Conserved Protein Domain Family
PGM_like1

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cd03087: PGM_like1 
Click on image for an interactive view with Cn3D
This archaeal PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this superfamily include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.
Statistics
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PSSM-Id: 100089
View PSSM: cd03087
Aligned: 43 rows
Threshold Bit Score: 468.974
Threshold Setting Gi: 118431870
Created: 21-Oct-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structures of Candida albicans AGM1 (N-Acetylglucosamine-phosphate mutase) and Pseudomonas aeruginosa PMM/PGM bound to their substrates and divalent metal ions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          # #  #                                                                        
1WQA_A         4 LFGTFGVRGIAne-kiTPEFAMKIGMAFGTLlkregrkkpLVVVGRDTRVSGEMLKEALISGLLSVGCDVIDVGIAPTPA 82
gi 118430994   6 LFGTDGVRGVIgs-elTPEFVLRLARAIGAYfgr----gsRILVGRDTRSGGELFEGLVAAGLAFEGVEVHLAGTLPTPA 80
gi 156937678   4 LFGTDGVRGITne-gmTPELAMKVAQAACTWlg-----ggKVLVGRDVRYGGDMLVSAVLAGLSSCGCEPYYAGLVPTPA 77
gi 159042249   7 LFGTNGVRLEFtkgnyDPGFLVKLAGAVATYvn-----agDVLLGFDVRVTSLPLVGVLYGVLSMYGINVDVIGPLPTPI 81
gi 10581623    3 VFGSSGTRGVAne-elTPGFVLRVAKAAGSVwr-----adRVAVARDTRTTGRMLENAAVAGLQSIGVDVDRLGVVPTPA 76
gi 76803207    3 VFGSSGVRGVVge-klTPPFVGRVAAAAATVld-----adTMAVARDTRTSGQLFADAAASALAAVGCSVARLGVVPTPG 76
gi 110667000   3 LFGSSGTRGVVge-giTPELVLQVAKAAGTVwe-----anQAIIARDTRTSSQSFVNAAVSGLTSVGIDVIRLGVTPTPS 76
gi 15790035   11 LFGTAGIRGDAve-tvTPQLALAVGTAAATTapg---dtpEFVVSRDGRETGPALIAAVTAGLAAGGARVIRGGVLPTPA 86
gi 57641712    3 LFGTAGIRGTLwe-kvTPELAMKVGMAVGTYks------gKALVGRDGRTSSVMLKNAMISGLLSTGMEVLDADLIPTPA 75
gi 118431870   7 LFGTAGIRGRYlr-kvTPLLAYQVGLALAGYvgs----ggSIVVAHDVRTTSPLLASMAASGVMAGGVDAILVGQVPLPA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          ###       #                                                   
1WQA_A        83 VQWATKHfnadGGAVITASHNPPEYNGIKLLEpNGMGLKKEREAIVEELFFKedfd-rakWYEIGe-VRRED---IIKPY 157
gi 118430994  81 LQLYVRDhgydAGVMVTASHNPPEYNGIKVVGgDGVEVPRDVEEGIEALFWEgkfs-tveWRSVAgqPKRVHd--AVDYY 157
gi 156937678  78 LQYAVPRlgydMGIMVTASHNPPQYNGVKVIGsNGVEVPRDAEREIEEIIFEnkvr-rvpYYEVKe-AKREGr--VLDVY 153
gi 159042249  82 HQYLTKAwgyrAGIMVTASHNPPHYNGIKLMDsNGVEVSRRVEEEVETIFFNgryketvdYRDIGa-VRFINveeGLRDY 160
gi 10581623   77 TQAYAERag-vPAVMVTASHNPSQYNGVKLVGsDGVELAVADLERVERAFTTeqfd-naaWDGVGa-DREVAs--AGRDY 151
gi 76803207   77 AQAYADRtg-rPVVMITASHNPPAYNGVKLVGgDGTELPRATLETIEDRLLAedfd-lvgYDAVGssTRIPD---APETY 151
gi 110667000  77 VVHYAGEtd-rPGIVITASHNPPEYNGVKLIGeTGVEIGVEGLERIEACVLNedft-pasWDNIGs-ITRTEt--VNTEY 151
gi 15790035   87 LAYASRGr---RGIQVTASHNPPSDNGIKLFA-DGREYDSDAERAIETRVAAdte--yaaWAEWGs-AESAT---VRPDY 156
gi 57641712   76 LAWGTRKla-dAGVMITASHNPPTDNGVKVFNgDGTEFYVEQERGLEEIIFSgnfr-karWDEIKp-VRNVE---VIPDY 149
gi 118431870  82 ASYSVVRsgskSGIMVTASHNPPWDNGIKIVDsRGMELTRSEEEELESIIEDgvegfladWNSVGi-LRIEKe--MLNYY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1WQA_A       158 IEAIKSKVDveai----kkrKPFVVVDTSNGAGs-LTLPYLLRELGCKVITVNAQPDGYFpaRNPEPNEENLKEFMEIVK 232
gi 118430994 158 VNRVVENVSaftq----rggGERVVVDCGGGATs-FTTVEILKRLGARPIPLSCKPDPLFssRDPEPTPDTLGPAASLVR 232
gi 156937678 154 IDGILADIDvqkv----knkEFKVVVDGANSVGs-LATPLVLRKLGAKVLCLNCNLDPSFpgRHPEPTPQSLEETSRAAV 228
gi 159042249 161 RDHLLSIINdepi----rrrGFRIVADFANSVNs-IALSYVLRGLNVKVYSINGHLDGEFpgRNPEPRPENLNVASRAVV 235
gi 10581623  152 RAQLSDAVDraai----aaaDLTVALDPGHGAGa-LTSPTFYRELGCDVVTVNAQPDGHFpgREPEPVREHLGDLGALVR 226
gi 76803207  152 VEELLDRLAtdglrerlaaaEPTVAIDPGNGAGc-VTSPRFFRELGCDVVTVNGQPDGHFpgRDPEPVADNLGSLRRLVR 230
gi 110667000 152 VDKLLTALEqdgsreaiadaNLTVAIDPGHGAGc-LTSPQFFRKLGCDVVTVNATPDGHFpgRPSEPIASNLTALRSLVT 230
gi 15790035  157 RAAVEAFARdhga----pldGTTVAVDCGNGVAa-VATPHVLRALGAHVVTLNANVDGHFpgRPSKPTPETVTDLREFVA 231
gi 57641712  150 INAVLDFVGhe--------tNLKVLYDGANGAGs-LVAPYLLREMGAKVLSVNAHVDGHFpgRKPEPRYENIAYLGKLVR 220
gi 118431870 159 MEDIVARTAvdg------etSLSMAVDCANGAAsgVTPIVLRSIGVRRVYTFNCHPDGYFpgRHPEPRPDVLEPFIKSSS 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  # # ##                                        #                     ##
1WQA_A       233 ALgaDFGVAQDGDADRAVFIDENGRFIQGDKTFALVADAVlkek---gggLLVTTVATSNLLDDiakk-hgaKVMRTKVG 308
gi 118430994 233 SSgaVFGVGHDADGDRAIVIDDRGRVVWGDRSGALLAGFVaevglakgplKVYTGVSSSIVVEDylrp-rgiEVVWTPVG 311
gi 156937678 229 AVgaDLIVAHDADADRAIIGDEAGEVHWGDRSGALLTEHLaekyp-hlpkRTFTGVSSSHIVVDgylrpkgiEVVWTPVG 307
gi 159042249 236 ESsaDFGVAYDGDGDRSLFIDEKGNVIWGDRTGTILALSMikn-----gdKVVTPVSSSVVVKWaveg-aggRVIWTRVG 309
gi 10581623  227 AAdaDVGIAHDGDADRAIFVDETGEYIEGDATLAALAEAElda-----gdTTVSAVNVSQRLVDvcdr-tgaTLELTPIG 300
gi 76803207  231 STdaDLGIAHDGDADRAMFVDETGSHIEGDAALAALADAElep-----gdAVVSAVNVSQRLVDvvad-adaELELTQIG 304
gi 110667000 231 ASnaDIGIAHDGDADRAVFIDEQGKQIAGEASLAALAAAElds-----nsATVAAVNVSQRLVDvcnr-vgaTLELTPIG 304
gi 15790035  232 TGdaAFGIAHDGDADRIVIVDGDGDIVHEDTIVAILADHYtrtsd-aadpVVVTTPNASGRIDDrvta-aggRVERVQLG 309
gi 57641712  221 ELgvDLAIAQDGDADRIAVFDEKGNYVDEDTVIALFAKLYveeh---gggTVVVSIDTGSRIDAvver-aggRVVRIPLG 296
gi 118431870 233 ILgvQAFIAHDGDADRTALGVPGYGFVKQDLVIALLSWWKlre----rkgSVVVSVDVGIEVEEvvee-lggRIVRSRLG 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                     # # #                                                     
1WQA_A       309 DLIVARAl-----yENNGTIGGEENGGVIFPeHVLGRDGAMTVAKVVEIFAksgkKFSELIDELPKYYQIKTKRHVeg-- 381
gi 118430994 312 APIIARAi-----lTQGGIAAFEENGGYMHPpHQYVRDGGMKAALLLAMLRatgeSLSSLLDRLPSYHPIKTKIPAs--- 383
gi 156937678 308 SVVIAHEl-----iKRGGVSGFEENGGFMNPvHQPVRDGAMTAALFLEMLAqrgkRASELFSALPKAYAIKGKVYRg--- 379
gi 159042249 310 SVDVSHKv-----iEEGALCGFEDNGGFIWPkHHPVRDGVSTTLLMMKVLSeekaKLSELNARMPAMLTARERMEMsr-d 383
gi 10581623  301 STQIMTRireleaeGDHVPVAGEGNGGIIFPeYRMTRDGAYTGARFLELLAdg-tPASEVVAPYDDYHNVRVNVDYdtea 379
gi 76803207  305 STYLISRirklrreGTSVPVAGEGNGGIMFPdYRIARDGAYTAARFLALVAd--rPASDVVADYSGYAYLRANIEYdhpd 382
gi 110667000 305 STNIITRiqelqksGVSVPVAGEGNGGIFFPkFRLVRDGAYIGAKFLRLICe--qPASSIIEPYTKYANARINIEHgsek 382
gi 15790035  310 ALHEGIAaar--ddGGDVVFAAEPWKHIHTA-FGGWIDGVASAAVLSRLVAda-gGLAPLRDPVTERPYRKVSVDCpd-e 384
gi 57641712  297 QPHDGIK-------RYKAIFAAEPWKLVHPK-FGPWIDPFVTMGLLIKLIDen-gPLSELVKEIPTYYLKKANVLCpd-e 366
gi 118431870 308 KIHEKLLq------EANAVLAAEPWKLIDPD-WGLWVDGVYQAALLAHISLatgkTPRELLDMLPYYPSARVSYVLggen 380
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                                                  # ###    #                      
1WQA_A       382 dRHAIVNKVAEmarer----gytvdTTDGAKIIFED-GWVLVRASGTEPIIRIFSEAkSKEKAQEYLNLGIELL 450
gi 118430994 384 -REEALCAVEAvkqefq---germvTIDGVKVIGEG-YWVLVRPSGTEPVVRIMLEArSEEEARALFERVLRAV 452
gi 156937678 380 eKEELRGLYEAlkskyq---dcqftEIDGLKVVCEN-FWFLVRPSGTEPVVRIMVEAtDPKKAKEVYSELESFV 449
gi 159042249 384 lAGKIVEALKGrnwg------geviTIDGLRVNYTD-SWFLVRPSGTENLLRVVIEAsSSDRFNTLRHEVMNSI 450
gi 10581623  380 qRGALLDAAEAralda----dadrtTIDGYRLDYGD-AWVLVRPSGTEPVVRIYAEStDHERAESLAEAFAADL 448
gi 76803207  383 eREAMLVAAEKvaeda----daeltTTDGYRLDYGD-AWVLVRPSGTEPLVRLYAEAgDRARAQTLLETFRDPM 451
gi 110667000 383 eLEALMRGAEEfaeea----dvtpnIIDGYRLDYDD-AWVLIRPSGTEPVVRVYAEAkEQTQAQTLADDAAGKL 451
gi 15790035  385 kKAAVMDAVADrlpdah--pdadveTEYGVRLAFADgSWALVRPSGTEPYVRVYAESsDVDELVDAVTDVVAST 456
gi 57641712  367 yKAEVVRRAAEeverklsseikevlTISGFRIALNDgSWILIRPSGTEPKIRVVAEApTEKRRDELFEMAYSTV 440
gi 118431870 381 eRDRLYEDVVEklshsltgnavrilPIDGVRIDYEDrSWLLFRKSGTEPKLRVYAQArEKERLVELLSRIHSMV 454

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