Conserved Protein Domain Family
GT1_AviGT4_like

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cd03802: GT1_AviGT4_like 
Click on image for an interactive view with Cn3D
This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.
Statistics
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PSSM-Id: 99975
View PSSM: cd03802
Aligned: 61 rows
Threshold Bit Score: 241.739
Threshold Setting Gi: 118138518
Created: 6-Dec-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                   #                                                    
2IV3_A         4 LKVALVNIplrvpgsdawisvppqgYGGIQWVVANLMDGLLELGHEVFLLGApgspagrpGLTVvp-------------- 69
gi 157405300   1 MRIALLAHlrhpi--------appfAGGLEAYTWHLAEGLSARGHDVTLFAAgdsdrrfvIDPVipvhheasfpgme--- 69
gi 149278550   1 MKIGIIAHlkhpi--------aapfAGGLEAFTHQITRTLIAYGHEVLLFASsssdatlpLVPIlsdqdydsrtgiri-- 70
gi 83955978    1 MKIAVIGHvrfpi--------arpfMGGMEAHCWHLCRGLRARGHDVTLFAAgdsdwggkVEPVvdvhydrefpwhk--- 69
gi 152968383  14 LRVAVLGPsrypv--------aepyAGGLESFVGNLVAGLRARGHRVLLFAAagspgaqpEALSgggwrpdelarada-- 83
gi 161319675   3 LRIAIVGHirhpi--------appfKGGMEAFTHGLARLLAARGHDVTLLASgds--gagLPPGvkllpiceahydarfp 72
gi 111017114   6 LRIALIASsrhpi--------rqpfPGGLESHVWHLARSLCADGHRVSLFAGpgsdpglgCAQLtvetletsaaarqdv- 76
gi 84497367    1 MRIAMFATsrqpi--------vepyAGGQEAHTASLVRGLRGLGHHVLLYATegtdsslaDELVpypqlpalsavaal-- 70
gi 32397720    1 MKIGIIGHlkfpi--------akpyAGGLEAFTHAYTNALKNRGHEVTLFASgdsdpqlpLQSIipnatipesharl--- 69
gi 145221086   1 MRVALIAPhhfpi--------repfAGGIESHVWHLARALIRQGHAVTLCAAagsdlameHPALtvtamprsaaasrv-- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2IV3_A        70 --------------aGEPEEIERWLRTadvDVVHDHsggvigp-aglppgTAFISSHHfttrp-----------vnpvGC 123
gi 157405300  70 ---hrgdaglkahvdAGYAAACDRIAAggfDVLHNNslsrlplerhrttaVPTVTSLHvppydalrwf-vhesltpghRI 145
gi 149278550  71 --krrdlpseyiaehHAYHRLMSEIDSynlDIVFNNslhyipitmanvinTPVLTVLHtppfyelglaihaertkpvvEY 148
gi 83955978   70 ---whgtpeltghldAAFERLLPRIAEggfDVVHNNslhrfpprfaarhrIPMVTSLHvppfevlkra-vadggapwsLF 145
gi 152968383  84 -smpaeafmvehhshLDVLTALRTTYAgevDVVHNHslhylplsladtlpVPVVTTLHtpptpwlts--alaagggsgAF 160
gi 161319675  73 whdfhgtealndhldACYARAARLLLEgrfDVVHNNalhrylprlsraerVPMVTSLHippfkvlrga-lmdgaapwhFS 151
gi 111017114  77 -smppmdflrdhhayLRLMLDLAGPLAdssDVVHNHslhylpvamapavpTPVLSTLHtpptpwlesa-lavragtdaHF 154
gi 84497367   71 -dhqlpepeflhdhaAMTSAVVDLLARsdvDIVHNQslhflplafsavlpAPLVTTLHtppfpwmel--gvalagehtAY 147
gi 32397720   70 --grmchdwiesvedEAYAALMLQLSTsdfDVIHNHslspiplqfshllpTRLMTTLHapalprmaaelrrrggdacgQF 147
gi 145221086  71 -fpppgaikesahhaFVELMSELADPAsgvDVVHNHslnpvpvlvarrlpVPVLTTLHtppfpaleaa-vgavarsgqAF 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                        ###                             
2IV3_A       124 TYSSRAQRAHcgg----gddAPVIPIPVdparyrsaadqvakeDFLLFMGRVSPHKGALEAAAFAHACgrRLVLAGPawe 199
gi 157405300 146 TATSRAHARGwwpdgvpqdvSVLANGIDpaawpf----qeegdGSAVWCGRMARVKGPHHAVAAARRAglPLTLFGPiee 221
gi 149278550 149 VTVSDQNAVNwkdy--ipdcRVIQNGIPldkwksy--tdpsadRYAVWFGRIHPDKGLHLAIEAAKLAgiKLKVAGRvad 224
gi 83955978  146 TTCSQRQLGAwfdagdppfaRVVPNGIDladwpf----rpegdGTAVWMGRITPTKGTHLAAQAAKIAgiPLRIYGTied 221
gi 152968383 161 TAVSSFTARQwapw--vphaQVVLNGVEprrwp-----lgpggRGLLWFGRIVPEKAPHLALRAAARAghHLDVVGPvgd 233
gi 161319675 152 TVVSARQRGIwwpegapetaQVVHNGIDlsewse----ggpgdGSAVWAGRITPTKGTHLAAEAAQIAgmPLRIYGAveh 227
gi 111017114 155 VAVSKHTAAAwsha--idriDVVPNGVDvdrwp-----qgdggPHLIWFGRLVAEKGAHVAIAAARRAgfAIRLAGPisd 227
gi 84497367  148 ACVSRANARDwttl--psppRVILNGVRddgvg-----pgvggPDLVWMGRLTPEKGADLAIRVARRVgrSLRLAGPisd 220
gi 32397720  148 INISNANADAwrsl--lpeqTVIHNGVDtsfwvr---ckeqkqRRAIWFGRILPDKGTHLALRAAHRAgiPLDVVGPisd 222
gi 145221086 149 AAVSRQAAAAwehvg-irrmALVRNGIDtsrwp-----agpggEDLVWSGRLLEEKGPHLAVDAALRAgrRIVLAGPivd 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #                               #                     
2IV3_A       200 PEYFDEITRry-gsTVEPIGEvgGERRLDLLAsaHAVLAMSqavtgpwggiwcEPGATVVSEAAVSGTPVVGTGNGCLAE 278
gi 157405300 222 PDYWQAEVApllggPIRYGGHcdGATLARRIGr-ASVFLFTpc--------weEPFGLVAVEAMACGLPVAGFAMGAAEE 292
gi 149278550 225 QRYFGERIApilddSITLLGLqeQPALNKLIGn-ACVCLVTpc--------wqEPFGLVVAEALACGTPVAGFKMGALPE 295
gi 83955978  222 QSYFDTEIApllgeRVQYGGHlqGADLTEAIAr-ASVLLFTpl--------wdEPFGLAAIEAMACGLPIAAVENGAIRE 292
gi 152968383 234 EEYFAAQVAprlgaGATYRGHlgGDDLARVVGr-ASAVLMTps--------wdEPFGLVAAEAAMSGTPVVAFDRGGVSE 304
gi 161319675 228 QDYFNDMVRphlygDVAYVGHldTAALGRAYGr-ASVALFTpq--------weEPFGLAAVEAMATGLPVAATPHGAVEE 298
gi 111017114 228 PGYFESTIApllgpGVTYLGHlaQPELATAIGg-SAAAVITpl--------wdEPYGLVVAEALACGTPVAAFARGGIPE 298
gi 84497367  221 RPWFEDVIApelddTIEYAGHlsHADLAALVRt-SAVALVTpr--------weEPFGLVAAEAAMWGTPVVALARGGLGE 291
gi 32397720  223 QNYFDSEVLpllrpDDAYHGHrtHEELCTLISr-SAVTLVTpc--------wdEPFGLVVAESLACGTPVAAFNRGALPE 293
gi 145221086 223 DHFFRRRIAptlgsRASYAGHlgQRELATLVGr-AAAALVTpl--------wdEPYGQVVVEAMACGTPVVAFAGGGIPE 293
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                                               
2IV3_A       279 IVPs-----vGEVVgygtdfapDEARRTLAgl-------paSDEVRRAAVRlwghVTIAERYVEQYRRLLA 337
gi 157405300 293 VVGe-----aGRLVsag---deAALAGAIGaa-------laIPRTVPHARVl--rLFTRERWLDRCEALYA 346
gi 149278550 296 LITkd----iGILVdyp---dcYALAAAIHea-------mkMDRNLIGSYAr--tKFELKVMMAQYEDLMT 350
gi 83955978  293 VAGd-----aARYAsa----dpDKLAMALRea-------iaIPRRAARERVe--gLFTLERMLVAYEGLYG 345
gi 152968383 305 VLRphvlpamGAVVpad---dvEAMAGAVEdv-------laLDRRDVRRAAl--aHLSFERAVSAYESILR 363
gi 161319675 299 VLGd-----aGVIAend---spEALAAALQka-------lmIPAEVPRARVa--rLFDAQVMVAKFEQLYQ 352
gi 111017114 299 VLSad----cGRLVvpd---dvDALARVIPqv-------vaLPRRVAREHAr--sHCSERRMVDAYVNIYR 353
gi 84497367  292 VVSpd----iGVLVda-----rGDEEQQVAgladaldaasaLRRVDVRRCAr--rDLGVERMVADYVDLYR 351
gi 32397720  294 LIGks----tGRLAkpg---svRELAQAILgc-------mkVPGEICRRVAq--eHYSFDRMVEQYESLYQ 348
gi 145221086 294 LVDeh----sGRLVepg---dvAALAAAVRea-------vaLPRAGVRRVAv--qRHGLARMVTGYVALYR 348

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