Conserved Protein Domain Family
Rhes_like

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cd04143: Rhes_like 
Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)
This subfamily includes Rhes (Ras homolog enriched in striatum) and Dexras1/AGS1 (activator of G-protein signaling 1). These proteins are homologous, but exhibit significant differences in tissue distribution and subcellular localization. Rhes is found primarily in the striatum of the brain, but is also expressed in other areas of the brain, such as the cerebral cortex, hippocampus, inferior colliculus, and cerebellum. Rhes expression is controlled by thyroid hormones. In rat PC12 cells, Rhes is farnesylated and localizes to the plasma membrane. Rhes binds and activates PI3K, and plays a role in coupling serpentine membrane receptors with heterotrimeric G-protein signaling. Rhes has recently been shown to be reduced under conditions of dopamine supersensitivity and may play a role in determining dopamine receptor sensitivity. Dexras1/AGS1 is a dexamethasone-induced Ras protein that is expressed primarily in the brain, with low expression levels in other tissues. Dexras1 localizes primarily to the cytoplasm, and is a critical regulator of the circadian master clock to photic and nonphotic input. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins.
Statistics
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PSSM-Id: 133343
View PSSM: cd04143
Aligned: 8 rows
Threshold Bit Score: 391.034
Threshold Setting Gi: 66911058
Created: 2-Sep-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
  next features
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Based on sequence similarity to Ras, bound to Mg2+/GTP analog

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #######                                        #  #                     
gi 21362868  20 YRMVVLGASRVGKSSIVSRFlNGRFEd--qYTPTIEDFHRKVYNIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILV 97
gi 41056181  20 YRMVILGSTKVGKTAIVSRFlNGRFEe--qYTPTIEDFHRKLYSIKGDVYQLDILDTSGNHPFPAMRRLSILTGDVFILV 97
gi 51703966  18 YRMVILGSSKVGKTSIVSRFlSGRFDe--qYTPTIEDFHRKFYSIRGDVYQLDILDTSGNHPFPAMRRLSILTGDVFILV 95
gi 7295299  167 YRLVMLGSSRAGKSSIVARFlGNRFEe--aYTPTIEEFHRKLYRIRNEVFQLDILDTSGYHPFPAMRRLSFLTGDLFILV 244
gi 66911058  95 RRVVVLGAPRVGKTALIRRF-LGEEVfeehYEPTSEDFHSKLYHIRGERYQLDILDASKERDFPAKRRLTILTGDIFLLV 173
gi 47215408  49 HRVVVLGAPKVGKTNILRRFlGGEFEe--gYEPTTEDFHRKVFYIKGQAYQIDLLEASGERNFPAKRRLSILTGDIFLLV 126
gi 38258272  25 YRMVILGSSKVGKTAIVSRFlTGRFEd--aYTPTIEDFHRKFYSIRGEVYQLDILDTSGNHPFPAMRRLSILTGDVFILV 102
gi 49257586  20 YRMVVLGASKVGKSAIVARFlNGRFEd--qYTPTIEDFHRKLYNIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILV 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                      ## #                             
gi 21362868  98 FSLDNRESFDEVKRLQKQILEVKscl-----knKTKEAAELPMVICGNKNDHGelcRQVPTTEAELLVSGDe-nCAYFEV 171
gi 41056181  98 FSLDNRESFHEVQRLKQQIYETKscl-----knKTKENVDVPLVICGNKGDREf-yREVQRDEIEQLIAGDe-qCAYFEI 170
gi 51703966  96 FSLDNRDSFEEVQKLKQQIMETKscl-----knKTKENVDVPIVICGNKVDRDf-yREVQAHEIDQLVGEDs-kCSYFEV 168
gi 7295299  245 FSMDSRESFEEVVRLRENILETKwaalnpgsgfKKKSLPKIPMILAGNKCDRDf--KTVQVDEVMGYIAGQdncCTFVEC 322
gi 66911058 174 FSVTDRDSLTEVCSLREEIFTAKsk------ltKSKENRQLPIIICANKADVDs-pRAVQRSDVAQCLGED---SVLFEV 243
gi 47215408 127 FSLDDGESFSEICELLSEIRAAKak------lrKLKTPAKIAAVVCGNKADLKa-pRGPRRPQVTEILGED---AAYFET 196
gi 38258272 103 FSLDNRDSFEEVQRLRQQILDTKscl-----knKTKENVDVPLVICGNKGDRDf-yREVDQREIEQLVGDDpqrCAYFEI 176
gi 49257586  98 FSIDNRDSFDEVKRLRKQILEVKscv-----knKTKETGEFPMMICGNKSDYGehhRKVRAEEAERLVSGDe-nCAYFEI 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       ##                                                                              
gi 21362868 172 SAKKNTNVDEMFYVLFSMAKLPHEMSPALHRKISVQYGDafhprpfc-----------mrrvkemDAYGMVSPFARRPSV 240
gi 41056181 171 SAKRNTNVDQMFQRLFTLAKLPNEMSPDLHRKVSVQYCDilhkkslk-----------nkkvkdgDAYGIVAPFARRPSV 239
gi 51703966 169 SAKKNSSLDEMFKALFTMAKLPSEMSPDMHRKVSVQYCEilhkkslk----------skkvkedgDAYGIVAPFARRPSI 238
gi 7295299  323 SARQNYRIDDLFHSLFTVSNLPLEMTPNHHRRLVSVFGApsplpphgsavggtkknalsikrrfsDACGVVTPNARRPSI 402
gi 66911058 244 SAKTCTNLEEVFEALAVLGGLPTETRPSLHRDISIHTYHalssrkr-------------nkravnEPCGAVHPLARRPSF 310
gi 47215408 197 SAKDGSGLDAAFRTLASLGGLPDETAPSRHQLISIVSYQslcgsqrgr---------gtrarglgAPCAAVDPVARRPSF 267
gi 38258272 177 SAKKNSSLDQMFRALFAMAKLPSEMSPDLHRKVSVQYCDvlhkkalrnkkll-ragsgggggdpgDAFGIVAPFARRPSV 255
gi 49257586 172 SAKKNVNVDKMFQVLFSMAKLPNEMSPALHRKISMQIGDtfhqksfr-----------lrrlkevDAYGMVSPSARRPSV 240
                       250       260       270
                ....*....|....*....|....*....|..
Feature 1                                       
gi 21362868 241 NSDLKYIKAKvlre------gqarERDKCTIQ 266
gi 41056181 240 HSDLMYIKEKaigg------gqtkDKERCIIS 265
gi 51703966 239 HSDLMYIRAKaigg------gqskDKERCVIS 264
gi 7295299  403 RTDLNLMRSKtmalnegegvrspsRWNRCALM 434
gi 66911058 311 SSDLRRVLGPstpk-------kstPIERCQIQ 335
gi 47215408 268 TSDLRMVLSSstk---------hnKPERCQIQ 290
gi 38258272 256 HSDLMYIREKasag------sqakDKERCVIS 281
gi 49257586 241 NSDLKYIKSKvlge------gqgrDREKCSIQ 266

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