Conserved Protein Domain Family
GT1_cap1E_like

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cd03808: GT1_cap1E_like 
This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides.
Statistics
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PSSM-Id: 99980
View PSSM: cd03808
Aligned: 176 rows
Threshold Bit Score: 215.107
Threshold Setting Gi: 56478784
Created: 6-Dec-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #                                                     
gi 1870159     7 KIMLITNhdDDIYCFRKEVIESlvEYGYEVLVSCPYGDKielMKSIQFEYEDITIDrrgINPLKDIRLFLSYIRLLRKYR 86
gi 114328416   2 KILEITNvdFALRHFILPVMRAarDRGHEVVGACADGPLlsaVRAEGFRVETVPMVr-rISPQAQWRAFRALVRLIRAEQ 80
gi 71906911    4 RVCQLCAvdFTLKHFLLPLIDGmqNHGWEVTAVCSDGPEipgLRARGYTVDTIPISr-sLNVFRHAVSVVRLAAYFRQQR 82
gi 147677431  21 RVIHVTTigITALRALLAQCRYfrEKGLEVGFVFSPSPEgniLRRLGFPVKEIYIDr-kINPWTDFRSIIKLYGFFRLVR 99
gi 159900517   5 LVLHIATadMGLRFLLLEQMQAihHAGYQVRGVASDGPYraeVEAAGIPVDVIKMPr-aITPNRDLLALTQLVRLFRELK 83
gi 68054174    5 KILQVCAldTTAETMLQPLLLAlqNAGHEVGIACADTGAaskLAAQGFTMHDIPIEr-kIDWTSNWKTIRSIVQILKDEQ 83
gi 156741331   4 RVAHITTidQSLRYLLLNQLRSiaDAGYQVTGISAPGPDvpaIEVRGIRHIAAPLTr-rLTPFADLRALMRLYRIFRQEH 82
gi 158337942   2 KVLHVCAlgATAETLLLPQIDYlrSQHLTVDIACSPDSAvdrLQAQGYTVHPIQIDr-kISPLLNFKTIQGLIQLMRSQA 80
gi 161786740   2 KILEITNvdFSLRHFLLPLMRGlrADGHEVVGVCADGPLladVRGEGFRVETVPLVr-sFSPLAQMQALIALVRLIREEK 80
gi 58039798    2 KILEITNvdFALRQFLLPLMRElrDAGHDVQGACAEGSHlepVRAEGFTVHGVPMAr-sFSPMAQYKAFVALVRLIRREK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 1870159    87 PDIDLTYTVKPNVYASLAAt-iLGIKYINNVTGLGSVLTMGSc--VRSLVLLLFRISFRKs-nCVFFQNEYNMKMLKTLG 162
gi 114328416  81 PDMVHAHMPISGFLARLAAracGVPCIAYTCHGFLFNQPSPL---PRRIVSWVMEAIAGRvthVFLTVSTEESRDARRLL 157
gi 71906911   83 FDILHVHTPVAALVARMAAflaRVPVVVYTAHGFYFHDEMPSw--KRRLFVSLERFAGRFt-nLLFTQSAEDAETAVQEG 159
gi 147677431 100 PRIVHTHTSKAGVVGRIAAslaGVPNVLHTVHGFPFHPGMPGv--KQRFYRQIEKWMAGLt-hIMFSQSREDVATALELG 176
gi 159900517  84 PTIVHTHNPKPGLLGQLAAriaGVPIIINTIHGFYFHEHSSAn--QRRFYIAMEKIAARCs-hAILSQNREDLNAALALK 160
gi 68054174   84 YDAVHVHTPVAAALGRVAAkraGTKHIVYTAHGFYFHEKMGRv--TYQLTYSVEKWLARFatdYLLLQSQEDYELANRKR 161
gi 156741331  83 FTIVHTHTPKPGLLGQLAArmaGVPVVVNTIHGFYFHEHMPPa--QRRFYITMERIAARCs-dLILSQSSEDLATALRLG 159
gi 158337942  81 YDLVHVHTPIAAVLGRIAAklaGVPTIVYTSHGLPFHQLTPP---LQYQMYFAIEYGCAKitnLILSQNHEDIETAAQKK 157
gi 161786740  81 PDIVHAHMPISGLLGRLAAwlcRVPCVAYTCHGFLFNQPGPAp--RRGLALVLEWLAGRIt-dRYFTVSVQEAEDARRLK 157
gi 58039798   81 PDLVHGHMPISGILARFAAr--LCGVRVVAYTCHGFLFNQPGswrRRMLSLILEWAAGRIt-dLYMTVSREEARDARRLH 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                         ###                            
gi 1870159   163 lil-gdSKLIPGSGVNIEKYPVqqypng--------gngiqgETIVFNFIGRILkEKGIDTYLAAAQIIksryPKTEFNI 233
gi 114328416 158 ih---rHAIPVGNGRDPAVFRPdpearrri----rqalgtpmDRPVVIVVSRLVrHKGHLELLEAMRSV----PEAELWV 226
gi 71906911  160 isp-agDTLAIGNGVDAGRFDPsvigaggem---rralgipeEAFVIGIIARQViEKGIMEFLEAAIAAagknQEIHILM 235
gi 147677431 177 ikprrgDLIYIGNGVDLGEFDPglypiprrcl-vrkelaigeTEPVITMIGRINrEKGYHDLVEALQGVk--dLPWRALF 253
gi 159900517 161 iar-peQISFLGNGINLQVFDRravsqadiqa-arqelgipaDAQVIGAVGRLVaEKGYHELFQACQQLmatrPNLHLLV 238
gi 68054174  162 fkn-ttRLMHLGNGIDLTRFYPrpr--------------qttGPFTFLFIGRIVeEKGILELLTAFEQVvsvqPDVRLMI 226
gi 156741331 160 icp-peRIQLLGNGIDIRRFDRsrvdpahlah-irqslrlppDVSVIGFVGRLVaEKGVIELARAVQQVqshfGPVTLLI 237
gi 158337942 158 lcp-esKLVYLGNGVDIDRFSRsvldsdhqsrlrdelgipasAKLIVGTVGRLTrTKGSGYLIEAAAQLveefPQLHILV 236
gi 161786740 158 ih---pAPLAVGNGRNPSLFQPdpearrri----raelgvaeGAVVIIAVSRLVrHKGYPELLKAMEQV----SGAMLWV 226
gi 58039798  158 ln---rNSIAIGNGRDPRRYHPdpetrarl----rrelgvpeDRPVVIVVSRLVrHKGHPELLRAMEDL----PEAELWV 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                              #                      #                  
gi 1870159   234 IGFIEPTESNyel------kicDLEKKGIVYYLGqQKDAIPHITRSHAIIHPSVYgEGMSNVLLENASsGRVLITTDNPG 307
gi 114328416 227 VGERLSSDHGedlepafqqaaaPDALGPRLRRLGyREDIPALLAAADIFTLPSWF-EGLPMSIVEAMLcGLPVVATSVRG 305
gi 71906911  236 VGERLASDHAgdvea--eleraGAALGKRLVATGaRKDIPELLAAMDVFCLPSWR-EGMPRTIIEAMMmGKAVIATDIRG 312
gi 147677431 254 IGPDEGFLPAvkk------qieRSGLEDRIRVLGqRGDIADLLSVTDIYVLPSYR-EGLPRSLIEAQAmALPCVATDIRG 326
gi 159900517 239 VGPEEPNKADglta----ataaKYGIAERTHFAGlRRDMPVLYRLMDVLAHPSYR-EGFPRAPMEATAmGVPVVASDIRG 313
gi 68054174  227 AGEMMESERDqttkh---tfrkRIREIPNIDYLGfVEDVPELLHQVDAFVLPSHR-EGVPRSIIEAMAtAKPVIATNIRG 302
gi 156741331 238 VGGVDRDKADaltp----etiqAAAGTATCVFAGiRQDMPEMYALMDIFALPSYR-EGFPRAPMEASAmGIPCVVTDVRG 312
gi 158337942 237 VGGELKSDPEpyyhql-sekieQLNLKSHVTFTGdRTDIPEMLGLMDIFVLATFAhEGLPRSILEAMAmSVPVVTTDIRG 315
gi 161786740 227 VGERLESDHGeslds--cfeeaQRVLGARLRCLGyREDVPALLAAADIFTLPSHF-EGLPMSVIEAMLtGLPVVASDIRG 303
gi 58039798  227 VGERLPSDHGadltt--afacaRDRLGPRLRMLGyREDVPELLRAADVFALPSHF-EGLPMSVIEAMLtGLPVVATDVRG 303
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                                                                       
gi 1870159   308 CKEIVKdRETGYIFQGGnVEELVSILEvflGLENEKRKEMGLQGRMyiEQYFSRQIIIDAYLD 370
gi 114328416 306 PREQVVdGETGFLVPPRaAAPLAQALTr-lATSPALCARMGMAGRQraLDHYVEQIVIGRSLD 367
gi 71906911  313 SREEVVpGETGLLVPTRsPEALAEAFLa-lAGDRQKVVSMGLKGREraLALYDEAQVVALQIR 374
gi 147677431 327 CREVVEdGVTGLLVKPGdSVTLGRALRk-lLLEPELRFKMGREGRLrmCRFFNEAEVARRIMA 388
gi 159900517 314 CRETVVhSLNGMLVPVRdVAALAHSLGr-mIDDRVLREAFARLTRRvaQREFDQQRVFDRVLL 375
gi 68054174  303 CREEVVdGKTGYLVEVQdETQLARRMLe-lVEQPDVASEMGRAGFEraMKHFNEADVIKRQLN 364
gi 156741331 313 CREAVEhGWNGFLTPLRdVDALAHALVq-lLQDESLRATMGDAGRRmaLERFDEQQIFQRVIG 374
gi 158337942 316 CREAVLpGQTGEIVPSQtSTPLANALRp-lLADPDLRTAYGAAGRQrvEAEYDENVVFKRLFS 377
gi 161786740 304 PREQVVnGRTGLLVPPGeAVPLARSLGc-lVRDPDLRYRMGEVGREraRARYDEDIVVGRTKM 365
gi 58039798  304 PREQVLdGKTGFLVPPGlSRPLAKALRt-lTQDAALRQKMGAAGRQvaLEAYDERHILKHVVA 365

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