Conserved Protein Domain Family
GT1_LPS_heptosyltransferase

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cd03789: GT1_LPS_heptosyltransferase 
Click on image for an interactive view with Cn3D
Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Statistics
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PSSM-Id: 99964
View PSSM: cd03789
Aligned: 157 rows
Threshold Bit Score: 125.06
Threshold Setting Gi: 9937238
Created: 9-Nov-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative active
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1PSW_A        2 KILVIGpswVGDXXXSQSLYRTLQARyp-qaIIDVXAPaWCRPLLSRxpeVNEAIpxplgh-------galeigERRKLG 73
gi 26250278   7 RILLIKmrfHGDMLLTTPVISSLKKNyp-daKIDVLLYqDTIPILSEnpeINALYgiknkka-----kasekiaNFFYLI 80
gi 37528662  10 RILIIKlrhHGDVLLITPVINTLKDNyp-avEIDVLLYkETEPILADfpaVANLFsidrqwkk---qgvkthlgHEWRLL 85
gi 37678477   3 KILVIRndkIGDFMLAWPSFAMLKQSmp-eaHITALVPsYTQELARLcpwIDDVLldptekagk--eatkqlvqEIKSRQ 79
gi 39984241   7 SILIINirlIGDVILTTPLIGILKNAfp-daAIDFLVNrGTGEFLEKdprVRRVIysekgs--------vaaggAREGGY 77
gi 49609647  10 KILILKlryHGDMLLTTPLISTLKANyp-naKIDVLLYqDTMPILSAnpeIHQLYglkrkts-----tllekirNFTEIW 83
gi 71905794  21 RALVIKlrhHGDVLVSSPVFSVLKAHap-qiEIDALVYaDTAEMVTLhpaIAEVHtidrkwkq---lgavgqlkAELALY 96
gi 71905801  28 RILVIQtakIGDFVATTPVFRALRRRlp-evEIVALLHpVNVPLAKGldsIDRIIvlpkq---------gfkgwAGKRWL 97
gi 73542695  14 RALVLCiggLGDVVWASASIDALRETygsdiEIDLLLKhRSGELFKHdprISRILilrggprlpllvnphkwliLAQALI 93
gi 77972919  28 RILVIKlrhFGDVLLTTPLLNTLKANyp-qaKIDVLLYgGTQDMLREnntVNHAFivdrglkh---aglkaqisGEKALF 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1PSW_A       74 HSLRekryDRAYVLpnsfksal--------vplfagipHRTGWRGexry-------gllNDVRvldkeawplxveryial 138
gi 26250278  81 KVLRankyDLIVNLtdqwmvai--------lvrllnarVKISQDYhhrqsaf-wrnsftHLVPlqggnvvesnlsvltpl 151
gi 37528662  86 KRLRhrqyDLVINLtdqwysaf--------vtrftgakVRIGFDLakrrslf-wkkcftNFVPtehsqflhiveqnlsal 156
gi 37678477  80 FDASinlfSTTYNAllvwkagiky----rlapatkiaqIFYNRRIkqkr-------sqsAKPEyqynldliraflneqkv 148
gi 39984241  78 FRDIfrryDLAINMnasdrgsf--------aallagkkTRVGFTLgdnfgqa-lwkkmlFHRLiplpcqnhvallcksva 148
gi 49609647  84 QTLKqnnyDLIVNLadqwpial---------lvkllgcRSIALDRgnnlkgkiwrlffdTCVPpvgahiveqnlylltpl 154
gi 71905794  97 NTLKargyDLIIHLtehwrgaw--------lcrllkprWAVGPAVrgrsk-----rwkqSFTHiqtmhnplrhmaesnld 163
gi 71905801  98 LDLLaegyDGVLILspnlsnllvpfwagvpkrvsvladRRQGSSRlawp-------fltYGEPhrrgqlfretalraiag 170
gi 73542695  94 RYPYhlilDLTINRtdffpslgwc----fpaahkvkvyKVRHEVDppet-------hrtTVVQrllayctpqhiaqramp 162
gi 77972919 104 NALKehhyDLILNLsdqwraaa--------ycrllkpgFSIGFHYpkrdtwl-wrychsTLVDipnagerhtvlnnldil 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                      ##                               
1PSW_A      139 aydkgixrtaqdlpqpllwpqlqvsegeksytcnqfslsserPXIGFCPgaef------gpaKRWPHYHYAELAKQLIde 212
gi 26250278 152 gleslvk-----------qttmsyppaswkrmrreldhagvgQNYVVIQptar------qifKCWDNAKFSAVIDALHar 214
gi 37528662 157 sllnlplin--------ttvtmsyrqqdkeavlmlldkhgvdQKYIVVQptsr------wffKCWDEKKMSKTINALQsd 222
gi 37678477 149 tavepqap---------fllfdetelsvqklklseqlsieahKPWVMVHagtg------gsaNNLTLAQYAELLKGIEqd 213
gi 39984241 149 dalglaadr--------lsasvhwdaadagrvrqvlekarldGAYFVIHpfar------wryKLWTMEKFAELSDRVAer 214
gi 49609647 155 klpasntc----------fklslhyrqedaqsianqrptlltQRYVVIQpttr------qyyKYWDNDKFAQVIDYLKtk 218
gi 71905794 164 slrrigiqpgp---derrltlvpgaaaegavaahlagfglrgKDFIHVHpasr------wffKCWPVERMAALVDRLQaa 234
gi 71905801 171 lgikvdavl-------lalpnevrgaesgqaklnawspicqrPLVGFGLgag-------nrmKALDAAQVAALAGQIVnh 236
gi 73542695 163 --------------------------slrrpdidirarygltSPFICLHtgnssfyhnrantRLWPVGKWIELLDGWSry 216
gi 77972919 175 eplqltdintd----vtmsysaqdvervkllcqqygmgddpiHNYIVIQpsar------wkfKTWASESFSQLINHLTeq 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                                   ##           #  ##  #               
1PSW_A      213 --gyQVVLFGSAkdHEAGNEILaalnteqqawCRNLAGetqlDQAVILIAaCKAIVTNDsGLXHVAAAlnRPLVALYGps 290
gi 26250278 215 --gyEVVLTSGPdkDDLACVNEiaqgc-qtppVTALAGkvtfPELGALIDhAQLFIGVDsAPAHIAAAvnTPLISLFGat 291
gi 37528662 223 --gwTIVVTSGPdrKEEEMVAKilsnc-lkerVISFAGqltlPQLAALIDgANLFIGMDsVAMHMAAAlkTPGIALFGps 299
gi 37678477 214 ---fQLIVTAGPgeTEKAQQLLkeyaq-lggqGVVYDKneglVDFTRSIAcADLFIAGStGPLHIAATldVPTVGFFPsk 289
gi 39984241 215 y-glRPVWTASPsaVEVSMVQQgagl--crhaPLVIKGefslNQMACLLSgASLYIGLDtAVTHMAAAagIPLVALYGpt 291
gi 49609647 219 --nlEVVLTCGPseDDLNVVRDihsqc-mhkpDMTFAGktsfLELAALIDnAVLYIGVDsAPMHMAAAlnTPLVCLFGpt 295
gi 71905794 235 --ghVVVLTAAPsqDEKNMLAAiqar--lakpAFSLSGqlslKELAALTQaSKLFIGVDsAPMHIAAAvgTPTVALFGps 310
gi 71905801 237 t-paTLVLIGTDadRAAAETVLaqlp---agrAIDTTGqwglDELPVLLGaLDCFVGVDsGATYMADAlgVPVVDFMGpa 312
gi 73542695 217 fphhQPVLIGTPaeAEHIAQIAdky-----psVINLCGktplPEMMALIAdADLLIGTDtGPTHVAAAfgTPVIAIFGpt 291
gi 77972919 245 --seTVLLTGGKdqAELDYIAEiiagctqtekVINLSGqlalPELAVLIDnAKLFVGVDsVAMHMAAAlqTPSVVLFGps 322
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                                                                  
1PSW_A      291 spdf----tpplshKARVIRlitgyhkvrkgd----aaegyhqslidiTPQRVLEELNA 341
gi 26250278 292 dhifw---rpwsnnMIQFWAgdyremptrdq-------rdrnemylsvIPAADVIAAVD 340
gi 37528662 300 klvfw---rpweakGEVIWAgdygdlpdpddv-----dtktdirylnvIPSEMVIAAAR 350
gi 37678477 290 rsstplrwrplnseGRHLAFcppkgggeamea----dmsrididaalvQLNPWVSPYLS 344
gi 39984241 292 elnrw---fpwdnqGPLEQVpplsggrii----------vvrkedrecVPCGEAGCGGR 337
gi 49609647 296 dyklw---rpwcehYKQIWAgeyqqmpaqqn-------ydqtvkylscIPAQAVIQASE 344
gi 71905794 311 gdkqw---gpwgvpSRVVAStvhpcrpcgadg----cgggkvsdclvsIAVDEVMAAAQ 362
gi 71905801 313 daedq---rpigrrAVVIRSaepcapcshaf-------dapyschlgtRACIANMPIAA 361
gi 73542695 292 lshvt---gpagdsNRLRIVkpwtgtliedvqvdqvveashelisadgNPRAAEVAMKG 347
gi 77972919 323 nlnqw---hpwqapHTLLWAghyrtlphpnei-----dtdttdrylnaIPVSDVIAAVD 373

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