Conserved Protein Domain Family
Arl9_Arfrp2_like

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cd04162: Arl9_Arfrp2_like 
Arf-like 9 (Arl9)/Arfrp2-like GTPase
Arl9/Arfrp2-like subfamily. Arl9 (Arf-like 9) was first identified as part of the Human Cancer Genome Project. It maps to chromosome 4q12 and is sometimes referred to as Arfrp2 (Arf-related protein 2). This is a novel subfamily identified in human cancers that is uncharacterized to date.
Statistics
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PSSM-Id: 133362
View PSSM: cd04162
Aligned: 8 rows
Threshold Bit Score: 250.443
Threshold Setting Gi: 9506653
Created: 26-Sep-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
  next features
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Based on alignment to Arl2

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #######               ##                     #                           
gi 62460578  34 DLVCIGLTGSGKTSLLSKLCSe-SPDSVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASS 112
gi 9506653   34 DLVCIGLTGSGKTSLLSKLCSe-SPDNVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASS 112
gi 49523127  41 DIVCIGLTGSGKTSLLTHLCNe-SQENIVPTTGFSIKAIPFQSAIMNVKELGGATNIRKYWSRYYQGSQGVIFVLDSASS 119
gi 37589537  79 EVLVLGLDGAGKSTFLRVLSGkpPLEGHIPTWGFNSVRLPTKDFEVDLLEIGGSQNLRFYWKEFVSEVDVLVFVVDSADR 158
gi 27734809  79 EVLVLGLDGAGKSTFLRVLSGkpPLEGHIPTWGFNSVRLPTKDFEVDLLEIGGSQNLRFYWKEFVSEVDVLVFVVDSADR 158
gi 41581483  20 QILVLGLDGAGKTSVLHSLASnrVQHSVAPTQGFHAVCINTEDSQMEFLEIGGSKPFRSYWEMYLSKGLLLIFVVDSADH 99
gi 45581709  52 QILVLGLDGAGKSSIIHALSTdtTRSSSAPTHGFNSAQILHQGLRIELLEVGGSHNLRTYWKQYLKNAHIMVFVVDSTDS 131
gi 62859163  95 QILVLGLDGSGKTSVLNSIVTnrGNHSTVPTEGVHAVCITNGNSKMEFLEVGGSEQLRQFWERYLDRALALIYVVDSSDH 174
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    ## #                                      ###      
gi 62460578 113 edDLETARNELHSALqhpqlctLPFLILANHQDKPaar--svqEVKKYFelep------largKRWILQPCSLDd----- 179
gi 9506653  113 edDLEAARNELHSALqhpqlctLPFLILANHQDKPaar--svqEIKKYFelep------largKRWILQPCSLDd----- 179
gi 49523127 120 edDLETARNELHSALqhpqlctLPFLILANHQDKPaar--svqEIKKYFelep------largKRWILQPTSVDn----- 186
gi 37589537 159 l-RLPWARQELHKLLdkd--pdLPVVVVANKQVRAvrgqlgpgDIHSEMleqgqgalpgpmawRGWLRCCPHLFylcp-- 233
gi 27734809 159 l-RLPWARQELHKLLdkd--pdLPVVVVANKQDLSeam--smgELQRELglqa------idnqREVFLLAASIApa---- 223
gi 41581483 100 s-RLPEAKKYLHQLIaan--pvLPLVVFANKQDLEaay--hitDIHEALalse------vgndRKMFLFGTYLTkngsei 168
gi 45581709 132 r-RLHLARQELHQLLhee--pdLPLMVLANKQDRTtal--clpEIHSELslhr------itseREVTLLGTSAIsdgaah 200
gi 62859163 175 s-RLPLAKMHLHQLIqhs--ssLPLVVLANKQDLEnay--hitDIHDALalse------icekRKLYLIGTHVAtdgsel 243
                       170
                ....*....|....*..
Feature 1                        
gi 62460578 180 ---mEALKDSFSQLINL 193
gi 9506653  180 ---mDALKDSFSQLINL 193
gi 49523127 187 ---mEAVKDSFSMLLNL 200
gi 37589537 234 vlipASVFLPLCLPIIS 250
gi 27734809 224 ---gPTFEEPGTVHIWK 237
gi 41581483 169 pstmQDAKDLIAQLAAD 185
gi 45581709 201 strlQTVKTLLEERLQS 217
gi 62859163 244 pssiEDTRELLAQLLLE 260

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