Conserved Protein Domain Family
GT1_WabH_like

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cd03811: GT1_WabH_like 
This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.
Statistics
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PSSM-Id: 99982
View PSSM: cd03811
Aligned: 247 rows
Threshold Bit Score: 185.619
Threshold Setting Gi: 71282361
Created: 15-Dec-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       #                                                                 
gi 60459541     2 RILFVIDGlp--gGGAEKVVLTLAAQflRDGDRVSLISLRDvceyplpegldyqvva----------------------- 56
gi 153809654  403 NILIYAGDld--lNGITTVLYSQLHEl-DLTRYNYFISFRSlyvkdhpermerlpegvgiyplasem-------nmdllt 472
gi 56310587   882 KQSLLIYGgpfmgNGITTATINLIANidRSKYTVTLVIDPGsiindetrmtqfeklpqdinviarvgrm---dmtledry 958
gi 116874056  150 KKIIVMYCggfknNGITSSALNLMRNlnKEKYQIVVIEAENlsyyeqlnfnkipahvvkvqipgdinifpneeqafldfh 229
gi 50955319   424 KILLYLGGmr--pNGITTSALNLLNNidHDRYDVSTFFAQSrnraaigkqqqihpavrqfprvggmn------gtkllhl 495
gi 160880468  408 NILVYCSNlv--mNGITTSLLNLMSLidKEKANYYLFFRQNqfiktpmrlsvlppnmglmplcgsti------ewkwmea 479
gi 154483840  427 KIFISLGRal--qNGITHSFLSLLNNlnYDRFDVTAYLYEPiaddqilrinqinknvrvlvrtggnv-------atkeel 497
gi 26249529   905 NISLVVDPks--iHGFQERFEQFKRV--SPDIQVIGTCGNMlynieekwlndkln------------------------- 955
gi 56797554   716 NILFYTGPfi--pNGITNSFKNLIHHlqNSHFNIFVSIDPNsiyshkerleqfqlvsenikvlp-------------rig 780
gi 69937305   439 RLLIEPGGmi--pNGITASLKSLIANldFERFDPYILIDAPvmdselnrmeqfhefdprcnwilrsgd----mlltdeer 512
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 60459541    57 ----drcrkpwrkltelsrRARQLDAAVVRAEQqg-qFDLVLSNlhktdriVARSRALRe---rNVWFCLHGVFSasylg 128
gi 153809654  473 mavqllklkghtgswaehrLHTAYRREWKKHFGst-eFACVIHYngyeaytTSLLEEAPc----PRSIWIHNDMArevhl 547
gi 56310587   959 ihglmnqryeldspaakkiLKDSWKQEYDRVFGqa-kFDALIHFegynrfwAGVFTSVNdg--rKTSIYMHSSMKeeyql 1035
gi 116874056  230 shplehlmkngptkflteeIKAIYQREWNRVLGni-sVDIALDFdgyfkywTLLVASSNs---pKKIIYQHNEMMqeysk 305
gi 50955319   496 erhldfrrgrtarhaediaQNQLWDDEWYRCFGds-rFGYVVDFsgygpfwAILLLHSPd---aQRAIWLHNDLAadahr 571
gi 160880468  480 vyhklyfrfnmdskflqkrMNRLYQREFDKRFQnv-rIDKIVHFsgytpdiTLYLQQAEa----RKVIFIHNNMFeeyke 554
gi 154483840  498 skmyfsmafnckgsyekmlPEKYFEREARRLVGdc-nFDSVVEFcgyspilALILPKIKn---kKTAIWQHNDLIadanr 573
gi 26249529   956 ------nqftlaskemydiLDHAYQREFLRLFGys-hIDHLIHFegynqswVIRFANAPkdtvrNKIIFQHNDKLsewre 1028
gi 56797554   781 slnltleefciekenldeeKSLQNYKREFRRLYadvkFKTVINFegynvfwVKLFSSVN-----NNLIFLHNNMQgefek 855
gi 69937305   513 piyqnfrlgndlnpedlpvIRRIFEREARRILGdt-rFDVAIEFggyapywTGVIACSNa---aRKVCYQHSHLWaeytn 588
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 60459541   129 hrtgfdrw--mkqqkikriyqgRNAVTVSDAVGRDLVEEfal----rpaQLKTIYNPFDITALRAEaead---------- 192
gi 153809654  548 kgnmnp------yllkeayhtyDHIVPVSEDLIQPVVSEfga----drsRITAIHNCHDYQSVLERslapvafnedtls- 616
gi 56310587  1036 kfpyl-------kamfgygaqaNKYISVSKSTMQRNQSNlaqpfnipleKFDYTDNLQQPEQTRILaaepllp------- 1101
gi 116874056  306 klgkefkhqadlniifpvynyfDVIVSVSKQTGEVNKQHlehiv-qdtsKMTYIHNLIDYEYILRSskevs--------- 375
gi 50955319   572 evhgekrmlhsltelftlysqyDHLVSVSPTLSEINRASlady--aapeKFVSALNTVDADHILENaaadlrelavdeet 649
gi 160880468  555 kknfhf------nilkhafesyDKIIAVSDETKNSIKKIgdf-----mdKVEVLNNAHNVEDILVKaklpfvmeeetel- 622
gi 154483840  574 klghkkplrrkmsiifnlyprwDRLVSCSHSVMEVNEKNlsrp--eiegKFSYAKNTINYMRVLDSldndcty------- 644
gi 26249529  1029 rfpyl-------rvvfdfyksyNKIVSVSEKTMELNRDNlseffniehdKFIYCDNVQNPDEVIKKsddidt-------- 1093
gi 56797554   856 rfpyl-------eqnfkcyknyKKILSVSKQTNEQNKKNlaykyniaetTFDFLENMINNEDIIEKskekldkk------ 922
gi 69937305   589 ldaarnrr--tlnavfqlyhcfDQIVAVSDETRAVNEAHlkqyy-patgPARTVRNTLDVKRVAERarlpvslah----- 660
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              ###                                                        
gi 60459541   193 ----------serPDGDYLIHVGRFhpGKRHDRLLEAYAQSgi----dAPLVLLGQGKPEQEQrlrqLAKTLHIDDRVWF 258
gi 153809654  617 -nvsletlqsvldSDAPKFISIGRFspEKGHKRLLDAFEQYwkehpdtWLIIIGGVGNLYDETl--aHTRALRASDHIIL 693
gi 56310587  1102 ------edeqyfqGTGKVFITIGRLsmEKDHAKLINSFAQIaad-ypdSRLLIVGDGALRHALs--qQIAELKLENQVHL 1172
gi 116874056  376 --------didlsADTFNFVTMGRLspEKNHQGLIKAFHQLqkk-radSQLFIIGLGELEEELk--qYIIDLELENKVHI 444
gi 50955319   650 gcvpdwaealladDGVKTFVNVGRLspEKNQARLIRAFADVyae-npkTRLLIVGSGPLTGELe--aLIVERGLAGSVFL 726
gi 160880468  623 -svpyeeftkmleGDSTKFITIGRFspEKGHMKLMSAFNEFhkdhpntKLIVIGGYGTLFNDTv--dFSRKLESAKDIYI 699
gi 154483840  645 ------knfslpaSNETSFVTMGRLstEKNHGNLVRAFGEYvke-ypnSKLYIIGEGPLREQVe--gEIARLNLKDKVIL 715
gi 26249529  1094 -------sgfifeNDKIYFITLGRLsvEKDQQKLINAFCRLqkl-ypnIELLILGDGPLKIDLq--rQIITLGLEKSVHL 1163
gi 56797554   923 ------lekkyfkKDYKIFINIARLsiEKDQAKLIQAFKVIndk-ypkTLLLILGEGPLKEDLe--kLIKDLKLDKKVFL 993
gi 69937305   661 ----peagllfqdPTLFRFIALGRLspEKRYDRLIGALARIape-hpnAVLLICGAGPVRDKLv--qLARRKGVAEQVRF 733
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                     #                                                   
gi 60459541   259 KGfQKNPLPWIKgARMLVLSSDSEGFGNVVVEALLlHIPVASTRCPgGVTEILTGELARGLAdltspalaqtmqsiyhNP 338
gi 153809654  694 IRaVTNPMPILKrCDLFLLSSYYEGQGIVLMEAATlGIPVMACDVS-GCHSFLKKYGGLLLEdseagll---hgmqlfAE 769
gi 56310587  1173 LGlRSNPFPLLKkADCFVLSSNHEGQPMTLFEAMIlEKMIIATDIV-GSRGVLENRSGYLVEnsvaglaqgladflagKL 1251
gi 116874056  445 LGqLENPFPVLKaCDAFVLSSIHEGQPMVLLECLVlEKKIVSTNIP-GSYSLLKNGYGLLVDstvegla---egmekvML 520
gi 50955319   727 TGmQPNPHAIMArADCFVLSSDYEGQPMVILEALVlDLPIVTVEFA-SAKNALPAGSGLVVPqtdagva---gglrayLA 802
gi 160880468  700 VKsTSNPFTILKqCDLFLLPSDREPLGLVLLEADTlGVPIVATDIP-GSGDFIREHHGYLVEnsekglr---kgmedfLE 775
gi 154483840  716 TGnLINPFTLMKnCKCFILPSIYEGQPMVLLEARIvGLPIIVSDFS-SVKDSLMENGQYLINsseesil---gglrafSE 791
gi 26249529  1164 LGrISNPFPLLKrADCFVLSSNHEGQPMVLFEAMIlDKPIISTDIT-GSRSALEGRSGVLVEnsvdglf---ngmrdfIL 1239
gi 56797554   994 LGrIFNPFPYLKkADCFVMSSNHEGQPMTLLEALVlNKAIVATDIP-GNVSVLDNRGGLIVEnnvngli---dgmkkiIN 1069
gi 69937305   734 LGqVSNPYPLLAhADACMMSSDYEGQPMVLLEALClGTPCIGSDIP-GIRSVLKDGVGHIVApteeafa---aamkaaIE 809
                         410       420
                  ....*....|....*....|....*
Feature 1                                  
gi 60459541   339 PAIDDAALekf---svVSICQQYRQ 360
gi 153809654  770 GKVLPLHIdae--cinRTSAAQVEA 792
gi 56310587  1252 TLTTYDIEey----qqQAINRFYHL 1272
gi 116874056  521 GYNDFKQFdyk---ayNRTARQMLE 542
gi 50955319   803 GDVPANHFdgta-ynrKAVAEFYTA 826
gi 160880468  776 GKVKPLNIsft--kynQSIVKRFED 798
gi 154483840  792 GKVPKCNFdpk--qynREAVEEFEN 814
gi 26249529  1240 GRLEFKHFdies-yqkNALSMFYEK 1263
gi 56797554  1070 RSIEIFYFntk--eynSQCLEKLVT 1092
gi 69937305   810 GRLPPLKPadiggayiEETMREFED 834

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