Conserved Protein Domain Family
R3H_Smubp-2_like

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cd02641: R3H_Smubp-2_like 
Click on image for an interactive view with Cn3D
R3H domain of Smubp-2_like proteins. Smubp-2_like proteins also contain a helicase_like and an AN1-like Zinc finger domain and have been shown to bind single-stranded DNA. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA.
Statistics
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PSSM-Id: 100070
View PSSM: cd02641
Aligned: 9 rows
Threshold Bit Score: 85.0962
Threshold Setting Gi: 42734059
Created: 2-May-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
RxxxH motifputative
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:RxxxH motif
Evidence:
  • Comment:The RxxxH motif gives R3H domain its name.
  • Citation:PMID 9787637

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                       #   #                         
1MSZ_A         18 VDHFRAMIVEFMASKk-MQLEFPPsLNSHDRLRVHQIAEEHGLRHDSSGEGKRRFITVSK 76
gi 42734059   776 RLQLESIVNTFMKTSm-ESHSFPStLSSFERLVVHELAEKNKLNHQSVGEGENRVITISK 834
gi 47224512   472 YSEIKKQVELFLKDGdrTELQFPPfFNSHDRLLVHQVAEELGLTHESKGEGRDRRITVSR 531
gi 53136864   379 TNKFKAVLEAFLEGDe-PQLDFPSsLSPHDRMLIHLLAEEHGLQHVSTGEGRDRYISVRK 437
gi 120952590  719 RKEIKEQLLNFLKDPdkTELEFPStLNSHDRLLVHELSEEIGLRHESQGEGKSRHITVSR 778
gi 109105146  726 VDHFRATIAEFMASDk-TQLEFPPsLNSHDRLRVHQIAEELGVRSAQGQPASKEQQASGQ 784
gi 157871976   96 VRHYHRLLLAFIEDKskYELELPN-LSSLDRMVVHALAEKCNLSHESTGDRADRVMHLKK 154
gi 71655878   137 KKNLYAMVKAFVDDPnaEEMSFPPtLSAAERHMVHEIALNFNLHHRSAGCKSERVLTLKK 196
gi 62360056   131 KKHLQSMVKAFVDDPtaHELSFPPtLSAAGRQQVHKFAHTFGLFHKSSGSQNERFLTLRK 190

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