Conserved Protein Domain Family
GT_2_like_c

?
cd04186: GT_2_like_c 
Subfamily of Glycosyltransferase Family GT2 of unknown function.
GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.
Statistics
?
PSSM-Id: 133029
View PSSM: cd04186
Aligned: 51 rows
Threshold Bit Score: 127.29
Threshold Setting Gi: 54040191
Created: 5-Jul-2006
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
Feature 1:Probable Catalytic site
Evidence:
  • Comment:Residues conserved among GT families of 2, 7, 13 and 43

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                  #                                      
gi 91202670    43 IIIPVFnkveYTKKCLEALFkntp-------gdiyEIIVVDNASSDETpeflkrmin--------klevitnqeNMGFTS 107
gi 34499335   557 VIIPSKdkleCLTPCLQSLFritg-------yqnfEVLIVDNGSEDPEtfefyqemkaqh---pdririlsydaPFNFSA 626
gi 108758629    8 ISIVNHsnpeLLHDCLRTLYattr-------dssfEVWIVDNATGGRGvdamrrdfp--------qvrwlfnteRKGFSA 72
gi 60492498     7 TIVTYKnpdsVLLKAINSFLntk---------levRLYIIDNSPTDYLkdisydpr----------veyifmnsNNGFGA 67
gi 76580750    54 SIVVYRpdvrQLTRTLSSLLvalekldgsrpgartALYLVDNGGAPGSlpafdemlarg-----idctvinghgNVGYGR 128
gi 83746217     7 SIVLYNnpidQIRHCIESLQvda----------rvHVLLVDNSENKGSyaglaaen----------veildapgNVGFGR 66
gi 3608391      8 TISIVTynsrYIFNVLDQLKaelgt------dsiyDIHIYDNHSETAYleklttyep--------fitihraeeNQGFGH 73
gi 82523731    15 SIVLHNsclmLLRRTLHSLFiaireaqqtdclryvTVTLVDNASGRYYreeletlvanwpesagcqlmcslqpgNRGFGH 94
gi 54040191    10 ITVPVFgqheYTHALVADLEre-----------gaDYLIVDNRGDYPRigterv---------------stpgeNLGWAG 63
gi 3135684      6 SVVVYReteeTLDDLLDSLAaqasc-----pdtvvRVWLRNNDPADADrwdrfvhdrswy---pfeisishspqNVGFGR 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              ##                                                         
gi 91202670   108 ACNQGAkia---kgnYLVFLNNDTEPQPGWLesmvkl-aesdsKIGIVGSKlvypdgrlqeaggiifcdgsgs------- 176
gi 34499335   627 QCNLGArea---rgeYLLLLNNDTEVIFPQWlermla-taqqpGVGAVGARllypevglvqhagivlgmpggmysva--- 699
gi 108758629   73 NHNQVLrqa---rgrHFCIFNDDTIVHEGAFdalvrf-mddnpRVGMAGARllnadgtiqnctfrpmslagqlfdivf-- 146
gi 60492498    68 GHNVILrdpe-kmgkYHLILNPDISFEEGTLeklydy-megklDVGNVMPKviypngelqylckllptpkdwivrmflp- 144
gi 76580750   129 GHNHAIerv---asrYHLILNPDVDLDENALvtaidf-fdahsDVGLVAPRvddeqghtqylcrryptlfdlfvrgfmpa 204
gi 83746217    67 GHNLVLgrlaalrseVHLVVNPDIVVKPGCVqsvtdv-lrqrkDVALVGPRvvspdgdlyrsckllptpwnlfarrfa-- 143
gi 3608391     74 GHNQVLfna---stkYAIIFNPDVLVTKDVLdrlldr-ikidkNIAVVSPKvlnedgttqylvrqkldvfdymlrfipfq 149
gi 82523731    95 GHNTVIegl---ksdYHLVLNPDVELEKDTLcvglsa-leankDIVLVSPRvngeagdqeflckryptvlvlllrgfapg 170
gi 54040191    64 GSELGFrlafaegysHAMTLNNDTRVSKGFVaalld--srlpaDAGMVGPMfdvgfpfavadekpd-------------- 127
gi 3135684     78 AHNATFema---dapFFFVLNPDTRLHSTAVsalrkaidtsagDVGAWELRqlpyehpkly------------------- 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 91202670   177 ---------nfgrggnpyeegfndacevdyCSGACLLVRkelFENIGGMDHRYSp--aYYEETDLCFAAreKGYTVMYAP 245
gi 34499335   700 ----dhifegmdylypgymnrsltmqnysaVTAACLLVEkqiYDLVGGFDEESLq--vCFNDVDFCLKVqaAGLRNVYNP 773
gi 108758629  147 ---lprplhflkamaidpaqyghdearvswVLGACIVVReeaLAEVGLLDEQMSpl-gNTEDTDWCVRAwkAGWEVAFCP 222
gi 60492498   145 ---iksiknridynfemkfadydremnipyLSGCFMFLRksvIEGIGVFDEGIFm---YGEDTDLNRRIy-RKYKTMYYP 217
gi 76580750   205 girnafsrrlaryemrdvinatdvvwdpaiVSGCFMLFRtdvLKALGGFDARYFl---YFEDYDLSLRTh-DVARVAYVP 280
gi 83746217   144 ---prpfyaaadaryelqafdydrelrlhnLSGAFLAFRseaFAALGGFDPRYFm---YLEDVDICRRAa-SLGAVIFVP 216
gi 3608391    150 --fvkkifdkrlsiyecrdlsdtettdikmGSGCFMLIDrekFVEIGGFDERFFm---YFEDNDLCLRFgkAGYRILYTP 224
gi 82523731   171 -fflrlfhnrlsayemrdqcrsdqpvdvaiASGCFMLVRspvLRDVGGFDETFFl---YFEDFDLSLRLe-GCGRLVFEP 245
gi 54040191   128 ---------------aesyvpraryrkvpaVEGTALVMSrdcWDAVGGMDLSTFgrygWGLDLDLALRArkSGYGLYTTE 192
gi 3135684    136 ---------------------dpvslstdwVTGAAVVFRraaFAQVRGFEPRIFm---YGEDVDLSWRMraAGWVLHYVP 191

                  ....*...
Feature 1                 
gi 91202670   246 nsvvIHHE 253
gi 34499335   774 fvvlYHSH 781
gi 108758629  223 eaviTHLT 230
gi 60492498   218 qvtiTHHF 225
gi 76580750   281 rvliRHYG 288
gi 83746217   217 qaevVHEH 224
gi 3608391    225 fetvVHMY 232
gi 82523731   246 smriLHHG 253
gi 54040191   193 mayiNHFG 200
gi 3135684    192 havvVHPT 199

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap