Conserved Protein Domain Family
GH18_hevamine_XipI_class_III

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cd02877: GH18_hevamine_XipI_class_III 
Click on image for an interactive view with Cn3D
This conserved domain family includes xylanase inhibitor Xip-I, and the class III plant chitinases such as hevamine, concanavalin B, and PPL2, all of which have a glycosyl hydrolase family 18 (GH18) domain. Hevamine is a class III endochitinase that hydrolyzes the linear polysaccharide chains of chitin and peptidoglycan and is important for defense against pathogenic bacteria and fungi. PPL2 (Parkia platycephala lectin 2) is a class III chitinase from Parkia platycephala seeds that hydrolyzes beta(1-4) glycosidic bonds linking 2-acetoamido-2-deoxy-beta-D-glucopyranose units in chitin.
Statistics
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PSSM-Id: 119356
View PSSM: cd02877
Aligned: 55 rows
Threshold Bit Score: 288.369
Threshold Setting Gi: 19072991
Created: 1-Jun-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                                    #                                     
2UY2_A          6 TNIAVYWGQNsag--------tqESLATYCESs-dADIFLLSFLNQFp--------TLGLNFANACsdtfsdg------- 61
gi 9971105     29 HKLTVYWGAEdd----------tTTLDDVCNDs-sYDVVNLAFLSHFfsa----ggYPKMSIGNLDgpsqaqkkag--at 91
gi 46128419    18 GGLNGYWGQLg-----------sEPLKAYCDSh--PEYITLSFVNQApeqn--psnLPGTNFAGHCaggtygnsn----- 77
gi 66844760    31 AQNVVYWGQNgggt------venNDLASYCTStsgIDIIVLSFLYQY---------GNGNTIASGTigqscyisps---g 92
gi 85074694    23 AKVNVYWGQRg-----------dARLRDHCDQa-nFDYVTIGAHCDAtyy---tngTTSGHMNGKCsv------------ 75
gi 113531039   22 HKIVAYWGQNavynslkprqyweKDLVDFCRDy-nYDIIVLSFLNVFfdrk-nkdrMPGFNFAFHCetpvapeyp----- 94
gi 116193493   20 PAVNVYWGQKgv---------atDRLRTFCDDs-sFEYVTVGFINKSpeqdpsslkYPGSDFAVHCveakykdpnevdsn 89
gi 126032267   32 AQNVVYWGQNgggt------venNDLSAYCTPtsgIDIIVLSFLYQWgqg----ssALGGTIGQSCgittsge------- 94
gi 126032275   12 GLLNGYWGQYtt----------tEGLRPHCDSg--VDSITLGFVNGApda----sgYPSLNFGPNCwaesypgnlglpsk 75
gi 171685035   20 PEVNVYWGQTa-----------gSRLSTFCDAs-gFDYVTVGFLNKSpsqdpsganWPGTNFGSHCdgvyykyngan-tn 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
2UY2_A         62 -llhctqiAEDIETCQSLGKKVLLSLGGASGSYlf----sDDSQAETFAQTLWDTFGEGtga-------------seRPF 123
gi 9971105     92 glqdgsslVKSIKNCQSKGKPVILSMGGATDYSdvq--lnSDAQGQQIANTVWNLFLGGtdh------------kelRPF 157
gi 46128419    78 llsecytiQEGIPYCKDRGVKILLSIGGVYSDEgsnykvtTDDKGRDFADFLYKSFGPHnehsnpir--pfdsidndGNT 155
gi 66844760    93 qpqncdalASAIKTCQSRGVKVILSLGGAVGAYsl----sSQAEAETIGQNLWEAYGNTqgng-----------nvpRPF 157
gi 85074694    76 -------vASDIKHCQEKGKKVLLSLDGVEHMGsrf-slsSEAKAEEFASFLWGAFGPYdakwtg-------prpfdFAG 140
gi 113531039   95 kmfrcpkiEAGIKECQKNGKQVLMSLGGAVGRVgf----sGVDEAKLFAYRVYHLLLEGtdl------------qaiRPF 158
gi 116193493   90 llarcgqiAADVRYCQKKGKKVLLSIGGQWDPPhtdytisSGPAGEYFADFIWGAFGPYnkdwegkprpfddyygaeEGD 169
gi 126032267   95 -pqncdalTAAITKCKTAGVKIILSLGGASAFSsf----qTADQAAQAGQYLWNAYGGGsg--------------vtRPL 155
gi 126032275   76 llshcmslQSDIPYCRSKGVKVILSIGGVYNALtsnyfvgDNGTATDFATFLYNAFGPYnasytgp-----rpfddiTTG 150
gi 171685035   87 vqsdcgkiAADIRYCQKKGKKVLLSIGGEWKTTany-dlsNEAEGRRFALFVWQAFGPRiagstvprpfddyylnaeEGE 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   # #                                        #                          
2UY2_A        124 DSAVVDGFDFDIENNne----vgYSALATKLRTLFaegt-----kqyYLSAAPQCPYPDa----sVGDLLEn--aDIDFA 188
gi 9971105    158 GDVKLDGVDLDNETNdg----tgYLAMTKQFKANFqkdt----skkyYITAAPQCPYPDq----sEPLDVCq---LLDWV 222
gi 46128419   156 VHAAVDGFDFDIEHDlpn---gpYIAMINRLRELDeg---------lTITGAPQCPTSDey--fyMKDMIKs--aKFDAL 219
gi 66844760   158 GSTFVNGWDFDIESYsgn---eyYQYLINKLRSNFasdp----snqyYITGAPQCPIPEp----nMQVIVTk--aQFDYL 224
gi 85074694   141 HRVSVDGFNLDGELKlngagegaYAAMAKKLRELYngn------aelLLTAAPGCSLDDv----kMKAIFDn--aQFDAL 208
gi 113531039  159 GSAIMDGIDLDIENGyy----syYTDFVKELRRLEkags-----qkiLIGAAPQCPFPDrllgpsAGRVLGdvpkLVDEI 229
gi 116193493  170 EHFVFDGFDFDIEHKfed--qtgYVAMVRRLRGLTsldt----srkyLITAAPECPLEDky--fkMKTIINe--cQFDAL 239
gi 126032267  156 GNNVMDGFDLDIESNpgt--nenYAALVSALRSNFasdp----srqyVISGAPQCPLPEp----nMGVIIQn--aQFDYL 223
gi 126032275  151 LPTSVDGFDFDIEADfpn---gpYIKMIETFRSLDss---------mLITGAPQCPTNPqy--fvMKDMIQq--aAFDKL 214
gi 171685035  166 ENFVFDGFDFDIEKSydanqskgYIAMISSLRQFMatpqlnpnnrqfLITAAPECPLNDpy--ykMKHIIKn--sKFDLL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           # #                                                                           
2UY2_A        189 FIQFYNNyc----------svSGQFNWDTWLTYAqtvspnknikLFLGLPGSAsa------agSGYISDTSLLESTIADI 252
gi 9971105    223 QVQFYNNgncn------iaqrGFAKAVKNWSKGIgsg-----vqLYIGALASGad------gdEGYVHAATLNRAVNQVK 285
gi 46128419   220 FVQFYNNpwcdav---sqgheGESFNYDKWVEIIeesdcskdakLYVGLPASEeaa-----pgGGYLEPEDLKDLVCELT 291
gi 66844760   225 WVQFYNNpgc---------svNGPINYDQWVSNLantps-anakIFIGVPASPlgatgtssgaQYYLQPSALASLVAEYK 294
gi 85074694   209 FIQFYNNpsce-------aasASGFNYLQWEKAIaagms-keakLFIGLAGASda------agSGYIEPLEAAALINTYK 274
gi 113531039  230 YIQFYNNwcht------gnerVFYGHVKKWVDYSkktd---gpmIFVGVPGNKkas----gnpLHYRTPSELAKIYQNLK 296
gi 116193493  240 FIQFYNNdmc---------agVNNNNFDAWASYLkntas-knakIFLGLPGSKaa------agSGYLQPSQAHALINKHK 303
gi 126032267  224 WVQFYNNneypgdpcslglpgDAPFNFNNWTTFIqstps-kdakVFVGVPAAPlaangapsgeVYYATPSQLADIVNDVK 302
gi 126032275  215 FIQFYNNpvcdai---pgntaGDKFNYDDWEAVIagsaksksakLYIGLPAIQep------neSGYIDPIAMKNLVCQYK 285
gi 171685035  242 FVQFYNNpgc---------hgVTNNNFDTWASHLqstas-sgakIFIGLPGSTnavq--ngeaSGYLTPTNLRTVINKFK 309
                         330       340       350
                  ....*....|....*....|....*....|....*....
Feature 1                     #                          
2UY2_A        253 ASss-sFGGIALWDASQAfsne-----lngePYVEILKN 285
gi 9971105    286 AMnlpnFGGAMLWEAHSAvk---------ngNYQKKIKA 315
gi 46128419   292 TKp--hFGGVSLWDLTRGagni-----iegkSYNEHVMD 323
gi 66844760   295 DNp--aFGGVMMWSAGFSdanv-----nngcTYAQEAKR 326
gi 85074694   275 TRs--sFGGAMVLDAFRGqtla------ngmTFLDVINT 305
gi 113531039  297 DEp--rFGGIMFWDASFDqnnv-----idgkHYSEHIAA 328
gi 116193493  304 NKp--aFGGVMVWDAVYGsekf------sgtRYYDLMHE 334
gi 126032267  303 SNp--aFGGIMMWSAGFSdtnv-----ndgcNYAQEAKN 334
gi 126032275  286 DRp--hFGGLSLWDLSRGlvnn-----ingtSFNQWALD 317
gi 171685035  310 GRa--aFGGVMIYDATYGasnivsgsspaglNYYQYARS 346

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