1ZJ6,1YZG,1Z6Y


Conserved Protein Domain Family
Arl5_Arl8

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cd04153: Arl5_Arl8 
Click on image for an interactive view with Cn3D
Arf-like 5 (Arl5) and 8 (Arl8) GTPases
Arl5/Arl8 subfamily. Arl5 (Arf-like 5) and Arl8, like Arl4 and Arl7, are localized to the nucleus and nucleolus. Arl5 is developmentally regulated during embryogenesis in mice. Human Arl5 interacts with the heterochromatin protein 1-alpha (HP1alpha), a nonhistone chromosomal protein that is associated with heterochromatin and telomeres, and prevents telomere fusion. Arl5 may also play a role in embryonic nuclear dynamics and/or signaling cascades. Arl8 was identified from a fetal cartilage cDNA library. It is found in brain, heart, lung, cartilage, and kidney. No function has been assigned for Arl8 to date.
Statistics
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PSSM-Id: 133353
View PSSM: cd04153
Aligned: 14 rows
Threshold Bit Score: 299.65
Threshold Setting Gi: 70875594
Created: 1-Sep-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              #######                                                  
1ZJ6_A        3 ILFTRIWRLFNHq-EHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVIn------nTRFLMWDIGGQESLRS 75
1YZG_A        3 LIFAKLWSLFCNq-EHKVIIVGLDNAGKTTILYQFLMNEVVHTSPTIGSNVEEIVVk------nTHFLMWDIGGQESLRS 75
1Z6Y_B        3 ILFTRIWRLFNHq-EHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVIn------nTRFLMWDIGGQESLRS 75
gi 71022941   3 VAFSSLWTSLFGskELKICILGLDNAGKTTLMYKMTLGSVVSTAPTVGSNTEQFEYk------nLKFMLWDVGGQTSLRT 76
gi 17551732   3 LIMAKLFQSWWIgkKYKIIVVGLDNAGKTTILYNYVTKDQVETKPTIGSNVEEVSYr------nLDFVIWDIGGQESLRK 76
gi 26514148   4 RLFTKFWRLFNSr-VYKVIILGLDNAGKSTILYQFVLKEAVQTSPTIGSNVEEVKWk------nLHFVMWDIGGQTSVRA 76
gi 57229193   3 VTFSSLWSRLFArkETKVLLIGLDNAGKSTILYRITTGAVVASAPTVGSNHEIYDYk------gVRFGLIDIGGQTSLRS 76
gi 70875594   3 TLFSSFWSLFVPsrNYKLVILGLNNAGKTSILYHLQLGHAITTQPTLGGNMEQLSVahgpnnntIQFTCWDLGGQEQLRD 82
gi 15228912   3 AFMSRFWFMMFPakEYKIVVVGLDNAGKTTTLYKLHLGEVVTTHPTVGSNVEELVYk------nIRFEVWDLGGQDRLRT 76
gi 66824125   6 SIFASIWNRFFNnaEYKVIIVGLNAAGKTTTLYKLLLDEVVSTTPTVGSNLEEFVYr------nIRLLMWDLGGQDLLRS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                         ## #                          
1ZJ6_A       76 SWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEd-LRKAGLLIFANKQDVKe---cMTVAEISQFLKLTSIk-dH 150
1YZG_A       76 SWNTYYSNTEFIILVVDSIDRERLAITKEELYRMLAHEd-LRKAAVLIFANKQDMKg---cMTAAEISKYLTLSSIk-dH 150
1Z6Y_B       76 SWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEd-LRKAGLLIFANKQDVKe---cMTVAEISQFLKLTSIk-dH 150
gi 71022941  77 SWTSYLASTDAVIFVLDSNDRERVTLARQELHRIAQDEq-VAKAPILVWANKQDIKg---aMTPAEISESLALTAFr-eR 151
gi 17551732  77 SWSTYYVQTDVVIVVIDSSDTTRIPIMKEQLHNMLQHEd-LARAHILVLANKQDLPg---aMNPAEVSTQLGLQTLrgaR 152
gi 26514148  77 SWTTYFSGSDFVILVIDSTDRERLCLTKQELYKLLIAEe-LKRSKMLIFANKQDVSg---cMSVAEISHNLNLTSIr-dH 151
gi 57229193  77 SWSQYFNGTEAVILVIDSCDGPRLGLVKQELMKIVADEs-LSTALLLVLANKQDLPvsqgrLTPAQISEALSLTDLr-qR 154
gi 70875594  83 SWALYYEQTDAVIFVVDAADVSRFAVARKVLQGLLNNEpcLRKAVLLVLANKQDLRg---aVSPVEMIEALGLGAVr-dH 158
gi 15228912  77 SWATYYRGTHAVIVVIDSTDRARISFMKDELARLLGHEd-LQNSVILVFANKQDLKd---aMTPAEITDALNLHSIk-nH 151
gi 66824125  80 TWNQYYINTQAVILVIDSTDRARVNLIKEELFKMLAHEn-LKKSIILIYANKQDLKd---aMSPTELSTLLSLHSIk-dH 154
                       170       180
                ....*....|....*....|....*
Feature 1              ##                
1ZJ6_A      151 QWHIQACCALTGEGLCQGLEWMMSR 175
1YZG_A      151 PWHIQSCCALTGEGLCQGLEWMTSR 175
1Z6Y_B      151 QWHIQACCALTGEGLCQGLEWMMSR 175
gi 71022941 152 TWQIFGCSALTGKGLTEGLDWLAHT 176
gi 17551732 153 KWQINGCCAVKGEGLPEALEWIANN 177
gi 26514148 152 PWHVQPCCALTGEGLPQGLDWIATQ 176
gi 57229193 155 EWQIMGCSALTGAGLMEGMDWLVTN 179
gi 70875594 159 TWTLMGCSAATGASLREAMAWVAQK 183
gi 15228912 152 DWHIQASCAVTGEGLYDGLGWIAQK 176
gi 66824125 155 DYHIQACCALTGQGLESGLDWLVSH 179

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