Conserved Protein Domain Family
LbH_Dynactin_5

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cd03359: LbH_Dynactin_5 
Dynactin 5 (or subunit p25); Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping protein Arp1, and dynamatin. In vitro binding experiments show that dynactin enhances dynein-dependent motility, possibly through interaction with microtubules and vesicles. Subunit p25 is part of the pointed-end subcomplex in dynactin that also includes p26, p27, and Arp11. This subcomplex interacts with membranous cargoes. p25 and p27 contain imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), indicating a left-handed parallel beta helix (LbH) structural domain. Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity.
Statistics
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PSSM-Id: 100049
View PSSM: cd03359
Aligned: 28 rows
Threshold Bit Score: 173.169
Threshold Setting Gi: 71419742
Created: 19-Jul-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13278858   13 YIETASGNKVSRQSVlCGSqNIVLNGkTIVMndCIIRGDLa-------------------------nVRVGRHCVVKSRS 67
gi 28950219   10 YIETDTGNKVARKATlVGTqNIMLGGkTVIQpdVMIRGDLartippaqsa--------sggpanntaVAIGRYCFLSRGC 81
gi 50548731   11 YVITESGNRISRKAAlSGLqNIVLGGkTVIDhgSKIRGDLqrpgs------------------tapiIAIGRYCIISTQV 72
gi 50307391    3 WIETGQGTRISKQANvLGPdKIVLAGqCVISpkCTLEGNVllmenydksasa----sakrknhnrytISVGRYCILEPGV 78
gi 50414045    3 WIETTSGNRISKKSKiFGSnSILINGnCTINdeVLLQGDVriagk------------------qqatIQIGKCCYLGTGA 64
gi 154294234  10 YIETDTGNKVSRRSQiIGTtNIILGGkTVIQaeVIIRGDLlrtlppstq---------gekagnavaVAIGRYCFFSRGC 80
gi 146185760  42 YYETQTGNKLCKKNLiRGSdNIFIYGkVIMQqkNIIRGDLg-------------------------rINLGKYLILCEGV 96
gi 119491466  10 YIETDTGNKISRRSQiHGTqHIILGGkTVIQadAVIRGDLyrssssstssasadgsrpsqpstpsvaITIGRYSYISRQA 89
gi 111060899  15 YIETDSGNKVSRRSAiTGTaNITLGGrTVIMadVQLRGDLhptrstpsq---------sgkevtptsISIGRCTVISTGS 85
gi 150865115   4 WIETSSGNRISRSAHiSGSdRIVINGnATIHpgVQIHGDVqllanks--------------stdtttATLGKFCYLRPNC 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13278858   68 VIRPP----FKKFSKGva---------ffPLHIGDhVFIEEdCVVNAAQIGSyVHVGKNCVIGRRCVLKDCCKILDNTVL 134
gi 28950219   82 CLRPP----GRMYKGVft---------fmPLRLGDhVFVGPgTVVQAAQIGNhVHIGGKVVIGEFAIIKDYVKVLDGSVV 148
gi 50548731   73 TVEPP----CKDEAKEny----------yPVRIGDyVYIGDnSVTQAVQIGSnVEIGDNCEIGKFCIIKDCVIVDPGSVI 138
gi 50307391   79 RVKPP----VVGYRKSeddlnsgkvaihsDLLMNSyVWIGQdCKVYCKKLGSrVVLGANTHLNRCCEIGDVVIIDDNLVV 154
gi 50414045   65 KITPP----VLKYEDEesi--------hgPLLIGGyTIIGKnSVVRLANIGSrVLVELGCDLGNLSIVYDCCLIRSGTII 132
gi 154294234  81 ELRPP----GKIYRGTfs---------yfPLKIGDhVYVGPgSIIEAAMLGNhVNIGANVVVGKFVIVKDFVKILEGTVV 147
gi 146185760  97 TLRPSy---QVQANDQik---------ysHITIGDyVIIDSnSIIQAQKIGSnVHIGKNCIIGHRANISDNVKILDDTII 164
gi 119491466  90 VLRPP----SRLHRGLht---------fyPLKIGDhVFVGErAVVEAATVGNhVHIGREAVVGSMAILKDFAYVLDGAVV 156
gi 111060899  86 VIKPP----CRISRGQvh---------yyPMKIGDnVFVGPgCTIQAISISShVHIGEKVTINQFAIIKENVKILPNTVI 152
gi 150865115  70 QIIPPvlqeCSDSDSTty---------hgPVTIGAyTIIGSnTVVKSANVGNrVLIEDDCVLENLSIIYECCVIRKGTVV 140
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 13278858  135 PPETVVPPFTVFSGCPGlfs----gelPECTQELMID-----VTKSYY 173
gi 28950219  149 PPNMVIPSFSIVAGQPAri-------iGEIPEGGIEAf----ELRDLY 185
gi 50548731  139 PPRTVCAPFTRWAGVPAvei----evlSESTAEMVQL-----RNRQRY 177
gi 50307391  155 PERYKIPSYSRVSRHPDvatsivvkplPPMFAPVIEN-----WCQKRY 197
gi 50414045  133 PPKMVIPPFSDVSGVPGidfc--ikdlSNSYKKLIEI-----EARELQ 173
gi 154294234 148 PPNMVIPSFSVVGGCPGrv-------vGEVAEGEIEGm----DLREIY 184
gi 146185760 165 PPDTVIPPYTVYGGKPAryi----aelPETVSYIHRE-----QAIKYY 203
gi 119491466 157 PAGMVVPSWCVVGGAPAri-------vGEVGEGYGVEgaeggMARERY 197
gi 111060899 153 PANMVIASGSVVGGRPArv-------iGEVGEGWGVSgg--gGTGGGL 191
gi 150865115 141 PPKTIIPPYSEVSGVPGkdfr--isslNSCYKRLIEI-----EAKELQ 181
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