1WHR


Conserved Protein Domain Family
R3H_encore_like

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cd02642: R3H_encore_like 
Click on image for an interactive view with Cn3D
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Statistics
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PSSM-Id: 100071
View PSSM: cd02642
Aligned: 32 rows
Threshold Bit Score: 51.4493
Threshold Setting Gi: 50550543
Created: 28-Mar-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
RxxxH motif
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:RxxxH motif
Evidence:
  • Comment:The RxxxH motif gives R3H domain its name.
  • Citation:PMID 9787637

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                 #   #  
1WHR_A        29 DRMMLLKLEQEILEFINDnn---------------------nQFKKFPQ-------------------MTSYHRMLLHRV 68
gi 50550543  190 ARNHVLKIEQSILSLVATsteegtpadpknegtpevtnnaedEPSSFQSpsplpnlp----shvtvegPTPYHRLLIYKL 265
gi 50550543   16 SRLLVLKIEKQLQQFLDAq----------------------kNASLLPPtapvaqqqqhkppsltldsMNSFNRLLTHRI 73
gi 147810539  16 CKHLVLSIEEALVNFLQDdns-------------------ldGVMELEP-------------------MNPYERLLVHRL 57
gi 125524045 114 SKHLVLSTEETLVGILQNqyhnsdddeded-divaayrgtnrNILELQP-------------------ASSYQRLLLHRL 173
gi 91092772  171 SLEQVKQSEDDLIAFFKSt----------------------pSQVYVKCp------------------ASYFERLLLHAI 210
gi 67476690  118 QNSFVQTIDKLILNYIKNkd---------------------sDILEFKL-------------------ENNYERLLCHAI 157
gi 168029172 257 DRLTILRLEQEVERFIRNps---------------------lQILEFQPm------------------PSSYLRLAAHRV 297
gi 157357565  81 ERLSILRMEQDIEKFIHDpt---------------------qQQLEFQQl------------------PTSYLRLAAHRV 121
gi 162460965  52 HRLMVLRMELDIQNFMQNpq---------------------lQEFEFQNf------------------PTSYLRCAAHRV 92
                         90       100       110
                 ....*....|....*....|....*....|....
Feature 1                                          
1WHR_A        69 AAYFg-----MDHNVDQt-------gKAVIINKT 90
gi 50550543  266 VQYYn-----FTYDVDEk-------tHKITIYRP 287
gi 50550543   74 AEYYg-----LDHVVVDg--------HAVKIFYR 94
gi 147810539  58 ADIFgpsilvSDIIWQYqesq-pptmSHQLLRRN 90
gi 125524045 174 ADIYg-----FVHESVGeg-----edRHLVLQRC 197
gi 91092772  211 AQYHd-----LQSLGMNed-----gnKRVEIYNT 234
gi 67476690  158 ADYYn-----LNSYSTGng-----kfRVTRVNTS 181
gi 168029172 298 AQHYn-----LQSMVVDggs---aegTRIVAKKT 323
gi 157357565 122 AQHYs-----LQSMVLLdnnlpdgsgSKIIVRKT 150
gi 162460965  93 AQHYg-----LETIVADslve--gsvSRIVARKT 119

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