1H5R,1G97,1LVW,2GGO,2PA4,1TZF


Conserved Protein Domain Family
NTP_transferase

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cd04181: NTP_transferase 
Click on image for an interactive view with Cn3D
NTP_transferases catalyze the transfer of nucleotides onto phosphosugars.
Nucleotidyltransferases transfer nucleotides onto phosphosugars. The enzyme family includes Alpha-D-Glucose-1-Phosphate Cytidylyltransferase, Mannose-1-phosphate guanyltransferase, and Glucose-1-phosphate thymidylyltransferase. The products are activated sugars that are precursors for synthesis of lipopolysaccharide, glycolipids and polysaccharides.
Statistics
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PSSM-Id: 133024
View PSSM: cd04181
Aligned: 159 rows
Threshold Bit Score: 129.623
Threshold Setting Gi: 126465683
Created: 14-Nov-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site
Evidence:
  • Structure:2pa4_a; Udp-Glucose Pyrophosphorylase FromCorynebacteria Glutamicum In Complex With Magnesium And UDP-Glucose.
    View structure with Cn3D
  • Comment:Active site with UDP-glucose and two Mg++ molecules bound

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           ####             ##                                                        # 
1H5R_A         6 GIILAGGsGTRLYPvtmavSKQLLPiyDKPMIYYPLSTLMlagirDILIISTpqdTPRFQQLLgdgsq-wglnLQYKVQP 84
gi 19917033    3 AVVLVAGkGTRMEPltsdcPKVMLKvaNKPILEHILNSAIeagieGFIFITGy-lEEQIKAHFgdgsk-wevsIEYVQQK 80
gi 73660086    3 AVILAAGeGSRMRPltftrPKVMLPiaGKPILEHLLMEVSaagikEFVLVVGy-rDEQVRSYFadgak-wgvkISYCQQT 80
gi 2622712     3 AVILTAGeGTRMRPltltrPKTMLPvaGKPILQYSVDALRdngvhDIVMITGy-hEEAVRSHFgdgsg-sgvnITYVRQE 80
gi 148642715   5 AIILSAGeGSRMRPltltkPKTMLPvaGKPIIQYNIESLRdngitDILLIVRy-kEEIVRNYFgdgsd-fgvnISYKTQK 82
2GGO_A         3 AFILAAGsGERLEPithtrPKAFVPilSKPLIEYQIEYLRkcgirDITVIVSsknKEYFEKKLk--------eISIVTQK 74
gi 15897645    3 AVVLAAGkGERLEPithtrPKPFVPvlETPLILRHIRILKkyinkIIIVINSn-hKDYFKTIEg---------VSLVEQT 72
gi 126465748   4 AIILAAGkGLRLRPitetrPKPLIPvlCKPLLQWQLEALAginevDEVVIVVsylKEQVEQFVgkln--mpfkITLLDQG 81
gi 163798592  31 ALILCAGkGTRLRPltdntPKPMIPiaGKPIVVHLVDKIKds-vnNIYILVGy-qKEAIINYFtsneeyynynIQFIEQI 108
gi 38258700    3 AIILCAGkGERLRPltenrPKPMIPiaGKPILQHIIEKVEdl-vdNIYLIVKy-kKEKIVDYFknh-----pkIKFLEQG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        # ##                                            
1H5R_A        85 sp-dGLAQAFIIGeefi-------ggddCALVLGDNIFyghdlpklmeaavnkesGATVFAyhvndperYGVVEfdkngt 156
gi 19917033   81 eq-lGTANAIGYArghv--------egaFLVLNGDMLIeqedlka----lvsreeEAVICVkevenpsdFGVLEten-dk 146
gi 73660086   81 rq-lGTAHALKQLenql--------egnFLVMNGDILAesadis-----alaagsETTLSVlevsdpssLGVLEtdg-dr 145
gi 2622712    81 er-lGTAHAIGQAseli--------ddeFIVLNGDIITdpglmgdligsyherkpETLMVLrevpdpssFGVVKveg-dr 150
gi 148642715  83 df-lGTANAISYGedfi--------ddsIIVLNGDIILddeiiheiikkynylspDTLMLLtevedpsaFGVVEien-gn 152
2GGO_A        75 ddikGTGAAILSAkfn----------deALIIYGDLFFsnekeic----niitlkENAIIGvkvsnpkdYGVLVldnqnn 140
gi 15897645   73 eg-kGTAAALRAAekyle------gdeeFLVIYGDLLFeedald-----kivnteGEAILAresedprkFGVIVkdsenr 140
gi 126465748  82 ee-lGTGDAILKAirkr-------gidgKILIIYGDIFlkdwnel---kqlvltrKDFIVGvevdnpsdYGVIVvdeyns 150
gi 163798592 109 kq-lGTGHAVLMLkeylesnnaledlndFLVINGDIVFednlndfi--nediddsKNYMGAlrvpnpenFGVILtdndnn 185
gi 38258700   76 ei-dGTGQAVLTAkdyv--------ddeFLVINGDIIFeddle-------eflkyKYAVAVkevknpenFGVVVlddenn 139
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                             #                                                         
1H5R_A       157 aISLEEKPlepk-----snyaVTGLYFYDn-DVVQMAknlkpsargeleITDINRIYleq-grLSVAMmgrgyAWLDTG 228
gi 19917033  147 vVRIIEKPknpp-----tnlaNAGIYLFRe-SIFDFIdktqpsvrreleITDSIQMLins-gaPVGYSsl-egRWIDIG 217
gi 73660086  146 vRCIHEKSanpp-----anlaNAGLYLFTp-RIFKAIsdtplsprgeyeITSSIQLLidn-gtEVGYRrl--vYWQDVS 215
gi 2622712   151 vREIIEKPgpdag---agnliNTGIYVFSp-AVFDYIertplsrrgeyeITDTIMMQvrddlpVRAIIsd--rDWIDVG 223
gi 148642715 153 iKNIVEKPkreea---psnlvNAGIYIFNk-DIFDKIreteisergeyeITDSVSLQiednktVIGHKts--kDWIDVG 225
2GGO_A       141 lSKIIEKPeipp-----snliNAGIYKLNs-DIFTYLdkisisergeleLTDAINLMakd-hrVKVIEye--gYWMDIG 210
gi 15897645  141 lVRIVEKPenpp-----sniiNAGIYKFTy-DIFSYIdkislssrgefeLTDAVNLIgn---kVKVVTyn--gIWLDIG 208
gi 126465748 151 fKGIIEKPaipp-----snliNAGLYFLDarDILKHSdielsp-rgeleFTDILSSMarngveIKVYQls-kgKWIDIG 222
gi 163798592 186 iLKIVEKPskeelpslnsnlvNAGIYRFKk-DIFDILkdlkpslrneieLPDAIDELils-hkIKAITin--gYWDDIG 260
gi 38258700  140 iIELQEKPenpk-----snliNAGIYKFDk-KIFELIektkisergereLTDAIKHLike-ekVKGIKln--gYWNDVG 209

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