Conserved Protein Domain Family
LbH_G1P_AT_C_like

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cd03356: LbH_G1P_AT_C_like 
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Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the eukaryotic translation initiation factor eIF-2B subunits, epsilon and gamma. Most members of this family contains an N-terminal catalytic domain that resembles a dinucleotide-binding Rossmann fold, followed by a LbH fold domain with at least 4 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). eIF-2B epsilon contains an additional domain of unknown function at the C-terminus. Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity.
Statistics
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PSSM-Id: 100046
View PSSM: cd03356
Aligned: 19 rows
Threshold Bit Score: 78.0522
Threshold Setting Gi: 62738715
Created: 19-Jul-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1YP4_D      332 VIGEGCVIk-nCKIHH-SVVGLrSCISEgAIIEdSLLMGAdyyetdadrkllaakgsvpiGIGKnCHIKRAIIDKnARIG 409
gi 18203317 357 LIGPETQIgekSSIKR-SVIGSsCLIKDrVTITnCLLMNSv-------------------TVEEgSNIQGSVICNnAVIE 416
gi 15488926 361 LLGSGTVIgsnCFITN-SVIGPgCHIGDnVVLDqTYLWQGv-------------------RVAAgAQIHQSLLCDnAEVK 420
gi 20517031 266 IIGNEVVIeenAVVGPnVVIGRgTIIKKgSHVKnSVLWEDv-------------------YVGEnSELNGAVVCNkVRID 326
gi 89210730 269 FIGEGTRIgkgARVAN-SIIGRnNYIQPhASIKkSILWDNn-------------------FVGAnAEIRGAVITEnVVVR 328
gi 91081755 305 VTGDKVVLndnKKIAN-SIIGDnVTIGKnVQIEhSFILSNt-------------------KIADnVIITHSVIGPnCHIK 364
gi 1709086  256 LIDPTAKIsstAKIGPdVVIGPnVTIGDgVRITrSVVLCNs-------------------TIKNhSLVKSTIVGWnSTVG 316
gi 15623406 252 YISSGVNIsedSFIFN-SIIGKnTSIGNgVYIDqSILMEDv-------------------KVDSfSYIRDSILGDkDNLG 311
gi 70606038 254 YIGDNTTVgegSSIRN-SIIGVnNRIGNgSCVEeSILMNDv-------------------MLGDfSLIKESVIGDeVSLG 313
gi 21542400 307 RIEESAEIdkdSVIKR-SFISDnCRIGEkTKLKeSIIAKGv-------------------VIGNgASISNSIICDgVEIG 366
                        90       100       110
                ....*....|....*....|....*....|....*.
1YP4_D      410 DnVKIInkdnvqeaaretdgyfiksgIVTVIKDALI 445
gi 18203317 417 KgADIKd------------------cLIGSGQRIEA 434
gi 15488926 421 ErVTLKpr-----------------sVLTSQVVVGP 439
gi 20517031 327 SnARILen-----------------aVIGEGVRIKA 345
gi 89210730 329 ErGSIFdl-----------------aAVGEKVVIGE 347
gi 91081755 365 AnSRITas-----------------sIIGKDVVIEN 383
gi 1709086  317 QwCRLEgv-----------------tVLGDDVEVKD 335
gi 15623406 312 KwVRLDs------------------vILGDEVVIYD 329
gi 70606038 314 KwNRVDg------------------aIIGDGVLIHD 331
gi 21542400 367 EnADVTn------------------cIVAKDQKVPA 384
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