Conserved Protein Domain Family
Arl2l1_Arl13_like

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cd04161: Arl2l1_Arl13_like 
Arl2-like protein 1 (Arl2l1) and Arl13
Arl2l1 (Arl2-like protein 1) and Arl13 form a subfamily of the Arf family of small GTPases. Arl2l1 was identified in human cells during a search for the gene(s) responsible for Bardet-Biedl syndrome (BBS). Like Arl6, the identified BBS gene, Arl2l1 is proposed to have cilia-specific functions. Arl13 is found on the X chromosome, but its expression has not been confirmed; it may be a pseudogene.
Statistics
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PSSM-Id: 133361
View PSSM: cd04161
Aligned: 10 rows
Threshold Bit Score: 249.232
Threshold Setting Gi: 68129729
Created: 26-Sep-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
  next features
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Based on alignment to Arl2

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #######               ##                     #                           
gi 52139042  23 TLVMVGLDNAGKTATAKGIQGe-HPEDVAPTVGFSKIDLRQGKFQVTIFDLGGGKRIRGIWKNYYAESYGVIFVVDSSDE 101
gi 33598956  23 TLLMVGLDNAGKTATAKGIQGe-YPEDVAPTVGFSKINLRQGKFEVTIFDLGGGIRIRGIWKNYYAESYGVIFVVDSSDE 101
gi 57210115  23 TIPIIGLNNSGKTVLVEAFQKl-LPSKTDHCMKSELTTLLLDEYELSIYDLNGDLKGREAWPNYYAQAHGLVFVLDSSDI 101
gi 27545295  23 TLVMVGLDNAGKTATVRGIQGe-SPLDVAPTVGFSKVDLKQGKFEVTIFDLGGGKRIRGIWKNYYSESYGVVFVVDSSDV 101
gi 37590416  23 TVLVVGLDKAGKTSCVRGMLRv-PPGDVGPTHGCVRTELRLENYLVNILDIGGGLEVRGSWREHYGEAHGIIFVVDSSDR 101
gi 66730533  23 TIIVIGLDNSGKSHLVAAFQRl-IPSKMHSEMRPTQTTLLLDDYQVSVYDLTGDLKGREKWPNYYAEAHGLVFVVDSSDI 101
gi 47225339  23 TILVVGLDKAGKTCAIRGMSKasYTGETRPTQECIRNELRVDNYLVTLLDVGGSAELRGTWREHYGEAHGIIFVLDSSDK 102
gi 68129729 100 TLATFGLDRAGKTCALSVLESgeADKKYTPTVGFAPIKFPLDDYNLCVFDLGGAANFRGIWVHYYHDCFGIVYVIDSAAS 179
gi 71425205  78 TLGTFGLDNAGKTTLISALGGq-IEVNTTPTVGFTPTKFQTEKYDICIFDLGGAANFRGIWVHYFHDCHGLMFVIDSAAD 156
gi 71747426  77 TIGTFGIENAGKTTIISALGGn-IEKNPMPTVGFTPTRFQTDRCDLCIFDLGGGANFRGIWVHYFHDCHGFMFVIDSAAD 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    ## #                                 ###           
gi 52139042 102 e-RMEETKETMSEVLRHPRISGKPILVLANKQDKEgalgeaDVIECLSLeklv-nehkCLCQIEPCSAVlgygkkidKSI 179
gi 33598956 102 e-RMEETKEAMSEMLRHPRISGKPILVLANKQDKEgalgeaDVIECLSLeklv-nehkCLCQIEPCSAIsgygkkidKSI 179
gi 57210115 102 r-RMQEVKIILTHLLSDKRVAGKPILILANKQDKKkalmpcDIIDYLLLkklv-kenkCPCRVEPCSAIrnlerrnhQPI 179
gi 27545295 102 q-RIQETRDTMAEVLRHPRIAGKPVLVLANKQDQDgamaeaDIIETLSLeklv-nenkCLCQIEPCSAVlgygkkvdKSI 179
gi 37590416 102 q-RMKEVKETLVDLLKHPRVAGKPLLVLANKQDKMnallgnELIEILSLerlv-nqsrSLCHIEPCSASmdlrrwsdRKT 179
gi 66730533 102 a-RIQEVKIILTRLMFDKRVSGKPILILANKQDKKdallpcDIIEYLLLerlv-netkSMCRVEPCSTIrnlpkrhqQPI 179
gi 47225339 103 q-RIMEVKEILVDLLKEPRVSGKPLLVLANKQDKMnallgnELIEILSLeklv-nesrSLCHIEPCSALmdlrrwpdRRT 180
gi 68129729 180 deRVAESLKVLHETLQHPYVKGKPLLVLANKKDLPesr-gvGVVPQGFLeeamgepgaPHRVLATCAIEd------dPVL 252
gi 71425205 157 daVVRESLNVLRDLSQHRYIKGKPILVLANKKDLEnar-gtKVIPNGFLdklf-grntAYRVVASCGIEe------dPAL 228
gi 71747426 156 daVVEESLNALRTVAQHKHVRGKPVLVLANKKDLKssrgveIVSEGLLEelf---gdvSLYHLVPSCGIee-----dPEL 227
                       170
                ....*....|
Feature 1                 
gi 52139042 180 KKGLYWLLHI 189
gi 33598956 180 KKGLYWLLHV 189
gi 57210115 180 VEGLRWLLAV 189
gi 27545295 180 KNGLNWLLNN 189
gi 37590416 180 LRGLRWLLRA 189
gi 66730533 180 VIGLRWLLAA 189
gi 47225339 181 QRGLRWLLRA 190
gi 68129729 253 VEGIEWLLEA 262
gi 71425205 229 EEGVEWLLSV 238
gi 71747426 228 EKGVDWLLTK 237

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