Conserved Protein Domain Family
GH18_zymocin_alpha

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cd02878: GH18_zymocin_alpha 
Zymocin, alpha subunit. Zymocin is a heterotrimeric enzyme that inhibits yeast cell cycle progression. The zymocin alpha subunit has a chitinase activity that is essential for holoenzyme action from the cell exterior while the gamma subunit contains the intracellular toxin responsible for G1 phase cell cycle arrest. The zymocin alpha and beta subunits are thought to act from the cell's exterior by docking to the cell wall-associated chitin, thus mediating gamma-toxin translocation. The alpha subunit has an eight-stranded TIM barrel fold similar to that of family 18 glycosyl hydrolases such as hevamine, chitolectin, and chitobiase.
Statistics
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PSSM-Id: 119357
View PSSM: cd02878
Aligned: 22 rows
Threshold Bit Score: 485.276
Threshold Setting Gi: 13276769
Created: 21-Jul-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative active
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                                 #                                         
gi 125727     384 KKIAYWLda-----kdKLAMDpkni--pngpYDILHYAFVNINSDFSIdd---saFSKSAFLKVTs-SKKIPSFGGWDFS 452
gi 39837086   222 DNIVYWLda-----egPLASDpdni---gsdYSRVHYAFVNINSDFTIdd---snISNSYFLNIK--NNKVASFGGWDFS 288
gi 66851585   440 KTIGYFEafdq--lraCLRMSvdei--paqkYSHVHFAFATVTPGFDVdts-sveDEFRRFVKRTg-FKKILSFGGWAFS 513
gi 146415332  173 KNIGYWLdv-----sgGMALDpttl--ddgsYTAIHYAFVPIKSDMTIdd---skFKISKFLSLKk-TKKVASFGGWDFS 241
gi 116196152   78 HRIAYFEafnf--dwaCLRMDvaqi--dtskYTHVHFAFLDLTEDFDVdvv-ryrEQFIRFTKLKg-VKRIVSFGGWTMS 151
gi 126032297  493 KKVTYYEswnl--drsCMHMDvrtvgdlgqgYTHLHFAFVNITKDLKVsvq-dprGQFEHFKGLSg-IKRIAAFGGWSFS 568
gi 115399638  551 RRVTYYEaynm--drdCLNMDvrei--ndddLTHVHFAFAGLTSNIEImfddsykDQFGAFIEMHapWKKILSFGGWAES 626
gi 46126383   518 LNVGYFQgynl--grpCLNMDvtklpqlttaYTHIHFAFAGLTSDFSVliepatrEQFIKFKEVKgsWKKIISFGGWAGS 595
gi 31071313   868 KNIAYWLdadgpmasdPFNYDdg-------sYDAIHYAFVNINSDFSId-----dSKFSNSKFLNs-NLKNSSFGGWGFS 934
gi 170940077  220 KKIGYFEawst--drdCLWMDatsi--detqFTHIHFAFADVTPDFRVdvs-kvqAQFNKFKALKr-SKRIIAFGGWAAS 293
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                               # # #                                     
gi 125727     453 TSPSTYTIFRnavktdqNRNTFANNLINFMNKYNLDGIDLDWEYPGAPDIPdipaDDSSSGSNYLTFLKLLKGKMPs-gK 531
gi 39837086   289 TNPSTYKIFRegv-ksqNRDKFTSNLVVFAQKYNLDGIDLDWEYPGAPDIPgipaDDKNNGKNYLEFIKLLKSKLPg-gM 366
gi 66851585   514 TDPSTFQRFRdat-kpeHRDTFVTNLVSFMSRHNLDGFDFDWEYPGAPDIPditpGSPDEGQNYLAFLQRLRSKLPs-gK 591
gi 146415332  242 TSPSTYQIFRngv-qvaNRDKLATNLVNFMTKYNLDGIDLDWEYPGAQDIPgipsDDLNNGQNYLELVKSIKSKLPs-gK 319
gi 116196152  152 TSLATYNIFRdav-kpeNRQTFARNLADFANEWHLDGIDIDWEYPGAQVLPeipkGSLDDGKNLASCLVLLRDLLGp-dQ 229
gi 126032297  569 VGVDTYATLRqai-kpeHREFFATQVVDFLKQHKLDGVDFDWEYPGATDLPip-aGSPEDPANYLRFLQLLRKKLPa-eM 645
gi 115399638  627 TDAATFQRYKdvv-kpeNRERFANNVVAFVNKHKLDGIDFDWEYPGATDIPgv-pGGQGETDHYLNFLKLMREKLGd--K 702
gi 46126383   596 TDASSFQIYRdai-kpaNRNKFAYNVMTVLNNHKLDGVDFDWEYPGSASSD----GSSTDTANYVEFLKIMRSKIGksgK 670
gi 31071313   935 TSPSTYQIIRkgv-qigNVVKFANNVVNFLNKYNLDGLDFDWEYPGAPDILgipaDDPKNGNNYLNFLILVKAMLPa-gK 1012
gi 170940077  294 TSPTTFQIFRagv-nsaNRATLANNIANFVREHGLDGADIDWEYPAAPDLPdippADPIDGPNYLAFLRLLRAGLPt-gK 371
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                         ##                                              
gi 125727     532 TLSIAIPSSYWYLKNFPISDIQnTVDYMVYMTYDIHGIWEygka--------nsyINCHTPRKEIEDAIKMLDKAGVKFN 603
gi 39837086   367 SLSIAIPSSYWYLKNFPLKDIQqYLDYMVYMTYDIYGVWDmdk---------dsrIKCHTNKTAVIDALKMLDKAQIEIG 437
gi 66851585   592 SLSIALPASYWYLKQYPVKQMAkYVDYFIYMTYDLHGQWDvdnqwaipgcpagncLRSHVNKTETHDALVMITKAGVEAR 671
gi 146415332  320 TLSVALPNTYYYLSNFPVKAMQdYVNYFIFMTYDYPGATQn-------------tLFCHTDKDQVVQSLEMLDKAGVKMW 386
gi 116196152  230 SLSIATPASYWYLKGFPIAKMSaALDYIVYMTYDLHGQWDfgsrwadpgcpdgncLRSHVNLTETLNALSMITKAGVPSN 309
gi 126032297  646 SLSIAAPASFWYLKAFPIADIAkTVDYIVYMTYDLHGQWDfnsrwasdgcpkgscLRSHVNMTETLNALAMITKAGVEAR 725
gi 115399638  703 SLSIALPASYWYLKPFPVEKMAkYLDYFIYMTYDLHGQWDfgnknaspgcangncLRSHVNKTETHDALAMITKAGVPAN 782
gi 46126383   671 TMSVALPAAYWYLKPFPVTQIApLVDYMVYMTYDLHGQWDygnptinsgcpdgncLRSHVNKTETLDSLAMITKAGVDPA 750
gi 31071313  1013 TLSVALPASYWYLKAFPIYQMHnYVDYFIYMTYDIHGTWDlsk---------dnaVKCHTNKTEIVDALKMLNKAGLNLS 1083
gi 170940077  372 SLAIAAPASYWYLKGFPIREMGsVLDYIVYMTYDLHGQWDagsrwsqdgcpsgmcLRSHVNMTETYNALVMVTKAGVPAN 451
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #                                                                       
gi 125727     604 KVFGGVANYGRSYKMVNTNCYNYGCGFQReggnsrdmtntpgvls----------dseiididssdkkndrWVDTNTDCI 673
gi 39837086   438 KTYGGISNYGRSYKASSTSCMSENCPFSGpgnkrditntpgvlae-----------selnaiasssaknkrWTNNEIMCD 506
gi 66851585   672 QLVVGVTSYGRSFRMNDASCSGPFCTYAGdrthsmasaapctatggyia---naeihdilqshgnysivkaYVDKESDSN 748
gi 146415332  387 KTYGGLANYGHTYTLKSTSCTAIGCEGSGpgkagpvsgeagtltd-----------feinaiakssrknkrWTDSTSMCD 455
gi 116196152  310 KIAVGISSYGRSFQMTTPGCTGPMCTYTGpasgakpgrctntagyl--------anaeineiiarksnvqtFHDASSDSD 381
gi 126032297  726 QVVVGVASYGRSFEMNDPKCKGPMCTFTGpqslaapggctnssgyis------naeildimedrksypvqaWYDEKTDSD 799
gi 115399638  783 QVVVGVSSYGRSFGMADPNCTGPMCKFTGsfnctntsgyisnaelm--------llsdnallgydgyharsWHDDDSDSD 854
gi 46126383   751 KVVVGISSYGRSFRMKDPKCTGVTCQFTGsfsvseaepgvctgepgylsdaeirliaydakkgkagvtaktWYDKASDSD 830
gi 31071313  1084 KVRGGLANYGRSYKLANPSCYAVGCPFTGggekgpitntdgilad-----------seiinidasksknqrWTDSTSECI 1152
gi 170940077  452 KIIVGVSSYGRSFKMKDPNCRGPMCEYTGtasvshatagpctgvqgyi-----snaeiqeyknvndinvatHYDQATRSN 526
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
Feature 1                                                 #     
gi 125727     674 FMKYDg-------NSVVSWPKSRYDLEDMFKNYGFAGTSLWAANYF 712
gi 39837086   507 FMIYDgd-----sVVGWPKPEQRNSMQDFFRTHWLKGSFFWVDNYF 547
gi 66851585   749 ILLYGnpg--avdWVAYMDGAVKARRIDWIKSLNFGGSTDWAIDLQ 792
gi 146415332  456 VMVYDnn-----nWVAWPKAGQRDAMREFFRGAGLGGSSLWLTNYA 496
gi 116196152  382 ILVYDtv-----hWVAYMDNVTKADRIARYQRLNMWGVSDWAVDLE 422
gi 126032297  800 YLIYNqt-----qWVAYMSKSVKEARIKKYQALNFGGISNWAIDLE 840
gi 115399638  855 IMVYGedeh-ahsWVAYMSEDTKAGRIEWVKGLNFGGVSDWAIDLG 899
gi 46126383   831 IMTYGtqgkgmtdWVAYMGPTTKLKRTQWVQGLNFGGVVDWAVDLE 876
gi 31071313  1153 FMVYDt-------NNVVGWTANRNNLQNYYQQNGLRGSSLWLTNYF 1191
gi 170940077  527 IAIINg------tWIAYMDTAEKNARSNMYRGWNFGGTSDWAIDLD 566

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