Conserved Protein Domain Family
GT1_like_3

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cd03813: GT1_like_3 
This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.
Statistics
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PSSM-Id: 99984
View PSSM: cd03813
Aligned: 34 rows
Threshold Bit Score: 481.736
Threshold Setting Gi: 29827550
Created: 15-Dec-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981969     5 KIGLILEGTYPYvtGGVSNWVHTLLTNLpeFEFEIYHLKAVTEpq-tiKYKIPENVTAVHELNIFgd----------feS 73
gi 42740563    2 RIGLVVEGSYPFvsGGVASWVQMIIQQFkeHEFTIFAIVPQIKteeeyQYEIPNNVKDIIMIPLQ--------------S 67
gi 119952640   6 DVAIVMESTYPYlkGGVSAVVHDIVTHNpdLSYGIIHITWDSDspmtdLYGMPSNVRWVRTVFLSmeehr-----hnflS 80
gi 15023615    2 KICLICEGSYPHvtGGVSSWVHMLIKQMpeHEFVLYCIVAEEKskgnfKYEIPSNVVEVKEIFLDyilkqksslqksypI 81
gi 157151143   2 RICLVLEGSYPYvhGGVSTWMHQYITEMkeHEFIVWVIGANEEkkgqfVYEFPPNVVEVREVFLDslagse---vgnkeS 78
gi 119025414   2 RICLVLEGCYPYvhGGVSTWMHSYITAMkeHEFVLWVIGAKAKdrgkfVYDLPSNVVEVHEVFLDdalrlsgehakvifT 81
gi 88711381    6 QVLLISEGTYPYnfGGVSTWAHDLCTKVsnVDFTIYSINSGVEhk--aRYPIGTNIKKIIQVPMWspeep----ldcvdY 79
gi 20094519   14 TVTVVTEATYPValGGVTTWVQRLIKYSpdVVFNVLCMTGPERte--pVVEIPANVRDVVIQEIVp-------------K 78
gi 29827550   14 RVTLLTEGTYPHshGGVSVWCDQLVGGMpdIDFDVIAVTGTGRep--iVWDIPGHVSRVAAVPMWgpap------egraP 85
gi 15807629   20 RIALYTEGTYPQahGGVSVWVDQLVRGLsdHQFAVQAIAGLPFt---rMALEVPGNVQVEQVPLWgppp------ggagG 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981969    74 DSSQKANLESLerivsqlsi---------erdirsivsFAIDFIRENAGKNv---------rKMLKTKGFWNILLKIYEe 135
gi 42740563   68 ESDSKHIKTNLttdevq----------------tlqkwFTFQANDTEALQIlgnkqklgtlhSFFESREFYEIVKESYLy 131
gi 119952640  81 VSAKDLGMTAQqreelshrlfna----lyalsergeveHLWDLIDEGLNERtrqy----plwALLGSREFMQTLQERMPq 152
gi 15023615   82 GTSGEESIKNLiigge------------------vnfnILYEFLRSKELKKp---------tDFFMSKNFFDIVVSAYEd 134
gi 157151143  79 GELTDAEYEALkqlvf-----------------cakpdWSLIFNLLQDGKIqr--------dSFLASEEFFQMIQQLCTe 133
gi 119025414  82 DEEVKALRELVnlsd--------------------pdwDVLFNLFHNKGVHp---------lSFLQSNEFIDLFTKICMe 132
gi 88711381   80 DIKYSDILKSReftteeitstlfiphfkkfiaeiyseeISLKVLSTCFYKMwqffq-kydykTAMTSKAVWNTFCETLQl 158
gi 20094519   79 GNKLRRWLDRItpthrlrwstaaktlratfermvegepLSEPMLKELWKVSkspts-vlassTMYELARYVHYLASQYEd 157
gi 29827550   86 RGRRRNRLASAyeqfltall---------dpcaedrfgTALYVMARAAADGmlspf-lrgdrAISILTAVWNRPGLAVRe 155
gi 15807629   91 RLWQQAHRRAFagevltayetl-----ltglcrldvptFSVALRRLSDLGQrgs------ltPALDSARAAQLTLNLWDr 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981969   136 ff-----------------serGLTEFYWMIMNLFLPVvn--vlQFVPNRCDLFHVPSTGYASLVGMNgkfvhdvPLVIT 196
gi 42740563  132 ee-----------------ssgSFLNYFWMWRSMFTPIiq--ilQIDFPELDLIHSVSTGYGGLLGAAisaksdiPFILT 192
gi 119952640 153 l-------------------nlSLANSFWTLRNFFSLAfa--vlGETMPRAKVYHAHTTGYASLLGAAaardhdtAFLLT 211
gi 15023615  135 ky-----------------psiPFNEFFWGVRAMLLPLly--ivSNELPKADLYHSVSTGYAGIAGSLagtlynkPFIIT 195
gi 157151143 134 ry-----------------amqPMSDVFHTIRSMLFPLlt--llSSDIPIADAYHAISTGYGGILATLasvrtkkPLLLT 194
gi 119025414 133 ey-----------------pyvAYADAFHTVRSMLLPVly--lmTGEVPKAQIYHAISTGYGGLLACLggsinhaPVLLT 193
gi 88711381  159 vvpee------------elekvSLEDVTIAMRWIYRFLip---iAIDVPKVDISHVTISGIAVLPALSlkykyntPILAT 223
gi 20094519  158 kc-----------------ennPFSDVFWVAVNIASFVlgaaagARRLPNCDVAHAQNSGVCGFLCSVakavrnvPFIIT 220
gi 29827550  156 arp----------------tlhDAITATALLEHALRPL------ATPLPRDGVAHAVSGGVAALPGLAalerhgvPLLVT 213
gi 15807629  160 eaqtlaaqrdrlsprlprptvaEALDVQIWLEHALRPL------TAVPPEADVGHAVSNGFAAMLALHglwqrgtPFVLT 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981969   197 EHGIYHKEREREIilst------------wvpdAYKPMWIELFRIISMiAYRVSDALTTLYRKNQIYQLELGADPEKMFI 264
gi 42740563  193 EHGIYSREREEEIlqst------------wipiEYKKRWVSFFHHLSHqAYEQAADVITLFGRNSAYQKELGAPAHKLKI 260
gi 119952640 212 EHNLYVRDTVNTLldrnmalsiteddyrtfdvtAEQRAWMAWWTEMGRfCYPSARLITYLYPSAITEAARLGSDIDKSVV 291
gi 15023615  196 EHGIYTREREEEIiksk------------wikgYLKDMWIQFFYTLSKcSYDTADKVITLFNKNREIEIELGCKPSKIEI 263
gi 157151143 195 EHGIYTREREEEIirad------------wilpSMRKQWIDFFYTLSDaVYSKADCITSLFSKAREIQIDMGCDPEKCRV 262
gi 119025414 194 EHGIYTREREEEIlsae------------wvapAFRQRWIRFFAMLSQeIYRRAWRVTSLFGRARQTQIDMGAPASKCLV 261
gi 88711381  224 EHGVFIRERIIAIssad-------------ysyFLKKMLINFSECITRlVYHYADKITTVSKFNISWEKFYGANVSNIDV 290
gi 20094519  221 EHGILLRELDTRLegy---------------grTTRELFKECFRSMMLtSYEQCEEIIEISDYHAELALEQGAPEDKIKV 285
gi 29827550  214 EHGVYLRERYLGYrtap-------------yrwPVKAVVLGFFRLLAEeTYLRAALITPGNRYNRLWEEQGGADPESIRT 280
gi 15807629  234 EHGIYLRERYIEFrrgr-------------hapGYKTMLLRFYRLLCSvAYQNAALVLPGSHYNRRWEERLGADPDRIQC 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981969   265 IPNGINVEEYDLpp-------------ekHEGFVVGFVGRVa---RIKDLKTAIRAISIVkevvgekLTFLIIGPV--DA 326
gi 42740563  261 VPNGVTLSDYKGlrkp----------khnSDKLIISAIIRVv---PIKDVKTMIYAAKLLlek-dipFIFYLLGPDt-EE 325
gi 119952640 292 VPNGMVIEEFDDkyrarqqalvkmeqegsDYVWHLVYIARVv---PIKGLLDLLSSLEILrdrgfpnLHLDVLGPTe-HV 367
gi 15023615  264 VENGIPIQDFANisce----------rdtENTINIGSVLRVv---PIKDVKTMLESFSVVsye-iknCNFYLIGPTd-ED 328
gi 157151143 263 ISNGIDYEAFSTi---------------pHEGDGFINIGAAvrmaPIKDIKTMIYAFYEVsaq-mpnVRLYVMGGV--DD 324
gi 119025414 262 IPNGIQYERFCDip--------------lKPEDGWVDIGAVvrlaPIKDVKTLIHAFSELsnr-vdnVRLHILGGV--DD 324
gi 88711381  291 IYNGVDDSFFKPrpkp----------ehlKNTPTVVAAARIf---DLKDILTMIRTCKVVkkk-vpnVKFFVYGNKd-AV 355
gi 20094519  286 VYSGIETWKYSPgdler--------kynePEVLEVGTITRIe---RVKGIDVLIEIAARTveh-ignVVFHVVGPV--ED 351
gi 29827550  281 VYNGVDPAAFPPag-------------pePDAPTLSWAGRVd---PIKDLETLIRAFALVrsq-lpeARLRLFGGTprGG 343
gi 15807629  301 VYNGIDPNIFPPae-------------sePEGPVVSWVGRVd---PLKDLETLIRAFDLVrrr-rpdARLRLFGGTpvGN 363
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981969   327 EDYLAECKRlvrvLRLEDTVEFLG---PQNVKEYYpkFDLLLLSSVSEGQPLVILEAMAaGVPIVATDVGACRDIIYdkd 403
gi 42740563  326 PEYAQECRDliqqLGLKEHVIMTG---RVNIKDYLkqTDILVLTSISEGQPLAMLEGMAsGLPWVVTDVGSCKELIYgqd 402
gi 119952640 368 PEYYEACLAkidaLGLHDHVTIHG---TVNVRDMLdqFDLLVLPSYNEGQPIVILEAMAaGIPTVGSDVGGVAQQIAddl 444
gi 15023615  329 EEYYKECLRlv-rELELKNVIFTG---RANVKDYIgkMDIMVLSSISEGQPLAMLEGMAcKKPFVTTNVGSCSELIYgvd 404
gi 157151143 325 KAYANECYDlv-rKLKLDNLIFTG---RVDIKEYLkrMDFMILTSISEGQPLSVLEAMAaGKACVTTDVGCCRELLEgra 400
gi 119025414 325 QDYADECYElv-kQLEVKNLEFTG---RVNVVEYMrkLDFTVLTSISEGQPLSVLESFAaARPCVTTDVGCCRELLEgee 400
gi 88711381  356 PEYTKECEAlvkyLQLEDNFYLMGf--HNNPELIYaeGDVSILTSISEGFPYTVIESMScAIPVVATDVGGVSEALDe-- 431
gi 20094519  352 EAYYEECRKlvkeYGLEDIVRFHGpctPDEVVKWLrrFHIFLLPSRSEGLPMALLEAMScGCPVVASEVGAVPYIVDr-- 429
gi 29827550  344 EAYRERCEAlaaeLGHAEAVTFEGr--VDDIKDAYaaGNVVMLSSISEGFPFTLIEAMScGRATVSTDVGGVREAVGd-- 419
gi 15807629  364 EGYEQHCRQvaagLNLDEHVKFEGr--VDDITDAYraGQVVALTSVSEGFPYTVIEAMAmGRPPVATRVGGVPEAVGd-- 439
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4981969   404 --------gqCGIVVPPKdHLSMSKAIIKLYEDKELRDTFSKNAK-KVVQKYRv-ETMIEKYRNLYL 460
gi 42740563  403 ed----pygqCGFVVPPVsPEQVATHLEWYYRHPESIQQFGNNGR-NRIEAYYqlSGVVDSYRKLYL 464
gi 119952640 445 ytadgrtigpCGETVTPGdVVQMADGIEAVIGNLDSYAAYAANAR-TRVQELFqmHEVMSSYNQIYR 510
gi 15023615  405 d-----nfgsAGIVVPVMnYVKMGNALIKLCKDKALRLSMGENGY-KRASTKYtfEKFINRYKDIYK 465
gi 157151143 401 dd----nlgpAGYCVPPTdLSGLADAMLRMASVEEERLVMGKTAK-KRAELYYqyDQMIDQYRQMYK 462
gi 119025414 401 gd----dlgvAGFYVPPMyREGLARAMERMCASRKLREAMGQVGR-ERVKTYYrhERMLDEYRALYL 462
gi 88711381  432 ---------kCGFICKPKdHDEIGERVISLLKNEKLKKWMGENARkKVVENFTi-ENFVSEFEKTYE 488
gi 20094519  430 ---------nFGRTFRSEdADEAARHLVRLLYDPELMFEMAHHAT-KRAKQYDv-MRMCHDYFREYC 485
gi 29827550  420 ----------TGLVVPPRdPAAMAAAALKLLGDPERRRSMGEAARlRVIEQFTl-RQTVDTFRSIYL 475
gi 15807629  440 ----------AGLIVRPRdALGVANALTKLLDDPALRQQLGQAAR-ARVMDLFtlDGCLDAYRRAYP 495
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