Conserved Protein Domain Family
R3H_RRM

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cd02639: R3H_RRM 
R3H domain of mainly fungal proteins which are associated with a RNA recognition motif (RRM) domain. Present in this group is the RNA-binding post-transcriptional regulator Cip2 (Csx1-interacting protein 2) involved in counteracting Csx1 function. Csx1 plays a central role in controlling gene expression during oxidative stress. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Statistics
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PSSM-Id: 100068
View PSSM: cd02639
Aligned: 11 rows
Threshold Bit Score: 84.6559
Threshold Setting Gi: 50406743
Created: 13-Apr-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
RxxxH motif
Feature 1:RxxxH motif
Evidence:
  • Comment:The RxxxH motif gives R3H domain its name.
  • Citation:PMID 9787637

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                         #   #                            
EAA59660     300 TLSYYSQLLLFKEDts--rDSIIFPPn-LTPVQRRTVHTLAHNMGLGHASRGTGd---QRQVQVFK 359 Aspergillus nidulans FGSC A4
EAK84806     444 TLEIYSRVLLFKDDrm--rDELAFSRs-LTPLERRTVHLVAQRLGLFHYSMGDGd---ERYAIVTK 503 Ustilago maydis 521
AAW46085     314 TLDIYSRVLVFKEDrm--rDELAFSKn-LSPTERRIVHLVAQRLGLTSVTRGEE----EQCVVVTR 372 Cryptococcus neoformans var. ...
Q09868       358 ILNVYSHILLFYYRsd-ntNDLVFDSs-TTQEERRVAALLASRLNLNHSVTGDGe---AKQVVITM 418 fission yeast
EAT83231     326 VLQFYGQLLIFKEDpa--rDQMTFPPn-LSPPQRRIIHTLAHQLALAHVSKGTGe---QRQVHIFK 385 Phaeosphaeria nodorum SN15
XP_001729838 375 TMEVYSRVLAFKDDrm--rDELAFSKs-LTPAERRVVHLVARSFGLNHFTVGSGd---DCYVMVTK 434 Malassezia globosa CBS 7966
XP_001558752 217 TLNYYTELLFFKQDae--rEVLTFAPt-VSPADRRIIHTLAHNMGLDHHSQGHGe---LRQVQIVK 276 Botryotinia fuckeliana B05.10
XP_502874    408 TLEFYSQLLLFRDDak--rTEIVYSHplLLPQQRQIVMSLCDQLGLIFNSEATGlvvvTRQRQYYE 471 Yarrowia lipolytica CLIB122
XP_447471    315 TLEIYSQLLLFKDReh-lyTELIYPSg-IANSLRRILDLCCSALGLIESSDPNFit-iRRKTNNYD 377 Candida glabrata CBS 138
XP_456659    333 ILELYSQLILFRDDmaksiFELAFPSs-LGIAHRKILSILCSYLNLLELYDNGLii-iRRKQGQPA 396 Debaryomyces hansenii CBS767
EDN64566     305 TLEIYSQLLLFKDRek-yyYELAYPMg-ISASHKRIINVLCSYLGLVEVYDPRFii-iRRKILDHA 367 Saccharomyces cerevisiae YJM789

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