Conserved Protein Domain Family
GT1_PIG-A_like

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cd03796: GT1_PIG-A_like 
This family is most closely related to the GT1 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.
Statistics
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PSSM-Id: 99970
View PSSM: cd03796
Aligned: 23 rows
Threshold Bit Score: 589.951
Threshold Setting Gi: 19171366
Created: 6-Dec-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #                                                                 
gi 11863130   34 NICMVSDFFYPnmGGVESHIYQLSQCLIeRGHKVIIVTHAYGnr-kGIRYLTSGlKVYYLPLKvmyNQSTATTLFHSLPL 112
gi 124802802  28 CICMVSDFFYPnlGGIETHIFELSKNLIkKGFKVIVVTNFNNnr-hGIRWMGNGiKVYYLPFQpflDVVSFPNIIGTLPL 106
gi 28974405   22 CICMVSDFFFPslGGIETHIYHLSQCLIqRGYKVVAITHYTDgr-hGVRYLSNGlKVYYLPFVpvhDNATLPTFFSFFPL 100
gi 8571458     3 NICLICDFFYPclGGVEMHIFQLGLCLIeRGLKVIIITHKYQgr-sGVRYMTNGlKVYYCPFIpaiQTVVLFTYVGTLPI 81
gi 67613172   16 NICMVSDFFYPglGGVEMHIYELSQCLMvRGYKVIVVTHSRNdr-yGIRYMGIGlKVYYLPYKsiyDNVVYPSLFTLFPL 94
gi 50545501    4 NIAMVSDFFYPqpGGVELHVYQLSQRLKqRGHSVVIITHAYDsr-tGVRILTNGiKVYYVPFFvlyRNSTFPSVFSAFPI 82
gi 67482656    9 RICLASDFFYPnmGGVEFHQYQIAHFFVkHGHKVVVITHQYGnr-tGVRVLKNGiKVYYLPLLrmfNECCFPTGMSEHAL 87
gi 3875385     9 SIALVSDFFCPnaGGVETHIYFLAQCLIeLGHRVVVITHGYGnr-kGIRYLSNGlKVYYLPFIvayNGATLGSIVGSMPW 87
gi 116056835   6 CVLMLSDFFLPtiGGVELHIHALASRLRaRGHKVVVFTHAQPgregVVRWLAGGiKVYHVPRVvlyDNCTFPSFMGNFKL 85
gi 441475      4 NIAMLCDFFYPqlGGVEFHIYHLSQKLIdLGHSVVIITHAYKdr-vGVRHLTNGlKVYHVPFFvifRETTFPTVFSTFPI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 11863130  113 LRYIFV---------RERVTIIHSHssfSAMAHDALFHaktmGLQTVFTDHSLFGFADvssVLTNKLLTVSLCdt-nhII 182
gi 124802802 107 CRNILY---------REKVDIVHGHqatSALAHQFILHaktlGIKTIYTDHSLYSFSDkgcIHVNKLLKYCINdv-dhSI 176
gi 28974405  101 IRNILL---------RERADIVHGHqatSPLAHEASLVaralGMHVVYTDHSLFGFADmacIHLNKVLRFVLHdl-daCI 170
gi 8571458    82 FRQILL---------REEIHIVHSHaatSYLGGELLLHaksmGFKTVFTDHSLFAFNDaasFHVNKILKYILCei-dhSI 151
gi 67613172   95 FRQILI---------REKIDIVHGHqsvSMLALECLFHattmGYRVVFTDHSLFGLSNydsIHANNFFRINLSci-dnVI 164
gi 50545501   83 LRNIFI---------RENIDIVHGHgslSSLCHEAILHartmGMKTVFTDHSLFGFADagsIAGNKALKFTLSdv-ghVI 152
gi 67482656   88 IRNILI---------REQIQILHAHqsfSAISLESMFFarllGIRVFLTEHSLFGLKGlasIMLNSVLQYSLAns-dgAI 157
gi 3875385    88 LRKVLL---------RENVQIIHGHstfSSLAHETLMIgglmGLRTVFTDHSLFGFADasaILTNKLVLQYSLinvdqTI 158
gi 116056835  86 FRKVRErdgaaqvciREGVTIVHAHq-gCTMMHEGILYartmGMKCVFTDHSLFGFADvgaIHMNKLLDMTLSdt-qhVI 163
gi 441475     83 IRNILL---------REQIQIVHSHgsaSTFAHEGILHantmGLRTVFTDHSLYGFNNltsIWVNKLLTFTLTni-drVI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                       ###              
gi 11863130  183 CVSYTSKENTVLRAa--------lNPEIVSVIPNAVDPTDFTPdpf-------rrhDSITIVVVSRLVYRKGIDLLSGII 247
gi 124802802 177 CVSHTNRENLVLRTe--------sNPYKTSVIGNALDTTKFVPcisk-----rpkfPRINIIVISRLTYRKGIDLIVKVI 243
gi 28974405  171 CVSHTHRENFVLRAg--------vPPSRVYVINNAVDASTLVPdpsk-----rpkpPEIRVVVLSRLTYRKGIDLLVTVI 237
gi 8571458   152 SVSHVSKENLSMRAs--------lDPRNISVIPNAVDCSRFTPnpqk-----ryplNTINIVVICRMTFRKGVDLLVDVL 218
gi 67613172  165 CVSHTNKKNLIYRSl--------iSPKNVTVIPNAIDSNDFLPnpnyk----spinNEVIVISICRMTYRKGVDLLVEII 232
gi 50545501  153 CVSHTCKENTVLRAs--------lDPSIVSVIPNAVVSKAFTPdptr------adpNYITIVVISRLYPNKGADLLTVII 218
gi 67482656  158 AVSHCTKENMCIRAk--------rDPTKIYVIPNALESSKFQPdisk------rdpNNINIVILSRLVYRKGIDLAVGII 223
gi 3875385   159 CVSYTSKENTVLRGk--------lDPNKVSTIPNAIETSLFTPdrnq------ffnNPTTIVFLGRLVYRKGADLLCEIV 224
gi 116056835 164 CVSHTAKENTILRSgyllgdepglAPDRVSVIPNAVDAARFRPdlsk------rtkGRITVVVTSRLMYRKGVHLLAGVI 237
gi 441475    153 CVSNTCKENMIVRTe--------lSPDIISVIPNAVVSEDFKPrdptggtkrkqsrDKIVIVVIGRLFPNKGSDLLTRII 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                       #                     #          
gi 11863130  248 PELcqkYPDLNFIIGGEGPKRIILEEVRERyqLHDRVRLLGAlEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQ 327
gi 124802802 244 PLVcqkYPFIKFIIGGEGPKRLLLEEMREKyhLHNSVVLLGKvKQENVKNILQTGHIFLNTSLTEAFCIAIIEAASCGLL 323
gi 28974405  238 PPIckkLPNVNFVIGGYGPKRIILEEMREKhgLQDRVELIGAvSHDKVCALLQSGHIFLNTSLTESFCIAIVEAAACGML 317
gi 8571458   219 QIIckqHPEIYFIIGGDGPKKKILEETIQRynLQNQTELLGSvPGHQVKDVLNRGHIFLNTSLTEAFCIAIVEAASCGLC 298
gi 67613172  233 PRIcnsDPNVRFILGGDGPKKHLLHEMCKKynLSNRVELLGSvPHTQVCRVLQRGHIFLNTSLTEAFGISIIEAASCGLL 312
gi 50545501  219 PRIcalHPRVKFLIAGSGPKEIDLQQMRERyrLQERVELIGSiRHEEVRDLMVTGNIYLHPTLTEAFGTVIVEAASCGLL 298
gi 67482656  224 PYIcskYPKVNFIVGGNGPMMLNFEEMREKyqLQSRVKLLGAiQHCETRDVLVQGDIFLNCSLTEGFCIAIIEALSCGLH 303
gi 3875385   225 PKVcarHKSVRFIIGGDGPKRIELEEMLERfkLHERVVILGMlPHNQVKRVLNQGQIFINTSLTEAFCMSIVEAASCGLH 304
gi 116056835 238 PFAcarHKNLDFLIAGDGSMRQHLEKVIDDenLRGRVTLLGHvPHERVPEVLRRGDVFLNASLTESFCIAILEAASCGNL 317
gi 441475    225 PKVcssHEDVEFIVAGDGPKFIDFQQMIEShrLQKRVQLLGSvPHEKVRDVLCQGDIYLHASLTEAFGTILVEAASCNLL 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 11863130  328 VVSTRVGGIPEVLPENLIILCEPsvKSLCEGLEKAIFQLKsgtl---------------------------papENIHNI 380
gi 124802802 324 VISTDVGGISEVLPHDMMILAKPnhIELCKAVDKALKIVQkvdsnlfhervnmslltyvniyiyiyiyiyiiymNNFIYN 403
gi 28974405  318 VVSTNVGGIPEVLPPHMVLLSEPddVQVTRRLEEAISIVHtv------------------------------dpFSFHEQ 367
gi 8571458   299 VVSTNVGGISEVLPQNMVLYADPtpEDISHKITQAIPIAKnf------------------------------yvYQQHEL 348
gi 67613172  313 VVSSNVGGIPEILPQEFLRLSNPsiSNMVNELNIAVNIIRegk----------------------------fdpYSSHKK 364
gi 50545501  299 VVTTDVGGIPEVLPSHMTVFASPseDSLVDSTMKAIAILEkke----------------------------vdpTTFYNE 350
gi 67482656  304 VISTHVGGIKEVLPNSLIKYSMPtvEDLCKKVEEVIPICKee------------------------------rsWEFHNA 353
gi 3875385   305 VVSTRVGGVPEVLPIGEFISLEEpvPDDLVDALLKAVDRRekgl--------------------------lmdpTEKHEA 358
gi 116056835 318 VVATAVGGVPEVLPDDVMFLAKPdvESILDALEDCLDALPha------------------------------dpWKLHTR 367
gi 441475    305 IVTTQVGGIPEVLPNEMTVYAEQtsVSDLVQATNKAINIIrska---------------------------ldtSSFHDS 357
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
Feature 1                                                            
gi 11863130  381 VKTFYTWRNVAERTEKVYDRvsveavlpmdkrldrlisHCGPVTGYIFALLA 432
gi 124802802 404 LTKMYSWEKVAEKTVKSHNTyimniekvymnvlnyanpSLFNRIRKIYEINT 455
gi 28974405  368 IREHYSWHDVAARTERVYFSllfpehasyppcsassplAAPCNCGHAPLCLE 419
gi 8571458   349 VKKMYSWEQVAERTEKVYYKilqtqnqti-lkrfkdcySNGQIYGLFLMILL 399
gi 67613172  365 ISAMYSWHDIAKRTVSVYQKsnqvdiigt-kerilriyNTGNLIGKIFALIA 415
gi 50545501  351 IKGMYKWSEVARRTEKVYDSineeslneplldrlakfyACGEWAGKLFVICV 402
gi 67482656  354 VKSFYSWERVATRTEQVYHEvlqkpqddl-pshfnkmyYEGVYSGPFMFFLH 404
gi 3875385   359 VSKMYNWPDVAARTQVIYQKaveseptgr-lgrlkgyyDQGIGFGIMYIVVS 409
gi 116056835 368 VSELYNWDDVARRVEIAYGRayetydtf--mgrlyriyRRGIIFGKMLWCVS 417
gi 441475    358 VSKMYDWMDVAKRTVEIYTNisstssadd-kdwmkmvaNLYKRDGIWAKHLY 408

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