Conserved Protein Domain Family
GT1_YqgM_like

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cd03801: GT1_YqgM_like 
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This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.
Statistics
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PSSM-Id: 99974
View PSSM: cd03801
Aligned: 472 rows
Threshold Bit Score: 161.015
Threshold Setting Gi: 157149249
Created: 6-Dec-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2GEJ_A        22 RIGMVCPYSFDv----pGGVQSHVLQLAEVLrd--aGHEVSVLAPASPhvklpdyvvsggkavpi-----pyngsvarlr 90
gi 148656503   4 GVAMVMHDFYPs----vGGAQTHTLALSRALra--rGVDVIVVTRPYPgaasyeevegiptyrv------gvsggraiag 71
gi 117923728  13 LVLLLSERVPLqswaqkGMLERELALYRAMQp---hLRSITLLSDGNRheldfrpqvpgmhil---------cnrwglrp 80
gi 158333583   7 SIVQTTIGRFHhf---hLARQLERFNLLSAIftgypLSKLRDETGIPIekihsfpwvqmpym-----------argrikl 72
gi 115522838   4 EIVQVVQELSSv-----GGVETVASELARAFsr--aGIANIVLTSAVGeavekgttidrvagwlsriptrgllrhigrai 76
gi 159900099   6 HVAMIIQGYFPr----iGGAERQLAALAPFLaa--eGVAISVLTRRYAgfkpfeiidnvpvhr--------lpipgpvpt 71
gi 87306440    5 RIAMVTRRFWPl----vGGAEMVMANLAQQMrr--qAADVRIVTARWHkawperivhreipilrl-----pnpqlrgwgt 73
gi 115373924   4 RIAMLSAVFPPs----vGGIQTHTLRLSQRLva--hGAQVVVLTRHHQglprrefvegvevlrlg-----qgdarrevat 72
gi 153004291  29 RVAMLTALYPPs----vGGIQSHTFSLSRALaa--kGAEVHVVTRRAAghplhavegrlhvhrvg----appgssgplat 98
gi 145219483   3 LTLFFTNNTSLktwdsvGMLDREVALYRKYMe---kGVKVSFVTYGHKdrmlytrrldgieil---------cnerrlpn 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2GEJ_A        91 fgpathRKVKKWIaegdfDVLHIHEPnapslsmlalqaaegPIVATFHTSttkslt------------------------ 146
gi 148656503  72 wsyliaGLAVLLRerrryQILHCHQMispmtla-lmgralpGKRLVINPHgrgprgdvaki------------------- 131
gi 117923728  81 whyqrwLKMPWRGwqrghVLFKSNQLssallgl--slanhfKQKSITRCGyllsefaalhhg------------------ 140
gi 158333583  73 drwnwlNREWAWQahqtlDLYVSKHVkeftt-----lialsGSGLVSGLKaqrlggyyicdrgsshiryqdeilreehtr 147
gi 115522838  77 vvpvftLAATLGIrkyprAVVMSHGDs--------------FKGDVLVVHainaqslaekrsagsw-------------l 129
gi 159900099  72 aalvftAAAIPLLwrlkpNLVHAHEMfspatta-iaakqalGLPYAVTAHrsgplgdvlr-------------------- 130
gi 87306440   74 lrymmsLGKYLQKhqaelDAVYVSMLkhsayma-verlkntSTPIVLRAEgggetgdcr--------------------- 131
gi 115373924  73 atyladSLRVLVSrrdelDVMHAHQMlsptsvg-llarkalGIPLVINPHacgpqgdvqyl------------------- 132
gi 153004291  99 layvagAARLVASltprvDVVHAHQLlspssaa-llvkalaGTPVLLNPHacgtigdvgv-------------------- 157
gi 145219483  71 slytklIPLLHASalrktDIIKSNQTpgaltal--aaarfhKKPMLARCGymhsefiererg------------------ 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2GEJ_A       147 --------lsvfqgILRPYHEkiiGRIAVSDLARRWQMEALgs---dAVEIPNGvdvasfad-------------aplld 202
gi 148656503 132 ----trlrpltgklRVAAALLwgdAFVAIARDIHHELRTMGvpe-arIWDIPNGvdverfapatp------aerqalrrn 200
gi 117923728 141 ---aaslarvrafsREHRAFHgahRAVVTTPHMHSLLQQRYgidpqkIFVQPNYvdcdlfq--------------paprv 203
gi 158333583 148 wnvpykgidprvidKEEAEYEsanYITVPSEFVRQSFIEQRvsp-dkVRKISYGarldrf----------------hpis 210
gi 115522838 130 wlinpmhiwvgfreHWMVGGLrfrMFVAVSPRVRAELQEVYsvpasrIRVIPNGidlerfkpdpv------agrsirqef 203
gi 159900099 131 -----mqqrpfgkgRLERITKtadAFFTISREIDQEFEQILgieakrRHYVPNGvdpekycpiaae-----aktalrrel 200
gi 87306440  132 -----wqaeanfglRIRAVCQqadAIVAPSAAIREELLAAGydp-akLHFIPNGvaipsagnqqrrfdarmalqsaqplf 205
gi 115373924 133 ----rnahwlaggwRLDAARRwadAFVSISEPIREELRGSGige-drIWRIANGvdldtfrpaga------eerqalrdp 201
gi 153004291 158 -----lsstalgrlRLRATVAradAFVAISGPIHAELRGAGvpe-erILTIPNGveldrfrpadp------dergalrra 225
gi 145219483 131 ---ehskqaiealnYESKLFSaadGIEVTTPMMQESIEKRIsgtngkVTVIPNYvntel------------------fap 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2GEJ_A       203 gyPREGRTVLFLGRYdePRKGMAVLLAALPKLVarfpdvEILIVGR--GDEDELREqa---gdLAGHLRFLGQVddATKA 277
gi 148656503 201 lhLPDTPLIMFAGRFt-VAKGLDILLNAWAQRDavl-adARLVLVGd-GELRERLVqqahslgLDRSVIFTGST--TDTA 275
gi 117923728 204 qqNATTQRLLLVGRLh-PEKNILALLQAMIGLPk-----LHLDLIGq-GEQLETLQqfv--aqQALSVTFHGALphRALV 274
gi 158333583 211 kpKPDEFRILFVGSVs-FRKGFLDLLQAFNDFKhp---nKKLVVIG--SVSSNIIPfie--kySIDQVTFIGKIpnKELP 282
gi 115522838 204 niPSTAELLLFVGHEf-RRKGLAHAIDALERLGs----nVWLLVVGsdNPAPYVKMak----rATGRLVFAGSR--SDLP 272
gi 159900099 201 nlPTEGTITLYAGRLs-EEKRVRYLVEAWPAIRakh-pdATLLILGq-GPEEANLKa-----kTSDGVIFGGAV--HNVP 270
gi 87306440  206 sfRNDTPLAVYTGRLh-PKKGLLTAIEAWPHVLqrf-pnAKLVLVGe-GPQESQLRerinafgLQERVFLPGVF--DDVS 280
gi 115373924 202 lgLPRGPVVTYSGRLa-PEKGVDVLLEAWALLVrar-peATLVLLGn-GPEEAALRrrvaqlgLGASVRPMGAV--SDVP 276
gi 153004291 226 lgLPPGPLVVYTGRLa-PEKGVDLLLAAWPAVVarl-paARLWLLGe-GTERARLEeaarrtgVADSVALPGAA--PDVA 300
gi 145219483 190 ssSVKDIDILFIGRLn-PQKNLQTLLKALQGLKl-----KIAIIGKg-PLEDELKSqa---qeLELDIEWPGNIpnPDLP 259
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2GEJ_A       278 SAMRsaDVYCAPHLGgESFGIVLVEAMAAGTAVVASDlDAFRRVLAdgDAGRLVPVDd-aDGMAAALIGiLEDDQLRAGY 356
gi 148656503 276 PYLRaaDAFVLPSRT-EGMPVALLEAMACGLPCIATRvGGSAELIDd-EQNGRLIAPedvDALVRALPEaLSMPVWGERA 353
gi 117923728 275 DFYQqcDLFVLPSLQ-EGHPKALLEAMACGAPVLASDaPGNRDVVMh-GNNGWLCQTd-sASIRHALQQlLPNQAQRQSL 351
gi 158333583 283 RYYSesHVFVLPSIE-EGLAMVMGEALACGCPVIATEnAGVSDLLQd-GREGFIVPIrqpQAITDKLQLlSDCPDLREKL 360
gi 115522838 273 AFYSaaDAFVLPTAY-ETFSLVCMEAMACAVPVFATPvGGIEDYLVd-GVNGFQIQMn-gEDIATKIAAaFADPQLMRRL 349
gi 159900099 271 PYLQaaDVFVLPSIA-EGFSVAMLEAMASELAVVITDvGGARDAIDd-TVHGLVIPPddqPALEQALLAvLGDQASRQRM 348
gi 87306440  281 DLLDaaDLFLLPSHE-EGMSLSLLEAMAAGLPVIATDiPGNRQLVEs-GRNGLLFPVddaTALQAEIINvIHQPRAAKRL 358
gi 115373924 277 AWLRasDVFALASRT-EGLPVALLEGMACALPAVATRvGGTPEVLDd-GVHGRLVPSenpSALAEGLIE-ALAPGTGARW 353
gi 153004291 301 PFVRaaDAAVLPSRT-EGMPVALLEAMACGVPAVATAvGGSVEVLRd-GVTGRLVPPerpDALAAGLLEaLREPDARERA 378
gi 145219483 260 NWLNrsKIFVLPSHY-EGHPKTLIEAMATGLPVIGGDaPGIREIISh-LKTGWLCPTd-tGGISEAVEElMASEALRQHL 336
                        410       420
                 ....*....|....*....|....*
2GEJ_A       357 VAraservHRYDWSVVSAQIMRVYE 381
gi 148656503 354 RQr----iVERYAMDAVAQTYIGLY 374
gi 117923728 352 GQqarhyaLQEVSLPVIAAREMALY 376
gi 158333583 361 SKnalkrvKQLGGWDCYGDQWFKFL 385
gi 115522838 350 QDgar-ttASAYGWDRVGQHYIDLL 373
gi 159900099 349 GQaarqrvQQEFALSVIAKQLRGLY 373
gi 87306440  359 GEaaradvTQKYSLTAAATRHLNLF 383
gi 115373924 354 GAaararvEARFSLDAIAHRLLQLY 378
gi 153004291 379 RAard-evAARYGLDRVADTFLEVY 402
gi 145219483 337 SNnargfaIDKYSLGTIAEQELNLL 361
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