Conserved Protein Domain Family
GT1_like_2

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cd03814: GT1_like_2 
This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.
Statistics
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PSSM-Id: 99985
View PSSM: cd03814
Aligned: 116 rows
Threshold Bit Score: 224.411
Threshold Setting Gi: 148554731
Created: 15-Dec-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10175309    2 RIALFTDTYIPQvNGVARTMKRLVDHLek-rQVEYALYMPETIekldrfe----------------snihtfaSLPFFLY 64
gi 23125983    8 TLLFLFTTFLPEvTGSAIFNWERVQWFakqgIYRIIVLAPDWQeqsklpv----------------vppdlaeNLILETY 71
gi 16082094    2 RILYFTDTYYPTpDGVSVYLKEVKQKLed-eGHEVMIFSVTGDsrehnv-------------------yvpkyTAPFLPY 61
gi 158333767   2 KIAIITSGFLPVvDGVTVADFNRMKKLsq-wGHQVRVFCPDYSslasvypnwqdytge-ilpnievvnlpsdaFMGLDFE 79
gi 145299758   2 KYLILSFFFYPEvNGISQSVFYRCKELas-rGNTVSLLVPGYPtlsdqsavvilkslgvriigmplavhcnpmTSPFPDH 80
gi 17232833    7 RIALFSGLYAPFlTGVSVAVHQRVHWLlk-qGHEVLLVHPQINdkfpknvgsrpmagleelkpfpnfssfafpTQPLIFY 85
gi 154247727   2 RIAILSSGYLPVlDGVTVSVDARVQRLaa-rGHDVLLLAPRPAddlrrpaglp-----------dgvvfvglpGTPFGAA 69
gi 113476717   4 KIAIIASGFLPVlDGVTVSGYYRVQKLsq-fGHQVLLFCPDYSplahlyp-----------------nwkdytGNIFPGI 65
gi 119486566   2 KIAILTSGFPPVlDGVSVSGLYRVQKLsq-wGHEVLVCYPDYSpladlyp-----------------nwkdyvGDILPGV 63
gi 120537058   2 HIVDVTMFYAPAsGGVRTYLQAKREILsqvpGLRTSLLVPGAErdslgn-------------------hhtlpALRLPLG 62
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10175309   65 PECRIALPNVFKLrqql--------------tsfqPDLLHIA------TPFNVGLSGLQHGk-------kYGIPMVGSYH 117
gi 23125983   72 PSQPWLLYPLLHVpkfstaryi-----nqriahykPDLINVVdverlfLFSTWHLPGRRYAk-------nNKILYITEYH 139
gi 16082094   62 PQYRVPVSFIPFRvfrra-------------lefnPDIVHLH------NAFYMSSVGYLVAr-------rIGVPPVATFH 115
gi 158333767  80 RNVSWRARPYLMQsle----------------efqPDILHVDepe-rlSVGLLQPPGINYAk-------qAGIPCVCFYR 135
gi 145299758  81 RCTRTLADEIASFq---------------------PDVLLVD------EPMPLYMDAGFCLsdii-civpEQCLTIALCH 132
gi 17232833   86 KSLPQPLSYRHWSdskll-------------sdfqPDIIVVEeaa-qmRGLYSGLLQGYGRpvgvkyakrTHTPIISVFH 151
gi 154247727  70 AGDINPGPAAHAVieqal-------------aafhPDLIHVD------EPERLAWGIRRLPglgf--arrHGIPAVAFFH 128
gi 113476717  66 QVINLPSTPFLDFernvgfntyk--ivvrelekfqPDIIHVDepe-rlFFAFFRLAGIKFAr-------eNNIPCICTFR 135
gi 119486566  64 RVVGLESTPMFGVdfernvswksyptvvrelenfqPDVIHVDepe-rlFFGFFRLAGLKYAk-------qVGIPCVSFFR 135
gi 120537058  63 QGYRFPLRARLWRdalg---------------alaPDIIEAG------DPYVTAWAALDASq-------rLGVPVVGFYH 114
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10175309  118 THFD-----HYLHYYKLQFMSawl------wkYVKWFHQPFERTFVPSVETmr-hlQKHGFQRLALWTRGVDCERFHPKQ 185
gi 23125983  140 TDYCn---hVSTYPAGNLLREilw------kpITKYLYNKCDITIAISPTAskilqKMGISNAITIPMYGLDLSAYTPSR 210
gi 16082094  116 TDVSrm--kESINMPFKNLAFdlg------erYSLFLYRKCRMVMAPSATVee-ylKIRGVKNVVTLPLFVDTDKYRYVP 186
gi 158333767 136 TNFI-----EYAEDYFDWPAAaiaglqnvfklLLRRVYNAYDQTFTTSPITqekiiKLGIKNSRYAGLVGFDTDQFSPNL 210
gi 145299758 133 VDLA-----SLCTNYGMSKDAaai------nsKVDTIYGQYDAVFVPSVFLkn--nYLLNINSTVVSFLGVDTEMFKPSL 199
gi 17232833  152 TDIV-----AYIKYYFGDIFFslvrp--liplLVKQFSDNYDLNVFPSREQlkkyhNLKCQRSEYVPYQGIDCEKFHPRN 224
gi 154247727 129 TNFVd----YWGQGSRLAPLLdpfka--vgwrLVTVLYNRFDATLVPSAQThrrltGFGLRNGVCGRFNGADTARFSPAL 202
gi 113476717 136 TNFL-----EYFEDFLPLPKGinlmlqlifekSFVSIYNKYDLTLVSSTIThqkiiGMGIKNAMYINFHGFDIEKFNSAT 210
gi 119486566 136 TNFI-----EYAEDFLPVPSFlipmiqgivgkIFALIYNAYDLTLVSSRITvekleTMGIKNLQYANLLGFDAGQFNPNL 210
gi 120537058 115 SDLPrlmgdRFGRQVGRRLER-----------YVVNLYRRFDSVLAPCQAMad-rlRDWGIDQVRVQPLGVDLQRFHPSC 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10175309  186 RHRSYainll----pkdkAVLLYVGRLApEKDLATLVAIMSLLprel-nekiQWMIVGDGPSLPEMkk----qCPSNVTF 256
gi 23125983  211 RNRQFletwlt-pqekdnKVILFLGRIAlEKRIDILIKAFSTLqlkq--knsSLIIAGDGPVEVVQklknlakSIPNIHF 287
gi 16082094  187 ADSGE-------------RYILYLGRITvDKGIYRVLDLAEAMkse----dvRFKIAGVGPELDRIrrivkyhGMKNVEI 249
gi 158333767 211 RQPNYfaqnydlpevdqqVKLVFVGRLTpDKGWGFTFKAMREFlpridrdkvALIVAGDGSMREEIaee-lgaLTPHVHL 289
gi 145299758 200 CHEVTd-----------vMKVIYVGRLSrEKNLHLFIDAAENLreqg--lniEWTFVGSGPMLETLet---lsTSGNIRF 263
gi 17232833  225 IIHNPipn-------dgrPTLLFVGRITaEKNVTQLIDMYPLIaaki--pdvHLVIIGSGPLDEEIrrr-vqkFPSGITF 294
gi 154247727 203 RAPGYwgrnwglpglddrPVMLIAGRLTpDKGWSSWDKALPKLarrl-gdnlGLVIAGDGALRPRVerl--aaTLPQAHV 279
gi 113476717 211 ITTNFwelnyqipnlnnkVKIVFLGRLTeDKGWKFTLGAFVKLqqlvnienvAIIIVGDGPMREEIsnr-lsqVTNHVYL 289
gi 119486566 211 RQEGFfeqrygltdfdrkVKLIFLGRLTpDKGWTFTLRTFERLvkmvdrdrfAVLIAGDGPMRSPIeqh-lsqLIPSVHL 289
gi 120537058 183 KDPALreelg---lapetRLLVFIGRNSrEKNIDILLATMKRLgn-----gyHLLLIGPGMPRQVPa------NVTSFDR 248
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10175309  257 TGylKGEELAAAYAsADLFVFPSATETFGNVVLEAFAsGTPAIVADRGGVTEIVEhgKSGMICKAGDahtfiQAIEHLLM 336
gi 23125983  288 IGfvHGEKKANLLAaSDIYCSPAPYETFGRTLVEAMAsGTPAITVNSGGVSDYILdgINGYLVEPNDvealtHAILKILR 367
gi 16082094  250 LGyvDDQRKMDLMAnASLFVYPSSADTFGISVFEALAsGVPVMVSEDFPVKENTEa-ISYVKFGDIRs----AVETAERI 324
gi 158333767 290 LGrvDPTQIPVLLAnSDIHITTSEKEARGLTILEAFAsGIPVVAPRAGGVVENIEhgCNGYLYEPQSvhdfaSKLQALIE 369
gi 145299758 264 MGerPSEIVAMELKrNDLFITGCDFEAFGITVSEAMAcGLPVMTSYRGGNAEQYEhfSSGINFDIADmdsllNGMKYFYY 343
gi 17232833  295 WGesHGTELLGWFArADVFVNPSVTENFCTTTNEALAsGTPVVAAIAPSTSEQVFpgMNGLLAEANNpkdfaQKIITILE 374
gi 154247727 280 LGavPHADLGALLAnSDAYATFSRCENASLAICEALAgGVPVIAPRAGGIPGQVRhgENGLLFAPGDvvdfvNQMARLVE 359
gi 113476717 290 LGriSPKHIPNILKnSNFHVTASEKETRGLTVLEAFAaGIPVVAPEAGGVTENIQngRNGLLFTPGNqesfcDKLKLLIE 369
gi 119486566 290 FGrvPPADVPAILAnSDVHVTASEKEARGLTILEAFAtGIPAIAPRAGGVIENIQtgENGFLYTPQDcedfaEKLKQLIE 369
gi 120537058 249 CC--GIYEVARVLAsSDAMLHAGTRETFGLIAQEAMAsGIPVVGAKAGALKENVPl-GAGILCRPLDpeamaDACQSLFR 325
                        410       420       430
                 ....*....|....*....|....*....|....
gi 10175309  337 NRSKRAEMGYEARQya-lTQSWERifDDLLEQYE 369
gi 23125983  368 NENRNVIQRACEDAk---QFSLEQacENLHNYYQ 398
gi 16082094  325 LHEDRRKLAAEARHlvesKYSLERhiSSLLEIYD 358
gi 158333767 370 SPTLRRGMGDYAPSsv-eSYSWDRafQTLVELWE 402
gi 145299758 344 HKAERIKMGEIARRs---VTSWSMavDNMEIAIS 374
gi 17232833  375 NPELKSALSEQARPsi-iGYDWSAcmEKFESKLY 407
gi 154247727 360 DKALAARLRGTLAAer-gMLDWEPafEAWLDAVS 392
gi 113476717 370 DSNLRKEMGINGREti-sKYSWDNavANLVKIWQ 402
gi 119486566 370 NSDLRKQMGFKGLCcv-eDYSWDQtvENLVKIWE 402
gi 120537058 326 NDVVASGRYARRYVe--lHFSWESamKNLLEHYR 357
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