Conserved Protein Domain Family
R3H_NF-X1

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cd02643: R3H_NF-X1 
R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes. The Drosophila homolog shuttle craft (STC) has been shown to be a DNA- or RNA-binding protein required for proper axon guidance in the central nervous system and, the yeast homolog FAP1 encodes a dosage suppressor of rapamycin toxicity. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Statistics
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PSSM-Id: 100072
View PSSM: cd02643
Aligned: 11 rows
Threshold Bit Score: 114.377
Threshold Setting Gi: 17552206
Created: 28-Mar-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
RxxxH motif
Feature 1:RxxxH motif
Evidence:
  • Comment:The RxxxH motif gives R3H domain its name.
  • Citation:PMID 9787637

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                                       #   #                         
gi 47217476   857 KDDARKDLKFVAEVEEEMKNLVELtnkg--kqpkRSHCFPPmNREHRKMVHELAEAYaLESVSYDsePKRNVVITA 930
gi 2498629    971 KEDARKDLKFVSDVEKEMETLVEAvnkg--knskKSHSFPPmNRDHRRIIHDLAQVYgLESVSYDsePKRNVVVTA 1044
gi 118086317 1081 KEDARKDLKFVSDVEKEMRMLVEAvnkg--kytkKSHCYPPmNRDHRRIIHELAQVYgIESVSYDnePKRNVVITA 1154
gi 115621218  865 KDMYRKSPPFVADVEKDFANLISSvntes-qqptQIYTFPPmARDQRAFVHEMANLYcLSSDSTGqeTTRHVIITA 939
gi 91083637   818 RNWAKKDPQFCQKVHEKLTELVQLakqs--kqksRSYSFESmNRDKRHFVHEYCEHFgCESAAYDaePNRNIVATA 891
gi 41712398   996 RGFAKKNPALTKSVYETLTDLVKLakes--kqrsRSHSFPTmNREKRQLVHELCEVFgIESVSYDkePNRNVVATA 1069
gi 118343906  890 MNMAKTDLAFIRTVEKDLINLVESvswl--dttkQSHPFPSmKRDKRQAVHELAEAFqCKSESLDeePNRNVVATA 963
gi 158591803  852 KNKLKTNYKDILDVEDTLIELLHDlnaqp-nvtsVSHSFPPmHSELRRIIHEYSEHFgIETVSYGqePQRNVVATA 926
gi 156397911  899 LAEAKFNFPFIKSIEEVFYGLIESttkg--sltqKSHAFNPmNSHQRRIIHELASHYnLCSRSYDqePKRNTVVTA 972
gi 167881587  882 RTYAKKDPALIKMIHDRLSELVKLakesk-hqksRSFSFPVmNREKRHVVHEMCGMFgIESVAYDaePNRNVVATA 956
gi 17552206   860 KEMVRTNIDFVKSVEKILIDLVIQilsgeayhdtFRAHLPAmSIEKRRFVHEYANFFnIASESVDspPKRSIVLTA 935

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