Conserved Protein Domain Family
GT1_CapH_like

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cd03812: GT1_CapH_like 
This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).
Statistics
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PSSM-Id: 99983
View PSSM: cd03812
Aligned: 50 rows
Threshold Bit Score: 261.767
Threshold Setting Gi: 506704
Created: 15-Dec-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #                                                                  
gi 506704      3 KVMHIFSrm-nrGGAELRTMDTMKLln---rEFEFHVCATSGKrg--eLDDELESMGITIhy-lDIKKFSFPFKFIKLl- 74
gi 94969757    4 RVLHVVGgl-nvGGTETWLAKGMPFvd--reRYEFDFLVFGDEdq--hYARMVERAGGGVir-cSSPQNPVRFAISFLrv 77
gi 158314000  95 TVLEVLPrm-drAGEVIRAVNLLRRld--pqEYRLLFCVTSGApg--sLDDEIRALGGEVyy-cRADLRFPLAFYRLL-- 166
gi 109900308   4 KVLHVFGim-nrGGAELRTLSTLEKmr--klGVEYEFLVLSGQkg--vLDQEITERGSKV----HYCPLSLTFFFQFMsi 74
gi 68194642    3 RILHFQGrm-glGGAESFMMNLYRKid--rtNYQFDFLIYEDYadvqdYHSEIERLGGRIfv-vPNPKKNIFKYLIEVnk 78
gi 15900282    3 KVLHLFTtl-dsGGVESFLFNYYSHid--rkKIQFDFIVPGKEqg--fLEDKMKELGAKVyhvpLLRKKPLHQFLSLAri 77
gi 78610764    2 HFISGIKs----GGVEQMLVNYTTQlnknsdYIQYIIYQHEPDk---nSLKKLEEAGNICiq-iPDKMHFPIRNIIWSik 73
gi 154504886   3 KVLVVETtkcgyDGITNVIKNYFLYqe--dpEIQMDLVTINEAvp--eLKTFLEQKGRRNyq-lPYRNRNPLKYVMKLrk 77
gi 5739465     4 KILHLVGtl-dvGGIEKWVVNMINYel--enKNELDFYLYSLDp---hKKQIVKQINLDEnsitYTNKKNIFSRMYGFyc 77
gi 161508001   9 KLIMFEEkf-glGGIETFITNVLSCin--reKFDVRLVTINKAtd--qYDSLFKKLDIPMvvlvPDVEINPIKRFKKGlp 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 506704     75 --------KKKNIDVVHSHILf-MSGLIQLLSfs-aNVRNRITHFRTSKDskeqynkirkar-nkvlkaiieifsTKILY 143
gi 94969757   78 -------lRKAKCDAVHAHVYc-ASGLVLMLAal-aGVKVRIFHSHTAQDehrgfgcrsiyf--rvaralirrfaTRGIA 146
gi 158314000 167 --------RSVRPDIVHSGVAt-FSGVVLAVArv-aGVSRRVAHFFSSADqsgdslrgrlqr--mvgrvlldafaTDLLA 234
gi 109900308  75 -------lKAEKYDVVHSHVSl-VSGVILFISwl-gGIKRRVAHFRSTHDvenpsvlrrir---dkllrrllltfSHYIA 142
gi 68194642   79 ------llKKESFSIVHNQVYf-GGGINLWLAkk-nGIRQRIAHSHATEDgksqnivmnvlr--kfltklllqnaTDYLA 148
gi 15900282   78 -------iKKGDYDIVHCHGYksAIGLILSKIi---GCKIRIIHSHMAYVtensfqkvlrk----lvtilvkilaTHWFA 143
gi 78610764   74 ------liRKYRPDIVHAHMSl-LNFFPLLAArv-lAVKHRISHSHISRDnvapkfmipv------fkllvrfssNSYLA 139
gi 154504886  78 ------ilKEGGYQIIHVHGCs-GTMAVEMLAaklaGIKVRAAHAHSTACthttsdkil--------rpfflkwcNCRYA 142
gi 5739465    78 ------lmKKISPDVIHYHPGy-SSGIYLFISki-fFKKINIVHSHSDRRsidrrssifkkiyifimkflinrlsDYKIA 149
gi 161508001  84 afktylkqHISPDTIIHFNVSn-SIDLLYVKIakskGIKVRIAHSHNSSAtsnlkklahk-----mgmillantpNYYFT 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                        ###             
gi 506704    144 VSNIANRNLismk--lfpKKHKTIYNGFEISNINkn------------------fkKEENSFIYVGRFIHTKNQLFLLDV 203
gi 94969757  147 VSAVAAAPIfptnwefvpEKWRVSPTGIELAPFSdasvresv-------rrelnipETATVVLHVGRFAPVKNHALLVKI 219
gi 158314000 235 VSEAAMRGRwret-wrldPRCRVIYNGVELEPFGvaiagqrpmpdlpeldefgeamAPQLTVLHVARPDPVKNRARAIEI 313
gi 109900308 143 GVCEATLDAfwhvdwradSRFKVIYNGFEQHNVVhrenfwq---------ddlgisADNKIIINVSRMHEQKNHPRLVEI 213
gi 68194642  149 VSQEAGESLfq------nHPFEIVHNGIDLELYSknseakvn------krkeldisMSTFVVGNIGRLEKQKNQSYLLEI 216
gi 15900282  144 CGEDSAKWLygek-aykdGKIEIIFNAIDLKKYQflsdvrek-------crreldvSNKFVLGNIARLSDQKNQSYLFNV 215
gi 78610764  140 CGKDAGTYLyg------kKNFMVINNAVEIQKYKfskekrrk------krdlygigSDDLIFGNIGRMSPQKNQLFLIEI 207
gi 154504886 143 CSDAAGKWLyk------gMPFSLISNGIDLEKFQydpvvrer-------lrneydlEDKLVIGHVGRFCEEKNHKKILEI 209
gi 5739465   150 VSERAGKSLf-------yGSFITHYCGVPDIMLSlpdi--------------kkvsSSEFKIYHIGRNSDAKNYPFIFSI 208
gi 161508001 158 CSNLAASWLfpkk-vlknQNYYFIRNAIDTKKYQfniskreq-------irkkygwTDNLVFGEVGRFNKQKNHKFLLET 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                          #                     #       
gi 506704    204 IEILKkefntnIEITFVGNIQTDYGKkflsianerglNKNIKVIGe-VNNPLDYLKTSEYFLFPSELEGLPGALIEAHHh 282
gi 94969757  220 AERAIrqr-leVVFVLVGDGPLRSQLelevc--arglGRAFRFAGv-RDDVARLLRAADVFVLPSLYEGFPLAYVEAQAa 295
gi 158314000 314 VAAMCarg-ldVRLRIVGRQTEEETErlmtlarglgvSDRVEFIGe-RLDIPKLLVTSSLLLVTSLREGLPSVVLEACAv 391
gi 109900308 214 FCEYCqkn-ndAVLVLVGKEDPEIKQqlqrmsalnnvDERIFYLGe-KAQVLPFMKHADIMLFPSKWEGLPGAVLEAASl 291
gi 68194642  217 FLEILkmn-sdSYLILVGEGSLRNKLkakav--eldiEKRVKFLGe-RNDIPELLSVMDVFVMPSLYEGLPMVGLEAQAa 292
gi 15900282  216 LKELIlik-pnVILLLVGNGEDEQKLkqkal--elnlTPYVLFLGr-RTDISDLLSAMDVFLLPSKYEGLPVSLVEAQAs 291
gi 78610764  208 FSKIIsnc-nnAKLLIIGNGELEEQLkakvs--elglNNNVIFTGs-VIDTSEYYSMMDVFLLPSLYEGLPIVSIEAQIa 283
gi 154504886 210 AKELQkrh-qkIKLVFVGDGPLKQETeeka----redKLDVLFVGl-SDVVEQWLQAMDVFVFPSLFEGLPLGLVEAQAa 283
gi 5739465   209 AHSLRey--enVHIYCMGAGLELLQKksq-----eenLKNMHFLGfiENPLSHIYIHANVFIMPSLWEGLPLSVVEAQKc 281
gi 161508001 230 FKEIVqkr-enAILVLVGAKDCLYDDiksya-eelgiEKKVIFFGk-TSKVADLLQAFDVFMLPSLYEGLPFVLVESQAa 306
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
Feature 1                                                                                
gi 506704    283 NCIVISSNIKENSEVNQyf-kDSSFELeli-pktWASTIKKLISrkkhiSFNDSNVFDInmttQELKEIYMS 352
gi 94969757  296 GLPCVISDAITPAADLIpe-rVVRLSVtde-pgiWAQVLLDSAAipdseLIAERFTEFSmeasMERMVECYR 365
gi 158314000 392 GTPVLSSDLPGVGEIARvlpgITMLPLgtp-neiWANTAADLAVvp--pTMDERREAMRrlrrSPFTMENWQ 460
gi 109900308 292 GVPVLASDIPGVLEIAQqldvVHYFPLaqs-dqsWAQQVTQLLSqpvdhEVGRQTFKSSmfqlDNNVKQLHA 362
gi 68194642  293 KLKLVLADTISKDTKLTn--nVDFVSLdet-pqeWAKKVIKEPYankitQELKSYDVSYtteqMESIYSRDH 361
gi 15900282  292 GLQILSSDTVTQEVDVTk--nISYLPIneesvllWKDKVLSLTSeecnrFEINNSMTDGlydiCYQASKLLN 361
gi 78610764  284 GLKCLFSENIDKDVDILs--tTKLIPInqg-vdlWIEEALKPDYrisreIIEQMDMYDIkkewHKLDEYYLN 352
gi 154504886 284 GLPCILSDRIASMTKIId--eVQFLKLeas-dqvWADAVLKEAAendriKNQEKIKQQLrdrnFDIRLNCKQ 352
gi 5739465   282 NVPCLVSDTITKECDIGm---AEFLPLdv---siWQERILNIYKeg-ylMKEVNKSKFSl--eQDILFFKKI 344
gi 161508001 307 ALSSLVSNTVTDEIKLTk--yIVFDSLkns-pkeWADTAIKLTSvarepDSTSLIKEGYdvnsMVKNLEQLY 375

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