -dsVEKIVEFKDantqekeinTCNAGVYVIDsRLLKELLPLIDNNnaaKEYYLTDIVKLAkekDVMIKAVFvd-edEFMG 219
gi 75498108  141 -gsLREIVETQDdens-deefLANAGIMVAYaKNLRELVEKIECNgstYEYYLTDIVSIAvksNLNVGYVTtd-eeEATG 217
gi 42520463  155 ndnVQKVLKSEDei------lLANSGIMVSYaKDLYTLIKEVKFNdstNECCLNDIIPIAasnNLRAGYVVad-ekEAMG 227

                 ....*..
Feature 1               
1G97_A       226 VNDRVAL 232
gi 67906680  223 VNSKVDL 229
gi 109892130 223 VNSKKDL 229
gi 15611691  223 VNSQTER 229
gi 81666111  237 VNSKIQL 243
gi 189040835 222 INDKFQL 228
gi 118474348 223 INDKFAL 229
gi 30721656  220 INDKFEL 226
gi 75498108  218 INSRNDL 224
gi 42520463  228 VNNKEDL 234

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