Conserved Protein Domain Family
LbH_WxcM_N_like
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cd03358: LbH_WxcM_N_like 
WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization and transacetylation reactions of keto-hexoses. It contains an N-terminal LbH domain responsible for the transacetylation function and a C-terminal isomerase domain. The LbH domain contains imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), typical of enzymes with acyltransferase activity.
Links
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Statistics
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PSSM-Id: 100048
View PSSM: cd03358
Aligned: 56 rows
Threshold Bit Score: 110.283
Threshold Setting Gi: 18160129
Created: 31-Jul-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
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Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structures of E. coli galactoside acetyltransferase and Enterococcus faecium streptogramin acetyltransferase Vat(D) bound to CoA and their respective substrates.
  • Comment:Active acetyltransferases in this family are trimeric, with active sites located at the interface between two LbH subunits. The trimer structure contains three active sites and each subunit contributes to two active sites via residues located on two surfaces.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                               # #                           # #                  # ##  
gi 14090396   34 LGRDCNICDGVFVEsDVIVGDRVTVKCgVQLWDGVRLGDDVFVGPNATFTNDLFPRSRvyp-ekFLGTVVESGASIGANA 112
gi 4981287   117 IGPYTVIGKGVTVEnRTTIGRYVKIETnAYITALSTIEDYCFIAPEVTFTNDNFLGRTeerkkfFKGPTLKKGARIGANA 196
gi 56381541  117 IGQYVIVGRGVCVEnHVQIGDRTKIQSnSYITAYTTLEDHVFIAPCVTTTNDNYMGRTeerfakIKGATVKRGARVGGGA 196
gi 20807146  117 IGDMTIVGRGVAIEnYCKIGSRCKIETnAYITAYSELEDEVFIAPCVATSNDNSAGRDpdrfskMKGVTAKRKSRIGVNA 196
gi 28211864  117 IGEKTIIGKGATIEnFCKVGSSCKIQTnVYLTAYSEVEDSVFIGPCAVTSNDNYAARSkerfgkFKGVTVKKGGRIGAGA 196
gi 52002444  115 IGRESIIGRNAMVEnNTRIGSKATIQTgCYITADMTIEDEVFIGPCCSTSNDKYMGKGny---pYQGPTIKRGAKIGNNA 191
gi 91773571   68 IGNDVSIGTHSIVErENTIGNNVRIHSnCFVPEFVIIDDDVWIGPSTTILNVLHPPCPrfe-dcAKSVHIKKGAKIGGNV 146
gi 89896090  193 IGKNVVIGSGAAVEnDTRIGDYTKIQTgSYITAYMELEERVFIAPMVTTTNDNYMGRTekrfksIKGPTICRGARIGGGA 272
gi 86147244   95 AGKNFQIGTLSDIQgDCEFGDYVRLHSnVHVGKLSKVGDYVWLFPYVVLTNDPHPPSNv-----MQGVVIEDYAVIATMS 169
gi 147677446 146 IGRRVIIGRGAVLEnDVSVGDYSKLQTgAYLTAHTSVSARAFIAPMVITANDNQMGRTeerlseKRGPCIEEGARIGAGA 225

                         90       100       110
                 ....*....|....*....|....*....|....*....
Feature 1          #           ##    ##        ## #     
gi 14090396  113 TILAgTTIGSGAMIGAGAVVTRSVPPNAIVVGNPARIVG 151
gi 4981287   197 TILPgVVVGEDALVAAGSVVTRDVPDRKIVMGIPARVVR 235
gi 56381541  197 ILLPgVTVAEETFVAAGALVTKDTEPRTVVKGFPARFSK 235
gi 20807146  197 TILPgKVIGEDAFVGAGSVVTKDVEDGKIVVGNPGRVKK 235
gi 28211864  197 TILPgKIINEDGFVAAGTVVTRDVKAKTIVVGNPSKYYK 235
gi 52002444  192 TLLPaVVVGEGAVIGAGAVITKDVPAGKTAVGNPGRLMK 230
gi 91773571  147 TIGPrVSIGERSFIGMGSVVTKDIPDRVLAYGNPAKVIC 185
gi 89896090  273 ILLPgIRVAPETFVAAGALVTKDTEAKRVVKGFPAKELR 311
gi 86147244  170 VILPgVTIAKGCLVGASSTVAKSTQEDMLYSGNPAKLIG 208
gi 147677446 226 LLLPgVRVAAETFVAAGSLVTRDTRPGTVVMGRPARFVR 264

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