2DKC,2DKD


Conserved Protein Domain Family
PGM3

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cd03086: PGM3 
Click on image for an interactive view with Cn3D
PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into GlcNAc-1-phosphate as part of the UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthetic pathway. UDP-GlcNAc is an essential metabolite that serves as the biosynthetic precursor of many glycoproteins and mucopolysaccharides. AGM1 is a member of the alpha-D-phosphohexomutase superfamily, which catalyzes the intramolecular phosphoryl transfer of sugar substrates. The alpha-D-phosphohexomutases have four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.
Statistics
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PSSM-Id: 100088
View PSSM: cd03086
Aligned: 36 rows
Threshold Bit Score: 571.845
Threshold Setting Gi: 156098799
Created: 21-Oct-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2DKC_A; Candida albicans AGM1 (N-Acetylglucosamine-phosphate mutase) binds GlcNAc-6-Phosphate and Zn phosphate; defined at 3.5A contacts.
    View structure with Cn3D
  • Structure:2DKD_A; Candida albicans AGM1 (N-Acetylglucosamine-phosphate mutase) binds GlcNAc-1-Phosphate and Zn phosphate; defined at 3.5A contacts.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                                                                      ##
2DKC_A        23 TYGTAGFRMKADk----LDYVTFTVGIIASLRSKYLQgk-------------------------------tVGVMITASH 67  Candida albicans
CAJ07046      43 TYGTAGFRFKADl----LPPVAARVSMIAALRSVYCQrkraveg---------------------hsvpctVGVMVTASH 97  Leishmania major
AAX69692      30 PYGTSGFRTIGTl----LPPVASRVVYVAVLRVWWAIkkgnfg----------------------glngcsVGCMVTASH 83  Trypanosoma brucei
XP_001014682  33 AYGTAGFRDDAQy----LEHVCLRIGVFMGLFAKVDNhk-------------------------------vLGIQVTASH 77  Tetrahymena the...
XP_001457689  22 SYGTSGFREESKy----LKFVGWRVGIFIGQMSKNTKl--------------------------------kLGVMITASH 65  Paramecium tetr...
EDP31851      32 SYGTAGFRANATy----LPFIVFRVGYLAGIRARYLNq--------------------------------tIGVMITASH 75  agent of lympha...
XP_001611201  29 YYGTCGFRASVEtpqnhLDHVVYRCGILLALMPFLRGpnrpssqaiseerpvha-hddtsgvednlnrtvsAGVVITASH 107 Babesia bovis T2Bo
XP_951792     21 IYGTAGFRANTEnppgnLEHVAYRCGLLFASLPFISEpyfqkysrs-----------------fsfngsmgLGIVVTASH 83  Theileria annul...
XP_729993     38 YYGNSGFRGKYKndrcdLINVLNKSGIILGLLFIKYNyklaqkynllefdidldknniidivykhkikwknIGIVITASH 117 Plasmodium yoel...
XP_965900     19 YYGTAGYRSKTSd----LNNILCRASLIAYLRSTTFAgk-------------------------------iIGVMITASH 63  Encephalitozoon...
Feature 1                                                                                        
2DKC_A        68 NPPEDNGVKVVDPLGSMLESSWEKYATDLANAspspsndsegeknslvev------------------------------ 117 Candida albicans
CAJ07046      98 NPYVDNGFKIIDVDGGMLAESWEEWCTRAANAssgsdlarvmmdcla--------------------------------- 144 Leishmania major
AAX69692      84 NPCGDNGLKLIDVDGGMLETSWETTCTQAANAstgeellkvlndcinlhg------------------------------ 133 Trypanosoma brucei
XP_001014682  78 NPIRDNGIKVSDFDGSMIRTELEKQLEVFVLDpnldnavaelvkvl---------------------------------- 123 Tetrahymena the...
XP_001457689  66 NKIIDNGFKIVPPKGGMLSIEEEQNIEIFYKSdeivkse----------------------------------------- 104 Paramecium tetr...
EDP31851      76 NPMEDNGVKIVDPMGGMLDAAWENYADLIVNAsdseflrksqefl----------------------------------- 120 agent of lympha...
XP_001611201 108 NGPEDNGIKILENNGNLLDPFWENKLTQFINWrddigkylsnmlrs---------------------------------- 153 Babesia bovis T2Bo
XP_951792     84 NPCSDNGIKLFSPSGRTLECAWEPIFTSFVNTrdpiqstlsnmft----------------------------------- 128 Theileria annul...
XP_729993    118 NPFDENGIKIIDKDGRQINEIYENYLSDLSNKhlkyikenknnnckiediinniidtivhiflketqinlydnkiynhik 197 Plasmodium yoel...
XP_965900     64 NPVEYNGIKIIDHNGDMLDEVWEEYSDRIVNCddeklaremkkilrs--------------------------------- 110 Encephalitozoon...
Feature 1                                                                                        
2DKC_A       118 --iknlvsdlkidlsipanVVIARDSRESSPALSMATIDGFQSVPnt------kYQDFGLFTTPELHYVTRTLNdpd--- 186 Candida albicans
CAJ07046     145 ----hdpsvfqpkpysycqVHFSRDTRPSGGEIVNAGLRTLHLLRnt------tARSYPPVSTPCMHFAIAKANelg--- 211 Leishmania major
AAX69692     134 --leqpkpedvkircpfgaVHLSRDTRPTGVDILSAIFSSLQAIGv-------tYADHGVLTTPQLHYLVGRANreqltg 204 Trypanosoma brucei
XP_001014682 124 ------tgikgfdnknqgmVFVGQDTRPSCPKLVHLIEQGLKSVGt-------lVRKTGEVTTPMLHHNVWFFNlfphnl 190 Tetrahymena the...
XP_001457689 105 ------------tlydtgiVYVGRDTRPSSESLCQIVLEGIKEAGa-------nGINLGIVTTPQCAFLVYATNlglv-- 163 Paramecium tetr...
EDP31851     121 -------rqfsgrvvenatVFTAIDTRPSSKYIEEAALCGAQCARv-------gGRRLGLLTTPQLHYIVRCQNdss--- 183 agent of lympha...
XP_001611201 154 ------haieyistkqiykIFIGCDTRDSGPHLCHMLDKGIKAAAeafmlkgviSINLGVVTTPTVSYILHNNLn----- 222 Babesia bovis T2Bo
XP_951792    129 -------kfgykprdlnlnILIGCDTRPSCLSLVSNLTLGIKAIYkllnltnsnVNFIGMITSPTISYLLSSNTt----- 196 Theileria annul...
XP_729993    198 kidniiyycniynkivktnICIGFDTRDSGLHLNKIIINTLTSLNis-----kcINNMCYITTPSMHFLXYIMNselvnn 272 Plasmodium yoel...
XP_965900    111 -----csnqselgegvrghVVLGRDTRDSGERLCNNIRSVLGKLNc-------tVDDYGVVTTPELHFLVRKCNte---- 174 Encephalitozoon...
Feature 1                                                                                        
2DKC_A       187 -------------------------------------------------------------fgKPTEDGYYSKLAKSFQE 205 Candida albicans
CAJ07046     212 ------------------------------------------------------------ladESESPSYYNELLAGFEE 231 Leishmania major
AAX69692     205 p--------------------------------------------------------gamkpaDFTSALYAKEVFGSLGE 228 Trypanosoma brucei
XP_001014682 191 ---------------------------------------------------------trsswtEQFTASYFNTYWTFFDE 213 Tetrahymena the...
XP_001457689 164 ------------------------------------------------------------nqiESKQEFFVEYFCDIFLQ 183 Paramecium tetr...
EDP31851     184 -------------------------------------------------------------ygVPTEAGYYAKVQNALAG 202 agent of lympha...
XP_001611201 223 --------------------------------------------------------------gATDDTQYVEALKEAFIG 240 Babesia bovis T2Bo
XP_951792    197 --------------------------------------------------------------wAKDDEMYISFLSNSFNK 214 Theileria annul...
XP_729993    273 fiqdiffqlgknqicktkrdlfylnsfnlkllknvqdlyfgipekwnididskndemysnilaYNSDEFYFDYFIYLFNN 352 Plasmodium yoel...
XP_965900    175 -------------------------------------------------------------nrVVDKAEYMKNIAHNFNS 193 Encephalitozoon...
Feature 1                                                                                        
2DKC_A       206 IYTICesnn---------ekiDITIDAANGVGAPKIQELLEKylh----------keISFTVVNGDYKqp----nlLNFD 262 Candida albicans
CAJ07046     232 MYRFAgsgfpsr--ekegnpqQLVVDCANGIGSLMVKELINAsrqqsdfvalatffeLHQVDCNCQDEt------mLNTK 303 Leishmania major
AAX69692     229 LLRFVtegnggt---nprqrqKIVIDAASGVGAVALKSLLKCaqevts---gvfeefFDVTVLHDNVDdi----naLNYM 298 Trypanosoma brucei
XP_001014682 214 FMTELgfqk--------kndeHILLDLSNGVGGVRIGPFREAlq-----------kyYNLDIINDTEHr------lLNEQ 268 Tetrahymena the...
XP_001457689 184 LVKTPik-------------gTLVIDGAEGVGGIWMKQFQERla-----------tlLTIKRINYGEEsh-----lLNDC 234 Paramecium tetr...
EDP31851     203 LNFVTrcgk--------ayipTLHLDCANGIGAQKFPLMCISws------------vLVVNLMNDQKTq-------LNDK 255 agent of lympha...
XP_001611201 241 AVYALqslgcvtkhdgltkmrPLCYDCAYGVGAYVIVRFFHClel----------lgIDASVCNNPETdpinaqklLNDR 310 Babesia bovis T2Bo
XP_951792    215 IYNKLqdlglvdfsqnvdnpeELFFDCSYGVGGYKVIRFFDLfrk----------lgIIPSICNFHRFgkd---qdLNYK 281 Theileria annul...
XP_729993    353 LYNYIntiydnif-iknckkeIIYVDCSNGIASLKIDKFNDIfk------------iLKKNIFKFNCLqnd--nnvLNFE 417 Plasmodium yoel...
XP_965900    194 LSSITkg------------nlRMMIDTANGVADMKLKELDGMld-----------gkLNYEVLNDPKGi-------LNLD 243 Encephalitozoon...
Feature 1                                               # # ##                                   
2DKC_A       263 CGADYVKTNQKLPKNVkpv------------nnKLYASFDGDADRLICYYqnn-------dnkFKLLDGDKLSTLFALFL 323 Candida albicans
CAJ07046     304 CGADYAKQHATPSAAMsawpstcp--pgvnpttAHFYSLDGDADRIVAFLydpk-----rdskWVLLDGDRISILYAMLL 376 Leishmania major
AAX69692     299 CGADYTQKAQYPSNDTkewaaayekrrsdkneeVHYYSLDGDADRVVAFFhdret----gedvWRLLDGDRISILYALSV 374 Trypanosoma brucei
XP_001014682 269 CGAEFVHKSQDYPIHSiekiks-----ypdiskVRVVSYDGDSDRIVYFLprsd------fkqIDLLDGDKMISLFALYF 337 Tetrahymena the...
XP_001457689 235 CGSEFVQKEKKLPKCFvyd------------ptYRYASLDGDADRLVYYSfne--------nkLQIIEGDRFAILFAMYI 294 Paramecium tetr...
EDP31851     256 CGADYVKIEKKFPRNFdki-----------qafERCAAFDGDADRLVYFYrda-------sneFVLIDGDKIAALFAKYI 317 agent of lympha...
XP_001611201 311 CGAHYVVSAMKPPRSVels------------egQWCASFDGDADRLVYFTpkd--------nsVLLIDGTRLLVLTVKFM 370 Babesia bovis T2Bo
XP_951792    282 CGASYVYSTSCFPQALkksfn--------iyfnKRFCCFDGDADRVLYYIpcdpvpnangeytVLQLHGDRLLIVTMMLL 353 Theileria annul...
XP_729993    418 CGADYVYNKKKIPSNIplny----------fsdSKFCAFDGDADRIIYFFikndn----lenqIEILDGNKIACLLFKCI 483 Plasmodium yoel...
XP_965900    244 CGADFVKTKKRAPRLEalsssg-----fsqaanRICASFDGDVDRLIFFTgp---------kdTEIFDGDSQAVFLALYI 309 Encephalitozoon...
Feature 1                                                                                ###     
2DKC_A       324 qqlfkqi---------------dptkisLNIGVVQTAYANGSSTKYVEDvl-------------kiPVRCTPTGVKHLHH 375 Candida albicans
CAJ07046     377 hkwlge-----------------eqmraLDVAVVQTAYANGASTEFLEKql-------------hmQVYTSATGVKNLHP 426 Leishmania major
AAX69692     375 rewigg-----------------ealklLDVGVVQTAYANGASTDYIQRgl-------------glRTYSSQTGVKNLHP 424 Trypanosoma brucei
XP_001014682 338 kkaleklqtkveavnktgilnvdlkpseWVIGMVQTPYANGSSTIYLRDql-------------klTTFFSPNGVKNLHP 404 Tetrahymena the...
XP_001457689 295 kqqlek-----------------qpalkLTIGIIQTAYANSASTKYITEkl-------------giEAKYAPTGVKYLHR 344 Paramecium tetr...
EDP31851     318 teqvtg----------------aglsdvFMVSVIQTGYANGNSTKFLRDkm-------------gvHVCCVATGIKNLQK 368 agent of lympha...
XP_001611201 371 kllmdls--------------qpderqpISIGILVNRYANGAAVQYIESmvaqwns---pssriiwELQFCNVGVKHFQA 433 Babesia bovis T2Bo
XP_951792    354 wtfla------------------nhkkkLTVGIFQTRYSNGSSVNYIDAlidryss---enknvswKHEYFNSGLKNAEK 412 Theileria annul...
XP_729993    484 ikmlsnisik--------neankvdrkkIDINIIHTAYVNSAFTNYINSvinsvstdipifnhiniNVICTKTGMKNLDN 555 Plasmodium yoel...
XP_965900    310 rslld------------------riesrLSIGVVLSYYSNNAAVDVLPPes--------------fKVVMAQTGVKNFVS 357 Encephalitozoon...
Feature 1                   # # #                                                                
2DKC_A       376 EAENFDIGVYFEANGHGTVIFNpeaekkifd--------------------------------ykpnndneaKAIKVLQN 423 Candida albicans
CAJ07046     427 IARARDVGIYFEANGHGTVLLSekvlag--------------------------------------aasagpEKAALFAA 468 Leishmania major
AAX69692     425 IAHKCDIGAYFESNGHGTILLNgdaidak-------------------------------------vpslpsKTRHVLSL 467 Trypanosoma brucei
XP_001014682 405 NAHKYDIGIYCESNGHGTFLVKekktaelekfyhlrie------------------dfkgtpenlqvlkeflHEVKQLYR 466 Tetrahymena the...
XP_001457689 345 AAHEFDIGIYFEANGHGAVIYKnhvlq-----------------------------------------kvkeFELFELEL 383 Paramecium tetr...
EDP31851     369 EAVKYDIAVYFEANGHGTVYFSprfydilrtv------------------------------ithkdevdqtIQIKRLLY 418 agent of lympha...
XP_001611201 434 KALDYDIAIFYESNGHGNVIFNkth--------------------------------------------rylGDADLMEK 469 Babesia bovis T2Bo
XP_951792    413 LAEKYDISVYYETNGHGNVVYNrtfhskdcyqnlsdqstniqspksfdalelssldtcmtnstissltdfkeEFSDTLLF 492 Theileria annul...
XP_729993    556 IARKSSIGILFESNGHGSIYANssnldawa----------------------------------kqfdiqkdPYFIALKK 601 Plasmodium yoel...
XP_965900    358 AAREFDVGIYFEPNGHGSVCFSqaci------------------------------------------deieKGSTKSHA 395 Encephalitozoon...
Feature 1                                                                                        
2DKC_A       424 FSQLINQTVGDAISDLLAVLIVVHYLKLSPSDWDNeYTDLPNKLVKVIVPDRSIFKTTNa---ERTLVEPKGMQDEIDKL 500 Candida albicans
CAJ07046     469 MRRLMSQYCGDAIADMLMCEVALKALNLTFQDWADlYVDRPCKQIKVTVAHRGRITNTPd---ERRALAPAGMQDEIDAA 545 Leishmania major
AAX69692     468 LPRLISQVCGDAIANVFACELILLAHKMSFDSWLRlYTDIPSTQLKVKVKNPKVITNTQd---ERRALTPPGLQEAIDAA 544 Trypanosoma brucei
XP_001014682 467 FIRVQNQCVGDSITNMLCIEAALATLNMTGQDYLNlYTDLKCKNSKVTIRDKSKLKMSYa---EDNVQEPKEIQEKINAI 543 Tetrahymena the...
XP_001457689 384 FLRLSNQAIGDAITNILMTEFLLNKLEMNIQDWLLiYLDYPALSTKLYVKNKQIIKTNYe---ETSLIEPIDLKQKVDEI 460 Paramecium tetr...
EDP31851     419 FSKLLNTVVGDAMTDLLAVEMILKHYDWTVENWNNmYKELPNVQRKLRAINRSVFQMSAd---ETTCVKPRKLQGAINTI 495 agent of lympha...
XP_001611201 470 VSYIFRNPIGDAVANTLFVELALYTLGLTYNDVLGfYNDLPCVNDTVNVPQHKLQYFRScsenDTILLEPRELQDLVEES 549 Babesia bovis T2Bo
XP_951792    493 DFLGIFFPSGDGIMNSLFLELTFRILKLSFHDCLNfYTDFPSSHFQYHLTPELKTLFSSta-nETVLKEPKILQDKIDSK 571 Theileria annul...
XP_729993    602 YLLFFNQTTGDAIIDFIAIELSLNFLNLNINQWNMfYTSIPSLYINIECPRYILNKIIPhpqhELYLIEPKSLQNQIEEI 681 Plasmodium yoel...
XP_965900    396 ILKILANLFDPCIGDALANFVIFKALMGSADDLRK-FRENPSRLLTVKIVDKNSIKVDQ----KNQVIEPKELQDKIDVE 470 Encephalitozoon...
Feature 1                           # ###    #                      
2DKC_A       501 VAQYPn--------GRSFVRASGTEDAVRVYAEADTQNNVEELSKAVSELV 543 Candida albicans
CAJ07046     546 VSLALsrc----eaARAFVRPSGTEPVVRVYAEATDPSVCECLSAEVAKIV 592 Leishmania major
AAX69692     545 VAAANeatpssatvARAFARPSGTEPIVRVYAEAATHAVSSKLANDVEEIV 595 Trypanosoma brucei
XP_001014682 544 VAKHPg--------SRAFIRPSGTEDIVRIYAESADSAQVDAVTNEIKDMI 586 Tetrahymena thermophila SB210
XP_001457689 461 MSKYDn-------sYRTCIRPSGTENVVRVHSEGPQLEIIREIDSRINELL 504 Paramecium tetraurelia strain d4-2
EDP31851     496 VSKYTd--------GRSFVRPSGTEDVVRIYAEAATEHDAEAIANEVEVVV 538 agent of lymphatic filariasis
XP_001611201 550 TSRYNg--------ARAFIRPSGTEPKCRIYAEAPTMEEALLLVDEIKTHI 592 Babesia bovis T2Bo
XP_951792    572 TKEFSf--------CRAFLRPSGTEALLRIYVEGETQEIVQNVQNYIVNEI 614 Theileria annulata strain Ankara
XP_729993    682 VKKTDmk------yGRCFIRPSGTENLIRIYAEAETVKQMDEILDKVQKVV 726 Plasmodium yoelii yoelii str. 17XNL
XP_965900    471 ALSLG---------GRSFVRPSGTEDVVRVYAECPSEADADLLCLKVAQHV 512 Encephalitozoon cuniculi GB-M1

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