Conserved Protein Domain Family
R3H_NRF

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cd02640: R3H_NRF 
R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB proteins that can silence the IFNbeta promoter via binding to a negative regulatory element (NRE). Beside R3H NRF also contains a G-patch domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Statistics
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PSSM-Id: 100069
View PSSM: cd02640
Aligned: 9 rows
Threshold Bit Score: 79.7481
Threshold Setting Gi: 3417428
Created: 13-Apr-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
RxxxH motif
Feature 1:RxxxH motif
Evidence:
  • Comment:The RxxxH motif gives R3H domain its name.
  • Citation:PMID 9787637

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      #   #                         
O15226       603 KRDIEQIIRNYARSeshTDLTFSReLTNDERKQIHQIAQKYGLKSKSHGVGhDRYLVVGR 662 human
NP_650449    331 FADYRRLIENYVRSddiRDMQFEPtFSKEERTTLHQIARQFGLRSASYGSGeSRRLLITK 390 fruit fly
NP_001012905 681 KRDIEQIIRNYAHSeshVDLTFSTeLTNDERKQIHQIAQKYGLKSKSHGQGrDRYLVVSR 740 chicken
NP_001039125 703 KRDIEKIIRNYAASynqDDLTFSKeLSNEERKYIHQISQKYGLKSKSHGHGnERFLVVSR 762 western clawed frog
XP_001357916 328 LGDYRKMIENYVKSddmRDMQFEPtFSKEERASFHKIASKYGLRSGSYGNGeSRRLLITK 387 Drosophila pseudoobscura
XP_001600262 319 KKKCMEVLQNYAKGdtsVDMVFSPsFSNDERGLIHQLARTIGLKSQSYGPKnQRTLTISK 378 jewel wasp
XP_001653266 349 INFYRQMMQNFKDSyleYDLVFSSeFTKEERALFHSMAQQLQLKTRSYGNDnDGTRQFVL 408 yellow fever mosquito
XP_001629432 248 KGSVHKVILDFINSs-dQDMKFSPeLSKEDRALVHQLSKRYGLRHQSYGKDaERYLVISK 306 starlet sea anemone
CAA20315     528 INDVYQRMQQFKHSa-iEEISLPP-CRKYVRRLVHALANDLNLKSRSYGSGnKRYTMLSK 585 fission yeast

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