Conserved Protein Domain Family
GT1_WavL_like

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cd03819: GT1_WavL_like 
This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.
Statistics
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PSSM-Id: 99989
View PSSM: cd03819
Aligned: 37 rows
Threshold Bit Score: 291.436
Threshold Setting Gi: 19713867
Created: 15-Dec-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #                                                                  
gi 51892236    5 LLAAMALDl---GGAETHVISLARELhrrGHRVVVASAGGRMvplleergiphivvpmasrNPLAMARAYRRLRRLIaEH 81
gi 19713867    1 MNILMALSqleiTGAEVYATTIADELierGNKVYIVSDTLTTptkaeyi-----klefnkrSLLKRIEHIKFLYNLIkEK 75
gi 39545763    1 MNILMALSqlevTGAEVYATTVGNELtrrGHQVFYVSDTLTKahagpgf-----klrfnkrSILRRFWHVFYLVYLIkKH 75
gi 18653291    1 MNILMALSqlevTGAEVYATSVGNELtrrGHQVFYVSDTLTKahdglff-----klrfnkrSIPRRFWHVAYLVYLIkKH 75
gi 15836707   12 VQLLPALCs---GGVERSTLEVAAALvqaGHRAIVVSAGGPLvafllsiga-ehitldigrKSLLTLRHIAALRRLFaQL 87
gi 120553731   4 LQALPALYs---GGVERGTVEFAAELvkrGHQSFVVSNGGPMaeqvrgqgs-thihmpihrKTPASFGQVLPMRKLLqEL 79
gi 50083724    4 MQLLPELNs---GGVERGTLEIARALvkaEHQSLVVSHGGRLvaqleaegs-thltlpihkKSLSSLWQIRPLRQLIeAH 79
gi 154149084   4 VQILPELNe---GGVERGVVELNREFvknGIENFVITKGGKLagiiekdggklilhdvcskNIFTAPVRILKLRKILkEI 80
gi 88705775    4 LQVLPALDt---GGVERGTLDIARALvqaGHSSSVLSGGGRMvsrlqkqgs-dhvlwslgkKSPLSLRHVRPLRRWLaSQ 79
gi 152991185   4 VQLLPELNe---GGVERGVVELNRELvkrGIESIVISRGGKLveliekeggkhivfdvcskNLLTAPYRIAKLKKVFeQI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 51892236   82 QIGLIHAHARIPAWLCALAVRgk----giPLVTTYHGVYNAgfpWKYLTTFGQRAIAVSEDVRRHle-gpLGAPPAIIRV 156
gi 19713867   76 DIQIVHAHSRASSWSCQVACKla----giPLITTTHGRQPIhfsRKLIKAFGNYSIAVCENIKKHmi-ndIGFSENKVSV 150
gi 39545763   76 HIQLVHAHSRASGWSSYVACKlt----gtPMITTVHGRQPVhasRKAFHALGFRAVAVCEDIASQii-dnLGVDPAIVQV 150
gi 18653291   76 QIQLVHAHSRASSWSCHIACRlt----ntPMVTTVHGRQPVhasRKKFHAMGDKALPVCEAIREQli-tdLSVPESQLHV 150
gi 15836707   88 RPDIVHARSRLPAWLTWYALHglffspkpRFVTTVHGLNAPn-pYSAVMTYGERVICVSNVVHDYvlrhyRRTDPQRLRT 166
gi 120553731  80 KPDIVHVRSRMPAWIIHLALKtlprnehpAIVSTFHGMYSVn-pYSAIMARADQVIAVSNCVRDYvl-enFPVPENKLTV 157
gi 50083724   80 QPDIVHVRSRVPAWLTHFALRgipkqrrpHLISTVHGFYSVn-rYSAIMTQAEKVIAVSDSVVKYitdhyKNCPPQDIVR 158
gi 154149084  81 KPDIVHIRSRVPAWMVHFAKPk------cKIISTVHGANSVn-fYSKIMVKADRIIVPSNFIKEYii-knFNADESRISV 152
gi 88705775   80 HFDILHLRSRMPGWLCWLAWRgmdpatrpRLVTTVHGMHSVs-rYSEIVTCGERIIVVSESIRDYvlenyPRCDPDKLRL 158
gi 152991185  81 QPDIIHARSRVPAWLSFLAKGe------tPFVTTVHGFNSVn-aYSAIMTKGDRVICVSNPVKEYil-knYKVDEEKVRV 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                ###                                     
gi 51892236  157 IPNGFETGEFRPGldiapll------relgvdRTGPHVVHASRltdefADTAVALLQALPRLneq--fptIRLWILGDGN 228
gi 19713867  151 ILNPVNYKKLDLEkk----------------vNDKKVISIVGRls--gPKGDVAYDLLEILSqdellskyKVCLIGGKEL 212
gi 39545763  151 LRNGIETDKFQPVsa---------------pdNAKPVIAIIGRls--gPKGELCYRLLDEVLdld---acQVKVVSGSQL 210
gi 18653291  151 SRNGIETSTFQRCaa---------------pnNPKPVISIIGRls--gPKGELCYRLLTECLdld---ryQVQVITGTPL 210
gi 15836707  167 IPRGVDLARFRRRpypdrsarrwvrkyvpcldDNTRLLLMPGRgt--rLKGHGDALLLLAFLrrvs-dynVCLWLPGACE 243
gi 120553731 158 IQRGVNIDAFRNRaindqwldi--llsrfpqlAGKKIIMMPGRis--rWKGQLHFMEAMARIvrq--rpdCHGIIVGGAE 231
gi 50083724  159 IYRGIDPQAFPHGyqpsaqwin-hiytlfpqlENKFLICLPGRit--rLKGHETLIELMERLqte--ypnVHAVVVGGAD 233
gi 154149084 153 IFRGVNLENFDATkfeskekl----rnefglkKDDFIISCVGRis--nLKNIETIIKAIKILen----enIKLLVVGGVH 222
gi 88705775  159 IYRGINPLEFPRGhqpaeqwls-dwyrefpqlLDQRVVTMAGRlt--rLKGHHDFVDVIEQLrkt--gqpVHGLIVGGED 233
gi 152991185 153 IHRGVDFSKFDPKkidqkfie---efkakytlHNRFIVTSVGRit--qLKDYETFIEAIAILkkr--rpdIVGLIVGGVR 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        #                          #                    
gi 51892236  229 RYAEVarlad--evnrrLGREAARAVGh-RLDVPAFFnlADCVVAVA-------RTATEAMLCERPVIIAGEGGYRGILT 298
gi 19713867  213 PERFLk-----------FKKKYIEFIGyvPNIQEKIFe-SDIVIGAG-------RVAFESLLNKTALIAVGETEYIGFVN 273
gi 39545763  211 PERFV------------RFRDRVDFVGy-VEDVPALMaqCDLVIGAG-------RVAMEALLCGRPAFAIGEAKAIGLVT 270
gi 18653291  211 TERFS------------ALQDKVSFPGy-STNVEQIMaqSDLVIGAG-------RVAMEALLCGRPTLAIGEASCVGIIE 270
gi 15836707  244 PGRESylaeleaqarelGVTDRVVFTPp-TEHIVEAYaaSDLVLQLSrkpeafgRTVLEALAVGRTVLGWNHGGVGELLT 322
gi 120553731 232 PGKERflqelekersrlGLTDKVTFLGq-RNDMTNLYllADVVCHMStkpepfgRTVTEALASGTPVVAYNRGGAAETLQ 310
gi 50083724  234 PKKKAyldeleatiqdrGLREKITFVGh-TSEIREWLafSDIVLSLSnqaetfgRTALEALSVGTPVIGWNRGGVAEILS 312
gi 154149084 223 PKRKKyfeflkklicklDLKKSIIFLGs-ISEIAKIYalSDVVVSASikpesfgRSVAEAIALNRPVVASNHGGVKDIII 301
gi 88705775  234 PKRIAyareiyqavkerGLEEHLTFAGh-RGDLRDIYavSDVVLSLStqpesfgRTVLEPLSEGRPVVGYDHGGVAEILS 312
gi 152991185 226 EDKRDyfkklqdlvkvlELQNTIFFTGs-ISKIAEIYalSDVVVSTSkkpesfgRSIVEAMALNTPVVATNHGGALDIVK 304
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
Feature 1                                                                      
gi 51892236  299 PEriplyaGSNFTAREGGTPLNPAvla----adIAGLLAPGNEAERQRlgRAGREFVVASLS 356
gi 19713867  274 KEnl---dKSLASNFGDIGSMKYPk-------iEKEILLNDIKKALNLseNEKEELKDIIFK 325
gi 39545763  271 GQnl---dEALASNFGDIGPRDLAidfaalktqIAPALSSGSVFDVIRq-RIQAEYGLAGVV 328
gi 18653291  271 LDnl---nQAMATNFGDIGPQDLAid-----fqQIPALIEQGLSQPHCaqEITEQIKLNYDL 324
gi 15836707  323 QLq----pDGAVPPFDIAALQRRAaml----lmHSPELPPDIPYTLQTmqSATLQVYDELCT 376
gi 120553731 311 ACf----rDGLVTPDDTGAFASAVlgll--dkpRPEIELPERFLLRAQ--TEATLAIYQKLM 364
gi 50083724  313 HLy----pQGLIEVDDREALFHAVeq------hIKNLQPVAPVQQFSLddMCNKTLDLYQSV 364
gi 154149084 302 EDv-----NGYFFAPLDEKELAQKilm---akdLKFDGYSYIKSKFSLekMCNENLKIYKEV 355
gi 88705775  313 ALy----pRGAVPVRDTAAAATQVaa-----ilSGQVAPPRRNTQFLLdvMARDTLSVYEEL 365
gi 152991185 305 NG------YGELFEVGNAVDLAQK---------IESVKPKDFANYVQK--NFSLEKMVEQTM 349

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