Conserved Protein Domain Family
GT1_ALG1_like

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cd03816: GT1_ALG1_like 
This family is most closely related to the GT1 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and Dol-PP-Glc-NAc2, and participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. In humans ALG1 has been associated with the congenital disorders of glycosylation (CDG) designated as subtype CDG-Ik.
Statistics
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PSSM-Id: 99986
View PSSM: cd03816
Aligned: 25 rows
Threshold Bit Score: 537.967
Threshold Setting Gi: 67462551
Created: 15-Dec-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13325168   30 RAARHVVaVVLGDVGRSPRMQYHALSLAMh-GFSVTLLGFCNSKPHdellqNNRIQIVGLtelq----slaVGPRVFQYG 104
gi 145355010   1 MTKRRTAlVVLGDFGRSPRMQYHALSLARdaDRAVDVVCYSGTPPIda-lsREDAVTMRYvvgcr-wrwltRVPLALALG 78
gi 31376395    2 GKRGRACvVVLGDLGRSPRMQYHALSLARqaSFQVDIVAYGGSIPHeavlnHPSIHIHTMaqprf-iqyfpKILYPVTLL 80
gi 146413485  50 GNRKSIAiIVLGDLGHSPRMCYHSLSFSKl-NYYVSLCGYLQSEPSdeileDVNIDIKAIpmv-----enhGLPFLLFAI 123
gi 71021131   42 CLGRSAAvVVLGDIGRSPRMCLHVESLANe-GWKVAIVGYAGSTLPpa-lqRSSIKQHHLrsppswiarmpRAAFIAVAP 119
gi 57223143   46 HLHHTATvLVLGDIGRSPRMMYHSESLARh-NWRTFMVGYAETPPTsalleNPMVHLLGLkepp---kmvgLLPWILRAP 121
gi 68488606   49 NKRKTISiFVLGDLGHSPRMCYHASSFSKl-DYYVNLCGYVETEPShqivdDVNIDIIPIeaik----ntnNLPYIMFAI 123
gi 49654589   52 GKRKTVSiFVLGDLGHSPRMCYHAKSFSKl-DYYVNLCGYLEEQPPfdiidDINIDIYPItvtk----ntsNLPFILFAA 126
gi 17555286   10 DERSEAAvVVLGDVGRSPRMCNHAKMLADe-GFDVKLIGFFDSIPGeqimnHPRIKIVGIpppp---dfmdSLPAFVQLP 85
gi 45187534   60 TKSRRIAiYVLGDLGHSPRICYHARSFSAa-GWEVELCGYLEEQPPkdlldDPRVTIRALpga------snAGKSLGQTA 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13325168  105 VKVVLQAMYLLwkl---mwREPGAYIFLQNPPGLPSIAVCWFVGcl--cGSKLVIDWHNYGYSIMGLVHg---------- 169
gi 145355010  79 TRVAAQCAHLFwil---mtMQRCEEMLIQNPPCVPTFLVCGIVCra--rRTRLVVDWHNFAYTLFGMKRg---------- 143
gi 31376395   81 LKAFIQFTMLLwfl--fvkVPAPDIFLVQNPPSVPTLIAVKWASsw--rRAAFVVDWHNFGYTLLALSLg---------- 146
gi 146413485 124 EKICMQVVSLFsll---feLRGIDYIMIQNPPSMPLLLISIIFVklfsrNTKIIIDWHNLNYSILNLKYn---------- 190
gi 71021131  120 FKLLVQAVSLFvelt-tqvHPPPELILVQTPPALPTLLVVKAAAal--vKSRVVIDWHNLAYTILALRLg---------- 186
gi 57223143  122 IRIIYQVFSVIhtci-wrvPCNTEILLVQNPPSIPTLALAQFICla--tKTKLIIDWHNTGYSILGLRVg---------- 188
gi 68488606  124 LKVVRQCGKIWsil---wdTRGSDYIMIQNPPSIPILLIVILFKtvfsrETKLIIDWHNLNYTILNLRYn---------- 190
gi 49654589  127 KKMVVQFFQLLkll---ldFRGTDYVLIQNPPSIPILLIVLAYIkvfsrKTKLIIDWHNLNYTILNLKFq---------- 193
gi 17555286   86 LKLFWNFITLFlalafqtsAFNLRIILMQNPPALPTMIVCFMFSif--kFAKFSIDWHNYMYSILQNKYqltddqvfgnd 163
gi 45187534  133 RKVVLQTCHIVrql---weLRGCDYILIQNPPSIPLLPIVAIFKvl--tRTRLILDWHNFAYTVLQLRVg---------- 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13325168  170 ---PNHPLVLLAKWYEKFFGRLSH-LNLCVTNAMREDla---dnWHIRAVTVYDKPASFFKETPLDLQHrlfmklgsmhs 242
gi 145355010 144 ---DASATTRMLKWYERTQGKMWGdAHVCVTKAMGNFlek--ewKIEGARVVEDRAAERFREAAREATTpedal------ 212
gi 31376395  147 ---RNNLLVSLYRWSENHYGKMAT-GSLCVTKAMQHEld---qnWGVRAKVLYDQPPEFFRPALLEERHelfcrvrkdlc 219
gi 146413485 191 --nENHPLVRFLKLYEMILGRFAF-YNLTVTKRMKRFlvsdfgmNSKKISTLHDRPASSFKPLQELETTkmdi------- 260
gi 71021131  187 ---EKSKLVRLAEWLEKWSGRKAF-AHLFVTEAMKNHldl-nwkLQGDKLVLHDRPPAHFRRATLEETHslmckvlpqiv 261
gi 57223143  189 ---EGSRLVRIAKWFESTFGQTAY-AHLFVTKALQEFlir-ewdLKGRTSVLHDRPPTHFHRTVPMIQHelfsrllpelk 263
gi 68488606  191 --nLNHPFVKLVKLYEKILGQFAN-LNITVTKSMKKYlvkefgfQKSKIVTLYDRPGVQFQPLSNKREFms--------- 258
gi 49654589  194 --nLKHPLVRILKTYERVLGQFAD-YNITVTRQMKEFlikefnfNKKKIITLHDRPGEQFKPLESLGVTkqei------- 263
gi 17555286  164 kktKKAQIVRCVGFLEGLCGKLSD-YNLCVTNAMRRDlm---drWGIRASTFYDRPPTDTTIQEIHDLYlrlsqkerilq 239
gi 45187534  198 --rFLHPLVLVSYAVEFLFSRMAD-YHITVTAAMKDYlvqsfllPARRIAVMYDRPGEQFRPLPAGERGaalae------ 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13325168  243 pfrars---epedpvtersafterdaGNGLvtrlrerpaLLVSSTSWTEDEDFSILLAALEKFEQLTLDGHnl------- 312
gi 145355010 213 ----------------------drflRGTHenmtknkprFIVSSTSWTPDEDFGVLLDAAVAYDARKRAKGdhask---- 266
gi 31376395  220 hpigvydfisrelenqelnetlfttkFNADislkqnrpaLVVSSTSWTPDENFGILLEAAVMYDRRVAARSkgsetaeis 299
gi 146413485 261 ----------------------lnshPLFQditgvdkykILVSSTSFTPDEDFNILLDALKYYDSSEKNEP--------- 309
gi 71021131  262 psigdd---wlpscnlpdstpftqrtDGGElqwsqdrpaLVVSSTSWTADEDFGLLLRAAKLYEYRARLLAiqsslpphs 338
gi 57223143  264 pslpps----hldtndpthtafteisSEGLavlkhtrpaLIISSTSWTADEDFSLLITALDLYQSAVDSGSal------- 332
gi 68488606  259 -------------------------eHKLFedidiekykVLISSTSFTPDEDFNILLDALKNYENTPNTPP--------- 304
gi 49654589  264 ----------------------leshDIFRdiqniskykILVSSTSFTPDEDFNLLLSALNQYDNSLAERGlp------- 314
gi 17555286  240 g-------------kdedstilthksSNGVvqllttrpiVFLSSTSWTPDERFEILLDALVAYDKTIGLPR--------- 297
gi 45187534  269 ---------------------pfirgYIPAgfdvqrgdtILVTSTSFTLDEDINVLFGALKIYESAAAKFDttl------ 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13325168  313 ------------------------------------------------------------------psLVCVITGKGPLR 326
gi 145355010 267 ----------------------------------------------------------------sypdIVIIITGQGPRK 282
gi 31376395  300 ------------------------------------------------------------eeqhhypnLLFIITGKGPEK 319
gi 146413485 310 --------------------------------------------------------------------LLLIVTGKGPLK 321
gi 71021131  339 rssstaetvsatlspvsasscssasttshfsytdiadpirtskerrrpsigalrtptlpnepasslpkLLIIVTGKGELK 418
gi 57223143  333 ------------------------------------------------------------------pkLVVLITGKGALR 346
gi 68488606  305 --------------------------------------------------------------------ILLIVTGKGPLK 316
gi 49654589  315 -------------------------------------------------------------------pILIIITGKGPLK 327
gi 17555286  298 --------------------------------------------------------------------VLMIITGKGPLK 309
gi 45187534  322 ------------------------------------------------------------------prILLFVTGKGPLK 335
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13325168  327 EYYSRlih----qkhFQHIQVCTPWLEAEDYPLLLGSADLGVCLHTSSSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVK 402
gi 145355010 283 TMYEKkin----elaLEHVAFRTVWLDAADYPRALANAHLGVSLHTSSSGLDLPMKIVDMFGASLPVAAMRYAVIGELVQ 358
gi 31376395  320 EMYEEkik----rlnLRHVAFRTMWLAAEDYPLLLGSADLGVCLHTSSSGLDLPMKVVDMFGCGLPVCSVSYSCIQELVK 395
gi 146413485 322 QAFRErvkd---lrfLKKVIVKTAWLSVEDYPVVLAIADLGVSLHTSSSGIDLPMKIVDFFGCGIPVISLDFPAIDELVK 398
gi 71021131  419 ARYLAeiahleateaWQFVRIRTAWLESQDYPLLLGSADLGVSLHTSSSGLDLPMKVVDMLGCGLPVCALDFACLDELVC 498
gi 57223143  347 APFENivksr-eiskWKDITVRCVFVPAQEYPPLLGCADLGVSLHTSSSGKDLPMKVVDMFGCGVPVLAKDFQCISELVK 425
gi 68488606  317 GKFLEtvdk---lefTNKVCVKSAWLSSEDYPKVLACADLGISLHTSSSGIDLPMKIVDFFGCGVPVVSLDFPAIDELVK 393
gi 49654589  328 SQFLQkvkq---lnfLDNVIIKNAWLSSEDYPLILSVADLSISLHTSSSGIDLPMKIVDFFGCGIPVITLRFPAIGELVT 404
gi 17555286  310 AKYLQeih----eknLKNVDVLTPWLEAEDYPKILASADLGISLHTSTSGLDLPMKVVDMFGAKVPALALKFKCIDELVE 385
gi 45187534  336 GKYMEevr----nykWERCTIHFLWLSAEDYPRLLQLCDFGVSLHTSTSGLDLPMKVLDMFGSGLPAFVMDYPAIGELVQ 411
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13325168  403 HEENGLVFEdSEELAAQLQMLfsnfp---------dpagkLNQFRKNLREsq-------qlRWDESWVQTVLPLV 461
gi 145355010 359 EGVNGVLFAdATELAAMFAKLlrgd-----------erltLRALKHGAAKwg-------eqTWDDHWKRCALPVF 415
gi 31376395  396 DGKNGLLFSsSSELADQLLILfkgfp---------gncdaLMSLKAGAMEtgs------sgRWATEWEDCAKPLI 455
gi 146413485 399 HDYNGVVVT-GKDQAKVICQHlehlf---------rdqekLNRLKNGAIEes-------htRWNENWNRVMKPRF 456
gi 71021131  499 ERWNGVVFRdAEGLARQWESLlanh-----------plpnWLSTGGGMQEpfdpp-arsvlTPKTGWLCEPGNTS 561
gi 57223143  426 DGENGKVFGtGEELGEQMIDIlssfpsseklddlkgyfdrMNTPRRRATLptadvgedewsNWDDNWDNVVYNGI 500
gi 68488606  394 NKVNGLITNsKSDQTKEVARLvtevf---------tddalLRSIKEGALEes-------nsRWDENWMQTFSSIF 452
gi 49654589  405 HGTNGLITKsDKDSSVNESQEiyrllte-----afkndelLDKIKQGALKes-------nlRWEENWNNKMGKRF 467
gi 17555286  386 EKTNGYLFDdSEQLSRQIIELsrgfp---------nncneLIRLKKNTQEqk-------fdSWEVMWKRSATSGA 444
gi 45187534  412 DRVNGLRFTtRRELEQCLIFAikd-------------ehtRKVLKENALLes-------knRWHQRWASAMSELQ 466
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