Conserved Protein Domain Family
GT1_ALG11_like

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cd03806: GT1_ALG11_like 
This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides.
Statistics
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PSSM-Id: 99978
View PSSM: cd03806
Aligned: 39 rows
Threshold Bit Score: 470.531
Threshold Setting Gi: 126648906
Created: 6-Dec-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730730    72 KVFGFFHPYCnAGGGGEKVLWKAVDITLr----kDAKNVIVIYSGDFVNgenvt-----peniLNNVKAKFDYDLDSDRI 142
gi 116503305  48 SIVGFFHPYCnAGGGGERVLWTAIASIQr----sHPDIVNVVYSGDLDAske---------qiMSKIKSRFNITLDPSLL 114
gi 145350584  23 RVIGFYHPSGgDGGGGERVLFAAIAAAQra--teGRDVTCCVYAGATSArgdepv--edgdelIARARERFGIELRAPIN 98
gi 18029286   63 NSVAFFHPYCdAGGGGERVLWEAISAISe----kYPTRQIFIYTGDEASsk----------eiLSRAESRFNIKIENVTF 128
gi 159484382  33 GVVAFFHPFAdGGGGGERVLWCAVKAVHd----aSKTAKVVIYCREGLSaa----------alVEDAQRRFNIRIDKPIQ 98
gi 145484828  44 QTVAFLHPHCnAGGGGEKVLMCMIEKLQk-----TQKHNIVVYSAEEVDdq----------qiIEKANTRFSTHITNQDL 108
gi 70831395   30 NAVGFLHPSAaAGGGGERVLWVAIDSIQkddiknGIDRLYVLYCTQTSGksddgrceppqeylARVVQKQFHITLPRPIK 109
gi 146176727  45 LKIAFFHPYCnSAGGGEKVLWCLVYSLLncv-ayRENFELVIYTGDQVSge----------diLKKATDRFNINVLELKD 113
gi 70906106   26 NTVGFLHAAAgAGGGGERVLWVALDGLQhadaarGVKRQYVLFTNEYKPadrlsae-ssdqhlLSLVEKQFSIRLLRPVR 104
gi 123419458  28 NVVTFFHPNClDCGGGEKVLWVAVDALKe----hLPEMHLFAQDATNDSa-------------QEKVNKVFKINIPSNIK 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730730   143 FFIsl-kLRYLVDSSTWKHFT--LIGQAIGSMILAFESIIQCp--pDIWIDTMGYPFSYPIIARFLRriPIVTYTHYPIM 217
gi 116503305 115 HFVfl-kSRHMVEDSTWPRFT--LLGQSIGSIFVAWEAMTKLi--pDLYIDTMGYAFTFPLVAALGRi-PVGAYVHYPTI 188
gi 145350584  99 VIRl--tRERWARAETYKRCT--ILGQFIGGAWLGLEALWTFa--pDVFVDTVGHAATYPIARYLFGc-QTVAYVHYPTV 171
gi 18029286  129 IHLk---YRWMVEASTWPSFT--LAGQSAGSIFLAFEALLKLn--pEIVIDSMGYSFTYPLFWLFGC--KVGCYIHYPTI 199
gi 159484382  99 VVPl--rRVGLIQPERYPRLT--LVRQALGSVALGWEALRQVv--pEVYIDTTGWAFPYPLAWRAGA--AVVAYVHYPTI 170
gi 145484828 109 KFIp---ILNKQLLEPKKRFT--LLLQIFGQMRYALKCVNSFq--pDIFLDSTGLPFTFFIVKLLLPnvRVIAYVHYPFI 181
gi 70831395  110 VVHlrssMTKWLDGGRYPFLT--LLLQVVCGSILLFYESCVVntmtPTVIESVGIPGVYPLLSIFAGs-RIVAYTHYPII 186
gi 146176727 114 KIQf---IRVSGRKLLEPFRVatMILQAIGTMIYTFKCLLKYq--pDIFFDSTGFAFSYIVVKKFLGc-KVVSYTHYPFI 187
gi 70906106  105 FIYlrpaLTRWLSGDAYPRLT--LLLQTFWGGAALFYEVAVAnavtPIVVETVGVPFAYPLLRLLAGc-MVISYTHYPIV 181
gi 123419458  91 FVNv--gSADFIKPGYYKHFT--LIFQAIGSLVYAFKCLNKEv--pAIVIDTTGAPFASIVWKLFGGc-KVILYIHYPFI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730730   218 SKDMLNklfkm-----------pkkgiKVYGKILYWKVFMLIYQSIGSKIDIVITNSTWTNNHIKQIWQSn--------- 277
gi 116503305 189 STDMLArvksrrkwht-nsssissslvLSQAKLFYYRVFMYYYALCLRTASFLMVNSSWTRNHIDSILRHtdlfldaihl 267
gi 145350584 172 SRDMIArvesgrlmyn-nsrlfasskfLSGLKVLYYRAFAVVYGWCGRSCKCVMVNSSWTKSHIDALWRV---------- 240
gi 18029286  200 STDMLQkvskreadfn-nsetiannsvLSSGKLLYYQHFSKIYAFCGNRSSVVMTNSSWTQNHLDQIWAR---------- 268
gi 159484382 171 SSDMLAavwagsatavsndadiaespiKTAAKLLYYGALAGWYAGCGAVTRLAAVNSSWTRRHIAGLWRLar-------- 242
gi 145484828 182 STDMISqvekkearyn-nddeitksegKTKLKLWYYKFLFFFYSLCGKMTEFAYVNSTWTYNHMKQTWKSt--------- 251
gi 70831395  187 TPVMTQrvengemryn-nkgavarhgvLRKAKVLYYKLFAHIYRWMGKFPDLVMTNSTWTKGHIQQLWGHd--------- 256
gi 146176727 188 SSDMIQkvirneqsfn-nrgfiaqsglFSNIKFFYYLILTKMYKFMGNYVDMTFTNSTWTDDHIRSLWAPcrqv------ 260
gi 70906106  182 SSAMTQrvrsgevsht-nsptvawnpmLRCAKVVYYGVFSLLYRCMGFFPNVVLTNSSWTQNHVQSIFWPr--------- 251
gi 123419458 164 STDMLKavssgndqyn-nnqkiakskvLTSIKIIYYRIIAFIYSLCGYFADVITVNSTWTGNHIREIFRR---------- 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730730   278 -----------------TCKIIYPPCSTEKLVdwkqkf--------gtakgeRLNQAIVLAQFRPEKRHKLIIESFATFL 332
gi 116503305 268 lppflfikafssnnapsHATVVYPPCDTRAMSsfd--------------lraRQRVILSIAQFRPEKDHAAQLHAFHVLL 333
gi 145350584 241 -----------------DSRVVYPPCNVEDLSklpltrprlnargtpvkkdkSSIRVVSVGQFRPEKAHVVQIAAWKALK 303
gi 18029286  269 -----------------KSAKIFPPCDVSAFTkldsfp--------eieqkrIPFQIMSLAQFRPEKNHKLQVEAFKQLY 323
gi 159484382 243 ----------------rPPVLVYPPVDTAELQtlpl------------drklKQLYLVSVNQFRPEKNHRLQLEAFAAAK 294
gi 145484828 252 -----------------QLIKLFPPCQVDAFMrrk--------------qftNQFIIISFAQFRPEKQHLLQIEIIEALV 300
gi 70831395  257 -----------------VPVLVYPPCAVSHFMplrk------------lphqRINTVVSVGQFRPEKNHMLQLQSFALAL 307
gi 146176727 261 -------------etitESVKLYPPCNVTSLLelek------------nqenSTVQIMSFAQFRPEKDHMMQIRVFERVL 315
gi 70906106  252 -----------------ACIRLYPPCDVAGFAagsq------------ppalRNNRIVSVGQFRPEKNHMLQLVAFHAAM 302
gi 123419458 233 -----------------DPIILFPPCDTTDLSklpi-------------enrIPEQIISVQQFRPEKNLPLQLEIIRRLK 282
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730730   333 KNLpdsv--------spiKLIMAGSTRSKQDENYVkslqdwseNVLKIPKHLISFEKNLPFDKIEILLn-kSTFGVNAMW 403
gi 116503305 334 KANpgfksn----gkegvRLVMIGGSRNAEDANRVdel--rqlARKLEIEPYVEFIVNASYQVVLDWLs-kASVGLSTMV 406
gi 145350584 304 KFKtlssk------ienaILVFVGGCRDEADRERLadl--qqsVKDLELQDSVQFHVDVSYDEVKRELs-rASIGLHSMI 374
gi 18029286  324 ENPnlssd------rsklSLIMAGGVRNPGDEARVeel--qslISAYGLEKAITIEKNISFERIVELFe-tSSCGIHTMK 394
gi 159484382 295 RSPaaaaptlagaalreaRLKLVGGVRGPADEARLagl--kayAAELGIADSCEWIVNAPFSELRQLLg-gAVAGLHTMT 371
gi 145484828 301 DRLpsei-------sqsiKLYMIGSCRNADDDLLFeti--qdtINKKNLQDYISMHKNLPFQDIQKFLt-sGMIGLHTME 370
gi 70831395  308 PRLpt-----------daKLIMIGGARNEEDKQRAeav--kveAQRLGIADRVDVRVGAPFSEVSESLa-qCCIGLHTME 373
gi 146176727 316 SRLtdee-------khklQFRVVGSVRNDDDEQLLsnl--kkeVEQRHLSDKIQFIKNPSFKDILKIFe-qSDIGLHTMK 385
gi 70906106  303 PRLpr-----------daKLVMIGGARNADDRKRAeql--hvrAKELGIEEQVELLVNATVAEVQAELg-kCVIGLHTMR 368
gi 123419458 283 DTHpn------------mKLYIIGGCRNEADKKLLdg----lqEEIDRDKLPITLVPNCDFDILRNEYfarSSVGLHTMY 346
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730730   404 NEHFGIAVVEYMA---------SGLIPIVHASAGPLLDIVtpw------------------------------------- 437
gi 116503305 407 DEHFGINIVEFLA---------AGVIPVTHASGGPLLDIVvpf------------------------------------- 440
gi 145350584 375 DEHFGICVVEYMA---------AGAVPVAHASGGPFLDIIrdq------------------------------------- 408
gi 18029286  395 DEHFGITCVDFQA---------SGTIAVGHDSAGPKEDIFvdy------------------------------------- 428
gi 159484382 372 DEHFGISVVEYMA---------AGCVPIAHNSAGPKMDIVlpllldaqgaaalaaaaglgrggsdslggcggadgllgpa 442
gi 145484828 371 YEHFGITLVEMLA---------AGLIVVAHNSAGPKLDILa--------------------------------------- 402
gi 70831395  374 DEHFGIVLVEYIA---------CGCIPLGHRSGGVCLDIIt--------------------------------------- 405
gi 146176727 386 DEHFGIAVVEMMVdfylkyrenFNREFQSHKSAGPLKDIIq--------------------------------------- 426
gi 70906106  369 DEHFGIVLLEYLA---------AGCIPLGHRSGGVELDILn--------------------------------------- 400
gi 123419458 347 NEHFGICAVEYLA---------AGLIPLCNKSAGPLYDIV---------------------------------------- 377
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730730   438 ------------------------------------danGNIGKAPPQWELQKKYFAKLEDDGETTGFf---fKEPSDPD 478
gi 116503305 441 -------------------------------------ngKPTGYHARTPDEFAEAMRTVLSLSPDEEIai--rQRARTWA 481
gi 145350584 409 -------------------------------------hdGPTGFTADSVATFAETLEHLLLMRRTEREe---iSARARAR 448
gi 18029286  429 -------------------------------------kgGPTGFLATDAKSFADSMEKILLLPSEKKIk---iQENARNS 468
gi 159484382 443 adsplvldagahvspagaagagtcqaggggggavgggavQVTGFLATTVDEYAEAIIKVLTMDQRERLr---vAAAAQRQ 519
gi 145484828 403 ---------------------------------------NDVGFLCENLEDYVLSIVRIMQLTDEDRSr---yQLMGRKQ 440
gi 70831395  406 --------------------------------------sPNVGFLAATAEEYADCMAEIFRIKNDEPEtyrkfQECGMAT 447
gi 146176727 427 --------------------------------------nENFGFLCENEDEYVEATLKAVQMPKEVKQe---lVSNSRQK 465
gi 70906106  401 --------------------------------------sPDLGFLAVTAEEYAAAMVEICEMRLRDPDryvqfQKRGSEH 442
gi 123419458 378 ---------------------------------------KDENYLALTADEYAAKLEVAFKCDDSARLqf--rNSCSRFS 416
                        570
                 ....*....|..
gi 1730730   479 YNTTKDPLRYPN 490
gi 116503305 482 VQRFSEEEFEKG 493
gi 145350584 449 SDIFSETEFNSN 460
gi 18029286  469 CKRFSSEQFKTD 480
gi 159484382 520 AGRFSTERFLQD 531
gi 145484828 441 AVNFSDESFKDL 452
gi 70831395  448 IARFSDESFGEK 459
gi 146176727 466 AQEFSEDMFYIK 477
gi 70906106  443 VKSFDDSSFRTR 454
gi 123419458 417 YEEFSKQFIAAV 428
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