2PA4,2UX8,2E3D


Conserved Protein Domain Family
UGPase_prokaryotic

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cd02541: UGPase_prokaryotic 
Click on image for an interactive view with Cn3D
Prokaryotic UGPase catalyses the synthesis of UDP-glucose.
Prokaryotic UDP-Glucose Pyrophosphorylase (UGPase) catalyzes a reversible production of UDP-Glucose and pyrophosphate (PPi) from glucose-1-phosphate and UTP. UDP-glucose plays pivotal roles in galactose utilization, in glycogen synthesis, and in the synthesis of the carbohydrate moieties of glycolipids , glycoproteins , and proteoglycans. UGPase is found in both prokaryotes and eukaryotes, although prokaryotic and eukaryotic forms of UGPase catalyze the same reaction, they share low sequence similarity.
Statistics
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PSSM-Id: 133021
View PSSM: cd02541
Aligned: 42 rows
Threshold Bit Score: 328.723
Threshold Setting Gi: 32491118
Created: 7-Oct-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitetetramer
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:active site
Evidence:
  • Structure:2pa4_a; Udp-glucose pyrophosphorylase from Corynebacteria glutamicum with bound magnesium and UDP-glucose
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             ####             ##                                                        
2PA4_A        13 KTVVVPAAGLGTRFLPATKTVPKELLPVVDTPGIELIAAEAAe-lGATRLAIITApnKAGVLAHFERSSELEETLMergk 91
gi 47458952    6 RKAIIPAAGWGTRFLPITKVIHKELLPILKKPAIEILIEEAFe-aGIEEIILVISsrKQELKRYFEVNHDLELELFknkk 84
gi 54023746    8 RKAVIPAAGIGSRLLPLTKAIPKEMLPVGDKPVIEHTVRELVa-sGITDITIVVSggKSLIQDHFRPNPALVAQLRadgk 86
gi 15606788    5 RKVVLPVAGWGTRFLPATKAMPKEMLPIIDKPIIQFIVESFIn-iGIENIIFVTGrhKKAIEDHFDHNHELEEHLKkagk 83
gi 116626400  13 QSAVVPVAGLGTRLLPATKSQPKEMLPVARKPIVQYVVEELVs-nGIEQILFVTGrsKASIENHFDHDPELFQALTqank 91
gi 139438554   1 MKAIIPAAGLGTRFLPGTKCTPKEMLPVLDKPVIQYVVEEALdpeEVDDAIIVTSpgKPELLSYFQPDRSLENLLRergk 80
gi 15594552    1 MKGIILAAGYGTRFLPITKTIPKEMLPILNKPAIDYIIQEFId-sGIKDILLISSrrKKVLEDYFDREIELENIFLkenk 79
gi 159036350  21 VKAVIPAAGLATRFLPATKAVPKELLPVVDRPVLQYIVEEATq-aGITDILLVTGrgKTSMIDHFDRRPDLEERLAkkpd 99
gi 42560669    4 RKAVIPCAGFGTRFLPFTKSQAKEMLPIIDTPTIEYIVKEAVd-sGIKEILIILNdkKSEIMNYFSRNIQLEGFLYnkgk 82
gi 207082953   3 KQAIIPLAGLGTRLLPLTSVFAKELLPINGKPGLEYIINECId-aGIKQIIFIISkrKKMIKKYFYNDKFYKELIKkknd 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                               #  ####                     # ##                         
2PA4_A        92 tdqve---iirraadliKAVPVTQDKPLGLGHAVGLAESVLdddedVVAVMLPDDLVLPtg---vMERMAQVRae-fgGS 164
gi 47458952   85 wdllk---slkttninaKIRIVYQEKQLGLGHAIAVGAQWIdd--ePFAVILGDDLIKSke--paIKQLIREFdd-kqAS 156
gi 54023746   87 tafadaveevgelsrlgHITYLDQHGPYGNGTPVLNAARTMgd--ePMLVLWPDDVFVAet--prAQQLIEAYer-tgAP 161
gi 15606788   84 ekllr---evvkissliNPIYVRQKEQLGLGHAVLMAEPAVsq--ePFFVALGDIIVENee--eeLKKMIHLFrk-fgNS 155
gi 116626400  92 qdlls---eldvvalkaKFFYTRQRMQRGLGDAIMCAENFAge--ePFLVALGDSILGLnavskaVARMADVFdskraSC 166
gi 139438554  81 dayad----avahaggmPVDFRYQYEPKGLGHAIRSAADAVag--eNFLVLLGDYVVPNrd---iCDKMLAVSkehggAS 151
gi 15594552   80 kdel-----ekirskkiNISFIRQKEMLGTGNALLYAKPWInr--ePVVVAYPDDLCIGnp--plSLQLIKLYek-tgKN 149
gi 159036350 100 llaa-----vkqtedlaAIYSCRQPEQLGLGHAVGCAESHVge--qPFAVLLGDEFVKPte--plLPAMLELQar-tgGV 169
gi 42560669   83 iaele----qiktkydaSIHYIIQDEPLGLGHAISLCKGFInn--eSFAVLLGDDLFKCqt--paIKQLMDLYee-kqST 153
gi 207082953  82 prvike--ykkilkyrkMIKFVYQNKPKGTGDAVLKTKKYIkd--kYFLMLLPDDLIIKkn---cSKSMIQTHnk-fkSS 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      ##                               ##           #                   
2PA4_A       165 VLCAVEvseadvSKYGIFEIeadt-----------kdsdVKKVKGMVEKPAieDAPSRLAATGRYLLDRKIFDALRr--- 230
gi 47458952  157 ILGVQAveerdlNKYGVVVPfkgyd----------pkdkSFKIIGAVEKPKieNAPSNKAILGRYIFTPRIIDILTnl-- 224
gi 54023746  162 VLALMPmdpaesQRYGVPVVaddh------------gegLLRITGLREKPKpeDAPSSYAAIGGYVVTPGIIEELRrqta 229
gi 15606788  156 IVALMEvpkeevSKYGIAKVkkl-------------deeTYIIVDLVEKPSpeEAPSNLAIVGRYIFTPTIFEKLKv--- 219
gi 116626400 167 VIAVEEvpaeetRHYGIVQPeag-------------addVFRVVNLVEKPApkDAPSNLAIAGRYIFSPVLFDMIRr--- 230
gi 139438554 152 VIAVAAcapeevSRYGVIAGdrvgslegfenaaddepgaVWRIGGLVEKPApeAAPSNLYIVGRYLLSPLVMDLLAd--- 228
gi 15594552  150 IISIIEnpe-niNRYGVIDLyk----------------dEIHVKNIIEKPKigSEPSNKASIGRFLYNYEFFEHLEeg-- 210
gi 159036350 170 VLAFFEvdpaetTRYGIASVapaepe-------fadiadVVRVTGMVEKPKpeDAPSNLAVLGRYVLPGRIFNAIHr--- 239
gi 42560669  154 ILGTILidkkdcKKYGICKIess-------------ddnVYKVCSVIEKPDeqNAPSNVAIAGRYILTPEIFNYLDl--- 217
gi 207082953 154 VMASMSvnkktvSRWGIYKInkkl------------nitDYSIKGVIEKPKikEAPSNKAVIGRYILPKKIFTKLRk--- 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                    #                                           
2PA4_A       231 -iTPGAGGELQLTDAIDLLIDeghpVHIVIHQ--GKRHDLGNPGGYIPACVDFGLS 283
gi 47458952  225 -kPSKTSNEIDVIDAFSKLLKee-dIYAYQFS--GTRYDIGNIEGFVKATIDYALD 276
gi 54023746  230 awYEHRTGEVYLTDAINVHAAdn-pVFGQVIR--GRWYDTGNPADYLVAQFASALA 282
gi 15606788  220 -tKPGKGGEIQLTDAMRLLLEee-aIYACKVN--NTVYDTGNPKDYLKTVISFALR 271
gi 116626400 231 -vKPDKRGEIQLTDAIQFMCEegrrVMAVKLTpeEKRYDIGNFPSYFESFVEFALA 285
gi 139438554 229 -qQAGKGGEIQLTDAMARSLDre-aMYAVVIDp-LSGYDTGTPSGWMATNALMAAS 281
gi 15594552  211 -fKLHKKGEYYHIYALKKLMDqk-kVLYKNIE--GKRIDIGTLEGYLEAIINSAKK 262
gi 159036350 240 -tEPGSGGEIQLTDAMEILRTegvpVHAIVYR--GTRYDTGMPLGYLQTVVQIAAE 292
gi 42560669  218 -qLKGETGEIELTDSILKTISdv-dCYAKVID--GKRYDIGNKLGYLEAFVDFALN 269
gi 207082953 219 -lKPSKGGEIHITDAIQLLINdkekFIAHNFT--GKYLDCGTMDGYINSSKEIAKL 271

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