3FVV


Conserved Protein Domain Family
HAD_PGPPase

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cd02612: HAD_PGPPase 
Click on image for an interactive view with Cn3D
phosphatidylglycerol-phosphate phosphatase, similar to Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C
This family includes Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C, PgpC (previously named yfhB) which catalyzes the dephosphorylation of phosphatidylglycerol-phosphate (PGP) to phosphatidylglycerol (PG). This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319796
View PSSM: cd02612
Aligned: 30 rows
Threshold Bit Score: 141.675
Threshold Setting Gi: 21234234
Created: 3-Aug-2004
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #####                                                                       
3FVV_A         6 LALFDLDHTLLpldsdYQWADFLArtgr--agdpAEARRRNDDl-------------------MERYNRGELtae---qa 61
gi 45752404    3 LALFDFDGTITt---rETMPDFVRrs-------vSRRRLLVGQlll--------------aplVLGYKIGILsg----tl 54
gi 38639561    9 LSVFDFDGTLTr---hDSFIPFLRfaf----gnrAFSRRIVSMa------------------lPTLRCMGKQmtr--del 61
gi 239977088  27 LVAFDFDGTLTv---kDSFNAFLKw--------rAGPRWSFGVlrl--------------tpaLIAYVFDRNrgklkaaa 81
gi 82592543    8 VVFFDLDGTLHq---qDMFGSFLRy---------LLRRQPLNAllvlpl---------lpiiaIALLIKGRAar----wp 62
gi 21230795    3 LALFDFDHTVTt---cDTYARFLRqv------asPEQRAAARWqvg---------------pwVAGYRLGLVsa----pr 54
gi 15895495    4 LAIFDVDYTLTk---kETLFEFYKfmisknpkiiAKLPKILVAg-------------------ILFFAKILDag----ka 57
gi 16126167  123 LAVFDMDGTLLn---gDSTAVWLWe---------RAKRSPLRMlgila----------vapvaVPMVALPLTrr----ag 176
gi 19704227    7 AAFFDIDGTIYrn--aLLIEHFKKlvkye-lfddIQYRLKVEEaynlwdt-------rkgdydDYLLDLTQL-------- 68
gi 15893555    5 AAFFDIDGTLYre--gLISEVFKKliky---eiiDEEKWYKEVrpefekwdnrkgdyddyllkMTEIYVDALng----ls 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    ##                  
3FVV_A        62 AEFMLGLLaahspv--elaawhEEFMRDVIRPs----lTVQAVDVVRGHLa-aGDLCALVTATn-SFVTAPIARAFGVq- 132
gi 45752404   55 IRRVIVRFaysgipasvleaqgRDFAQSYLPNt----lRGEAMQRIAWHKa-qGHKVVVVSGGl-EAYLEPWCDSHGV-- 126
gi 38639561   62 KETLITTFltgveek-wvsskaEEFCELYWHRl----mRPAGLIAVANEVt-sGAIVTLCSASp-EIVLRPFAEKLRI-- 132
gi 239977088  82 VRQFLKGAtvaqi-----endaRAFAEAFAPSl----lRPDAVAVWRGWRa-kGAKMVIVTASp-DLIVAPFARGLGAd- 149
gi 82592543   63 MSLLLWGCtfghsea-rlqtlqADFVRWFRDNvt---aFPLVQERLTTYLlssDADIWLITGSpqPLVEAVYFDTPWLpr 138
gi 21230795   55 LRARVTRLvftgraldemqthgASYARTDLPGv----lRPEVMRRIDWHQa-qGHEVVLVSGSl-DLYLQPWCTQHGL-- 126
gi 15895495   58 KEMFISFIdgikee--dmkeyvKEFYDLKLSKi----lYVDAINTMKKLKs-eGYDIFLISASa-EFYLNELYNIKEVd- 128
gi 16126167  177 ASILLWIAtaglseq-qllascDDFARAFAERrcslswKPQALAALDQHAa-aGDRVVVVTAAp-LCLANALLRTLDRr- 252
gi 19704227   69 YVVAIKGLpvky------ndfiSNQVLLLKGNr----vYTYTREMIEWHKk-mGHKVFFISGSp-SFLVSRMAKKMGVd- 135
gi 15893555   76 KSQVEFIA--------------SQVVNQKGERv-----YTYTRDRIKWHKe-rGHKIITISGSp-IELVRNMAEKYGFd- 133
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                                      #                        ##  ##                
3FVV_A       133 -HLIATDPEy--rDGRYTGRIEGtpSFREGKVVRVNQWLAgmglalgdfaeSYFYSDSVNDVPLLEAVTRPIAANPS 206
gi 45752404  127 -ELICSSLQq--sDGILTGRYEGrqCVLTEKARLVRERYDlat-----yptIYAYGDTPEDLDMLAIATKQYYQWQE 195
gi 38639561  133 -KLIGTQLEt--kDGILTGRISGhnCRCSQKIIRLEKEYGplt-----dyhLRAWGDTRGDYELLSAATEPHWRHFH 201
gi 239977088 150 -LLIGTRLRcs-dDGRILGGLDGnnCRAKEKVIRLREVFGpdv------rlTAAYGDTSGDTEMLAIADEKGYRIFR 218
gi 82592543  139 vNLIASQIQ----RGYGGWVLTMr-CLGHEKVAQLERKIGtpl------rlYSGYSDSNQDNPLLYFCQHRWRVTPR 204
gi 21230795  127 -SLICNQLEh--aAGRLTGRYADg-DCGPHKAAQIRLRYTlaq-----ydcVHAYGDSREDRPMLALAQQRWYRGQQ 194
gi 15895495  129 -RVIGTRFTn--eNGIFRRKIIGenCKGEEKVKRLKEVLEeekie-vdfkeSYMFSDSLSDMPLFKLVGHPYLVNPK 201
gi 16126167  253 vEVLGTSLK----PGLGGWIANIh-CRNQRKCQALAEAGHga-------rwAYAYTDSLDDLPILRAADRPVIVKGG 317
gi 19704227  136 -DFCGSVYEideeTQTFSGKILKpmWDSAHKQEAIENFIKkyni---dlskSYAYGDTNGDFSMLSLVGNPRAINPS 208
gi 15893555  134 -DYRGAEYLld-eNDVYTGEVIPm-WDSKSKERAVHELEAkyni---dlgeSYAYGDTSGDLTMLKMVGNPVCINPT 204

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