Conserved Protein Domain Family
phosphohexomutase

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cd03084: phosphohexomutase 
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The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). These enzymes play important and diverse roles in carbohydrate metabolism in organisms from bacteria to humans. Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.
Statistics
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PSSM-Id: 100086
View PSSM: cd03084
Aligned: 13 rows
Threshold Bit Score: 309.287
Threshold Setting Gi: 18655891
Created: 12-Dec-2003
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2DKC_A; Candida albicans AGM1 (N-Acetylglucosamine-phosphate mutase) binds GlcNAc-6-Phosphate and Zn phosphate; defined at 3.5A contacts.
    View structure with Cn3D
  • Structure:2DKD_A; Candida albicans AGM1 (N-Acetylglucosamine-phosphate mutase) binds GlcNAc-1-Phosphate and Zn phosphate; defined at 3.5A contacts.
    View structure with Cn3D
  • Structure:2FKM_X; Pseudomonas aeruginosa PMM/PGM binds alpha-D-glucose 1,6-bisphosphate
    View structure with Cn3D
  • Structure:2H4L_X; Pseudomonas aeruginosa PMM/PGM binds ribose 1-phosphate
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         # #  #                                                                        
2DKC_A       23 TYGTAGFRMKAdk-----ldYVTFTVGIIASLRskyl------------------------------------------- 54
1KFQ_B       20 KPGTSGLRKKVsea---tqpNYLENFVQSIFNTlrkdelkpknvlfvggdgryfnrqaifsiirlayandisevhvgqag 96
1TUO_A       13 RFGTEGFRGVIare---ftfATLHRLAEAYGRHllerggglvvvghdtrfladafaralsghl----------agmglkv 79
1WQA_A        4 LFGTFGVRGIAnek---itpEFAMKIGMAFGTLlkregrkkplvvvgrdtrvsgemlkealis---------gllsvgcd 71
2DKD_A       23 TYGTAGFRMKAdk-----ldYVTFTVGIIASLRskyl------------------------------------------- 54
2FKM_X       12 IFRAYDIRGVVgdt---ltaETAYWIGRAIGSEslargepcvavgrdgrlsgpelvkqliqg-----------lvdcgcq 77
2FUV_A       44 KFGTSGHRGSAgrhs--fnePHILAIAQAIAEErakngitgpcyvgkdthalsepafisvlevlaan--gvdvivqenng 119
2H4L_X       13 IFRAYDIRGVVgdt---ltaETAYWIGRAIGSEslargepcvavgrdgrlsgpelvkqliqg-----------lvdcgcq 78
gi 401561     6 YFGTDGIRGRVgdap--itpDFVLKLGWAAGKVlarhgsrkiiigkdtrisgymlesaleag-----------laaagls 72
gi 14603253  56 EFGTAGLRAAMgpgisrmndLTIIQTTQGFCRYlekqfsdlkqkgivisfdarahpssggssrrfarlaattfisqgipv 135
gi 17131453 384 LFGQRGVQGLAnid---ispEFAVKLGAAYGSTlkpgakvtvsrdqrnvsrmvtrsliagl-------------msvgvd 447
gi 56122508  16 NFGTSGARGLVvdf----thNVCAAFTHAFLSViekhfkfdtvavaidnrpssfniaqacvf-----------aikqhgy 80
gi 66812932   5 IRSISGVRGVVgadq--swtPTLVANHIIAFTQllesshynqnqkkivvgrdsrvsgpwfemitn------gslisrgyq 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    ###           #                                    
2DKC_A       55 ------------------qgktVGVMITASHNPp----EDNGVKVVDplGSMLESSWEKYATDLANAspspsndsegekn 112
1KFQ_B       97 lmstpasshyirkvneevgnciGGIILTASHNPggkehGDFGIKFNVrtGAPAPEDFTDQIYTHTTKikeyltvdyefek 176
1TUO_A       80 vllkgpvptpllsfavrhlkaaGGAMLTASHNPp----QYLGVKFKDatGGPIAQEEAKAIEALVPEearaleg------ 149
1WQA_A       72 vidvgiaptpavqwatkhfnadGGAVITASHNPp----EYNGIKLLEpnGMGLKKEREAIVEELFFKedfdrakwy---- 143
2DKD_A       55 ------------------qgktVGVMITASHNPp----EDNGVKVVDplGSMLESSWEKYATDLANAspspsndsegekn 112
2FKM_X       78 vsdvgmvptpvlyyaanvlegkSGVMLTGDHNPp----DYNGFKIVVa-GETLANEQIQALRERIEKndlasgv------ 146
2FUV_A      120 ftptpavsnailvhnkkggplaDGIVITPSHNPp----EDGGIKYNPpnGGPADTNVTKVVEDRANAllagglqgvkris 195
2H4L_X       79 vsdvgmvptpvlyyaanvlegkSGVMLTGXHNPp----DYNGFKIVVa-GETLANEQIQALRERIEKndlasgv------ 147
gi 401561    73 alftgpmptpavayltrtfraeAGIVISASHNPf----YDNGIKFFSidGTKLPDAVEEAIEAEMEKeiscvdsae---- 144
gi 14603253 136 ylfsditptpfvpftvshlklcAGIMITASHNPk----QDNGYKVYWdnGAQIISPHDKGISQAIEEnlepwpqawddsl 211
gi 17131453 448 iqnldataipiartviptmgvaGGIHVRVHPDRa----DYILIEFMDhkGINISKAQEKKIEGAYFKedmrralthe--- 520
gi 56122508  81 gieyhgviptpalahysmqkniPCIMVTGSHIPf----DRNGLKFYRpdGEITKEDELAIVNSEYTFspvgvlphl---- 152
gi 66812932  77 vihidiastptvqymvektkssGGIVITSSHNPi----EWNGLKFIGpdGLFIAPKECEILFSMADKpeefkfsgyd--- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2DKC_A      113 slveviknlvsdlkidlsipanvviardsresspalsmatidgfqsvpntkyqdfglfttpelhyvtrtlndpdfgkpTE 192
1KFQ_B      177 hinldqig--------------------------------------------------vykfegtrlekshfevkvvdTV 206
1TUO_A      150 ------------------------------------------------------------------------ayetldLR 157
1WQA_A      144 ---------------------------------------------------------------------eigevrredII 154
2DKD_A      113 slveviknlvsdlkidlsipanvviardsresspalsmatidgfqsvpntkyqdfglfttpelhyvtrtlndpdfgkpTE 192
2FKM_X      147 -----------------------------------------------------------------------gsveqvdIL 155
2FUV_A      196 l----------------------------------------------------------------daaxasghvkavdLV 211
2H4L_X      148 -----------------------------------------------------------------------gsveqvdIL 156
gi 401561   145 ---------------------------------------------------------------------lgkasrivdAA 155
gi 14603253 212 -----------------------------------------------------------------idsspllhnpsasIN 226
gi 17131453 521 ---------------------------------------------------------------------igdvaypsqVI 531
gi 56122508 153 ---------------------------------------------------------------------etssqgadcYL 163
gi 66812932 150 --------------------------------------------------------------------qlgkiekcvdAN 161
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2DKC_A      193 DGYYSKLAKSfqeiyticesnnekiDITIDAANGVGaPKIQELLEkylhkeisfTVVNGDYKqpn---------llNFDC 263
1KFQ_B      207 QDYTQLMQKLfdfdllkglfsnkdfSFRFDGMHGVAgPYAKHIFGtllg-cskeSLLNCDPSedf--------gggHPDP 277
1TUO_A      158 EAYFEALKAHldlkal----sgfsgVLYHDSMGGAGaGFLKGFLRhvgl-eipvRPIREEPHplf--------hgvNPEP 224
1WQA_A      155 KPYIEAIKSKvdveai----kkrkpFVVVDTSNGAGsLTLPYLLRelg---ckvITVNAQPDgyf--------parNPEP 219
2DKD_A      193 DGYYSKLAKSfqeiyticesnnekiDITIDAANGVGaPKIQELLEkylhkeisfTVVNGDYKqpn---------llNFDC 263
2FKM_X      156 PRYFKQIRDDiama--------kpmKVVVDCGNGVAgVIAPQLIEalg---csvIPLYCEVDgnf--------pnhHPDP 216
2FUV_A      212 QPFVEGLADIvdxaai----qkaglTLGVDPLGGSGiEYWKRIAEhyk---lnlTLVNDQVDqtfrfxhldkdgaiRXDC 284
2H4L_X      157 PRYFKQIRDDiama--------kpmKVVVDCGNGVAgVIAPQLIEalg---csvIPLYCEVDgnf--------pnhHPDP 217
gi 401561   156 GRYIEFCKATfpnel-----slselKIVVDCANGATyHIAPNVLRelg---anvIAIGCEPNgv----------niNAEV 217
gi 14603253 227 NDYFEDLKKYcfhrsv---nretkvKFVHTSVHGVGhSFVQSAFKafdlvppeaVPEQKDPDpefp-------tvkYPNP 296
gi 17131453 532 DLYCTAFEKLlnvstl----nnsraKVVIDYVYAVSgAVLPQMLDkfg---adaVVLNASLNkn-----------aVTTT 593
gi 56122508 164 ERYVSLFYSDilk----------gkRIGVYEHSSAGrDLYASLFNqlg---aevISLGRSDEfv----------piDTEA 220
gi 66812932 162 QQHVGAILSLafldisk--irerrfKVCLDSVNGAGgPIMSYLLTqln---cevIGINLETTgl----------faHTPE 226
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        # # ##                                         
2DKC_A      264 gadyvKTNQKLPKNVkpv-------nnKLYASFDGDADRLICYYqnndnkfKLLDGDKLSTLFALFlqqlfkqid-ptki 335
1KFQ_B      278 n---lTYAHDLVELLdihkkkdvgtvpQFGAACDGDADRNMILGr-----qFFVTPSDSLAVIAANanlif--------k 341
1TUO_A      225 i---pKNLGVTLAVLgpe------tppSFAVATDGDADRVGVVLpg----gVFFNPHQVLTTLALYrfrk---------- 281
1WQA_A      220 n---eENLKEFMEIVkal-------gaDFGVAQDGDADRAVFIDen----gRFIQGDKTFALVADAvlke---------- 275
2DKD_A      264 gadyvKTNQKLPKNVkpv-------nnKLYASFDGDADRLICYYqnndnkfKLLDGDKLSTLFALFlqqlfkqid-ptki 335
2FKM_X      217 gk--pENLKDLIAKVkae-------naDLGLAFDGDGDRVGVVTnt----gTIIYPDRLLMLFAKDvvsr---------- 273
2FUV_A      285 ss--eCAXAGLLALRdk---------fDLAFANDPDYDRHGIVTp-----aGLXNPNHYLAVAINYlfqhrp------lw 342
2H4L_X      218 gk--pENLKDLIAKVkae-------naDLGLAFDGDGDRVGVVTnt----gTIIYPDRLLMLFAKDvvsr---------- 274
gi 401561   218 g---aTDVRALQARVlae-------kaDLGIAFDGDGDRVIMVDhe----gNKVDGDQIMYIIAREglrqg--------- 274
gi 14603253 297 ee--gKGVLTLSFALadk------tkaRIVLANDPDADRLAVAEkqdsgewRVFSGNELGALLGWWlftswkeknqdrsa 368
gi 17131453 594 dr--eTLLTQLGHVVeal-------kaNFGVQVSANGEQLILVDe-----sGYPIRGELLTALMVDmilts--------- 650
gi 56122508 221 vs--dEDRVLAREWSkky-------nlDAIFSTDGDGDRPLVADen----gEWLRGDILGLLTAIEln------------ 275
gi 66812932 227 pv--pSNLGQLCEMVvky-------kaDFGIAVDPDVDRCVFIDe-----hGKPLGEEYTLAMAVElvlgd--------c 284
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #                     ###                     # # #                   
2DKC_A      336 slniGVVQTAYANGSSTKyvedvlkiPVRCTPTGVKHLHHEaen-----fdiGVYFEANGHGTVIfnpeaekkifdykpn 410
1KFQ_B      342 ngllGAARSMPTSGALDKvaak-ngiKLFETPTGWKFFGNLmda-----gliNLCGEESFGTGSNhi------------- 402
1TUO_A      282 ghrgRAVKNFAVTWLLDRlger-lgfGVTTTPVGFKWIKEEflk-----gdcFIGGEESGGVGYPeh------------- 342
1WQA_A      276 kgggLLVTTVATSNLLDDiakk-hgaKVMRTKVGDLIVARAlye-----nngTIGGEENGGVIFPeh------------- 336
2DKD_A      336 slniGVVQTAYANGSSTKyvedvlkiPVRCTPTGVKHLHHEaen-----fdiGVYFEANGHGTVIfnpeaekkifdykpn 410
2FKM_X      274 npgaDIIFDVKCTRRLIAlisg-yggRPVMWKTGHSLIKKKmke-----tgaLLAGEMSGHVFFKerw------------ 335
2FUV_A      343 gkdvAVGKTLVSSAXIDRvvnd-lgrKLVEVPVGFKWFVDGlfd-----gsfGFGGEESAGASFLrfdgt---------- 406
2H4L_X      275 npgaDIIFDVKCTRRLIAlisg-yggRPVMWKTGHSLIKKKmke-----tgaLLAGEMSGHVFFKerw------------ 336
gi 401561   275 qlrgGAVGTLMSNMGLELalkq-lgiPFARAKVGDRYVLEKmqe-----kgwRIGAENSGHVILLdk------------- 335
gi 14603253 369 lkdtYMLSSTVSSKILRAialk-egfHFEETLTGFKWMGNRakqlidqgktvLFAFEEAIGYMCCpf------------- 434
gi 17131453 651 nprgTVVVPVHASSAVEQvarr-hdgRIIRTKANATALMEAcqkn----pnvVLGGSGETGFIFPql------------- 712
gi 56122508 276 --ikALAIPVSCNTAIEEsnk---faSIQRTKIGSPYVIAAfadla-kqfdsVAGFEANGGFLLAsdlqind-------- 341
gi 66812932 285 grrgNVCKNLSSSRAIDDickk-yesQVICAPVGEIQVAKKmqq-----vnaVIGGEGNGGVMLPdi------------- 345
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2DKC_A      411 ndneakaikvlqnfsqlinqtVGDAISDLLAVLIVVHyl------klSPSDWDNeyt-----dlPNKL-VKVIvpdrsif 478
1KFQ_B      403 --------------------rEKDGIWAVLAWLTILAhknkntdhfvTVEEIVTqywqq-fgrnYYSR-YDYEqvdsaga 460
1TUO_A      343 -------------------lpERDGILTSLLLLESVAat------gkDLAEQFKevealtglthAYDR-LDLPlkapldl 396
1WQA_A      337 -------------------vlGRDGAMTVAKVVEIFAks------gkKFSELIDelp-----kyYQIK-TKRHvegdrha 385
2DKD_A      411 ndneakaikvlqnfsqlinqtVGDAISDLLAVLIVVHyl------klSPSDWDNeyt-----dlPNKL-VKVIvpdrsif 478
2FKM_X      336 -------------------fgFDDGIYSAARLLEILSqd------qrDSEHVFSafp-----sdISTPeINITvtedskf 385
2FUV_A      407 -----------------pwstDKDGIIXCLLAAEITAvt------gkNPQEHYNelaar-fgapSYNR-LQASatsaqka 461
2H4L_X      337 -------------------fgFDDGIYSAARLLEILSqd------qrDSEHVFSafp-----sdISTPeINITvtedskf 386
gi 401561   336 -------------------ttTGDGIVAGLQVLAAMArn------hmSLHDLCSgmk-----mfPQIL-VNVRytagsgd 384
gi 14603253 435 -------------------vlDKDGVSAAVISAELASflat---knlSLSQQLKaiy-----veYGYH-ITKAsyfichd 486
gi 17131453 713 -------------------hpGFDSMFCIAKIIEMLTiq------erSLATVRSelp-----rvIYRT-HTIRcpwsakg 761
gi 56122508 342 --------------kelkslpTRDAVLPALMLLIASRn--------sTISQLINnlp-----qrFTWS-DRVKnfpsdss 393
gi 66812932 346 -------------------hiGRDAPVAATLALQLMAnrys---qapSISKLKEtlp-----tyEIVK-LKAGiegldpd 397
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                              # ###    
2DKC_A      479 kttnaertlve--------------------------------------pkgmqdeidklvaqypnGRSFVRASGTe--- 517
1KFQ_B      461 nkmmehlktkfqyfeqlkqgn-----------------kadiydyvdpvdqsvsknqgvrfvfgdgSRIIFRLSGTgsvg 523
1TUO_A      397 tpfreprplag-------------------------------------ltpkgvdtldgvkwlyeeAWVLFRASGTe--- 436
1WQA_A      386 ivnkvaemare--------------------------------------rgytvdttdgakiifedGWVLVRASGTe--- 424
2DKD_A      479 kttnaertlve--------------------------------------pkgmqdeidklvaqypnGRSFVRASGTe--- 517
2FKM_X      386 aiiealqrdaq-------------------------------------wgegnittldgvrvdypkGWGLVRASNTt--- 425
2FUV_A      462 alsklspexvsastlagd-----------------------pitarltaapgngasigglkvxtdnGWFAARPSGTe--- 515
2H4L_X      387 aiiealqrdaq-------------------------------------wgegnittldgvrvdypkGWGLVRASNTt--- 426
gi 401561   385 plehesv---------------------------------------------kavtaeveaalgnrGRVLLRKSGTe--- 416
gi 14603253 487 qetikklfenlrnydgknnypkacgkfeisairdlttgyddsqpdkkavlptskssqmitftfangGVATMRTSGTe--- 563
gi 17131453 762 almrylvethp-------------------------------------aqnlelidgvkirqpfddSWLLVLPDASe--- 801
gi 56122508 394 qqiiknaisspnnffns-------------------------lgyeslscssidetdgarftlnngDIIHLRPSGNa--- 445
gi 66812932 398 silaeytsqfin------------------------------------kpgvvinqedglkidsqdWWVHLRKSNTe--- 438
                       650       660       670
                ....*....|....*....|....*....|....
Feature 1          #                              
2DKC_A      518 DAVRVYAEAdtq--------nnVEELSKAVSELV 543
1KFQ_B      524 ATIRIYFEQfeqqqiqhetataLANIIKLGLEIS 557
1TUO_A      437 PVVRIYVEAqsp--------elVRALLEEARKLV 462
1WQA_A      425 PIIRIFSEAksk--------ekAQEYLNLGIELL 450
2DKD_A      518 DAVRVYAEAdtq--------nnVEELSKAVSELV 543
2FKM_X      426 PVLVLRFEAdte--------eeLERIKTVFRNQL 451
2FUV_A      516 DAYKIYCESflg-------eehRKQIEKEAVEIV 542
2H4L_X      427 PVLVLRFEAdte--------eeLERIKTVFRNQL 452
gi 401561   417 PLIRVMVEGe-----------dEAQVTEFAHRIA 439
gi 14603253 564 PKIKYYAELcapp-----gnsdPEQLKKELNELV 592
gi 17131453 802 PLVHLYANSh-----------eRDWVDETVRDYR 824
gi 56122508 446 PELRCYAEAs-----------dENQAKQYVTNVL 468
gi 66812932 439 HIIRVIAEAk-----------sVKEATDIATKFI 461

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