Conserved Protein Domain Family
GT1_Sucrose_synthase

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cd03800: GT1_Sucrose_synthase 
This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.
Statistics
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PSSM-Id: 99973
View PSSM: cd03800
Aligned: 75 rows
Threshold Bit Score: 341.443
Threshold Setting Gi: 62424347
Created: 6-Dec-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #                                                      
gi 401114     177 YIVLISVHGLVRGenmelgrdsdtGGQVKYVVELARAms-------------------mmPGVYRVDLFTRQVSSpdvdw 237
gi 17134123   272 RIVLVSAHGWFGQegvlg--rpdtGGQVVYVLDQAKNlekqlqeda------ilaglevlNVQPKVIILTRLIPNsdgtl 343
gi 160903298    2 KVLFLNPQGNFDKndshltehpdfGGQLIYVKEVSKEl---------------------aNLNVSVDIVTRQIIDrdwpe 60
gi 94266940   271 KVALISPHGWFGQdnvlg--rpdtGGQVVYILDQARAleqflaa---------dlrsaglEIEPKILIITRLIPEnegtt 339
gi 30249199   266 RLLILSPHGYFGQdnvlg--lpdtGGQVVYILDQVRAlekemhd---------rlqlqgvQVEPKILIVTRLIPDagdtt 334
gi 156270676   21 RIALISTHGYVAAhpplg--aadtGGQVVYVLELARKl---------------------gQLGYTVDLYTRRFEDqpef- 76
gi 10177148   275 NVVILSPHGYFGQanvlg--lpdtGGQVVYILDQVRAlenemll---------riqkqglEVIPKILIVTRLLPEakgtt 343
gi 148887789  280 NVVILSPHGYFGQanvlgmpdhpvDRLCIYLINVAPLenemllr----------ikqqglDITPEIIVVTRLIPEahgtt 349
gi 150020431    2 KIAFFNPQGNFDKkdshltehpdfGGQLIYVKELAKAm---------------------gKMGNKVDIITRKIIDkkwpe 60
gi 77166514   270 NIVILSPHGYFGQgnilg--lpdtGGQVVYILDQVRAlekemhrqlkeqgldvapqilvvTRLIPEAQGTRCDQRlesi- 346
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 401114     238 sygeptemlcagsndgegmgesGGAYIVRIPCGPRDKYLKke-----alWPYLQEFVDGALAHILnmskalgeqvgngrp 312
gi 17134123   344 cnq-----------rlekvygtENAWILRVPLREFNPKMTqnwisrfefWPYLETFAIDSERELLaefq----------- 401
gi 160903298   61 fsk-----------eldyfdinKNPTIVRIPFDGEKFLNKeq------lWPYLKEYVDNILSFYKgk------------- 110
gi 94266940   340 adq-----------rlepvrdtANVAILRVPFRYPDLSVVphwlsrfklWPFLDQFAVDVEEELRqefa----------- 397
gi 30249199   335 cnq-----------rlekvsgcTNTWILRVPFRKHNGEIIphwisrfeiWPHLEIFAGDVEREALaelg----------- 392
gi 156270676   77 ------------------devdERVRVVRIPCGGRDFIPKey------lHRHLMEWCENALRFIKknd------------ 120
gi 10177148   344 cnqrl-------ervsgtehahILRIPFRTEKGILRKWISrf-----dvWPYLETFAEDASNEISaelq----------- 400
gi 148887789  350 cnq-----------rlekisgtQHSRILRVPFRTEKGVVRdwvs-rfdvWPYLERFSEDVTNEIAvelk----------- 406
gi 150020431   61 fsg-----------dfdyypdaENVRIVRIAFGGDKFLNKer------lWDFLGEYVKNIYRFYQkeg------------ 111
gi 77166514   347 -------------------vgtENAAILRVPFRNAGGEVLpywlsrfevWPYLERYAMDAEREMLaele----------- 396
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 401114     313 vlpYVIHGHYADAGDVAALLSGAlNVPMVLTGHSLGRNKLEqllkqgrmskeeidstykimrriEGEELALDASELVITS 392
gi 17134123   402 grpDLIVGNYTDGNLVAFLLTRRmKVTQCNIAHALEKSKYLfsnlywqdle----ekyhfslqfTADLIAMNAANFVISS 477
gi 160903298  111 -niDFITTHYADGGYSGVLLRSKlGLNFSFTGHSLGAQKMDklnvssknfed-ldkeyhfsqriMAERLSMQYASKIIVS 188
gi 94266940   398 grpDLLVGNYSDGNLVATRLSTSmGVIQCNIAHALEKSKYLfsdlywhqfe----adyhfsiqfMVDLIAMNQANFIVTS 473
gi 30249199   393 ghpDLIIGNYSDGNLVATLLSRRlGVTQCNIAHALEKTKYLhsdiywqene----dkyhfscqyTADLLAMNSADFIVTS 468
gi 156270676  121 lnySFINSHYWDAGVAGQRLSEAlKIPHLHTPHSLGIWKKRqmetdypekadtfelefnfkeriQHELIIYRSCDMVIAT 200
gi 10177148   401 gvpNLIIGNYSDGNLVASLLASKlGVIQCNIAHALEKTKYPesdiywrnhe----dkyhfssqfTADLIAMNNADFIITS 476
gi 148887789  407 gqpDLIIGNYSDGNLVASLMAHKqGITQCNIAHALEKTKYPdsdiywknfe----ekyhfscqfTADLIAMNHADFIITS 482
gi 150020431  112 -fpDFVTTHYGDGGIAGAMFKKLtHIPYSFTAHSLGAQKKDkfknakdae-----eryrfsiriSAEKVAMKYASFIVTS 185
gi 77166514   397 gspDLIIGNYSDGSLVATLLSQRlRVTQCNIAHALEKAKYLysdlywrend----aqyhfacqfTGDLIAMNSADFIVTS 472
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 401114     393 TRqeideQWGLYDGFDVklekvlrararrgvschgrymprMVVIPPGMDFSNVVVhedidgdgdvkddivglegaspksm 472
gi 17134123   478 TYqeivgTPDSIGQYESykcftmpelyh-vvngielfspkFNVVPPGVNENSYFPytqtqnriesdrdrlee----mlft 552
gi 160903298  189 TSmeryeQYSHPLYADVseva---------------ndskYKVIPPGVNTEIFNDdltdldqdt---------------- 237
gi 94266940   474 TAqeitgTENSIGQYESyqfftmpglln-itsgidlfhprFNVIPPGVNQEVYFPwnrkrsrptklrrrvs-----ellf 547
gi 30249199   469 TYqeiagTREAEGQYESyqafsmpdlyr-vihgidlfdpkFNIVSPGANADIYFPysdpnrrlhslipeies----lifd 543
gi 156270676  201 TPvqldvLIEDYGLKRKh----------------------IHMIPPGYDDNRFFPvsdatrq------------------ 240
gi 10177148   477 TYqeiagSKNNVGQYEShtaftmpglyr-vvhgidvfdpkFNIVSPGADMTIYFPysdkerrltalhesiee----llfs 551
gi 148887789  483 TYqeiagSKDTVGQYEShtaftlpglyr-vvhgidvfdpkFNIVSPGADMQIYFPytekqhrltalhgtiee----llfn 557
gi 150020431  186 TQqekeeQYSHNEYIDVypei----------------kdkIFVIPPGVNTNIFYPddt---------------------- 227
gi 77166514   473 TYqeiagNKNSVGQYESysaytlpglyq-vihgidvfdpkFNIVSPGADGEVYFPytdtkrrlsglrqeie-----aliw 546
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              ###                                                        
gi 401114     473 ppiwaevmrfltNPHKPMILALSRPdpKKNITTLVKAFGECrplrelANLTLIMGNRDDIDDmsagn----------asv 542
gi 17134123   553 ledssqifgkldDPNKRPIFSMARLdrIKNLTGLAECFGQSqelqerCNLILVAGKLRIEESednee----------kde 622
gi 160903298  238 ---vaqienklnKQQKPFIVLSSRLdaKKNHIAVVKAYANSrdlqdkANLGIFLRGIPDPFTdiqklsekersiltpile 314
gi 94266940   548 sgedddclgrlaEPDKPLLFTIARLdrIKNLTGLVEAYGRDselrqrVNLVMVASVIDPQRSqdpee----------aae 617
gi 30249199   544 datnlpargylqDPDKPLIFTMARLdrIKNITGLVELYAASprlrslANLVIVGGKIDPQHSsdhee----------qeq 613
gi 156270676  241 ------mirqrfGFEGKVVLALGRLatNKGYDLLIDGFSVLaerepeARLHLAVGGENMDEQettiln--------qlke 306
gi 10177148   552 aeqndehvgllsDQSKPIIFSMARLdrVKNLTGLVECYAKNsklrelANLVIVGGYIDENQSrdree----------mae 621
gi 148887789  558 peqtaehmcalnDRKKPIIFSMARLdrVKNMTGLVEWFAKSkrlrelVNLVVVAGDIDPSKSkdree----------vae 627
gi 150020431  228 ---------deyKFSKLPIIVSSRLdpKKNIEFVIESFNKYlk--dgFELIIVLRKKPEEYTg----------------- 279
gi 77166514   547 gderpdargklqDHTKPLLFTIARLdrIKNITGLVEWYGRCerlrklANLVVVGGYIDKSQSadsee----------qvq 616
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                     #                          #                        
gi 401114     543 ltTVLKLIDKydlyg-svafPKHHNQADVPEIYRLaa-kmKGVFINPALVEPFGLTLIEAAAhGLPIVATKNGGPVDITN 620
gi 17134123   623 ivKLYRIIDEynlhgkirwlGVRLSKNDSGEIYRVic-drQGIFVQPALFEAFGLTILESMIsGLPTFATQFGGPLEIIQ 701
gi 160903298  315 eiEKADIKDKvy-------fFDLKSQLALATAYKLfs-klKSVFVLPSFYEPFGLAPIEAGAcGLAVVATKNGGPSEIFS 386
gi 94266940   618 irRMHEILEQyqlygqvrwiGKFLGKVETGEAYRLva-drGGVFVQPALFEAFGLTILEAMHsGLPVFATQFGGPLEIIE 696
gi 30249199   614 ihRMHQLMDEheldqqvrwlGMRLDKNLAGELYRYia-dkRGIFVQPALFEAFGLTIIEAMAsGLPTFATRYGGPLEIIQ 692
gi 156270676  307 rvKSLGLEDKva-------fSGYVADEDLPDIYRA-----ADLFVLSSRYEPFGMTAIEAMAsGTPTVVTIHGGLFRAIS 374
gi 10177148   622 iqKMHSLIEQydlhgefrwiAAQMNRARNGELYRYia-dtKGVFVQPAFYEAFGLTVVESMTcALPTFATCHGGPAEIIE 700
gi 148887789  628 ieKMHRLVKEynlngqfrwiCAQKNRVRNGELYRYic-dtRGAFVQPALYEAFGLTVVEAMTcGLPTFATCNGGPAEIIV 706
gi 150020431  280 --YERQLIEKakka--kgkfLVITSQKELAKLYNSaa-khRGIFALTSHYEPFGLAIIEAMAcKLPVISTRNGGPVEILD 354
gi 77166514   617 iaRMHQLIEEyklds-qvrwLGVMLQKNLAGELYRfiadsRGAFVQPALFEAFGLTVIEAMSsGLPTFATCYGGPLEIIQ 695
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                                                                         
gi 401114     621 alnnGLLVDPHdQNAIADALLKLVAd----KNLWQECRRNGLRni-----hLYSWPEHCRTYLT 675
gi 17134123   702 dkinGFYINPThLEETATKILDFVTkceqnPNYWNIISEKAIDrv----ysTYTWKIHTTKLLT 761
gi 160903298  387 dg-sGVLINPEdIQDIVEGLIKALNn---yDYFSKKVKKRVLE--------NYTWKSTARGYLE 438
gi 94266940   697 hehsGFLINPTdPQAMTARLNEFFAacqadPRHWQGFSQRGLEra----rsRFTWQLHCRSLTR 756
gi 30249199   693 nnrsGFHIDPNqGAATADLIADFFEknlenPQEWERISQGALDrv----asRYTWKLYAERMMT 752
gi 156270676  375 ygrhALFADPFdKEDLGITMMKPFKh----ERLYGRLSRMGAHka----rsLFTWTGIAQQLLA 430
gi 10177148   701 ngvsGFHIDPYhPDQVAATLVSFFEt----CNTNPNHWVKISEgglkriyeRYTWKKYSERLLT 760
gi 148887789  707 dgvsGFHIDPYhGVSATERIADFFEkcktdPSHWEKISNGGLQri----yeKYTWQIYADRLMT 766
gi 150020431  355 ngkyGHLVSTH-EEFKEAALKIKDN-----YEKLSEESYKRVMe-------KYTWERCAKEYLN 405
gi 77166514   696 egvsGFHIDPNhGEKAADRIADFFEh----CQTEAGYWDKFSQgalrriknHYTWELYAERMMT 755

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