Conserved Protein Domain Family
GT1_ALG2_like

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cd03805: GT1_ALG2_like 
This family is most closely related to the GT1 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.
Statistics
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PSSM-Id: 99977
View PSSM: cd03805
Aligned: 34 rows
Threshold Bit Score: 504.811
Threshold Setting Gi: 17569999
Created: 6-Dec-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #                                                                  
gi 1703249     7 RTIAFIHPDLGIGGAERLVVDAALGLq-----QQGHSVIIYTSHCDKSHCFEEVKNg-qLKVEVYGDF---LPTNFLGrF 77
gi 145343592  26 LRINIIHPDLGLGGAERLILDFARACs-----TAGHEIKLYTAFHDENRCFEDTVNtegKRVDWIQVYnslVPRNFAGrF 100
gi 67474983    6 KTAIIIHPDLGIGGAERLVVDIALALe-----HEDYDVKFYTSHHDKEHCFPETKGr--FQVFVHGDF---LPITLFGyF 75
gi 123429572   4 KKIAVLHPDLGIGGAERLIIDVAHAVm-----IDHKDTTVYTTHYDTNHCFPDTKD---LTIKVAAAW---VPRSIFGfG 72
gi 159486288   8 LRVAFIHPDLGLGGAERLVVDAAAELv-----RCGHTVDMYTAFYDPSRCFEETKTg-gFAVRTAGGW---FPRHFGGrL 78
gi 66823251    8 LNIAILHPDLGIGGAERLIVDLALGLk----sVGNNRITMYTSRHDPKRCFKETSNg-eLDVHVTGGY---FPRHIFNrF 79
gi 145529756   8 LKIAFLHPDLGIGGAEQLVVNLALALq-----KNHYVKIYTPHHDPNHSFPETNGQ---IPVEVRGNI---IPAHFFGyC 76
gi 118368712   8 LRIGFIHPDLGIGGAEQLIVNMAVALk-----KQGHNVIIYTPYHDPKHCFQATIDg-tIPVEVRGAI---VPQTIFGkL 78
gi 22330726    9 MNIAIIHPDLGIGGAERLIVDAAVELa-----SHGHKVHIFTSHHDKSRCFEETLSg-iFQVTVYGSF---LPRHIFYrL 79
gi 66361840   16 KRVAVTHLECGIGGAEQLMVLASLALqsykssNEKIELTLFTSYHDKSHSFSATNDg-rIKVKVYGNW---IPRTFFGyG 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 1703249    78 FIVFATIRQLYLVIqli---------lqKKVNAYQLIIIDQLSTCIPLLHIFss-aTLMFYCHFPDQLLAq-rAGLLKKI 146
gi 145343592 101 HAICANLRCLCVVFfa----------lwRDCGKVDVWILDQVPIPIFVLKIFa--qRTIFYCHFPDCLLAp-hNTTLQRL 167
gi 67474983   76 YIFFATIRALYLSIi------------vAWKTNADIYIVDQISIGVPILKLFn--kKVLFYCHHPDKCLCk-eGGFMKKI 140
gi 123429572  73 HIIFSLFSFLWLTIy------------aALTSKAEIFIVDQISAWVPILRLLcpraKIIFYCHFPDLRLAs-hKSLIRKI 139
gi 159486288  79 MALCAYIRCILVALhiawrt---vwsprADTAPYDVIIADQVAVVVPVVRVLlpssRVLFYCHFPDLLLTq-rTSLLKRL 154
gi 66823251   80 MVICAIIRNLLAALyi----------ifFSGQKYDVIVLDQISASIPLFKLFtn-sKVLFYCHFPDKLLTs-rTSLIKRL 147
gi 145529756  77 TAMCAYIRMILATLyi-----------iFFSGRWDVIIIDQVSVCLPLLWLFr--rKTIFYCHFPDKLLCverKSFIKKI 143
gi 118368712  79 WALCATIRVIFCTLyl-----------iCFGFKFDVVIVDQVSPAVPLLRLFn--rKCLFYCHYPDKLLCverRSILKKI 145
gi 22330726   80 HAVCAYLRCLFVALcv-----------lLGWSSFDVVLADQVSVVVPLLKLKrs-sKVVFYCHFPDLLLAk-hTTTLRRM 146
gi 66361840   92 TTLFSYIRIIYTSLimfffvmmtsfsleKTSRYYDVILNDQVSVINPILKLMt--rRLIFYCHFPDQLLVrkrDGSLRKM 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 1703249   147 YRlPFDLIEQfsVSAADTVVVNSNFTKntFHQTFKYLSNDpd----------vIYPCVDLSTIeiedidk---------k 207
gi 145343592 168 YRtPIDYVEEhcTGMADCIVVNSYFTAevFSRTFKRLYRKgis-------pevVYPTASLTELefthdvdat----frtf 236
gi 67474983  141 YRiPFDWLEE--KSMGLTFPSHSRTPQv-LYPTYNPILEE-------------SMNSESPFEE----------------- 187
gi 123429572 140 YRlPFDLIEKwgIKASHLIYVNSNFTAgvTKQEFGDIPVRv------------LYPCVDTSRQve--------------- 192
gi 159486288 155 YRaPLDYVEElsTGAAHLVLVNSNYTRgvFKETFRRLASRgmd--------psVLYPADLDSEla--------------- 211
gi 66823251  148 YRiPIDLFEEftTGCADQVLVNSNFTSsiYKQSFKHLKNSps----------vLYPIINTNEFdktkqshnfsnqpienn 217
gi 145529756 144 YRfFLDSFEEisMLFANLVLVNSQFTReiVKQAFPLYNKYgrq-------pevLYPAIEFSKFemapel----------- 205
gi 118368712 146 YRfFLDYIEEfsLLFANKILVNSNFTRevYQRSFKYLSKYnnp--------eiLYPAIDFSSFddtik------------ 205
gi 22330726  147 YRkPIDFIEEqtTGMADMILVNSNFTAstFANTFKRLNAQgsr-------pavLYPAVNIDQFi---------------- 203
gi 66361840  170 YRyVMDFLEEfgMRYCDYVFVNSIFTRkvYIETFKGLISNankypltlsypevLYPPVNLEDIpseeecencf--snski 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       ###                                                              
gi 1703249   208 ffktvFNEGDRFYLSINRFEKKKDVALAIKAFALSEdqi--------------------ndnVKLVICGGYDERVAENVE 267
gi 145343592 237 pgkslIFQERKIFLSINRFDSNKNLRLAILAFHKFIqqnr------------------ndatYMLILAGGFDSRLQDNVQ 298
gi 67474983  188 -----EPKEEFWFISINRYEGKKNHKVALEALSLLEddl--------------------knnVRIIIAGGYDLRVKENKD 242
gi 123429572 193 ----rKQSPTPLFVSLNRYERKKDHNLAIKALAKAItki---------------------pdAKLVIAGGYDDRVTENVE 247
gi 159486288 212 ----dFIAGGTTFLSINRFERKKGIGLAIEALHEVLlmraggasvtasggggaasaaagappPRLVVAGGYDPRLAENVE 287
gi 66823251  218 linpiKLDDKKFFLSINRYERKKDLKLALDAFSVFIsnsesgg------------sgkgkdeIYLVFAGGYDTGLKENVE 285
gi 145529756 206 nrldsRLESNNYFLSLNRYERKKNIALAIHAFAAFRqqlnsd---------------eniesVRLVIAGGFEQRVEENAQ 270
gi 118368712 206 qsapvDSKASPFFLSLNRYERKKNINLAIQAFAQFVkesa------------------snnqFKLIIAGGYDERIAENVE 267
gi 22330726  204 ----ePHTYKLNFLSINRFERKKNIDLAVSAFAILCkhkq------------------nlsdVTLTVAGGYDERLKENVE 261
gi 66361840  248 pqqlnRAPNVPFFLSLNRYERKKNIELAIKSFAILRdqyk------------------pgekLCLVISGGYDKRVSENIE 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                          #                     #       
gi 1703249   268 YLKELQSLadeyelshttiyyqeikrvsdlesfktnNSKIIFLTSISSSLKELLLERTEMLLYTPAYEHFGIVPLEAMKl 347
gi 145343592 299 VLRELRRLkdd----------------------lelSDSVLFLPSINNHQKQVLLHHSLCVLYTPNEEHFGIVPLEAMQy 356
gi 67474983  243 VYNELEQLshq----------------------lhiEDHVSLLKNFSNEEREYLFKKATAVLYTPPFEHFGIVPLEAMIk 300
gi 123429572 248 HYKELRELaekl---------------------eltEKQVELQRSISDQQKWDLIASATAMIYTPQNEHFGIVPIEAENa 306
gi 159486288 288 HLAELREAaaa----------------------mdlRHEVRFLPSFTDRQRTLLLAACRAVLYTPQHEHFGIVPLEAMAa 345
gi 66823251  286 HLQELKDKake----------------------yglENRVIFLITINEEQKQWLLLNCCCLIYTPSFEHFGITPLEGMYa 343
gi 145529756 271 HFEELNQIaqr----------------------qnvAEYVSFKKNISDSERTQLMSNALAVLYTPEREHFGIVPVEAMYn 328
gi 118368712 268 HHKELLSLake----------------------lnvEDKVVFKFSISNKERTQLLQTAQAVLYTPENEHFGIVPVECMYm 325
gi 22330726  262 YLEELRSLaek----------------------egvSDRVNFITSCSTAERNELLSSCLCVLYTPTDEHFGIVPLEAMAa 319
gi 66361840  310 YFEELLRLansyafnvyi--------gneciestdsCFSVVFLRSISDSLRWSLLRKSIGLLYTPENEHFGMVPCEAMSv 381
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 1703249   348 GKPVLAVNNGGPLETIKsyvagenessaTGWLKPAVPIQWa---TAIDESRKIlq----------ngSVNFERNGPLRV- 413
gi 145343592 357 HKPVVACNSGGPKETVIhg--------vTGFLCENTPESFa---CAMSKLARVsg-----------lAERMGNAAQLNF- 413
gi 67474983  301 GVPVIACNNGGPLETVQne--------lTGLLCDGSKEGFa---ACISRLCHDnn-----------lRQKLKLNAKKAT- 357
gi 123429572 307 GCPVIACNTGGPLETCNv---------eGCFICEPTVDAFa---DAMVEAASMk------------sHDKELRENAERFg 362
gi 159486288 346 GRPVVAVNSGGPTESVVtg--------vTGFLCDATPVAFa---GAMAGLMGGegpakkgaekgggkAEEMGAAARAHV- 413
gi 66823251  344 GKPVIAVNNGGPLETVVdg--------kTGYLCNPTVKDFa---NAFNKIINDpi-----------nSKKMGINGKQRV- 400
gi 145529756 329 QVPVIACNSGGPKESIQng--------vTGYLCESKTNEW----QQREKQRNGrk-----------rERTSYSIVWIRIi 385
gi 118368712 326 KRPVLACNSGGPKESVVdg--------eTGFLLQSNPSDWs---KKMDWIAKNps-----------kAAEMGQNGRKRA- 382
gi 22330726  320 YKPVIACNSGGPVETVKng--------vTGYLCEPTPEDFs---SAMARFIENpe-----------lANRMGAEARNHV- 376
gi 66361840  382 GTCVIACNSGGPTETIVhg--------kTGFLCEPNPENFairmNELIKISRDsi-----------eSSVWSSSCKERV- 441
                        490
                 ....*....|....*....
Feature 1                           
gi 1703249   414 ------KKYFSREAMTQSF 426
gi 145343592 414 ------GQKFDVVAFRRRV 426
gi 67474983  358 ------KEKFGFETFTKKV 370
gi 123429572 363 ------FKAFAKQLHDDIL 375
gi 159486288 414 ------EAKFSRRAFGEAL 426
gi 66823251  401 ------NDKFSFKPFAQNL 413
gi 145529756 386 snangqLCKDGYQNRKIKI 404
gi 118368712 383 ------IEKFGLEAFAESI 395
gi 22330726  377 ------VESFSVKTFGQKL 389
gi 66361840  442 ------TALFSQSIFQKRL 454

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