10 20 30 40 50 60 70 80 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....| gi 3142215 329 RIGWLTTWNt-kCGIATYSQHLVESapHGADVVFAPQVSAGdlvcadeef--------------vlrnwivgkESNYLEN 393 gi 67939115 7 HVALVSPFFplkGGIARFSTTLRNVllKRGRKVDGISFKRLypgillrgkavfepga-siepedgvlplidtlNPLTWFT 85 gi 67919337 2 RIAFISPFFplkGGISRFSGLLADElqVKGHAVRRLGFKKLypsfltgghapevpe--yrsaanggdavivlyNPLTWLT 79 gi 119358210 5 RIAFISPFSplkGGIARFSGQLMDAlrQSGYDVIPFGYRKLfpavffsqprfggehpetscsdigeepilvlyNPFSWVS 84 gi 78189823 2 RIVLLSPFPplkGGIAHCSGALHAAltAAGDAVVVLPFKKLypsfpsflfsals-------pptpsnatlvlyNPLTWLS 74 gi 150400827 2 KICLVGPTYpykGGISHYNTTLCNElsKRHNVFLISYKRQYpsflypgkeqinkdsnikvnettnfeyiidtiNPLTWIK 81 gi 76259645 2 RIAVVGPTYpfrGGIAHYSTMLVHHlrAAGHTTFFYSFTRQyptwlfpgrsdrdps--taplrveceylldpiNPFTWWR 79 gi 159899870 2 KLCVVGPTYpyrGGIAHYTTLLVKHlrEVGHHVRFYSYTRQyprwlfpgktdkdps--atplrveceyvldptNPITWWR 79 gi 150009368 2 RFAILSPIYpyrGGIAQFSGMLYTElvKEGHEVKAFNFKRLypdilfpgktqyveag-draieiesvrvldsvNPVSYFS 80 gi 148655256 2 KITLIGPTYpfrGGIAHYTTLLTHHlrQRHDVRLISYIKQYpkwlypgntamdpspd-esalrvecdrvltpmNPLTWWR 80
90 100 110 120 130 140 150 160 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....| gi 3142215 394 LQPhiDALRLDVIVIQFnYGFFNHRELSAFIrrqhdAGRSVVMTMHS---TVDPLEKEPSWNFRLAEMKEALALc----d 466 gi 67939115 86 TARsiRRIQPEIMICAYwLGPLSPIYWLLQRi----TGIKMIVLMHNy-tSHERFFAEKKFRDLLLKEADGVVTls---e 157 gi 67919337 80 LLRdlKRERPEVLLVAYwTGLLAPLLFAVRKl----SGIRTVVLLHNl-sTHEPFMFEPFLQKLLLASADGFITls---r 151 gi 119358210 85 AVRrlGQLKPDILLIAYwTGFLAPLCFMLRRm----TGIKTVILLHNf-sSHESFGIDPFFKRLVKFSADGFLTls---r 156 gi 78189823 75 AVRriREQKPELLVIAYwSGVLAPLALLFCRl----SGTRMLLLLHNl-tGHEAFWGESFLQRKLLSSVAGVVTls---h 146 gi 150400827 82 TYSkiKNENPDLVIFQWvHPFFTFVFFTITYllkkfTNIKILYICHNv-lPHERTKIDEFLIKMAFKNVDYFIVhskedy 160 gi 76259645 80 LVRrvRADQPDLLLLQWwVPYWTPSLTVISSllkrpPATKIAMICHNvlpHDGGGVIDRRLAMTVLRRADALIVhsepdr 159 gi 159899870 80 LCRkiRADNPDLVVLQWwVPYWTPSLSYISRwlkkhTKAKIVYICHNvmpHDGGGFLDRRMASTVLKQGDALIVhsdqdl 159 gi 150009368 81 TVNaiRSYAPDVLIISYwMSFFVPGYAHVANrm--kKHCKVITLIHNa-iPHEPRFFDKPLASLLFKQCHGFIVmsdnvr 157 gi 148655256 81 AFRmiQRDNPDLLLLQWwTPFWSPMLFVLTRlvrryTNVRILFLCHHv-iAPDGGMFDWYLARRILWRGHAFIVmseedf 159
170 180 190 200 210 220 230 240 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....| gi 3142215 467 RLLVHSiadmnrlkdlgltanvaLFPHGVINYSaasvt-------------rqqqSLPLIASYGFCLpHKGLMELVESVH 533 gi 67939115 158 YVARQVknsyp-------evpvkALFHPVYSPGgtlisrqda-----crtlgidpQERVLLFFGYVReYKGLDLLVDAMP 225 gi 67919337 152 EVAGALaaagn-------akpvvQLYHPPYPPFptfsgsvqpeksearhtlgydaEAPVLLFFGYVRrYKGLDLLLRAMP 224 gi 119358210 157 EVATELaesrc-------avpvsEQFHPVYDHRheltvlrdd----arqelglepETPLLLFFGYVRrYKGLDLLLQAMP 225 gi 78189823 147 TVTRQVqhvap-------slptlTLFHPIEKLPapsfsklea-----rkalgltsNAPVLLFFGYVRrYKGLDLLLQALP 214 gi 150400827 161 NNLKKIipna----------kvkQSVLPTYNIFktkktsked----trkslnidrNKKIILFFGIIReYKGLIYLIKSMP 226 gi 76259645 160 YRARALlpha----------rivKAFLPTYEPIltnaasavna--alrhqwqvpdQRRILLFFGFVRpYKGLEYLIQALA 227 gi 159899870 160 HRAQALlpqa----------avlKSQLPTFEEVakhtdsaaie--rlrgqlgissDHDILLFFGFIRpYKGLEYLIQALP 227 gi 150009368 158 YDLRKLypga----------kyiQNPHPLYNHFgskinknea-----crklgihpSKKNLLFFGLIRdYKGLDLLIEAMG 222 gi 148655256 160 ALLRRAlpwa----------rirGVTHPPYDVFsrtsllrve----ararlgldpDEPVLLFFGFVRrYKGLRHLIQALP 225
250 260 270 280 290 300 310 320 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....| gi 3142215 534 RLkqagkpvrLRLVNAEYPVGESRDLvaelkaaaqRLGVTDLIDMHNdflPDAESLRLLSeADLLIFAYQNtgeSASGAV 613 gi 67939115 226 EVvrr--hpgTRLVIAGEFYYGEKLFrer----ieQLGVGCRVSVYPgfvPPERMRLFFSvADAAVLPYREa--SQSGVV 297 gi 67919337 225 AIlav--wpeARLLVAGQFYEPEATFrel----igRLGIGESVDLRPgysSDRDAACYFAaADAAVLPYRQa--SQSGVV 296 gi 119358210 226 GIlrv--derVRLMVAGEFYEPLEGYrgm----idRLGIAGSVDLYPgyaTEERTSLLFAaADAVVLPYRSa--SQSGVV 297 gi 78189823 215 HVvaq--epsLQVVVAGYFYEPLPRYqqi----aeTLGITHNVTFHAgyvPSEKNATYFAaADGVVLPYRAa--TQSGVV 286 gi 150400827 227 KIine--vddINLLIVGEFWDDKDKYide----ikKLGIKNHIKIIDkyiPDEEVGIYFSaADVVVLPYISa--TQSAVI 298 gi 76259645 228 QVrqq---ldVHLLVVGEIWGSPAYYqry----aaEFGVTEAITFVDryvSNEELPAIFStADVVVLPYVSa--TQSAVV 298 gi 159899870 228 LVvqe---rpVHLLVVGEFWASPEFYqry----trEYGVEANVTFVNryvPNEELGPYFDlADVVVLPYISa--TQSAVV 298 gi 150009368 223 QLne-----dYHLIIAGECYGSFEKYqal----idASPAKERIFVHCeyiSDEEIPIYFSaADALVLPYRSa--TQSGVV 291 gi 148655256 226 LIrqh---vpVRLLVVGEFWEDDRPYrel----vrNLNLGDVVHFHSeyvPNEQIAVYFSaCDAVVLPYLEa--TQSGVA 296
330 340 350 360 370 380 390 400 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....| gi 3142215 614 RYGMATQKPVAVTPl-----AIFDDLDDAVFKFDgcsVDDISQGIDRILNsirEQDAWATRTQQRAd----aWREQHDYQ 684 gi 67939115 298 QQAYGFGCPVIVSGmgglpeAVDEGKTGVVVRDLd--PLSLADGICSFLEn-sKAVPYRENVDRYAah--fsWEVFAEKL 372 gi 67919337 297 QLACGYGLPVIVTPagglaaEVEQGRTGWIAGDLs--SEAIAAAVIGFLGd-pRRPAMPQSVREYAag--hsWERFAGEA 371 gi 119358210 298 SLAYGYGVPVIVTAvgglagMVEPRQTGWIAAEPs--VDALVEVVGRFLGe-rGDVDTSAAIRSYCqk--asWLVLAERT 372 gi 78189823 287 PMAFAYGVPVIVTPvgalseMVQHGTTGWIAKAAs--PDAIAAALREWLAnreRWSAMRSSIEAMRds--vsWERFAAEC 362 gi 150400827 299 QTAYAFEKPVITTNvgglpdVVDDNKTGIIVKSEn--SEELASAIINYFKn-dKERKFTENIKIKNke--fsWEKLIKDI 373 gi 76259645 299 QLAFGFGKPVITTNvgglpeVVQDGVTGLIVPPQd--AHALAQAIVRYFQd-dLAPCLTANVQASAteraesWPRLVSII 375 gi 159899870 299 QLAFGLGKPVITTRvgglheVVRDGVNGLVVPPQd--EVALAKAILRYFQa-eLKAPMTAAVHAERgqqlhgWEHLINCL 375 gi 150009368 292 SVAYNYDLPMLSTPvgdfknSIEKPGTGIVVPEIs--ATALAQGIEELFTp-sQQATIPANISKEKaa--lsWETLTRKL 366 gi 148655256 297 QLAIGFEKPMIATSvggmpeTIHNGETGLIVPPGd--SAALADAVVRFFRn-gLAEPFTRNIRTVRer--dsWLPLVHLI 371
....* gi 3142215 685 AVSRR 689 gi 67939115 373 EEFTL 377 gi 67919337 372 GSFIQ 376 gi 119358210 373 GRFLE 377 gi 78189823 363 QPFFA 367 gi 150400827 374 ENLVE 378 gi 76259645 376 TDLAH 380 gi 159899870 376 ERIGA 380 gi 150009368 367 LDFIN 371 gi 148655256 372 EELAE 376
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.",