1JV1,2ICY


Conserved Protein Domain Family
UGPase_euk_like

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cd04180: UGPase_euk_like 
Click on image for an interactive view with Cn3D
Eukaryotic UGPase-like includes UDPase and UDPGlcNAc pyrophosphorylase enzymes.
This family includes UDP-Glucose Pyrophosphorylase (UDPase) and UDPGlcNAc pyrophosphorylase enzymes. The two enzymes share significant sequence and structure similarity. UDP-Glucose Pyrophosphorylase catalyzes a reversible production of UDP-Glucose and pyrophosphate (PPi) from Glucose-1-phosphate and UTP. UDP-glucose plays pivotal roles in galactose utilization, in glycogen synthesis, and in the synthesis of the carbohydrate moieties of glycolipids , glycoproteins , and proteoglycans . UDP-N-acetylglucosamine (UDPGlcNAc) pyrophosphorylase (UAP) (also named GlcNAc1P uridyltransferase), catalyzes the reversible conversion of UTP and GlcNAc1P from PPi and UDPGlcNAc, which is a key precursor of N- and O-linked glycosylations and is essential for the synthesis of chitin (a major component of the fungal cell wall) and of the glycosylphosphatidylinositol (GPI) linker anchoring a variety of cell surface proteins to the plasma membrane. In bacteria, UDPGlcNAc represents an essential precursor for both peptidoglycan and lipopolysaccharide biosynthesis.
Statistics
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PSSM-Id: 133023
View PSSM: cd04180
Aligned: 4 rows
Threshold Bit Score: 322.968
Threshold Setting Gi: 116668103
Created: 17-Oct-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:active site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            ####          #                                            #               
1JV1_A      103 VAVLLLAGGQGTRLGVAYPKGMydvglpsrktLFQIQAERILKLQQvaeky--ygnkcIIPWYIMTSGrtMESTKEFFtk 180
2ICY_A       80 LVVLKLNGGLGTTMGCTGPKSVievr--dgltFLDLIVIQIENLNNky--------gcKVPLVLMNSFntHDDTHKIVek 149
gi 18423407 129 AAFVLVAGGLGERLGYNGIKVAlpretttgtcFLQHYIESILALQEasnkidsdgserDIPFIIMTSDdtHSRTLDLLel 208
gi 89284305 159 VALVIMAGGRNLRYDKDLVKSStdiglpssqcIMELIGRKLWTLKEidl------yssKLLEQLFNQKymAEKFQCYFqs 232
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #                          # ##                           #      
1JV1_A      181 hkyfglkkeNVIFFQQGmlpamsfdgki---ileeknkvsmaPDGNGGLYRALAaqnIVEDMEqRGIWSIHVYCVDNILV 257
2ICY_A      150 yt---nsnvDIHTFNQSkyprvvadefvpwpskgktdkegwyPPGHGDVFPALMnsgKLDTFLsQGKEYVFVANSDNLGA 226
gi 18423407 209 nsyfgmkptQVHLLKQEkvaclddndarlaldphnkysiqtkPHGHGDVHSLLYssgLLHKWLeAGLKWVLFFQDTNGLL 288
gi 89284305 233 in---qknsYPITDMQGklilknd------------tqchlfPCGTGDVVLQLIhnrHLNKLVeKGYRYIHFIGVENLLV 297
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1JV1_A      258 KvadPRFIGFCIQKgaDCGAKVVEKtnptepVGVVCrvd----gvYQVVEYSeislataqkr--------ssdgrllfnA 325
2ICY_A      227 Iv-dLTILKHLIQNknEYCMEVTPKtladvkGGTLIsye----gkVQLLEIAqvpdehvne----------fksiekfkI 291
gi 18423407 289 FnaiPASLGVSATKqyHVNSLAVPRkakeaiGGISKlthvdgrsmVINVEYNqldpllrasgfpd--gdvncetgfspfP 366
gi 89284305 298 KpldPLFIGIASENrkAINQKIVQVdrn-esEFYRIani---ngrASLLEFDsikkllkqkmvnnksqipkdiddapafL 373
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                                                              
1JV1_A      326 GNIANHFFTvpFLRDVVNvyepqlqhhvaqkkipyvdtqgqlikpdkpngikmekfvfDIFQFakKFVVYEVLRed-eFS 404
2ICY_A      292 FNTNNLWVNlkAIKKLVEadalkmeiipnpke------------vdgvkvlqletaagAAIRFfdNAIGVNVPRs--rFL 357
gi 18423407 367 GNINQLILElgPYKDELQktggaikefvnpkykdst----ktafksstrlecmmqdypKTLPPt-ARVGFTVMDiwlaYA 441
gi 89284305 374 FNTLISINFlvEFSHRVDlkqafeskclqltqetpqen-lvqqqngennilifekqigDIIELtdDINFVMVHEae-eFA 451

                ....
Feature 1         # 
1JV1_A      405 PLKN 408
2ICY_A      358 PVKA 361
gi 18423407 442 PVKN 445
gi 89284305 452 PIIF 455

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