Conserved Protein Domain Family
GH18_plant_chitinase_class_V

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cd02879: GH18_plant_chitinase_class_V 
The class V plant chitinases have a glycosyl hydrolase family 18 (GH18) domain, but lack the chitin-binding domain present in other GH18 enzymes. The GH18 domain of the class V chitinases has endochitinase activity in some cases and no catalytic activity in others. Included in this family is a lectin found in black locust (Robinia pseudoacacia) bark, which binds chitin but lacks chitinase activity. Also included is a chitinase-related receptor-like kinase (CHRK1) from tobacco (Nicotiana tabacum), with an N-terminal GH18 domain and a C-terminal kinase domain, which is thought to be part of a plant signaling pathway. The GH18 domain of CHRK1 is expressed extracellularly where it binds chitin but lacks chitinase activity.
Statistics
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PSSM-Id: 119358
View PSSM: cd02879
Aligned: 13 rows
Threshold Bit Score: 344.733
Threshold Setting Gi: 125590096
Created: 18-Jul-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative active
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                                  #                                     
gi 7268776     4 SDVVKASYWFpat-----------dfPATDIDSSLFTHLFCTFADLEAESYeitiat---wnqapFHAFTETVQQRNPHV 69
gi 30424403   34 TTRVKGIYWDrnp-----------lfPPASIDTSLFTHIFYAFVSPNKFTYkleeeedsttvatsLTTFTNTFKTKTPPI 102
gi 65736671   24 QNALKVGFWPaysv---------sefPPSKINSRLFTHLYYAFAELNAPTFevrvpp---gsektAEDFTPTVRRLNPSV 91
gi 20269861    4 PTIVNGGYWLssta---------gklPASNIDATLYTHLFCGYGEIDATSHevti------psteVSHFSEKVKVSNPSV 68
gi 7268772    11 NSIVKASYWFpdgksqsp-eclsqgtPSSFIDSTLFTHLFCAFADVDSSTHevtisa---ansyqFSSFTETVKEKNTDV 86
gi 147787797  26 SPPVKGAYWPswd----------esfPPSAIDTSLFTHVYYAFASPNNVTFkfdisn---stgisLLDFTSTLHRKKPSL 92
gi 147787798 269 SSGIKGAYWPswla---------eslPPVGIPTSYFTHLFYAFVQLDASAYqlsitq---pdeqwMGNFTATLHAKNPLA 336
gi 5814093    24 TAWIKSGFWYags-----------efPVPEIPSTMFTHIHFAFAYINASSFelyvsh---sdepyISTFSNTVKQKNPSV 89
gi 125590096  38 REAVRAGYYLaada---------hlrPLAALDASLYTHLYYYAVAVHPARRtlllppd-paaaslLGDFSRAVKAKNAAV 107
gi 157359500  23 ETWIKAGYWYags-----------esPIPDIKSGLFTHLLCAFADINPTTYqlsiss---seehyFSTFTDVVKRRNPSV 88
gi 168038986  30 GAVVRGGYWLqd-------------lPLVNINFNYETHVYYAFAGLDPSSYqvvapt---tdngqYATFVATAKSSNPSV 93
gi 168064304  20 SKIVKSGYWPyw------------atDTSNLNFEFQTHVFFAFAQIDPVTYevvpppp-sdgvsiFPTFTKLARKSNKCV 86
gi 22328814    3 TEVVKASYWFpdgasspttgsvvpqsSAVLIDSTLFTHLFCAFADLDPQTNsvvvsg---aheqeFSNFTKIVKKKNPHV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                # # #                   
gi 7268776    70 KTLLSIGGGnad-----------kdaFASMASNPDSRASFIQSTITVARSYGFHGLDLDWEYPRNEEEMYDFGKLLEEWR 138
gi 30424403  103 PTLLSIGGAtsn-----------stlFAFIASDPTARATFTNSTIQVARTFGFDGIDFDWEFPTTTKEMNDLGELLFQWR 171
gi 65736671   92 KTLISIGGGgsev----------rdnFAKLNSDASARQRFVKSSIALARRYGFHGLDLDYEYPEPQLEMENFVKLVSELT 161
gi 20269861   69 KTLLSIRGDsk--------------vFSDIAKVPTARDTFVNSSIKAAVDCGFDGLDLQWLYPSSPTDMQNFKTLIVKWR 134
gi 7268772    87 QTLLSIGGKdad-----------kavLASMASNSKNRKAFIDSSIDIARKKDFYGLDLAWEYPSNDVEMTNFGKLLEEWR 155
gi 147787797  93 KALLSIGGGggd-----------qqlFARMASKASTRASFIKSTVEVARKYGFDGLDLDWEFPESPKEMEDWGLLLQEWR 161
gi 147787798 337 KAFXSIGGGass-----------pytFSKMAGDPDNRAAFINSTIDVARKYGFDGLDLDWEFPTNPQDMSNLAILYSEWH 405
gi 5814093    90 ITLLSIWGGrde-----------spnFFAMTSQFSRRKSFITTSIKTARQYGFQGLDLIGVNPNTDANMTNMRSFIEEWR 158
gi 125590096 108 KTVLSIGRGggaggaaavagsgsdpaFAAMAADPASRAAFIGAAVKVARENGFDGLDVAWRFPASAVEMAEFGFLVAEWR 187
gi 157359500  89 VTLLSIWGGkgptglsilgervnssmVSLMVRQPSYRKSFIESAMKTARLYGFHGLDLFWLWPNTESDMKNMGALLDELR 168
gi 168038986  94 VTLLSIGGGaan-----------fttFGEMVSTSTRRQAFIDSSISLARQYSYEGLDLDWESPQSQTEMENLALLLQEWR 162
gi 168064304  87 KTLLSIGGGgsm------------spFSAMASSAANRKAFIQSSIQLALNNSFDGLDLDWEFPDTQVDMDNLAILLKEWR 154
gi 22328814   80 QTLLSIGGRnad-----------ksaFASMASNPTSRKSFIWSAISSARYYRFDGLDLVWKYPKDDVEMRNFGQLLEQWR 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               ##                       
gi 7268776   139 SAVeaesnssgttALILTAAVYYssny-------qgvpYPVLAISNSLDWINLMAYDFygpgwstvtgpp----aslylp 207
gi 30424403  172 RAIsdeaastsrpPLLLTAAVYFavnffl---sgerrmYPVDSINKNLDWVNVMSYDLrgsgsnvtgaps-----gmfds 243
gi 65736671  162 AAIreeartsgkpRLLLTEAVYFhqklfp---wevvteYPVQFIAAGLDWVNVMAYDFhgswenftgapa-----alrdp 233
gi 20269861  135 QAAvddarnnnrpERILVASVPNlpyie------knveYPGEAIKQNLDWVNLVCYDFytpaegsspdytgpssalfnrr 208
gi 7268772   156 AAVveesdktnqlPLLLTAAVYYspqy-------dgveYPVKAIADNLDFVNIMAYDFygpgwspvtgppaa-lfhdpsn 227
gi 147787797 162 AEVkkeaklkgraPLLITAATYFsvdffa---ygdyrkYQVGSAGKNLDLINLMCYDYrgswdtsatgaq----aalfdp 234
gi 147787798 406 AAVkkeahysgqyKLLLSSAVYFasdffl---sdvprsYPADAIKKYVDFVSPMCFDYhgswdtsvtgah----allydk 478
gi 5814093   159 TAInseskssgtrTLILTMGAYYspml-------dsmsYPIDTIIRNFDWVHLKAYAAlydpt----------------- 214
gi 125590096 188 AAVp--------rGFLLTATVYFsnhvfda--pfagvdYPSETVARSLDWVNVMAFGLrppgaananataf--daplydr 255
gi 157359500 169 AAVklesrnsgkaPLILTMAVHYvptl-------ysvsYHIEAIQRNLDWAHIPAYDYylpsrvnfthah----aalydp 237
gi 168038986 163 AAAhteaqssgntELLLTAAVSYqsillyt--gvgnqvWPITAFNTYLDWVNVMTYDYhgsweptttgeh----talydp 236
gi 168064304 155 AEAq--------kKLLLTAAVYFrnilyfwqpadqqrrYPIASINKNLDWINVMCFDYrgswesntgeht----alydpn 222
gi 22328814  149 EAIeddaertermPLLLTAAVYYspvy-------dsvsYPIREIKKKLDWVNLIAYDFysssttigppaa----lfdpsn 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                      #                                                 
gi 7268776   208 tdgrsgDSGVRDWTEAGl-PAKKAVLGFPYYGWAWTLadpdvngydanttgpaisdd----------geisyrqlqtwiv 276
gi 30424403  244 ksnvsvVGGLFSWIRGGv-APEKIVMGMPLYGKSWKLqdpnvhgigapnvgpgpgvd----------ggmayfqvvdfnk 312
gi 65736671  234 nskftaSVGIESFLAAGm-PPEKLVLGIPLFGRSWLLknnnevgigapavgagpvd------------galsfseiqnfi 300
gi 20269861  209 snslsaHFGIESWTKYV--PAKKIVFGIPFHGWAWTLanaaehdmfskatgscvwpm-----------dysevkshrrar 275
gi 7268772   228 pagrsgNSGLRKWLDEAklPPKKAVLGFPYCGWAWTLedaenngydaatdgaaispd----------gsityakirnyiv 297
gi 147787797 235 nsnistSYGVKSWIKAGv-PRSKLVMGLPLYGRTWKLkdptqhgigapavdvgpgde----------gvlsfsqveafnk 303
gi 147787798 479 asnistSYGISSWIEAGv-PPEKLVMGLPLYGRTWELkdqnkhgigdpavgtgpgdg-----------imaytnivdfns 546
gi 5814093   215 -sklntDYGIKEWIKRGl-PANKIVLGLAYHGYAWTLvnpkhntvrtparglaitqd----------gsisyryikqymk 282
gi 125590096 256 ashysaSYGVVSWLDAGv-PASKVVMGIPLYGRSWFLrnkansgvgapvvaagpkqrgsnatgamsyaevqwlaatatrg 334
gi 157359500 238 lsnvstDFGIREWISKGf-PASKLVLGLPYHGYAWTLvnpnhngigapasgiamtad----------gsmsykyikwflr 306
gi 168038986 237 nsdvdtDYGINNWLSAGm-QADKMCLGLAFYGKQWVLaslantgvgapatsggdpi-------------tyadivtynna 302
gi 168064304 223 lpvvstDDAVTDWITAGl-YPHKLVMGLAFYGKQWTLqslantgigaptqtdisskyt---------pvwseivvylqnd 292
gi 22328814  218 pkgpcgDYGLKEWIKAGl-PAKKAVLGFPYVGWTWSLgsgndaatsrvatsaegs--------------inydqikrliv 282
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
Feature 1                                                          #           
gi 7268776   277 dngatkvHDDMMVGDYCYAGTTWIGYDSEKSIVTKVIYAKQ-KGLLGYFSWHVGGDDNSELS 337
gi 30424403  313 qmgakvvYDKETGSVYSYSGSTWIGYDDPFTVSVKVGFAQA-LKLGGYFFWAAGYDTSDWKV 373
gi 65736671  301 rggarevFDTTTVSAYAYKDNVWVGYDNQQSVALKVQYAKE-KRLGGYFFWSVNQDIDAILP 361
gi 20269861  276 qceynipNDPRFGIAYAYVETTWIGYESESTIPVKIKFAKQ-NQLLGYFAWNISGDDDVNTL 336
gi 7268772   298 dngaatfHDPAVIGFYCYVGNTWIGYDDNQSIVYKVKYAKF-TGLLGYFSWHVGADYNCGLS 358
gi 147787797 304 enxatvvYDARTVSTYSYAGTSWIGYDDTRSTTVKIGFARA-LGLRGYFFWAVNDDSKWKIS 364
gi 147787798 547 ekgatvvYDEETVSTYSYAGTNWIGYDGPISTENKVKFAWE-QGLGGYFLWALGDDKNWTLS 607
gi 5814093   283 sygvtpvYNSTFVVNYVTIGSFWIGYDDVEAIRTKVSYAKD-KGLLGFAAFQIPSDDVNWEL 343
gi 125590096 335 sravitaYDNASVASYVSVGDVWVAFDGVAVVAEKLAFAAR-CGLLGYFLWPVNYDDANLTV 395
gi 157359500 307 sygatsmYNATYVVNYVTIGTTWIGFDDVQAIRAKISYAKE-KKLLGYNVFQVSNDDNWALS 367
gi 168038986 303 ggatveqDSTTVSMYSYKSDLTWIGYDNPDTIAAKVQYAQS-KSLLGYFAWALHQDDANFSL 363
gi 168064304 293 gwttvldDATVSMYSYNTQSLQWVGYDNEVTIKKKVEYAIRiKKLKGVFVWSLNHDDSNWSL 354
gi 22328814  283 dhkarpvFDSTVVGDYCFAGTSLIGYDDHQSVVAKVKYAKQ-KGLLGYFSWHVGADDNFGLS 343

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