Conserved Protein Domain Family
R3H_PARN

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cd02637: R3H_PARN 
Click on image for an interactive view with Cn3D
R3H domain of Poly(A)-specific ribonuclease (PARN). PARN is a poly(A)-specific 3' exonuclease from the RNase D family that, in Xenopus, deadenylates a specific class of maternal mRNAs which results in their translational repression. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA.
Statistics
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PSSM-Id: 100066
View PSSM: cd02637
Aligned: 15 rows
Threshold Bit Score: 56.1787
Threshold Setting Gi: 32267018
Created: 28-Mar-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
degenerate
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:degenerate RxxxH motif
Evidence:
  • Comment:The RxxxH motif gives R3H domain its name. In this sub-family, a RxxxY motif is more typical
  • Citation:PMID 9787637

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                                       #   #                                    
1UG8_A         13 IDQVIEKIEDFLQSee-kRSLELDPCTGFQRKLIYQTLSWK-YPKG--IHVETL-ETDKKERHIVISKVDE 78
gi 66499479   166 IEEICSRIDEFVTSe--tEELLIEKCNAFIRRLVYQEVKLR-WPNK--LKVESK-MNNFGCILVVQRLGTK 230
gi 156351496  186 VSGACSKIEEMVKDpd-gKRTSLPPCNGYLRKLIYQTVKHR-FRSG--IHLEKN-MNEKKECFIVATKVDD 251
gi 167862920  143 MAEIEERIGVFLASe--eKDFTITNCNGFQRKLVYQMIEAK-FRKQ--ISTSSV-ELENKHKGILVERKRT 207
gi 60390548   180 IRSVEEKVEALLKNt--dQTLDLEPCTGFQRKLIYQTLNSK-YSKG--LHVEAL-ETEKKERFIQISKVDD 244
gi 156548166  166 IDEICSGIEDYVNSeddgKELRIERCNAFIRRLVHQEARLR-WPNK--IRLETR-NENGNQFIIVSKIGTK 232
gi 145538409  166 IRELIDKLEKFNKSd--eKQITIETTNGYQRKVIYTYLEAY-QKNM--IGESLLkGEMKITKLTNAEKQAK 231
gi 91089451   173 VDDFMKRLSDFLESd--dDELELPKCNAFVRRLIYQTTGQK-FTNK--IVLHTK-QNKNKDRILVASKCKT 237
gi 123483715  572 MDKVDEKLLEFAESv--eQDLECIGITAIEDKLQEGVPETIeWLRRagIHVWVL-TGDKLETAIEIGKTSK 639
gi 115700039  228 IDDVSKRVGAFAAGt--aDELKLEPCTGYPSGLHLDTHTTE-DKKGrfIVVRRV-TEEEKKKLAQDKLQAE 294

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