Conserved Protein Domain Family
GH18_chitinase_D-like

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cd02871: GH18_chitinase_D-like 
GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (GH18) domain, a chitin-binding domain, and a fibronectin type III domain. The chitin-binding and fibronectin type III domains are located either N-terminal or C-terminal to the catalytic domain. This family includes exochitinase Chi36 from Bacillus cereus.
Statistics
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PSSM-Id: 119350
View PSSM: cd02871
Aligned: 22 rows
Threshold Bit Score: 279.991
Threshold Setting Gi: 50365163
Created: 1-Jun-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative active
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                                             #                            
gi 6226570    190 KWLIGYWHNFdngstnik-------------------lrnvstaYDVINVSFAEpispgsgtla--------ftpynatv 242
gi 124899078   30 KILMGFWHNWpsdagqgyrggr----------faempltdipdaYNVVAVAFMKgqgiptfr------------pyntsd 87
gi 1763985     35 GVVVGYWQNWcdgggyqggna------------pcvtldevnpmYNIVNVSFMKvydvadgriptf----kldptvglse 98
gi 16411336    44 QVLVGYWHSWkssgkdgyqqgt----------sadialkdtpkaYNVVDVSFMKgdgvnriptf---------kpvgind 104
gi 50365163   782 KTLVGYHYDWggnfenkial---------------ndkdlltssYNVINLSFLYstveyqmpt-----------yspnnp 835
gi 146302282 1142 KIILGYAHSWenagapfly-----------------fsqmvgskFNVVDYSFVEtvnrdgytpilttndtryltngvfnk 1204
gi 6752346     52 KVLQGYWENWdgaangvhppfgw---------tpitdpqigahgYNVLNAAFPVilsdgtalwe--------dgmdrgvk 114
gi 24209900    41 KVLQGYWENWdgakngvhppfgw---------tpiqnpdirkhgYNVINAAFPIiqpdgtalwe--------dgmdtgvk 103
gi 89257056   359 AGILPLWGKSssynisgqqintipisismpkdkeycdynpnvckYNVIIAAYLTytsskgfelsfne--engsskkiysp 436
gi 192810807  193 HILTGYWQNFvngasklk-------------------vrdipdqYDIIVLAFAEmdpanpggvtfnvdsalsaalggyts 253
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   # #                   
gi 6226570    243 eeFKSDIAYLQSQGKKVLISMGGangrieltdatkKRQQFEDSLKSIISTYGFNGLDIDLEGSslslnagdtdf----rs 318
gi 124899078   88 aeFRRQIGALNARQRAVLISLGGadahi--elhtgQEDDLAHEIVRLVETYGFDGLDIDLEQSaidya------------ 153
gi 1763985     99 eqFIDQVSELNKQGRSVLLALGGadahv--eletgDERAFADEIIRLTERYGFDGLDIDLEQAavtaa------------ 164
gi 16411336   105 sdFRAQVGALNKEGRAVLLALGGadghv--elkagDEEAFANEIIRQVETYGFDGLDIDLEQSaitag------------ 170
gi 50365163   836 aaIKEGVKALQSQGKRVLISMGGataehm-kfrndQKDQLKTAIKSVINEYGFDGLDIDWESEslkss------------ 902
gi 146302282 1205 qlLKNDIKSLRDSGVPVIVSIGGqnghvv-ldnvtQKNIFVNGLKAIIDEYQFDGVDIDFEGGsmnfnagglrdisyagi 1283
gi 6752346    115 vaTPAEMCAAKASGQTLLLSIGGatagid-lnstaVADRFVDTIVPILKEYNFDGIDIDIETGltgsgni---------- 183
gi 24209900   104 vaSPADMCEAKAAGATILMSIGGataaid-lsssaVADKFVSTIVPILKKYNFDGIDIDIESGltgsgni---------- 172
gi 89257056   437 eeLKAFITYMNSKGKHTIVSIGGkys------hinWETINFSDLVKIVQEYGFNGINFDLSSSdmpkndkva-------k 503
gi 192810807  254 aeLIADIQAKRAQGKKVIISIGGelgninlnnpspNVANFVNSMYGIMTQYGLDGLDIDLEHGmnv-------------- 319
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                    # #  
gi 6226570    319 pttpkivnLINGVKALKSHFga---nfVLTAAPETAYvqggyl----nyggpwGAYLPVIHALRn---DLTLLHVQHYNt 388
gi 124899078  154 ---dnqtvIPAALRMVKDHYakerknfIISMAPEFPYlr------------qnGKYVPYIKALEg---YYDFIAPQYYNq 215
gi 1763985    165 ---nnqtvIPDALKLVKDHYraegknfLITMAPEFPYlt------------tgGKYVPYIDNLEg---YYDWINPQFYNq 226
gi 16411336   171 ---dnktvIPAALKIVKDHYkaegknfLITMAPEFPYlk------------pgSAYESYLTSLAn---YYDYIAPQLYNq 232
gi 50365163   903 ---esknvTAEALKELKDEYksegkdfIITMAPEFPYlrki--------keadGNYKEFLDGLDg---YYDWINPQFYNg 968
gi 146302282 1284 sayprlknVVDAFKELKAYYgp---gfLLTAAPETQYvqggyt----tytdtfGSFLPIIQNLRn---ELDLLAVQLYNt 1353
gi 6752346    184 --nqlsasQSNLIRIIDGVLarmpsnfGLTMAPETAYvtggsi----vygsiwGAYLPIIKKYAen-gRLWWLNMQYYNg 256
gi 24209900   173 --ntlstsQTNLIRIIDGVLaqmpanfGLTMAPETAYvtggti----tygsiwGSYLPIIKKYLdn-gRLWWLNMQYYNg 245
gi 89257056   504 iaadkinkLITALRQNNHGF-------WLTFSPEWHYivaplakndkdniyvnHNYIELLDSLGmnkiDYIWLNTFADKp 576
gi 192810807  320 ------pnLTNAIRQLKQKVgn---dfVLTMAPQTIDmqn-----------pnTSYMQLYNNLKd---MTTVINVQYYNs 376
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 6226570    389 gsmv-----------------gldgRSYAQGTADFHVAMAQMLLQGfnvggss-----gpffspLRPDQIAIGVPASQQA 446
gi 124899078  216 ggdgvwv-----------dgvgwlkADDDEKKQDFLYYLTDSLVTGtrd------------ymrIPNDKFVIGLPSNPDA 272
gi 1763985    227 ggdgiwv-----------dgvgwiaQNNDELKEEFIYYISDSLINGtrg------------fhkIPHDKLVFGIPSSIDA 283
gi 16411336   233 ggdgvwv----------detnqwiaQNNDTLKESFLYYMADSFINGtrg------------ylkIPANKFVFGLPANVDA 290
gi 50365163   969 wgdgvlvetsedakktgvqqntyitNDNVDKRGEFYYLMSKYITSKpnnqn---------gfyqIPADKFIIGASTNEPA 1039
gi 146302282 1354 ggen----------------gldgqYYGTAKKSNMVTALTDMVIKGyniast------gmrfdgLPASKVLIALPACPSA 1411
gi 6752346    257 smy------------------gcagDSYSAGTVQGFTAQTDCLDKGlviqg---------ttvrVPYDKQVPGLPAQPGA 309
gi 24209900   246 emy------------------gcsgDSHKAGTVEGFIAQTDCLNKGlsiqg---------vtitIPYDKQVPGLPAQPGA 298
gi 89257056   577 ydgilsfy--------kdkdgehikITPADGYAKFLASLAWALTTRagydanmpkydeidkplhIPANKLVLMIPATKGT 648
gi 192810807  377 gcml-----------------grdgKCYSQGTVDFLTALSDLTLQW------------------VSPSQLGIGVPATSSA 421
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                        #                                
gi 6226570    447 ag--gGYTAPAELQKALNYLIKgvsyggsyt-lrqpagyvgLKGIMTWSINWDay-----------------tnNQFSNA 506
gi 124899078  273 aa-sgYVNNAQDAIHALERLENag---------------kaIRGLMTWSVSWDdgsdkn----------grpydWEFVRR 326
gi 1763985    284 aa-tgFVKEPQDLYDAFDSLTAqg---------------qpLRGVMTWSINWDmgtnka----------gqaynEQFIKD 337
gi 16411336   291 aa-tgYVTDPQIVKNVFTRLQAkg---------------tpVKGIMTWSVNWDagknka----------gvpynNSFSNA 344
gi 50365163  1040 g---rGAGSKEAFNKAYNLLNSdg---------------ikIRGLMTWSILFDafegmipdtyggtepkimwyrWSYSKW 1101
gi 146302282 1412 ag--sGYLTPTEGINAMHYLRTgttfsgrtytmqpggpypsLRGLMTWSVNWDassc--------------gnsSELSKA 1475
gi 6752346    310 g---gGYMSPSPVSQAWNHYNGa------------------LKGLMTWSLNWDgs-----------------knWTFGTN 351
gi 24209900   299 g---gGHMSPSNVAQVLSHYKGa------------------LKGLMTWSLNWDgs-----------------knWTFGDN 340
gi 89257056   649 thsdmVYVLSEKDIKEVVSLMKgnn--------------asFAGFAVWSIDFDatn---------------innGDLGND 699
gi 192810807  422 ag--gGYVSPTVVNNALNCLATgnscgsyk----paakypdIRGAMTWSINWDat-----------------tnYALAKT 478

                  ....
Feature 1             
gi 6226570    507 HRPF 510
gi 124899078  327 YGFL 330
gi 1763985    338 YGPF 341
gi 16411336   345 YGPI 348
gi 50365163  1102 FDES 1105
gi 146302282 1476 YAAY 1479
gi 6752346    352 VKSL 355
gi 24209900   341 VKGT 344
gi 89257056   700 YSHK 703
gi 192810807  479 VRPF 482

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