Conserved Protein Domain Family
GT2_RfbC_Mx_like

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cd04184: GT2_RfbC_Mx_like 
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis.
The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.
Statistics
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PSSM-Id: 133027
View PSSM: cd04184
Aligned: 36 rows
Threshold Bit Score: 249.427
Threshold Setting Gi: 107021960
Created: 6-Dec-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:Probable Catalytic site
Evidence:
  • Comment:Residues conserved among GT families of 2, 7, 13 and 43

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                               #                                         
gi 117927933  210 PTISVLVPVHNaaerWLRRCIDSVLAQSYPYWQLCLADDASSAPHVRQvleeyaarDARITAIFRpvnGHISAASNSALD 289
gi 114329054  417 VRLSIVMPVYNtpqdWLIEALNSVRAQWCDNWELLCINDASSEPHVETilrayaqqDPRIRILRTgnnVGIARATNFGLR 496
gi 139439186  289 PLVSIVVPCYKtdrvYLRELLDSVLAQSYDNWELLLMDASPEWDAVADlaa--gahDERVRRFGLpgnGGIVVNTNAGIE 366
gi 21109976    85 GMISVIIPVCNtpelFLREAIESVRTQTYQNWEICIHDDASNEPHVGRilaefkkrIPNLRVTRSetrSGIAATTNAALA 164
gi 17133623   478 PVLSIILPVYKlpltVLQETINSVIQQTYSNWELCIAFADIDNYQTIDylktlslqEKRIKLKVMaenKGISGNSNVSLN 557
gi 116625989  121 PLVSLIMPVYQpnleWLMAAVKSVRTQTYDDWQLLIVLDGGPSREVLNylqp-lasEDPRIQCLFsdrGGISSTLNLGLS 199
gi 116071634  681 SVISFIVPIFKtpllYLQQLLSSVQSQSYPNWELCLGGGDLDQDVLSYlnykmlsdHRIKYIEVNsseQGISVNSNAAIS 760
gi 2498851    319 PLISLVTPVHDaseaFLRECLASVSSQVYADWEWLLVDDASTAPHLARilreaaerESRIRVLTAsseGDTARATNEGFA 398
gi 147678915   77 PLISTILPLANieikYLEQTLNSVLRQAYPCWELCAVATDKINPYVIEiykkyqsiDDRFRLSFIsfnSGVVQVANAALS 156
gi 160939977  182 PMLSVVIPAYKtperYLREMLDSIMEQTYTNWEICVADGSPRGEGLERvlkkyadrDRRVRYEILgsnRGISGNTNAALD 261
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##                                                                   
gi 117927933  290 AAQGDFIALLDHDDELAPDALLHvaall---nehpdADMIYSDEDKin-edGVRQEPFFKPDWSPELLLSh-mYTCHLGV 364
gi 114329054  497 AASGQYVTFMDHDDYLEPDAVYHllkaa----getqADFIYSDEATtdeniASIAEVRGRPAFSHDYYLSh-pYIVHMLC 571
gi 139439186  367 QAMGDYIAFLDHDDILEPDALFHyvaalnnaaegerPQVLFCDEDMfq-ktGEWGQPVFKTKLNVDLLYSh-nCVTHFLM 444
gi 21109976   165 SARGRWVTFLDHDDVLDRNALAAvvdch----iktgSAVVYTDHDMlg-edGRLRNPYFKPDWNYDLFLAq-mYLGHLVS 238
gi 17133623   558 MASGEFVALLDHDDLLAPFAFYEvisel---nkqpdLDFIYSDKDCis-anSMVRSRLLLKPEWSPEILYsanYLTHLCI 633
gi 116625989  200 VCSGGYAAFIDQDDTLEPTALAHvaaai----thdePDIIYTDEDYvd-erGAAHLPLFKPAWSPALLFSc-mYFGHLIV 273
gi 116071634  761 ICTGKYIALLDHDDLLSANCALEiisih----eendCDFVYTAEDKvdgtgLNFYGPVYKNVYSEEKLLKn-nYITHLSS 835
gi 2498851    399 ACRGDFVGFLGAEDTLSPHALAEvalaf---laqpeLALLYTDEDGld-aqGHRSAPFFKPDWSPDLLRSv-dYVRHFLV 473
gi 147678915  157 MCVGEFVGFLDCGDELAPHALLEivkll---nrepkIDAIYTDEDRln-nkNKRSRPLFKPGWSPDLLLSm-nYVGRYLA 231
gi 160939977  262 MARGDFVILADHDDTLPPNAFYEvvkai---nenpdCQVIYSDEDKldmdgKALFDPHFKPDFNPDLLTSv-nYICHLFV 337
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
Feature 1                             #                          
gi 117927933  365 YRTELVRRIGGFrlgfegSQDYDLVLRLteqtdrIYHIPRVLYHWRR 411
gi 114329054  572 LKRELAHQLGGWdesmaiSADVDFVLRIiehartIAHVPRVLYRWRT 618
gi 139439186  445 VEKALIDRIGTSpedvagAQDYDLTLRClaagarFEHVAHVLYHWRV 491
gi 21109976   239 FEHDLIKRVGLTrsecdgSQDYDLVLRCvaagakVGHVPRVLYHWRM 285
gi 17133623   634 ARRTLLEKIGGFrpetdgAQDWDLFLRItentsrIARINSVLYHWRI 680
gi 116625989  274 VNTERARKIGGFrtaydgAQDYDFVLRLtdedarVVHIPRVLYHWRR 320
gi 116071634  836 FSRELIKEIGGFrpeydgAQDYDLILRAsshakkIFYLPRVLYHWRV 882
gi 2498851    474 VRRETLAQVGGLregfdgAQGHDLMLRLseatssIGHITEPLYHARE 520
gi 147678915  232 VRKSLLDKLNGFredvegVHYHDMLLRLseltknIVRLPEVLYHRRS 278
gi 160939977  338 IRQDLLKQVGGFrqefdgAQDYDFIFRCteaakrVYHIPKVLYHWRC 384

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